EA200901486A1 - СОЕДИНЕНИЯ И КОМПОЗИЦИИ, КАК ИНГИБИТОРЫ КИНАЗЫ c-KIT И PDGFR - Google Patents

СОЕДИНЕНИЯ И КОМПОЗИЦИИ, КАК ИНГИБИТОРЫ КИНАЗЫ c-KIT И PDGFR

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Publication number
EA200901486A1
EA200901486A1 EA200901486A EA200901486A EA200901486A1 EA 200901486 A1 EA200901486 A1 EA 200901486A1 EA 200901486 A EA200901486 A EA 200901486A EA 200901486 A EA200901486 A EA 200901486A EA 200901486 A1 EA200901486 A1 EA 200901486A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
kit
compositions
kinase inhibitors
pdgfr kinase
Prior art date
Application number
EA200901486A
Other languages
English (en)
Other versions
EA019524B1 (ru
Inventor
Сяолинь ЛИ
Сяодон Лю
Валентина Мольтени
Донателла Чянелли
Джон Лорен
Джульет Набакка
Тимоти Рамси
Вернер Брайтенштайн
Original Assignee
Айрм Ллк
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айрм Ллк, Новартис Аг filed Critical Айрм Ллк
Publication of EA200901486A1 publication Critical patent/EA200901486A1/ru
Publication of EA019524B1 publication Critical patent/EA019524B1/ru

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

В заявке описаны новый класс соединений, фармацевтические композиции, включающие такие соединения, и способы применения таких соединений для лечения или предупреждения заболеваний или нарушений, связанных с аномальной или характеризующейся нарушенной регуляцией активностью киназы, в особенности заболеваний или нарушений, которые включают аномальную активацию киназ c-kit, ТРФРРα и ТРФРРβ.
EA200901486A 2007-05-04 2008-05-02 СОЕДИНЕНИЯ И КОМПОЗИЦИИ КАК ИНГИБИТОРЫ КИНАЗЫ с-kit И PDGFR EA019524B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91605107P 2007-05-04 2007-05-04
PCT/US2008/062568 WO2008137794A1 (en) 2007-05-04 2008-05-02 Compounds and compositions as c-kit and pdgfr kinase inhibitors

Publications (2)

Publication Number Publication Date
EA200901486A1 true EA200901486A1 (ru) 2010-06-30
EA019524B1 EA019524B1 (ru) 2014-04-30

Family

ID=39595782

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901486A EA019524B1 (ru) 2007-05-04 2008-05-02 СОЕДИНЕНИЯ И КОМПОЗИЦИИ КАК ИНГИБИТОРЫ КИНАЗЫ с-kit И PDGFR

Country Status (11)

Country Link
US (1) US8338417B2 (ru)
EP (1) EP2152688A1 (ru)
JP (1) JP5160637B2 (ru)
KR (1) KR101145520B1 (ru)
CN (1) CN101720322A (ru)
AU (1) AU2008247442B2 (ru)
BR (1) BRPI0811516A2 (ru)
CA (1) CA2686382C (ru)
EA (1) EA019524B1 (ru)
MX (1) MX2009011951A (ru)
WO (1) WO2008137794A1 (ru)

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CN104458675A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选干细胞因子受体激酶抑制剂高通量筛选方法
CN104458674A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选血管内皮生长因子1激酶抑制剂高通量筛选方法
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CA2686382A1 (en) 2008-11-13
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