EA200100140A1 - Терапевтическая композиция на основе флавоноидов для применения в лечении опухолей цитотоксическими агентами - Google Patents

Терапевтическая композиция на основе флавоноидов для применения в лечении опухолей цитотоксическими агентами

Info

Publication number
EA200100140A1
EA200100140A1 EA200100140A EA200100140A EA200100140A1 EA 200100140 A1 EA200100140 A1 EA 200100140A1 EA 200100140 A EA200100140 A EA 200100140A EA 200100140 A EA200100140 A EA 200100140A EA 200100140 A1 EA200100140 A1 EA 200100140A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tumors
treatment
cytotoxic agents
flavonoids
application
Prior art date
Application number
EA200100140A
Other languages
English (en)
Inventor
Франсис Дарро
Роберт Кисс
Арман Фридман
Original Assignee
Лаборатуар Л. Лафон
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лаборатуар Л. Лафон filed Critical Лаборатуар Л. Лафон
Publication of EA200100140A1 publication Critical patent/EA200100140A1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Изобретение касается композиции, обладающей активностью в отношении пролиферации клоногенных клеток в опухолях и включающей терапевтически эффективное количество флавоноида, в частности соединения, выбранного из соединений формулы (I)в которой R, R, Rи R, Rи Rтаковы, как они определены в п.2. формулы изобретения. Указанная композиция предназначена для применения в лечении опухолей цитотоксическими агентами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100140A 1998-07-15 1999-07-13 Терапевтическая композиция на основе флавоноидов для применения в лечении опухолей цитотоксическими агентами EA200100140A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9809058A FR2781153B1 (fr) 1998-07-15 1998-07-15 Composition therapeutique a base de flavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques
PCT/FR1999/001714 WO2000003706A1 (fr) 1998-07-15 1999-07-13 Composition therapeutique a base de flavonoïdes destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques

Publications (1)

Publication Number Publication Date
EA200100140A1 true EA200100140A1 (ru) 2001-06-25

Family

ID=9528648

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100140A EA200100140A1 (ru) 1998-07-15 1999-07-13 Терапевтическая композиция на основе флавоноидов для применения в лечении опухолей цитотоксическими агентами

Country Status (12)

Country Link
EP (1) EP1096930A1 (ru)
JP (1) JP2002520356A (ru)
KR (1) KR20020003349A (ru)
CN (1) CN1139384C (ru)
AU (1) AU4789099A (ru)
BR (1) BR9912816A (ru)
CA (1) CA2337179A1 (ru)
EA (1) EA200100140A1 (ru)
FR (1) FR2781153B1 (ru)
IL (1) IL140588A0 (ru)
WO (1) WO2000003706A1 (ru)
ZA (1) ZA200100239B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069949A2 (en) * 2001-03-06 2002-09-12 Prendergast Patrick T Combination therapy for reduction of toxycity of chemotherapeutic agents
AU2003217982A1 (en) * 2002-03-06 2003-09-22 The Medical Research And Education Trust Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol
EP1808172A3 (en) * 2002-03-06 2010-05-26 Activephyto Technologies Limited Botanical extract compositions and methods of use
US20030229136A1 (en) 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
CN1679539A (zh) * 2005-01-20 2005-10-12 吴一心 抗肿瘤的协同药物组合物
US20060247305A1 (en) * 2005-03-11 2006-11-02 Regents Of The University Of Michigan Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof
GB0808974D0 (en) * 2008-05-16 2008-06-25 Veritron Ltd Plant extract and its therapeutic use
US9808439B2 (en) * 2015-07-29 2017-11-07 Macau University Of Science And Technology Use of tangeretin in cancer treatment
US9808477B2 (en) * 2015-07-29 2017-11-07 Macau University Of Science And Technology Use of nobiletin in cancer treatment
JP6775226B2 (ja) * 2016-06-30 2020-10-28 国立大学法人広島大学 抗癌剤作用増強物質およびそれを備えた抗癌剤キット
CN106562954A (zh) * 2016-11-11 2017-04-19 黄冈师范学院 (去甲基)多甲氧基黄酮联合紫杉醇类药物在制备治疗非小细胞肺癌的药物上的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0617304B2 (ja) * 1982-09-09 1994-03-09 理化学研究所 制癌剤
JPS5959627A (ja) * 1982-09-27 1984-04-05 Tatsuo Miyoshi 制癌剤
JPS60199817A (ja) * 1984-03-23 1985-10-09 Rikagaku Kenkyusho 制癌剤
JPS632925A (ja) * 1986-06-23 1988-01-07 Nippon Kayaku Co Ltd Cキナ−ゼ阻害剤および抗腫瘍剤
FR2633182B1 (fr) * 1988-06-23 1993-07-23 Beljanski Mirko Composition pharmaceutique anticancereuse et methode d'utilisation de l'invention
JPH04103532A (ja) * 1990-08-24 1992-04-06 Tatsuo Miyoshi 制癌剤
JPH04103529A (ja) * 1990-08-24 1992-04-06 Tatsuo Miyoshi 制癌剤
JP2514500B2 (ja) * 1991-09-14 1996-07-10 呉羽化学工業株式会社 多剤耐性抑制剤及び発現阻害剤
AU4272293A (en) * 1992-05-11 1993-12-13 Tsumura & Co. Apoptosis inducer
WO1996031206A2 (en) * 1995-04-07 1996-10-10 Warner-Lambert Company Flavones and coumarins as agents for the treatment of atherosclerosis
DE29719198U1 (de) * 1997-10-29 1998-04-23 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, 14558 Bergholz-Rehbrücke Flavono/Flavonoid-Zubereitung

Also Published As

Publication number Publication date
IL140588A0 (en) 2002-02-10
KR20020003349A (ko) 2002-01-12
ZA200100239B (en) 2002-01-09
FR2781153B1 (fr) 2001-08-03
JP2002520356A (ja) 2002-07-09
CA2337179A1 (en) 2000-01-27
EP1096930A1 (fr) 2001-05-09
CN1139384C (zh) 2004-02-25
FR2781153A1 (fr) 2000-01-21
CN1313765A (zh) 2001-09-19
WO2000003706A1 (fr) 2000-01-27
BR9912816A (pt) 2001-05-08
AU4789099A (en) 2000-02-07

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