EA200000748A1 - Способ введения мономерных аналогов инсулина - Google Patents

Способ введения мономерных аналогов инсулина

Info

Publication number
EA200000748A1
EA200000748A1 EA200000748A EA200000748A EA200000748A1 EA 200000748 A1 EA200000748 A1 EA 200000748A1 EA 200000748 A EA200000748 A EA 200000748A EA 200000748 A EA200000748 A EA 200000748A EA 200000748 A1 EA200000748 A1 EA 200000748A1
Authority
EA
Eurasian Patent Office
Prior art keywords
monomerial
introduction
insulin analogues
inhalation
administering
Prior art date
Application number
EA200000748A
Other languages
English (en)
Inventor
Ричард Деннис Димарчи
Роджер Гэррик Харрисон
Рональд Кейт Вольфф
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200000748A1 publication Critical patent/EA200000748A1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

(57) Заявленное изобретение относится к способу введения аналога инсулина с помощью ингаляции, способу лечения диабета путем введения аналога инсулина с помощью ингаляции и способу лечения гипергликемии путем введения аналога инсулина с помощью ингаляции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000748A 1998-01-08 1999-01-07 Способ введения мономерных аналогов инсулина EA200000748A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7075298P 1998-01-08 1998-01-08
PCT/US1999/000324 WO1999034816A1 (en) 1998-01-08 1999-01-07 Method for administering monomeric insulin analogs

Publications (1)

Publication Number Publication Date
EA200000748A1 true EA200000748A1 (ru) 2000-12-25

Family

ID=22097181

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200000748A EA200000748A1 (ru) 1998-01-08 1999-01-07 Способ введения мономерных аналогов инсулина
EA200000747A EA200000747A1 (ru) 1998-01-08 1999-01-07 СПОСОБ ВВЕДЕНИЯ AspB28-ИНСУЛИНА ЧЕЛОВЕКА

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200000747A EA200000747A1 (ru) 1998-01-08 1999-01-07 СПОСОБ ВВЕДЕНИЯ AspB28-ИНСУЛИНА ЧЕЛОВЕКА

Country Status (16)

Country Link
US (2) US20010007853A1 (ru)
EP (2) EP0951910A3 (ru)
JP (2) JP2002500192A (ru)
KR (2) KR20010033940A (ru)
CN (2) CN1287492A (ru)
AU (2) AU747619B2 (ru)
BR (2) BR9906796A (ru)
CA (2) CA2317739A1 (ru)
EA (2) EA200000748A1 (ru)
HU (2) HUP0100391A3 (ru)
IL (2) IL137105A0 (ru)
NO (2) NO20003051L (ru)
PL (2) PL342745A1 (ru)
TR (2) TR200001891T2 (ru)
WO (2) WO1999034816A1 (ru)
ZA (2) ZA99104B (ru)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
US6858199B1 (en) * 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
WO2001000674A1 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Insulin crystals for pulmonary administration
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
WO2002043580A2 (en) 2000-10-27 2002-06-06 Epic Therapeutics, Inc. Production of microspheres
EP1944016A1 (en) 2001-08-16 2008-07-16 Baxter International Inc. Propellant-based microparticle formulatons
US20030064033A1 (en) * 2001-08-16 2003-04-03 Brown Larry R. Propellant-based microparticle formulations
US7641823B2 (en) * 2001-12-07 2010-01-05 Map Pharmaceuticals, Inc. Synthesis of small particles
WO2003059253A2 (en) * 2001-12-21 2003-07-24 Smithkline Beecham Corporation Compositions and methods for altering glucose production
US6985798B2 (en) * 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
AU2003258985B2 (en) * 2002-06-27 2008-07-03 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US20070277820A1 (en) * 2003-10-27 2007-12-06 Timothy Crowder Blister packages and associated methods of fabricating dry powder drug containment systems
WO2005065756A2 (en) 2003-12-30 2005-07-21 Oriel Therapeutics, Inc. Dry powder nebulizers and associated methods of dispensing dry powders
US7624733B2 (en) 2004-02-09 2009-12-01 Oriel Therapeutics, Inc. Inhalers with extendable/retractable forward member and associated methods of dispensing inhalant substances
WO2006031775A2 (en) * 2004-09-13 2006-03-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
CA2618520C (en) * 2005-08-25 2015-01-27 Oriel Therapeutics, Inc. Drug containment systems with sticks, related kits, dry powder inhalers and methods
AU2007210177C1 (en) 2006-01-31 2012-11-01 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
EP2060268A1 (en) * 2007-11-15 2009-05-20 Novo Nordisk A/S Pharmaceutical compositions for pulmonary or nasal delivery of peptides
WO2010036836A1 (en) 2008-09-26 2010-04-01 Oriel Therapeutics, Inc. Dry powder inhalers with dual piercing members and related devices and methods
AU2009296538B8 (en) * 2008-09-26 2013-06-27 Oriel Therapeutics, Inc. Inhalers with airway disks having discrete airway channels and related disks and methods
WO2010036355A2 (en) 2008-09-26 2010-04-01 Oriel Therapeutics, Inc. Inhaler mechanisms with radially biased piercers and related methods
WO2010039200A2 (en) * 2008-09-30 2010-04-08 Oriel Therapeutics, Inc. Dry powder inhalers with endless strips and cooperating piercers and related methods
WO2010039201A2 (en) * 2008-09-30 2010-04-08 Oriel Therapeutics, Inc. Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods
MX2011003245A (es) * 2008-10-01 2011-04-26 Oriel Therapeutics Inc Inhaladores de polvo seco con mecanismos de perforacion giratorios y dispositivos y metodos relacionados.
JP5341532B2 (ja) * 2009-01-19 2013-11-13 第一電子工業株式会社 1対の誤嵌合防止キー及び該キーを用いた電気コネクタ
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
US9056173B2 (en) 2010-01-27 2015-06-16 Aespira Ltd. Dry powder inhaler
USD641076S1 (en) 2010-03-26 2011-07-05 Oriel Therapeutics, Inc. Dry powder inhaler
USD635246S1 (en) 2010-03-26 2011-03-29 Oriel Therapeutics, Inc. Dose disk for dry powder inhalers
US10238820B2 (en) 2014-01-08 2019-03-26 Seroton, Inc. Dry-powder inhalation device
US11491288B2 (en) 2014-01-08 2022-11-08 Seroton, Inc. Dispenser for dry-powder inhalation devices
WO2024100652A1 (en) 2022-11-07 2024-05-16 Kritzman Kadron Amnon High performance dry powder inhaler

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK179286D0 (da) * 1986-04-18 1986-04-18 Nordisk Gentofte Insulinpraeparat
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
US5230884A (en) * 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
EP0705275B1 (en) * 1993-06-21 1999-02-03 Novo Nordisk A/S Asp-b28 insulin crystals
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5451569A (en) * 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
AU5724996A (en) * 1995-05-05 1996-11-21 Eli Lilly And Company Single chain insulin with high bioactivity

Also Published As

Publication number Publication date
AU754707B2 (en) 2002-11-21
EA200000747A1 (ru) 2000-12-25
HUP0101293A2 (hu) 2001-08-28
IL137150A0 (en) 2001-07-24
AU2312299A (en) 1999-07-26
ZA99104B (en) 2000-07-07
CN1287491A (zh) 2001-03-14
HUP0100391A3 (en) 2001-12-28
KR20010033941A (ko) 2001-04-25
TR200001892T2 (tr) 2000-11-21
PL342745A1 (en) 2001-07-02
JP2002500193A (ja) 2002-01-08
HUP0100391A2 (hu) 2001-08-28
EP0951910A2 (en) 1999-10-27
KR20010033940A (ko) 2001-04-25
ZA99105B (en) 2000-07-07
CN1195543C (zh) 2005-04-06
BR9906813A (pt) 2001-03-20
WO1999034815A1 (en) 1999-07-15
JP2002500192A (ja) 2002-01-08
EP0951911A3 (en) 2002-06-19
CN1287492A (zh) 2001-03-14
NO20003051D0 (no) 2000-06-14
CA2317733A1 (en) 1999-07-15
EP0951910A3 (en) 2002-06-19
HUP0101293A3 (en) 2001-12-28
TR200001891T2 (tr) 2000-11-21
NO20003050L (no) 2000-06-14
NO20003051L (no) 2000-06-14
EP0951911A2 (en) 1999-10-27
CA2317739A1 (en) 1999-07-15
AU2107399A (en) 1999-07-26
US20010007853A1 (en) 2001-07-12
PL341592A1 (en) 2001-04-23
IL137105A0 (en) 2001-06-14
AU747619B2 (en) 2002-05-16
NO20003050D0 (no) 2000-06-14
BR9906796A (pt) 2000-11-14
US20010053761A1 (en) 2001-12-20
WO1999034816A1 (en) 1999-07-15

Similar Documents

Publication Publication Date Title
EA200000748A1 (ru) Способ введения мономерных аналогов инсулина
EA200100289A1 (ru) Способ введения инсулинотропных пептидов
ATE433324T1 (de) Verwendung von glp-1 oder analoge zur behandlung von schlaganfall
AP2000001888A0 (en) Method for treatment of diabetes using peptides analogues of insulin.
EP2022505A3 (en) GLP-1, exendin-4, peptide analogs and uses thereof
HK1008731A1 (en) Antibody for the treatment of insulin dependent diabetes
DE50015623D1 (de) Kovalent verbrückte insulindimere
DK0552256T3 (da) Fremgangsmåde til at behandle eller forebygge type 1 diabetes ved peroral indgivelse af insulin
PT915910E (pt) Analogos de exendina, processos para a sua preparacao e medicamentos que os contem
DE69738615D1 (de) Verwendung von glp-1 oder analogen zur behandlung von myokardischem infarkt
CY1110287T1 (el) Χρηση της ανθρωπινης παραθυρεοειδους ορμονης
CO4970787A1 (es) Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
CY1107584T1 (el) Μεθοδοι και συνθεσεις για την προληψη και θepαπεια της αναιμιας
MXPA05013340A (es) Composiciones y metodos para liberacion mucosal incrementada de la hormona del crecimiento.
EA200401365A1 (ru) Способы лечения илеуса
DK1146896T3 (da) Formuleringer, som indeholder monodisperse hexamere acylerede insulin-analoger
BR0308904A (pt) Método de tratamento de gastroparesia, e, uso de um composto de glp-1
ATE270306T1 (de) Einkettige insulinanaloge
DK0607278T3 (da) Fremgangsmåde til forstærkning af tarmabsorption
ATE157010T1 (de) Amylin oder amylinanaloga enthaltende zusammensetzung, welche auch wahlweise insulin enthält, zur behandlung von anorexie und verwandten zuständen
AR036591A1 (es) Uso de la hl en hiperestimulacion ovarica controlada
ES2181923T3 (es) 4-hidroxicumarin-3-carboxamidas para el tratamiento de la diabet es mellitus no dependiente de la insulina.
WO2002089848A3 (en) Use of an ampa receptor potentiator for the manufacture of a medicament for the treatment of type 2 diabetes
ECSP993116A (es) Procedimiento para administrar peptidos insulinotropicos
EA200000419A1 (ru) Применение тиазолидиндионов для лечения гипергликемии