DOP2016000251A - Inhibidores de las vías de señalización de wnt - Google Patents

Inhibidores de las vías de señalización de wnt

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Publication number
DOP2016000251A
DOP2016000251A DO2016000251A DO2016000251A DOP2016000251A DO P2016000251 A DOP2016000251 A DO P2016000251A DO 2016000251 A DO2016000251 A DO 2016000251A DO 2016000251 A DO2016000251 A DO 2016000251A DO P2016000251 A DOP2016000251 A DO P2016000251A
Authority
DO
Dominican Republic
Prior art keywords
compounds
inhibitors
wnt signaling
preparing
signaling road
Prior art date
Application number
DO2016000251A
Other languages
English (en)
Inventor
Kai Thede
Philip Lienau
Ningshu Liu
Stefan Golz
Ursula Mönning
Ludwig Zorn
Florian Puehler
Andrea Hägebarth
Daniel Basting
Franziska Siegel
Eckhard Bender
William Scott
Anja Giese
Dirk Schneider
Manfred Möwes
Jens Geisler
Original Assignee
Bayer Pharma Aktiengesellchaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiengesellchaft filed Critical Bayer Pharma Aktiengesellchaft
Publication of DOP2016000251A publication Critical patent/DOP2016000251A/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Abstract

La presente invención se refiere a inhibidores de las vías de señalización de Wnt de la fórmula general (I) como se describe y se define en la presente, a métodos de preparación de dichos compuestos, a compuestos intermediarios útiles para preparar dichos compuestos, a composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y al uso de dichos compuestos para producir una composición farmacéutica para el tratamiento o la prevención de una enfermedad, en particular de un trastorno hiperproliferativo, como un único agente o en combinación con otros ingredientes activos.
DO2016000251A 2014-03-20 2016-09-20 Inhibidores de las vías de señalización de wnt DOP2016000251A (es)

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JP (1) JP2017511309A (es)
KR (1) KR20160127838A (es)
CN (1) CN106459072A (es)
AP (1) AP2016009433A0 (es)
AU (1) AU2015233559A1 (es)
BR (1) BR112016021656A2 (es)
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CL (1) CL2016002354A1 (es)
CR (1) CR20160432A (es)
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DO (1) DOP2016000251A (es)
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IL (1) IL247366A0 (es)
MA (1) MA39761A (es)
MX (1) MX2016012173A (es)
PE (1) PE20170187A1 (es)
PH (1) PH12016501814A1 (es)
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MX2015013348A (es) 2013-03-20 2016-01-20 Bayer Pharma AG Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos.
SG10201914111XA (en) 2014-03-20 2020-03-30 Samumed Llc 5-substituted indazole-3-carboxamides and preparation and use thereof
WO2017167150A1 (zh) * 2016-03-31 2017-10-05 苏州云轩医药科技有限公司 一种3-氟吡啶杂环化合物及其应用
CN109879818A (zh) * 2019-04-04 2019-06-14 安徽丰乐农化有限责任公司 N-(4,6-二甲氧基嘧啶-2-基)-4-甲砜基-2-硝基苯甲酰胺的合成方法
CN115850202B (zh) * 2022-12-26 2024-06-25 上海科技大学 一种卷曲受体7的小分子抑制剂及其制备方法和应用

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BR9912729A (pt) * 1998-08-04 2001-05-02 Astrazeneca Ab Derivado de amida, processo para prepará-lo, e, uso do mesmo
KR20010110668A (ko) * 1999-03-17 2001-12-13 다비드 에 질레스 아미드 유도체
EP1720826A4 (en) * 2004-03-02 2007-10-31 Neurogen Corp HETEROALKYL SUBSTITUTED BIPHENYL-4-CARBOXYL ACRYLAMIDE ANALOG
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
DE602006021591D1 (de) * 2006-12-11 2011-06-09 Genetics Co Inc Aromatische 1,4-DI-Carboxylamide und deren Verwendung
WO2013093508A2 (en) * 2011-12-22 2013-06-27 Oslo University Hospital Hf Wnt pathway inhibitors
MX2015013348A (es) * 2013-03-20 2016-01-20 Bayer Pharma AG Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos.
CA2907528A1 (en) * 2013-03-20 2014-09-25 Bayer Pharma Aktiengesellschaft Novel compounds
AP2016009432A0 (en) * 2014-03-20 2016-09-30 Bayer Pharma AG Novel compounds

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PH12016501814A1 (en) 2016-11-07
CU20160139A7 (es) 2017-04-05
SG11201606913PA (en) 2016-10-28
AP2016009433A0 (en) 2016-09-30
BR112016021656A2 (pt) 2017-10-24
IL247366A0 (en) 2016-11-30
EA201691878A1 (ru) 2017-12-29
EP3119787A1 (en) 2017-01-25
CA2943001A1 (en) 2015-09-24
WO2015140196A1 (en) 2015-09-24
CN106459072A (zh) 2017-02-22
MA39761A (fr) 2017-01-25
MX2016012173A (es) 2017-01-19
PE20170187A1 (es) 2017-04-01
JP2017511309A (ja) 2017-04-20
AU2015233559A1 (en) 2016-09-15
CR20160432A (es) 2017-07-21
CL2016002354A1 (es) 2017-03-10
KR20160127838A (ko) 2016-11-04

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