DOP2006000243A - Derivados de pirazina - Google Patents

Derivados de pirazina

Info

Publication number
DOP2006000243A
DOP2006000243A DO2006000243A DO2006000243A DOP2006000243A DO P2006000243 A DOP2006000243 A DO P2006000243A DO 2006000243 A DO2006000243 A DO 2006000243A DO 2006000243 A DO2006000243 A DO 2006000243A DO P2006000243 A DOP2006000243 A DO P2006000243A
Authority
DO
Dominican Republic
Prior art keywords
compounds
pirazine
derivatives
preparation
pirazine derivatives
Prior art date
Application number
DO2006000243A
Other languages
English (en)
Inventor
Karl Richard Gibson
Cedric Poinsard
Melanie Susanne Glossop
Stephen Mark Denton
Mark Ian Kemp
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of DOP2006000243A publication Critical patent/DOP2006000243A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula y a sales y solvatos farmacéuticamente aceptables de los mismos, a procedimientos para su preparación, a intermedios útiles en su preparación y a composiciones que contienen dichos compuestos, y a los usos de dichos compuestos para el tratamiento de dolor.
DO2006000243A 2005-11-04 2006-11-03 Derivados de pirazina DOP2006000243A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73366205P 2005-11-04 2005-11-04

Publications (1)

Publication Number Publication Date
DOP2006000243A true DOP2006000243A (es) 2007-05-31

Family

ID=37890558

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2006000243A DOP2006000243A (es) 2005-11-04 2006-11-03 Derivados de pirazina

Country Status (27)

Country Link
US (1) US7572797B2 (es)
EP (1) EP1945630B1 (es)
JP (1) JP2009514937A (es)
KR (1) KR20080066073A (es)
CN (1) CN101356169A (es)
AP (1) AP2008004468A0 (es)
AR (1) AR057855A1 (es)
AT (1) ATE525372T1 (es)
AU (1) AU2006310215A1 (es)
BR (1) BRPI0618129A2 (es)
CA (1) CA2624621C (es)
CR (1) CR9954A (es)
DO (1) DOP2006000243A (es)
EA (1) EA200801011A1 (es)
EC (1) ECSP088412A (es)
ES (1) ES2371932T3 (es)
GT (1) GT200600475A (es)
IL (1) IL191059A0 (es)
MA (1) MA29926B1 (es)
NL (1) NL2000284C2 (es)
NO (1) NO20082496L (es)
PE (1) PE20070715A1 (es)
TN (1) TNSN08196A1 (es)
TW (1) TW200804353A (es)
UY (1) UY29893A1 (es)
WO (1) WO2007052123A2 (es)
ZA (1) ZA200803671B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0934061T6 (en) 1996-07-24 2015-01-26 Warner Lambert Co Isobutylgaba and its derivatives for the treatment of pain
EP1741708A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
MX2009011816A (es) 2007-05-03 2009-11-19 Pfizer Ltd Derivados de piridina.
JP2010526051A (ja) * 2007-05-03 2010-07-29 ファイザー・リミテッド 疼痛を治療するためのｎａｖ１．８チャネルモジュレーターとしてのｎ−［６−アミノ−５−（フェニル）ピラジン−２−イル］−イソオキサゾール−４−カルボキサミド誘導体および関連化合物
WO2009026434A1 (en) * 2007-08-21 2009-02-26 Alkermes, Inc. Pulmonary pharmaceutical formulations
KR101578235B1 (ko) 2007-12-10 2015-12-16 노파르티스 아게 유기 화합물
EP2241567A4 (en) 2008-02-13 2011-11-09 Eisai R&D Man Co Ltd Bicycloamine DERIVATIVE
EA019819B1 (ru) 2008-05-23 2014-06-30 ПАНМИРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Кристаллическая полиморфная форма с ингибитора белка, активирующего 5-липоксигеназу, фармацевтическая композиция на ее основе и применение в лечении
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) * 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9187475B2 (en) 2012-04-25 2015-11-17 Raqualia Pharma Inc. Pyrrolopyridinone derivatives as TTX-S blockers
EP3495359A1 (en) 2013-02-04 2019-06-12 Janssen Pharmaceutica NV Flap modulators
TWI644899B (zh) * 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
AU2015315167A1 (en) * 2014-09-10 2017-03-16 Epizyme, Inc. Isoxazole carboxamide compounds
AU2016224993B2 (en) 2015-02-27 2019-11-21 Calcimedica, Inc. Pancreatitis treatment
EP3331525B1 (en) * 2015-08-07 2020-10-07 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
GB201801128D0 (en) 2018-01-24 2018-03-07 Univ Oxford Innovation Ltd Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
MXPA04004714A (es) * 2001-11-21 2004-08-19 Upjohn Co Derivados de aril 1,4-pirazina sustituidos.
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
CA2543644A1 (en) * 2003-10-27 2005-05-06 Astellas Pharma Inc. Pyrazine derivatives and pharmaceutical use thereof
US7705042B2 (en) * 2004-10-22 2010-04-27 Janssen Pharmaceutica Nv Class of arylamide compounds useful as inhibitors of c-fms kinase

Also Published As

Publication number Publication date
ATE525372T1 (de) 2011-10-15
MA29926B1 (fr) 2008-11-03
AP2008004468A0 (en) 2008-06-30
GT200600475A (es) 2007-07-06
BRPI0618129A2 (pt) 2011-08-16
AR057855A1 (es) 2007-12-19
TW200804353A (en) 2008-01-16
UY29893A1 (es) 2007-06-29
CA2624621C (en) 2010-11-30
EA200801011A1 (ru) 2009-02-27
NL2000284A1 (nl) 2007-05-07
WO2007052123A2 (en) 2007-05-10
WO2007052123A3 (en) 2007-07-12
CR9954A (es) 2008-05-28
NL2000284C2 (nl) 2007-09-28
US20070105872A1 (en) 2007-05-10
CN101356169A (zh) 2009-01-28
ES2371932T3 (es) 2012-01-11
NO20082496L (no) 2008-07-24
ZA200803671B (en) 2009-03-25
US7572797B2 (en) 2009-08-11
TNSN08196A1 (fr) 2009-10-30
IL191059A0 (en) 2008-12-29
PE20070715A1 (es) 2007-08-11
EP1945630A2 (en) 2008-07-23
JP2009514937A (ja) 2009-04-09
CA2624621A1 (en) 2007-05-10
EP1945630B1 (en) 2011-09-21
KR20080066073A (ko) 2008-07-15
ECSP088412A (es) 2008-05-30
AU2006310215A1 (en) 2007-05-10

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