DK58285D0 - Peptider samt fremstilling og anvendelse deraf - Google Patents

Peptider samt fremstilling og anvendelse deraf

Info

Publication number
DK58285D0
DK58285D0 DK58285A DK58285A DK58285D0 DK 58285 D0 DK58285 D0 DK 58285D0 DK 58285 A DK58285 A DK 58285A DK 58285 A DK58285 A DK 58285A DK 58285 D0 DK58285 D0 DK 58285D0
Authority
DK
Denmark
Prior art keywords
chain
human insulin
bridging
insulin
lys
Prior art date
Application number
DK58285A
Other languages
English (en)
Inventor
-Unknown
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26064247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK58285(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK266584A external-priority patent/DK266584D0/da
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK58285A priority Critical patent/DK58285D0/da
Publication of DK58285D0 publication Critical patent/DK58285D0/da
Priority to GR851304A priority patent/GR851304B/el
Priority to EP90121887A priority patent/EP0427296B1/en
Priority to IE950351A priority patent/IE80630B1/en
Priority to ES543594A priority patent/ES8609483A1/es
Priority to FI852135A priority patent/FI89183C/fi
Priority to US06/739,123 priority patent/US4916212A/en
Priority to EP85303775A priority patent/EP0163529B1/en
Priority to JP60116297A priority patent/JPH0630613B2/ja
Priority to PT80551A priority patent/PT80551B/pt
Priority to AU43092/85A priority patent/AU590197B2/en
Priority to DE8585303775T priority patent/DE3583824D1/de
Priority to NO852132A priority patent/NO174351C/no
Priority to AT85303775T priority patent/ATE66490T1/de
Priority to DE3588125T priority patent/DE3588125T2/de
Priority to NZ212243A priority patent/NZ212243A/en
Priority to DK238585A priority patent/DK157938C/da
Priority to AT90121887T priority patent/ATE143374T1/de
Priority to CA000482722A priority patent/CA1304022C/en
Priority to IE133185A priority patent/IE66387B1/en
Priority to ES551941A priority patent/ES8702488A1/es
Priority to DK323687A priority patent/DK157933C/da
Priority to JP5121649A priority patent/JPH07121226B2/ja
Priority to JP5121694A priority patent/JPH0746998B2/ja
Priority to JP7142085A priority patent/JP2519023B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/94—Saccharomyces
    • Y10S435/942—Saccharomyces cerevisiae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK58285A 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf DK58285D0 (da)

Priority Applications (25)

Application Number Priority Date Filing Date Title
DK58285A DK58285D0 (da) 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf
GR851304A GR851304B (da) 1984-05-30 1985-05-28
AT90121887T ATE143374T1 (de) 1984-05-30 1985-05-29 Insulin-vorläufer
CA000482722A CA1304022C (en) 1984-05-30 1985-05-29 Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors
IE133185A IE66387B1 (en) 1984-05-30 1985-05-29 Insulin precursors process for their preparation and process for preparing human insulin from such insulin precursors
AU43092/85A AU590197B2 (en) 1984-05-30 1985-05-29 Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors
AT85303775T ATE66490T1 (de) 1984-05-30 1985-05-29 Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins.
ES543594A ES8609483A1 (es) 1984-05-30 1985-05-29 Un procedimiento para producir un precursor de insulina
FI852135A FI89183C (fi) 1984-05-30 1985-05-29 Dna-sekvens som kodar foer insulinprekursorer, vektorer innehaollande denna sekvens, insulinprekursorer och foerfarande foer framstaellning av dessa samt foerfarande foer framstaellning av humaninsulin
US06/739,123 US4916212A (en) 1984-05-30 1985-05-29 DNA-sequence encoding biosynthetic insulin precursors and process for preparing the insulin precursors and human insulin
EP85303775A EP0163529B1 (en) 1984-05-30 1985-05-29 Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors
JP60116297A JPH0630613B2 (ja) 1984-05-30 1985-05-29 インシュリンの製造方法
PT80551A PT80551B (en) 1984-05-30 1985-05-29 Process for the preparation of insulin precursors useful for preparing human insulin
EP90121887A EP0427296B1 (en) 1984-05-30 1985-05-29 Insulin precursors
DE8585303775T DE3583824D1 (de) 1984-05-30 1985-05-29 Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins.
NO852132A NO174351C (no) 1984-05-30 1985-05-29 Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten
IE950351A IE80630B1 (en) 1984-05-30 1985-05-29 Insulin precursors
DE3588125T DE3588125T2 (de) 1984-05-30 1985-05-29 Insulin-Vorläufer
NZ212243A NZ212243A (en) 1984-05-30 1985-05-29 Yeast strains expressing modified recombinant insulin
DK238585A DK157938C (da) 1984-05-30 1985-05-29 Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin
ES551941A ES8702488A1 (es) 1984-05-30 1986-02-13 Un procedimiento para preparar un precursor de insulina
DK323687A DK157933C (da) 1984-05-30 1987-06-25 Insulinprecursorer
JP5121694A JPH0746998B2 (ja) 1984-05-30 1993-05-24 インシュリン前駆体の製造方法
JP5121649A JPH07121226B2 (ja) 1984-05-30 1993-05-24 インシュリン前駆体をコードするｄｎａ
JP7142085A JP2519023B2 (ja) 1984-05-30 1995-06-08 インシュリン前駆体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK266584A DK266584D0 (da) 1984-05-30 1984-05-30 Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren
DK58285A DK58285D0 (da) 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf

Publications (1)

Publication Number Publication Date
DK58285D0 true DK58285D0 (da) 1985-02-08

Family

ID=26064247

Family Applications (2)

Application Number Title Priority Date Filing Date
DK58285A DK58285D0 (da) 1984-05-30 1985-02-08 Peptider samt fremstilling og anvendelse deraf
DK323687A DK157933C (da) 1984-05-30 1987-06-25 Insulinprecursorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK323687A DK157933C (da) 1984-05-30 1987-06-25 Insulinprecursorer

Country Status (15)

Country Link
US (1) US4916212A (da)
EP (2) EP0427296B1 (da)
JP (4) JPH0630613B2 (da)
AT (1) ATE143374T1 (da)
AU (1) AU590197B2 (da)
CA (1) CA1304022C (da)
DE (2) DE3588125T2 (da)
DK (2) DK58285D0 (da)
ES (2) ES8609483A1 (da)
FI (1) FI89183C (da)
GR (1) GR851304B (da)
IE (1) IE66387B1 (da)
NO (1) NO174351C (da)
NZ (1) NZ212243A (da)
PT (1) PT80551B (da)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US4963665A (en) * 1986-01-07 1990-10-16 Washington University Human preproinsulin-like growth factor I
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
DK463887D0 (da) * 1987-09-07 1987-09-07 Novo Industri As Gaerleader
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE58906966D1 (de) * 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
US6875589B1 (en) * 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
AU9172991A (en) 1990-12-07 1992-07-08 Cnc Development, Inc. Catalytic chemical reactor
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
CA2089541A1 (en) 1992-02-18 1993-08-19 Bruce H. Frank Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5891680A (en) * 1995-02-08 1999-04-06 Whitehead Institute For Biomedical Research Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
NZ303162A (en) 1995-03-17 2000-01-28 Novo Nordisk As Enzyme preparations comprising an enzyme exhibiting endoglucanase activity appropriate for laundry compositions for textiles
EP0741188A3 (en) * 1995-05-05 1999-07-14 Eli Lilly And Company Single chain insulin with high bioactivity
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
US5840542A (en) * 1995-07-28 1998-11-24 Mogam Biotechnology Research Institute Method for manufacture of proinsulin with high export yield
ES2364705T3 (es) 1996-03-01 2011-09-12 Novo Nordisk A/S Péptido supresor del apetito, su composición y uso.
DE69840035D1 (de) * 1998-03-31 2008-10-30 Tonghua Gantech Biotechnology Chimäres protein welches eine intramolekulare chap zur insulinproduktion
CN1125081C (zh) 1999-09-08 2003-10-22 中国科学院上海生物化学研究所 重组天然和新型人胰岛素及其制备方法
JP2003530316A (ja) 1999-12-22 2003-10-14 ノボ ノルディスク アクティーゼルスカブ スクランブルした一本鎖ポリペプチドの抽出的再生法
US7378390B2 (en) 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
DE60039074D1 (de) * 1999-12-29 2008-07-10 Novo Nordisk As Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern
US6521738B2 (en) 1999-12-29 2003-02-18 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
US6777207B2 (en) 1999-12-29 2004-08-17 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
ATE474930T1 (de) 1999-12-29 2010-08-15 Novo Nordisk As Verfahren zur herstellung von insulinvorläufern und analogen von insulinvorläufern mit verbesserter fermentationsausbeute in hefe
AU4935701A (en) 2000-03-24 2001-10-08 Genentech Inc Use of insulin for the treatment of cartilagenous disorders
EP1803730A1 (en) * 2000-04-12 2007-07-04 Human Genome Sciences, Inc. Albumin fusion proteins
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
ES2432967T3 (es) 2001-03-22 2013-12-05 Novo Nordisk Health Care Ag Derivados del Factor VII de coagulación
EP1377608B1 (en) * 2001-04-02 2009-09-16 Novo Nordisk A/S Insulin precursors and a process for their preparation
US7105314B2 (en) * 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
CA2446739A1 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
JP4537059B2 (ja) 2001-09-27 2010-09-01 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト ヒト凝固第ｖｉｉ因子ポリペプチド
AU2002364586A1 (en) * 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
WO2003059934A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
DE60335497D1 (de) 2002-09-13 2011-02-03 Cornell Res Foundation Inc Ergillus-phytasen
AU2003255988A1 (en) * 2002-09-13 2004-04-30 Edupuganti B. Raju Yeast protein expression secretion system
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
TWI345587B (en) 2003-06-17 2011-07-21 Sembiosys Genetics Inc Methods for the production of insulin in plants
CN1863908B (zh) 2003-09-09 2010-08-04 诺和诺德医疗保健公司 凝固因子ⅶ多肽
JP2007532096A (ja) 2003-11-14 2007-11-15 ノボ　ノルディスク　アクティーゼルスカブ アシル化されたインスリンの製造方法
ATE517119T1 (de) * 2003-12-03 2011-08-15 Novo Nordisk As Einzelketteninsulin
US20080171695A1 (en) 2005-02-02 2008-07-17 Novo Nordisk A/S Insulin Derivatives
ES2438145T3 (es) 2005-02-02 2014-01-16 Novo Nordisk A/S Nuevos derivados de insulina
BRPI0609079A2 (pt) 2005-04-18 2010-11-16 Novo Nordisk As peptìdeo, composição farmacêutica, método para o tratamento de cáncer, uso de um peptìdeo construto de ácido nucleico, vetor, hospedeiro, e, anticorpo
EP1917363B1 (en) 2005-08-16 2011-06-22 Novo Nordisk A/S Method for making mature insulin polypeptides
EP1926817A2 (en) 2005-09-14 2008-06-04 Novo Nordisk Health Care AG Human coagulation factor vii polypeptides
JP2009530243A (ja) * 2006-03-13 2009-08-27 ノボ・ノルデイスク・エー／エス アシル化単鎖インスリン
JP5864834B2 (ja) 2006-09-22 2016-02-17 ノボ・ノルデイスク・エー／エス プロテアーゼ耐性のインスリンアナログ
EP2069502B1 (en) 2006-09-27 2014-02-26 Novo Nordisk A/S Method for making maturated insulin polypeptides
JP5404411B2 (ja) 2006-11-22 2014-01-29 ノボ・ノルデイスク・エー／エス 活性化カルボキシペプチダーゼの製造方法
US10100098B2 (en) 2006-12-13 2018-10-16 Stelis Biopharma Private Limited Insulin production methods and proinsulin constructs
US7790677B2 (en) * 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
ES2558930T3 (es) 2007-08-13 2016-02-09 Novo Nordisk A/S Análogos de la insulina de acción rápida
EP2178910B1 (en) 2007-08-15 2014-10-08 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
JP5730569B2 (ja) 2007-08-15 2015-06-10 ノボ・ノルデイスク・エー／エス アシル及びアルキレングリコール部分を有するインスリンアナログ
CN101605889A (zh) * 2008-02-12 2009-12-16 伊藤火腿株式会社 含有高表达分泌胰岛素前体的融合蛋白、编码该融合蛋白的dna和胰岛素的制备方法
WO2009121884A1 (en) 2008-04-01 2009-10-08 Novo Nordisk A/S Insulin albumin conjugates
WO2010103038A1 (en) 2009-03-11 2010-09-16 Novo Nordisk A/S Interleukin-21 variants having antagonistic binding to the il-21 receptor
CA2764423A1 (en) 2009-06-26 2010-12-29 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and an amino acid
EP3395828A1 (en) 2009-07-17 2018-10-31 Rigshospitalet Inhibitors of complement activation
ES2583259T3 (es) 2009-12-01 2016-09-20 Novo Nordisk A/S Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina
AU2011222883B2 (en) 2010-03-05 2016-05-26 Omeros Corporation Chimeric inhibitor molecules of complement activation
CN102947331B (zh) * 2010-06-23 2016-08-03 诺沃—诺迪斯克有限公司 包含额外的二硫键的胰岛素类似物
CN102985440B (zh) 2010-06-23 2016-10-26 诺沃-诺迪斯克有限公司 包含额外的二硫键的胰岛素衍生物
EP2585483A1 (en) 2010-06-23 2013-05-01 Novo Nordisk A/S Human insulin containing additional disulfide bonds
CN103328006A (zh) 2010-12-14 2013-09-25 诺沃—诺迪斯克有限公司 包含胰岛素、烟酰胺和氨基酸的制剂
WO2012080320A1 (en) 2010-12-14 2012-06-21 Novo Nordisk A/S Fast-acting insulin in combination with long-acting insulin
CN103533952B (zh) 2011-03-15 2017-02-15 诺沃—诺迪斯克有限公司 包含半胱氨酸置换的人胰岛素类似物和衍生物
CN102675452B (zh) 2011-03-17 2015-09-16 重庆富进生物医药有限公司 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物
EP2720711A1 (en) 2011-06-15 2014-04-23 Novo Nordisk A/S Multi substituted insulins
CN104136041B (zh) 2012-02-09 2021-06-29 Var2制药有限公司 靶向硫酸软骨素聚糖
WO2013186138A1 (en) 2012-06-14 2013-12-19 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and arginine
JP2015532307A (ja) 2012-10-15 2015-11-09 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 凝固因子ｖｉｉポリペプチド
WO2014088836A1 (en) 2012-12-03 2014-06-12 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
US9867869B2 (en) 2012-12-12 2018-01-16 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
WO2014195452A1 (en) 2013-06-07 2014-12-11 Novo Nordisk A/S Method for making mature insulin polypeptides
GB201321489D0 (en) 2013-12-05 2014-01-22 Chemical & Biopharmaceutical Lab Of Patras S A Biologically active insulin derivatives
PL233560B1 (pl) 2014-12-05 2019-10-31 Mabion Spolka Akcyjna Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka
EA037848B1 (ru) 2016-07-14 2021-05-27 Общество С Ограниченной Ответственностью "Биохимический Агент" Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты)
KR20190043609A (ko) 2016-09-06 2019-04-26 케미컬 앤드 바이오파마슈티컬 라보라토리즈 오브 파트라스 에스.에이. 프로인슐린 유도체
WO2019034726A1 (en) 2017-08-17 2019-02-21 Novo Nordisk A/S NOVEL ACYLATED INSULIN ANALOGUES AND USES THEREOF
EP3821244A1 (en) 2018-07-13 2021-05-19 Varct Diagnostics ApS Isolation of circulating cells of fetal origin using recombinant malaria protein var2csa
EP3845240B1 (en) 2018-09-12 2024-11-06 Amphastar Nanjing Pharmaceuticals, Inc. Pro-insulin aspart structure and method for preparing insulin aspart
US20240239862A1 (en) 2019-12-30 2024-07-18 Gan & Lee Pharmaceuticals Co., Ltd. Insulin Derivative
CN114901680B (zh) 2019-12-30 2024-09-27 甘李药业股份有限公司 长效glp-1化合物
WO2022049409A1 (en) 2020-09-02 2022-03-10 Sia Terragen Express diagnosticum for sars-cov-2
WO2023144240A1 (en) 2022-01-26 2023-08-03 Novo Nordisk Research Centre Oxford Limited Glucose sensitive insulin derivatives and uses thereof
WO2023143458A1 (zh) 2022-01-28 2023-08-03 甘李药业股份有限公司 酰化胰岛素

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440859A (en) * 1977-05-27 1984-04-03 The Regents Of The University Of California Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
US4431740A (en) * 1979-09-12 1984-02-14 The Regents Of The University Of California DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
CA1202581A (en) * 1980-03-27 1986-04-01 Saran A. Narang Adaptor molecules for dna and their application to synthesis of gene-derived products
NZ196609A (en) * 1980-03-27 1984-02-03 Lilly Co Eli Preparation of proinsulin-like insulin precursors
ZA811895B (en) * 1980-04-07 1982-04-28 Univ California Expression of hormone genomic clones
JPS5750948A (en) * 1980-09-12 1982-03-25 Shionogi & Co Ltd Insulin analog and preparation
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
CA1204682A (en) * 1981-06-19 1986-05-20 Saran A. Narang Adaptors, and synthesis and cloning of proinsulin genes
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
DK368882A (da) * 1981-08-25 1983-02-26 Alan John Kingsman Expessions vektorer
WO1983003413A1 (en) * 1982-03-31 1983-10-13 Genetics Inst Creation of dna sequences encoding modified proinsulin precursors
AU1559483A (en) * 1982-03-31 1983-10-24 Genetics Institute Inc. Creation of dna sequences encoding modified proinsulin precursors
DK172738B1 (da) * 1983-04-07 1999-06-21 Chiron Corp Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
EP0243465A1 (en) * 1985-10-25 1987-11-04 Vivian L. Mackay Method of using bar1 for secreting foreign proteins

Also Published As

Publication number Publication date
FI89183B (fi) 1993-05-14
DE3583824D1 (de) 1991-09-26
DE3588125D1 (de) 1996-10-31
EP0427296B1 (en) 1996-09-25
DK157933C (da) 1990-08-27
ES8702488A1 (es) 1986-12-16
FI852135A0 (fi) 1985-05-29
JPH06141866A (ja) 1994-05-24
DK323687D0 (da) 1987-06-25
GR851304B (da) 1985-11-25
IE851331L (en) 1985-11-30
ATE143374T1 (de) 1996-10-15
EP0163529B1 (en) 1991-08-21
JPS611389A (ja) 1986-01-07
FI852135L (fi) 1985-12-01
PT80551B (en) 1987-04-09
JPH0746998B2 (ja) 1995-05-24
NO174351B (no) 1994-01-10
AU590197B2 (en) 1989-11-02
AU4309285A (en) 1985-12-05
US4916212A (en) 1990-04-10
EP0163529A1 (en) 1985-12-04
DE3588125T2 (de) 1997-02-13
FI89183C (fi) 1993-08-25
DK323687A (da) 1987-06-25
ES8609483A1 (es) 1986-09-01
PT80551A (en) 1985-06-01
NO852132L (no) 1985-12-02
CA1304022C (en) 1992-06-23
IE66387B1 (en) 1995-12-27
EP0427296A1 (en) 1991-05-15
NO174351C (no) 1994-04-20
JPH07309896A (ja) 1995-11-28
ES551941A0 (es) 1986-12-16
JPH0630613B2 (ja) 1994-04-27
JPH07121226B2 (ja) 1995-12-25
NZ212243A (en) 1988-05-30
JPH06141865A (ja) 1994-05-24
ES543594A0 (es) 1986-09-01
JP2519023B2 (ja) 1996-07-31
DK157933B (da) 1990-03-05

Similar Documents

Publication Publication Date Title
DK58285D0 (da) Peptider samt fremstilling og anvendelse deraf
EP0150126A3 (en) The synthesis of protein with an identification peptide
NZ513422A (en) G-CSF analogues that do not possess any hematopoietic activity and are useful as antagonists against G-CSF effect, such as overproduction of G-CSF
DK336188D0 (da) Propeptider
KR850004273A (ko) 안정성이 증대된 재조합 감마 인터페론 및 그의 제조방법
HU902697D0 (en) Process for the enzymatic removal of the n-terminal sequence of proteins
ES8802235A1 (es) Procedimiento para preparar un polipeptido
IL74426A (en) Atrial peptides and pharmaceutical compositions comprising them
EP0195680A3 (en) The synthesis of protein with an identification peptide
DE3380819D1 (en) A precursor of a c-terminal amidated peptide and production thereof
ES2044928T3 (es) Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
NZ216316A (en) Hepta and octapeptides with thymic humoral activity
ATE78872T1 (de) Herstellung von polypeptiden.
DK238585A (da) Peptider og fremstilling deraf
WO1990000179A3 (fr) Nouvelles proteins, adn les codant et leur usage
EP0327360A3 (en) Novel polypeptides and dna encoding said polypeptides
EP0266006A3 (en) Novel hypotensive diuretic peptides
DE3686036D1 (en) New fusion protein contg. small interleukin 2 ballast fragments
GB1210557A (en) Synthesis of polypeptides containing cysteine
CA1267086C (en) METHOD OF ADMINISTRATION OF EAR DIURETIC PEPTIDES
DK301090A (da) Insulinprecursorer