DK519189A - Spiro-isoquinolin-pyrrolidin-tetroner eller farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse - Google Patents

Spiro-isoquinolin-pyrrolidin-tetroner eller farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse

Info

Publication number: DK519189A
Authority: DK; Denmark
Prior art keywords: tetrons; isoquinolin; spiro; pyrrolidine; preparation
Prior art date: 1988-10-20

Application number

DK519189A

Other languages

English (en)

Other versions

DK170702B1 (da

DK519189D0 (da

Inventor

Michael Sotirios Malamas

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-20

Filing date

1989-10-19

Publication date

1990-04-21

1989-10-19 Application filed by American Home Prod filed Critical American Home Prod

1989-10-19 Publication of DK519189D0 publication Critical patent/DK519189D0/da

1990-04-21 Publication of DK519189A publication Critical patent/DK519189A/da

1995-12-11 Application granted granted Critical

1995-12-11 Publication of DK170702B1 publication Critical patent/DK170702B1/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK519189A 1988-10-20 1989-10-19 Spiro-isoquinolin-pyrrolidin-tetroner eller farmaceutisk acceptable salte deraf, fremgangsmåde til fremstilling af en del af dem og farmaceutisk præparat omfattende dem DK170702B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US26043488A	1988-10-20	1988-10-20
US26043488		1988-10-20
US35756389		1989-05-26
US07/357,563 US4927831A (en)	1988-10-20	1989-05-26	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (3)

Publication Number	Publication Date
DK519189D0 DK519189D0 (da)	1989-10-19
DK519189A true DK519189A (da)	1990-04-21
DK170702B1 DK170702B1 (da)	1995-12-11

Family

ID=26947989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK519189A DK170702B1 (da)	1988-10-20	1989-10-19	Spiro-isoquinolin-pyrrolidin-tetroner eller farmaceutisk acceptable salte deraf, fremgangsmåde til fremstilling af en del af dem og farmaceutisk præparat omfattende dem

Country Status (9)

Country	Link
US (1)	US4927831A (da)
JP (1)	JP2888559B2 (da)
KR (1)	KR0143998B1 (da)
CA (1)	CA1337351C (da)
DK (1)	DK170702B1 (da)
HU (1)	HU206211B (da)
IL (1)	IL92054A (da)
PH (1)	PH27278A (da)
PT (1)	PT92025B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5428066A (en) *	1989-03-08	1995-06-27	Larner; Joseph	Method of reducing elevated blood sugar in humans
US5045544A (en) *	1990-05-21	1991-09-03	American Home Products Corporation	N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5037831A (en) *	1990-05-21	1991-08-06	American Home Products Corporation	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5093496A (en) *	1990-05-21	1992-03-03	American Home Products Corporation	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5081241A (en) *	1990-10-11	1992-01-14	American Home Products Corporation	Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) *	1990-10-12	1991-11-26	American Home Products Corporation	Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) *	1990-10-12	1992-04-07	American Home Products Corporation	1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5130425A (en) *	1990-10-12	1992-07-14	American Home Products Corporation	Spiro-lactams and analogs thereof useful as aldose reductase inhibitors
US5106978A (en) *	1991-05-22	1992-04-21	American Home Products Corporation	Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US5169948A (en) *	1991-05-22	1992-12-08	American Home Products Corporation	Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors
US6384013B1 (en)	1992-03-19	2002-05-07	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) *	1992-03-19	2004-06-01	Eli Lilly And Company	Cyclic peptide antifungal agents and process for preparation thereof
US5221686A (en) *	1992-08-04	1993-06-22	American Home Products Corporation	Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
ES2433678T3 (es) *	1999-03-03	2013-12-12	Eli Lilly & Company	Formulaciones farmacéuticas de equinocandina que contienen tensioactivos formadores de micelas
CA2362016A1 (en)	1999-03-03	2000-09-08	Kenneth Philip Moder	Echinocandin/carbohydrate complexes
US6991800B2 (en) *	2002-06-13	2006-01-31	Vicuron Pharmaceuticals Inc.	Antifungal parenteral products
US6777048B2 (en)	2002-12-18	2004-08-17	Eastman Chemical Company	Polyester compositions containing silicon carbide
CA2534312A1 (en) *	2003-09-12	2005-03-24	Applied Research Systems Ars Holding N.V.	Sulfonamide derivatives for the treatment of diabetes
ATE378047T1 (de) *	2003-09-12	2007-11-15	Serono Lab	Benzothiazol-derivate zur behandlung von diabetes
AU2005231980B2 (en) *	2004-04-07	2011-09-08	Merck Serono Sa	1,1'-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors
JP2008509927A (ja) *	2004-08-12	2008-04-03	ワイス	Ｇｄｆ−８阻害剤を使用する、糖尿病、肥満、および心臓血管疾患のための併用療法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5241586U (da) *	1975-09-18	1977-03-24
JPS5241587U (da) *	1975-09-18	1977-03-24
FR2525603A1 (fr) *	1982-04-27	1983-10-28	Adir	Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique
FR2544317B2 (fr) *	1983-04-12	1985-07-05	Adir	Benzoazacycloalkyl-spiro-imidazolidines et les compositions pharmaceutiques les contenant

1989
- 1989-05-26 US US07/357,563 patent/US4927831A/en not_active Expired - Lifetime
- 1989-09-27 CA CA000613705A patent/CA1337351C/en not_active Expired - Fee Related
- 1989-10-17 JP JP1271423A patent/JP2888559B2/ja not_active Expired - Fee Related
- 1989-10-17 PH PH39372A patent/PH27278A/en unknown
- 1989-10-17 HU HU895335A patent/HU206211B/hu not_active IP Right Cessation
- 1989-10-18 PT PT92025A patent/PT92025B/pt not_active IP Right Cessation
- 1989-10-19 DK DK519189A patent/DK170702B1/da active IP Right Grant
- 1989-10-19 KR KR1019890015023A patent/KR0143998B1/ko not_active IP Right Cessation
- 1989-10-19 IL IL9205489A patent/IL92054A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PH27278A (en)	1993-05-04
PT92025B (pt)	1995-07-18
IL92054A0 (en)	1990-07-12
HU895335D0 (en)	1990-01-28
DK170702B1 (da)	1995-12-11
US4927831A (en)	1990-05-22
KR900006334A (ko)	1990-05-07
HUT52775A (en)	1990-08-28
JPH02164880A (ja)	1990-06-25
HU206211B (en)	1992-09-28
CA1337351C (en)	1995-10-17
KR0143998B1 (ko)	1998-07-15
JP2888559B2 (ja)	1999-05-10
PT92025A (pt)	1990-04-30
IL92054A (en)	1994-07-31
DK519189D0 (da)	1989-10-19

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Legal Events

Date	Code	Title	Description
1995-12-11	B1	Patent granted (law 1993)