DK2582391T3 - Arthritis-behandling - Google Patents
Arthritis-behandling Download PDFInfo
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- DK2582391T3 DK2582391T3 DK11796483.3T DK11796483T DK2582391T3 DK 2582391 T3 DK2582391 T3 DK 2582391T3 DK 11796483 T DK11796483 T DK 11796483T DK 2582391 T3 DK2582391 T3 DK 2582391T3
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (5)
1. Anti-IL-la-antistof til anvendelse ved en fremgangsmåde til mindskning af ledsmerter og stivhed associeret med arthritis i et menneske, der lider af arthritis, hvor antistoffet reducerer antallet af CD14+IL-la+ perifere blod-monocyter i mennesket og tydeligt mildner betændelses-tilstanden i såvel artikulære som ekstra-artikulære områder.
2. Anti-IL-la-antistof til anvendelse ifølge krav 1, hvor anti-IL-la-antistoffet er et monoklonalt antistof.
3. Anti-IL-la-antistof til anvendelse ifølge krav 2, hvor det ved det monoklonale antistof angår et IgGl.
4. Anti-IL-la-antistof til anvendelse ifølge krav 1, det hvor anti-IL-la-antistoffet er formuleret i en pharmaceutisk sammensætning, der er egnet til indgivelse ved injice-ring.
5. Anti-IL-la-antistof til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor det ved arthritis angår reaktiv arthritis.
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| US35617610P | 2010-06-18 | 2010-06-18 | |
| PCT/US2011/040819 WO2011159976A2 (en) | 2010-06-18 | 2011-06-17 | Arthritis treatment |
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| DK2582391T3 true DK2582391T3 (da) | 2019-01-21 |
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| US (4) | US20110311547A1 (da) |
| EP (1) | EP2582391B1 (da) |
| JP (2) | JP6324720B2 (da) |
| KR (3) | KR20180086297A (da) |
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| DK (1) | DK2582391T3 (da) |
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| PT (1) | PT2582391T (da) |
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| EP3075394B1 (en) | 2010-08-23 | 2018-11-28 | XBiotech, Inc | Treatment for neoplastic diseases |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| RU2622021C2 (ru) | 2011-09-23 | 2017-06-08 | ИксБиотеч, Инк. | Лечение кахексии |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| AU2018220862A1 (en) | 2017-02-16 | 2019-08-29 | Janssen Biotech, Inc. | Treatment of hidradenitis suppurativa |
| US10975146B2 (en) | 2018-06-29 | 2021-04-13 | Cedars-Sinai Medical Center | Interleukin-1 inhibition for combination treatment of pancreatic cancer |
| CN113488108B (zh) * | 2021-07-02 | 2022-05-06 | 温州医科大学 | 一种新型的用于急性前葡萄膜炎个体化复发风险预测的方法及其装置 |
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| CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4965198A (en) | 1985-12-24 | 1990-10-23 | Konica Corporation | Monoclonal antibody and method of manufacturing hybridoma producing the same |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| DK590387A (da) | 1986-11-13 | 1988-05-14 | Otsuka Pharma Co Ltd | Antistoffer mod interleukin-1 |
| US5034316A (en) | 1987-03-30 | 1991-07-23 | The Regents Of The University Of California | In vitro human monoclonal IgG rheumatoid factor autoantibody |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| FR2640146B1 (fr) | 1988-12-08 | 1993-12-24 | Commissariat A Energie Atomique | Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JPH04504253A (ja) | 1989-03-27 | 1992-07-30 | セントカー・インコーポレーテツド | ＩｇＭ抗体の安定化のための配合物 |
| US5407431A (en) | 1989-07-11 | 1995-04-18 | Med-Design Inc. | Intravenous catheter insertion device with retractable needle |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| EP0664713B1 (en) | 1992-10-14 | 2000-01-19 | Nycomed Imaging As | Therapeutic and diagnostic imaging compositions and methods |
| EP0614984B2 (en) | 1993-03-05 | 2010-11-03 | Bayer HealthCare LLC | Anti-TNF alpha human monoclonal antibodies |
| EP0659766A1 (en) | 1993-11-23 | 1995-06-28 | Schering-Plough | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| US5959085A (en) * | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| GB9405021D0 (en) | 1994-03-15 | 1994-04-27 | Unilever Plc | Skin treatment composition |
| GB9509620D0 (en) | 1995-05-12 | 1995-07-05 | Nat Blood Authority | Transepithelial transport of molecular species |
| WO1997002479A2 (en) | 1995-06-30 | 1997-01-23 | Yale University | Human monoclonal anti-tumor antibodies |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| SE9802402D0 (sv) | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| US20030040617A9 (en) | 1999-03-12 | 2003-02-27 | Rosen Craig A. | Nucleic acids, proteins and antibodies |
| DK1488806T3 (da) * | 1999-06-01 | 2016-02-08 | Biogen Ma Inc | Blokerende monoklonalt antistof mod VLA-1 og dettes anvendelse til behandling af vaskulære lidelser |
| DE19943790C2 (de) | 1999-09-13 | 2001-11-15 | Ericsson Telefon Ab L M | Verfahren und Vorrichtung zur Bestimmung eines Synchronisationsfehlers in einem Netzwerkknoten |
| US6399857B1 (en) | 1999-09-22 | 2002-06-04 | Paradigm Genetics, Inc. | Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species |
| US6380129B1 (en) | 1999-11-02 | 2002-04-30 | Richard J. Kraemer | Enhanced materials for treatment of contamination |
| US6811788B2 (en) | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| US20030232054A1 (en) | 2000-01-25 | 2003-12-18 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| US20020131954A1 (en) | 2000-05-02 | 2002-09-19 | Tobinick Edward L. | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| AU2007202323C1 (en) | 2000-06-29 | 2012-04-12 | Abbvie Inc. | Dual specificity antibodies and methods of making and using |
| EP1335024A4 (en) | 2000-10-19 | 2004-09-01 | Kyowa Hakko Kogyo Kk | ANTIBODIES WITH INHIBITION OF VPLF ACTIVITY |
| US20030026806A1 (en) * | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| WO2003014309A2 (en) | 2001-08-07 | 2003-02-20 | Immunex Corporation | Interleukin-1 receptors in the treatment of diseases |
| US7211602B2 (en) | 2001-11-16 | 2007-05-01 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| CN101914158A (zh) | 2002-02-14 | 2010-12-15 | 免疫医疗公司 | 抗cd 20抗体及其融合蛋白和使用方法 |
| TWI289668B (en) | 2002-09-06 | 2007-11-11 | Amgen Inc | Therapeutic human anti-IL-1R1 monoclonal antibody |
| AU2002332087A1 (en) * | 2002-10-08 | 2004-05-04 | Immunomedics, Inc. | Combination therapy with class iii anti-cea monoclonal antibodies and therapeutic agents |
| JP4450644B2 (ja) | 2003-03-03 | 2010-04-14 | 日本化薬株式会社 | Ａｍｆ類を有効成分とする医薬製剤 |
| US20040224893A1 (en) | 2003-05-06 | 2004-11-11 | Li-Hsien Wang | Methods of using IL-1 antagonists to treat neointimal hyperplasia |
| KR100493102B1 (ko) | 2003-06-30 | 2005-06-02 | 삼성전자주식회사 | 서브 하우징 스토퍼를 구비하는 휴대용 단말기의 힌지 장치 |
| HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| US7799327B2 (en) | 2003-12-24 | 2010-09-21 | Henry John Smith | Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment |
| US7105183B2 (en) | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| WO2006001967A2 (en) | 2004-05-25 | 2006-01-05 | Sloan-Kettering Institute For Cancer Research | Migrastatin analogs in the treatment of cancer |
| MXPA06014126A (es) | 2004-06-04 | 2007-07-18 | Regeneron Pharma | Metodos para utilizar antagonistas il-1 para tratar enfermedades auto-inflamatorias. |
| US20050276807A1 (en) | 2004-06-15 | 2005-12-15 | Advanced Biotherapy, Inc. | Treatment of acne |
| US7718674B2 (en) * | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| HUE025449T2 (en) | 2004-12-09 | 2016-04-28 | Janssen Biotech Inc | Immunoconjugates against Integrin, a method for their preparation and use |
| CN109187944A (zh) | 2005-08-02 | 2019-01-11 | 埃克斯生物科技公司 | 使用IL-1α自身抗体诊断、治疗和预防血管疾病 |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US20090215992A1 (en) * | 2005-08-19 | 2009-08-27 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
| BRPI0616446A2 (pt) | 2005-09-28 | 2011-06-21 | Cytos Biotechnology Ag | composição contendo conjugados de interleucina-1, vacina, uso da vacina, composição farmacêutica, processo para a produção da composição ou da vacina, bem como medicamento |
| CA2648223A1 (en) * | 2006-04-14 | 2007-10-25 | Novartis Ag | Use of il-i antibodies for treating ophthalmic disorders |
| US20110008282A1 (en) | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| AU2007251239B2 (en) | 2006-05-15 | 2013-08-22 | Xbiotech Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| CN107158376A (zh) | 2006-05-22 | 2017-09-15 | 埃克斯生物科技公司 | 使用抗IL‑1α抗体治疗癌症 |
| SG172656A1 (en) | 2006-05-30 | 2011-07-28 | Genentech Inc | Antibodies and immunoconjugates and uses therefor |
| FR2902659A1 (fr) * | 2006-06-23 | 2007-12-28 | Pierre Fabre Medicament Sa | Ester de dha et son utilisation dans le traitement et la prevention des maladies cardiovasculaires |
| DK2594586T3 (da) | 2006-09-01 | 2014-11-17 | Zymogenetics Inc | Monoklonale il-31-antistoffer og fremgangsmåder til anvendelse heraf |
| TWI496790B (zh) | 2006-09-08 | 2015-08-21 | 艾伯維巴哈馬有限公司 | 介白素-１３結合蛋白質 |
| EP2114443A4 (en) | 2006-12-29 | 2011-08-10 | Abbott Lab | IL-1A / IL-1B ANTIBODY WITH DOUBLE SPECIFICITY |
| US20090258070A1 (en) * | 2008-04-15 | 2009-10-15 | John Burnier | Topical LFA-1 antagonists for use in localized treatment of immune related disorders |
| ES2797126T3 (es) * | 2008-05-30 | 2020-12-01 | Xbiotech Inc | Usos de anticuerpos IL-1 alfa |
| US8242074B2 (en) * | 2008-09-12 | 2012-08-14 | Xbiotech, Inc. | Modulation of the amount or function of pathogenic CD14+CD16+ monocytes |
| JP5656848B2 (ja) | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体 |
| CA2749966A1 (en) | 2009-01-29 | 2010-08-05 | Abbott Laboratories | Il-1 binding proteins |
| EP2488201A4 (en) | 2009-10-15 | 2013-12-25 | Abbvie Inc | IL-1 BINDING PROTEINS |
| EP2575884B1 (en) | 2010-06-03 | 2018-07-18 | AbbVie Biotechnology Ltd | Uses and compositions for treatment of hidradenitis suppurativa (hs) |
| DK2582391T3 (da) | 2010-06-18 | 2019-01-21 | Xbiotech Inc | Arthritis-behandling |
| EP3075394B1 (en) | 2010-08-23 | 2018-11-28 | XBiotech, Inc | Treatment for neoplastic diseases |
| RU2013115927A (ru) | 2010-09-10 | 2014-10-20 | Апексиджен, Инк. | АНТИТЕЛА ПРОТИВ ИЛ-1β И СПОСОБЫ ПРИМЕНЕНИЯ |
| CN103298937B (zh) | 2010-11-17 | 2016-05-25 | 中外制药株式会社 | 具有代替凝血因子viii的功能的功能的多特异性抗原结合分子 |
| WO2012088094A2 (en) | 2010-12-21 | 2012-06-28 | Abbott Laboratories | Il-1 binding proteins |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| CA2831126C (en) | 2011-04-01 | 2019-11-12 | Xbiotech Inc. | Treatment of dermatological pathologies |
| JP5812669B2 (ja) | 2011-04-27 | 2015-11-17 | キヤノン株式会社 | 画像処理装置および画像処理方法およびコンピュータプログラム。 |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| RU2622021C2 (ru) | 2011-09-23 | 2017-06-08 | ИксБиотеч, Инк. | Лечение кахексии |
| US20130195877A1 (en) | 2012-01-31 | 2013-08-01 | Xbiotech, Inc. | Treatment of cachexia by targeting interleukin-1 beta |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| RU2671955C2 (ru) | 2012-10-04 | 2018-11-08 | ИксБиотеч, Инк. | Лечение сосудистого заболевания и его осложнений |
| CA2886757C (en) | 2012-10-04 | 2022-04-05 | Xbiotech Inc. | Treatment of anxiety with il1.alpha. antagonist |
| EP2975054A4 (en) | 2013-03-12 | 2016-11-23 | Zenyaku Kogyo Kk | ANTIBODIES TO STAPHYLOKOKEN, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF |
| US20150024031A1 (en) * | 2013-07-17 | 2015-01-22 | Baxter International Inc. | Methods And Compositions For Reducing Pain, Inflammation, And/Or Immunological Reactions Associated With Parenterally Administering A Primary Therapeutic Agent |
| NZ726911A (en) | 2014-06-03 | 2023-01-27 | Xbiotech Inc | Compositions and methods for treating and preventing staphylococcus aureus infections |
| AU2018220862A1 (en) | 2017-02-16 | 2019-08-29 | Janssen Biotech, Inc. | Treatment of hidradenitis suppurativa |
| US20210238273A1 (en) | 2018-04-24 | 2021-08-05 | Janssen Biotech, Inc. | Treatment of atopic dermatitis |
| CA3131011A1 (en) | 2019-02-28 | 2020-09-03 | Janssen Biotech, Inc. | Anti-il-alpha antibody for the treatment of hidradenitis suppurativa |
| EP3958903A4 (en) | 2019-04-24 | 2023-08-02 | Janssen Biotech, Inc. | ANTIBODY FORMULATION |
| WO2021119504A2 (en) | 2019-12-13 | 2021-06-17 | Janssen Biotech, Inc. | Materials and methods for monitoring inflammation |
| WO2021119499A1 (en) | 2019-12-13 | 2021-06-17 | Janssen Biotech, Inc. | Materials and methods for inflammatory molecular markers |
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| PT2582391T (pt) | 2019-01-11 |
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| CA2825986A1 (en) | 2011-12-22 |
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