DK203990D0 - Piperazinylderivater - Google Patents

Piperazinylderivater

Info

Publication number
DK203990D0
DK203990D0 DK203990A DK203990A DK203990D0 DK 203990 D0 DK203990 D0 DK 203990D0 DK 203990 A DK203990 A DK 203990A DK 203990 A DK203990 A DK 203990A DK 203990 D0 DK203990 D0 DK 203990D0
Authority
DK
Denmark
Prior art keywords
receptor
alkyl
hydrogen
image
various
Prior art date
Application number
DK203990A
Other languages
English (en)
Inventor
Lone Jeppesen
Marit Kristiansen
John Bondo Hansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK203990A priority Critical patent/DK203990D0/da
Publication of DK203990D0 publication Critical patent/DK203990D0/da
Priority to US07/744,556 priority patent/US5246935A/en
Priority to IL9921191A priority patent/IL99211A/en
Priority to ZA916652A priority patent/ZA916652B/xx
Priority to NZ23950291A priority patent/NZ239502A/en
Priority to PT98768A priority patent/PT98768B/pt
Priority to AU84413/91A priority patent/AU653956B2/en
Priority to IE298391A priority patent/IE73475B1/en
Priority to AT91915381T priority patent/ATE125802T1/de
Priority to CA002089768A priority patent/CA2089768A1/en
Priority to DK91915381.7T priority patent/DK0544765T3/da
Priority to EP91915381A priority patent/EP0544765B1/en
Priority to PCT/DK1991/000244 priority patent/WO1992003426A1/en
Priority to JP3514325A priority patent/JPH06500546A/ja
Priority to DE69111815T priority patent/DE69111815T2/de
Priority to FI930799A priority patent/FI930799A/fi
Priority to NO93930631A priority patent/NO930631L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK203990A 1990-08-24 1990-08-24 Piperazinylderivater DK203990D0 (da)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DK203990A DK203990D0 (da) 1990-08-24 1990-08-24 Piperazinylderivater
US07/744,556 US5246935A (en) 1990-08-24 1991-08-13 Piperazinyl derivatives and methods of treating central nervous system ailments relating to the 5-ht2 receptor system
IL9921191A IL99211A (en) 1990-08-24 1991-08-16 History of piperazinyl, their preparation and pharmaceutical preparations containing them
ZA916652A ZA916652B (en) 1990-08-24 1991-08-22 Piperazinyl derivatives
NZ23950291A NZ239502A (en) 1990-08-24 1991-08-22 Di-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof.
DE69111815T DE69111815T2 (de) 1990-08-24 1991-08-23 Piperazinylderivate mit Affinität zu 5-HT Rezeptoren.
AU84413/91A AU653956B2 (en) 1990-08-24 1991-08-23 Piperazinyl derivatives
PT98768A PT98768B (pt) 1990-08-24 1991-08-23 Processo de preparacao de derivados de piperazinilo e de composicoes farmaceuticas que os contem
IE298391A IE73475B1 (en) 1990-08-24 1991-08-23 Piperanzinyl derivatives with affinity for 5-HT receptors
AT91915381T ATE125802T1 (de) 1990-08-24 1991-08-23 Piperazinylderivate mit affinität zu 5-ht rezeptoren.
CA002089768A CA2089768A1 (en) 1990-08-24 1991-08-23 Piperazinyl derivatives
DK91915381.7T DK0544765T3 (da) 1990-08-24 1991-08-23 Piperazinylderivater med affinitet for 5-HT-receptorer
EP91915381A EP0544765B1 (en) 1990-08-24 1991-08-23 Piperazinyl derivatives with affinity for 5-HT receptors
PCT/DK1991/000244 WO1992003426A1 (en) 1990-08-24 1991-08-23 Piperazinyl derivatives
JP3514325A JPH06500546A (ja) 1990-08-24 1991-08-23 ピペラジニル誘導体
FI930799A FI930799A (fi) 1990-08-24 1993-02-23 Piperazinylderivat
NO93930631A NO930631L (no) 1990-08-24 1993-02-23 Piperazinylderivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK203990A DK203990D0 (da) 1990-08-24 1990-08-24 Piperazinylderivater

Publications (1)

Publication Number Publication Date
DK203990D0 true DK203990D0 (da) 1990-08-24

Family

ID=8109641

Family Applications (2)

Application Number Title Priority Date Filing Date
DK203990A DK203990D0 (da) 1990-08-24 1990-08-24 Piperazinylderivater
DK91915381.7T DK0544765T3 (da) 1990-08-24 1991-08-23 Piperazinylderivater med affinitet for 5-HT-receptorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK91915381.7T DK0544765T3 (da) 1990-08-24 1991-08-23 Piperazinylderivater med affinitet for 5-HT-receptorer

Country Status (16)

Country Link
US (1) US5246935A (da)
EP (1) EP0544765B1 (da)
JP (1) JPH06500546A (da)
AT (1) ATE125802T1 (da)
AU (1) AU653956B2 (da)
CA (1) CA2089768A1 (da)
DE (1) DE69111815T2 (da)
DK (2) DK203990D0 (da)
FI (1) FI930799A (da)
IE (1) IE73475B1 (da)
IL (1) IL99211A (da)
NO (1) NO930631L (da)
NZ (1) NZ239502A (da)
PT (1) PT98768B (da)
WO (1) WO1992003426A1 (da)
ZA (1) ZA916652B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364849A (en) * 1989-04-22 1994-11-15 John Wyeth & Brother, Limited 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives
US5453425A (en) * 1994-07-11 1995-09-26 Janssen Pharmaceutica N.V. Risperidone oral formulation
CN1146421C (zh) * 1996-03-25 2004-04-21 伊莱利利公司 治疗疼痛的组合物以及药物在制备所述组合物中的应用
US6258807B1 (en) * 1996-03-25 2001-07-10 Eli Lilly And Company Method for treating pain
CA2250042A1 (en) 1996-03-25 1997-10-02 Eli Lilly And Company Treating pain using a synergistic combination of an atypical antipsychotic and a drug used in treatment of pain
FR2753968B1 (fr) * 1996-09-27 1998-11-27 Sod Conseils Rech Applic Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US6344458B1 (en) 1998-12-17 2002-02-05 American Home Products Corporation Piperazine ethylamide derivatives
WO2001062711A2 (en) * 2000-02-22 2001-08-30 Cv Therapeutics, Inc. Substituted alkylene diamine compounds
CA2405758A1 (en) * 2000-05-12 2001-11-15 Solvay Pharmaceuticals B.V. Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
FR2821356A1 (fr) * 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
SE0103648D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinolone compounds
SE0103649D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinoline compounds
US6750367B2 (en) * 2002-05-09 2004-06-15 Bayer Polymers Llc Tetralin isocyanates
NZ538713A (en) 2002-08-12 2007-01-26 Takeda Chemical Industries Ltd Fused benzene derivative and use
MX2008010671A (es) * 2006-02-21 2008-10-01 Amgen Inc Derivados de cinolina como inhibidores de fosfodiesterasa 10.
US8575185B2 (en) 2009-02-26 2013-11-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing quinazolinedione derivatives
JP6154025B2 (ja) 2012-12-24 2017-06-28 ニューロガストルクス，インコーポレイテッド Ｇｉ管障害を治療するための方法
US9844554B2 (en) 2014-06-24 2017-12-19 Neurogastrx, Inc. Prodrugs of metopimazine
MA41168A (fr) * 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
US20200087264A1 (en) * 2017-02-24 2020-03-19 Shenzhen City Linglan Bio-Pharmaceutical Technology Co., Ltd Novel selective ligand for dopamine d3 receptor, preparation method therefor, and pharmaceutical application thereof
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA683208A (en) * 1964-03-31 Hayao Shin Phenylpiperazinylalkyl esters and amides
US3138597A (en) * 1964-06-23 Phenylpiperazinylalkyl carbamates
US2836595A (en) * 1958-05-27 Piperazine derivatives and process for
GB952142A (en) * 1961-05-26 1964-03-11 Miles Lab Phenylpiperazinylalkyl carbamates
US4202898A (en) * 1978-06-05 1980-05-13 Synthelabo Method of treating anxiety and depression
AU532411B2 (en) * 1979-03-01 1983-09-29 Duphar International Research B.V. Phenyl piperazine derivatives
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
ATE126512T1 (de) * 1989-05-19 1995-09-15 Hoechst Roussel Pharma N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
FR2655988B1 (fr) * 1989-12-20 1994-05-20 Adir Cie Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
NO930631L (no) 1993-04-23
PT98768B (pt) 1999-01-29
IE73475B1 (en) 1997-06-04
US5246935A (en) 1993-09-21
IE912983A1 (en) 1992-02-26
FI930799A0 (fi) 1993-02-23
AU653956B2 (en) 1994-10-20
DK0544765T3 (da) 1995-12-27
AU8441391A (en) 1992-03-17
ZA916652B (en) 1992-05-27
WO1992003426A1 (en) 1992-03-05
DE69111815D1 (de) 1995-09-07
NZ239502A (en) 1994-07-26
ATE125802T1 (de) 1995-08-15
DE69111815T2 (de) 1996-04-18
JPH06500546A (ja) 1994-01-20
EP0544765B1 (en) 1995-08-02
IL99211A0 (en) 1992-07-15
CA2089768A1 (en) 1992-02-25
IL99211A (en) 1996-01-31
FI930799A (fi) 1993-02-23
NO930631D0 (no) 1993-02-23
PT98768A (pt) 1992-07-31
EP0544765A1 (en) 1993-06-09

Similar Documents

Publication Publication Date Title
FI930799A0 (fi) Piperazinylderivat
PT75471A (fr) Procede de preparation d'ethers tricycliques
SE8704599L (sv) Teobrominderivat
FI832092L (fi) 1-aryloxi-2,3,4,5-tetrahydro-3-bensazepiner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel
GB8920521D0 (en) New compositions of matter
ES2142576T3 (es) Derivados del naftol y procedimiento de fabricacion.
DE69119013D1 (de) Benzen-, Pyridin-, Pyrimidinderivat
NO924598D0 (no) Fremstilling av substituerte piperidiner
ES455909A1 (es) Procedimiento para preparar derivados de piperacina.
DE69110124D1 (de) Indolderivate, herstellung und verwendung.
ES480391A1 (es) Un procedimiento para la preparacion de derivados de difeni-lamina.
ATE19068T1 (de) Pyridinderivate, ihre herstellung und verwendung.
IL59053A0 (en) N-azolyl-acetanilides their manufacture and their use as fungicides
FI925258A0 (fi) Foerfarande foer framstaellning av 2-substituerade 4,6-dialkoxipyrimidiner
FI964278A0 (fi) Menetelmä 5,6-dihydroksi-2-amino-1,2,3,4-tetrahydronaftaleenin johdannaisten valmistamiseksi
DK428087A (da) Dihydropyridin-5-phosphonsyre-cyclopropylenester
AU519287B2 (en) Imidazo(1,2-alpha) imidazole derivatives
FI824155A0 (fi) Foerfarande foer framstaellning av 3,7a-diazacyklohepta/j,k/fluoren
ES8606245A1 (es) Procedimiento para preparar fenoxianilinas y piridiloxianilinas sustituidas
ES8407042A1 (es) Procedimiento para la obtencion de un nuevo derivado del sulpiride.
ATE15184T1 (de) Fluorphenoxybenzylester, ihre herstellung und ihre verwendung als schaedlingsbekaempfungsmittel.
CH653840GA3 (en) Process for protecting keratin-containing materials from attack by keratin-eating insects and 5-phenylcarbamoylbarbituric acid compounds

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment