DK0641195T3 - Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning - Google Patents

Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning

Info

Publication number
DK0641195T3
DK0641195T3 DK93912763.5T DK93912763T DK0641195T3 DK 0641195 T3 DK0641195 T3 DK 0641195T3 DK 93912763 T DK93912763 T DK 93912763T DK 0641195 T3 DK0641195 T3 DK 0641195T3
Authority
DK
Denmark
Prior art keywords
pct
delayed
preparation
sec
date
Prior art date
Application number
DK93912763.5T
Other languages
English (en)
Inventor
Roland Rauchfuss
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Application granted granted Critical
Publication of DK0641195T3 publication Critical patent/DK0641195T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DK93912763.5T 1992-05-22 1993-05-21 Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning DK0641195T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4216948 1992-05-22

Publications (1)

Publication Number Publication Date
DK0641195T3 true DK0641195T3 (da) 1996-08-05

Family

ID=6459487

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912763.5T DK0641195T3 (da) 1992-05-22 1993-05-21 Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning

Country Status (11)

Country Link
US (1) US5792474A (da)
EP (1) EP0641195B1 (da)
AT (1) ATE136459T1 (da)
AU (1) AU4316393A (da)
DE (1) DE59302200D1 (da)
DK (1) DK0641195T3 (da)
ES (1) ES2086229T3 (da)
FI (1) FI110233B (da)
GR (1) GR3019734T3 (da)
HK (1) HK1005307A1 (da)
WO (1) WO1993024110A1 (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19522899C1 (de) * 1995-06-23 1996-12-19 Hexal Pharmaforschung Gmbh Verfahren zum kontinuierlichen Ersintern eines Granulats
DE19705538C1 (de) * 1997-02-14 1998-08-27 Goedecke Ag Verfahren zur Trennung von Wirkstoffen in festen pharmazeutischen Zubereitungen
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8486447B2 (en) * 2003-02-03 2013-07-16 Novartis Ag Pharmaceutical formulation
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
JP2007513147A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 押し出し機を使用して、好ましくはポロキサマーとグリセリドを含有する多粒子結晶性医薬組成物を製造するための噴霧凝結方法
CA2547239A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
EP1691787B1 (en) * 2003-12-04 2008-07-02 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
JP2007513139A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
WO2005053653A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US20110059140A1 (en) * 2007-12-21 2011-03-10 Gerhard Winter Extruded rod-shaped devices for controlled release of biological substances to humans and animals
EP2249811A1 (en) 2008-01-25 2010-11-17 Grünenthal GmbH Pharmaceutical dosage form
DK2273983T3 (da) 2008-05-09 2016-09-19 Gruenenthal Gmbh Fremgangsmåde til fremstilling af en pulverformig mellemproduktformulering og en fast slutdoseringsform under anvendelse af et sprøjtestørkningstrin
RU2547555C2 (ru) 2009-07-22 2015-04-10 Грюненталь Гмбх Экструдированная из горячего расплава фармацевтическая лекарственная форма
SI2456424T1 (sl) 2009-07-22 2013-10-30 Gruenenthal Gmbh Oksidacijsko stabilizirana odmerna oblika, varna pred zlorabo
CN102821757B (zh) 2010-02-03 2016-01-20 格吕伦塔尔有限公司 通过挤出机制备粉末状药物组合物
CN103269688A (zh) 2010-09-02 2013-08-28 格吕伦塔尔有限公司 包含无机盐的抗破碎剂型
PL2611425T3 (pl) 2010-09-02 2014-09-30 Gruenenthal Gmbh Odporna na ingerencję postać dawki zawierająca polimer anionowy
CN103841964A (zh) 2011-07-29 2014-06-04 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
EA201400173A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
WO2013156453A1 (en) 2012-04-18 2013-10-24 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
BR112015026549A2 (pt) 2013-05-29 2017-07-25 Gruenenthal Gmbh forma de dosagem à prova de violação contendo uma ou mais partículas
EP3019157A1 (en) 2013-07-12 2016-05-18 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
CA2947786A1 (en) 2014-05-12 2015-11-19 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising tapentadol
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
MX2017013637A (es) 2015-04-24 2018-03-08 Gruenenthal Gmbh Forma de dosificacion resistente a alteraciones con liberacion inmediata y resistencia contra la extraccion por solventes.
WO2017042325A1 (en) 2015-09-10 2017-03-16 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
EP3492070A1 (en) 2017-11-30 2019-06-05 BIT Pharma GmbH Process and device for preparing a solid dispersion

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
DE3024416C2 (de) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
FR2581541B1 (fr) * 1985-05-09 1988-05-20 Rhone Poulenc Sante Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system

Also Published As

Publication number Publication date
FI110233B (fi) 2002-12-31
EP0641195A1 (de) 1995-03-08
WO1993024110A1 (de) 1993-12-09
GR3019734T3 (en) 1996-07-31
HK1005307A1 (en) 1998-12-31
ATE136459T1 (de) 1996-04-15
DE59302200D1 (de) 1996-05-15
US5792474A (en) 1998-08-11
FI945465A0 (fi) 1994-11-21
AU4316393A (en) 1993-12-30
EP0641195B1 (de) 1996-04-10
FI945465A (fi) 1994-11-21
ES2086229T3 (es) 1996-06-16

Similar Documents

Publication Publication Date Title
DK0641195T3 (da) Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning
DE69326163D1 (de) Verfahren zur herstellung von arzneiformen und kontrollierte freigabe und die soerhaltenen arzneiformen
ES542483A0 (es) Procedimiento de preparacion de una forma galenica para ad- ministracion por via oral
NO174877C (no) Fremgangsmåte for fremstilling av et legemiddel med antitumorvirkning
FI905781A (fi) Menetelmä farmaseuttisten koostumusten valmistamiseksi, jotka sisältävät sokerialkoholia ja homogeenisesti dispergoituna hiukkasmaista aktiivista yhdistettä
DK1173265T3 (da) Apparat og fremgangsmåde til krystallisation med ultralydstråler
BG42671A3 (en) Method for injecting of gelatine composition
FI943687A0 (fi) Uudet 11-bentsaldoksiimiestradieenijohdannaiset, menetelmät niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
AR019365A1 (es) Compuesto de 1-piperidin-3-fenil-butil-naftamida, proceso para prepararlo, composicion farmaceutica y uso para fabricar un medicamento util para eltratamiento de una enfermedad por antagonistas de taquicininas neuropeptidicas endogenas
HU211845A9 (en) Orally administrated solvent-free pharmaceutical composition with delayed active-substance release and a method for preparing thereof
OA09528A (fr) Nouveaux dérivés N-substitues de la quinoléine leur procédé de préparation les nouveaux intermédiaires obtenus leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
FI894899A0 (fi) Menetelmä dispergoituvan kiinteän lääkeainekoostumuksen valmistamiseksi
NZ337584A (en) Preparing a glass-like plastic mass from sweetening agents in charging, melting and vacuum zones of an extruder
FI943688A0 (fi) Uudet 11-bentsaldoksiimi-17beta-metoksi-27alfa-metoksi-metyyli-estradieenijohdannaiset, menetelmät niiden valmistamiseksi ja näitä sisältävät lääkeaineet
AU9151398A (en) Method for producing active agent preparations with controlled release from a matrix
US3474107A (en) N-aromatic substituted acid amides
DK287982A (da) Fremgangsmaade til tidsstyring af frigoerelsen af aktive stoffer fra midler med indhold deraf navnlig fra farmaceutiske praeparater
FR2658516B1 (fr) Nouveaux produits sterouides comportant un radical spiro en position 17, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2705570B1 (fr) Nouvelle formulation d'aérosol médicamentaux à base de fusafungine, son procédé de préparation et les compositions pharmaceutiques qui la contiennent.
JPH09183764A (ja) Ｎ−ベンゾイルプロリンエステル誘導体
DE60005805D1 (de) Verfahren zur mikroverkapselung von arzneistoffen
MX9700821A (es) Nueva utilizacion y derivados novedosos del imidazol, su procedimiento de preparacion, los nuevos intermediarios obtenidos, su aplicacion a manera de medicamentos y las composiciones farmaceuticas que los incluyen.
ES2123796T3 (es) Derivados de acidos fosfono-succinicos y su utilizacion como medicamentos.
JPS55157586A (en) N,n'-tetramethylene-cis-epoxysuccinic acid amide and its preparation