DK0471036T4 - Indkapslingsfremgangsmåde - Google Patents

Indkapslingsfremgangsmåde

Info

Publication number
DK0471036T4
DK0471036T4 DK90908830T DK90908830T DK0471036T4 DK 0471036 T4 DK0471036 T4 DK 0471036T4 DK 90908830 T DK90908830 T DK 90908830T DK 90908830 T DK90908830 T DK 90908830T DK 0471036 T4 DK0471036 T4 DK 0471036T4
Authority
DK
Denmark
Prior art keywords
agent
effective amount
solvent
microdroplets
emulsion
Prior art date
Application number
DK90908830T
Other languages
English (en)
Other versions
DK0471036T3 (da
Inventor
Thomas R Tice
Richard M Gilley
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23363857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0471036(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Southern Res Inst filed Critical Southern Res Inst
Publication of DK0471036T3 publication Critical patent/DK0471036T3/da
Application granted granted Critical
Publication of DK0471036T4 publication Critical patent/DK0471036T4/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Glass Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Electron Tubes For Measurement (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Surgical Instruments (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Press Drives And Press Lines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Separation By Low-Temperature Treatments (AREA)
DK90908830T 1989-05-04 1990-05-02 Indkapslingsfremgangsmåde DK0471036T4 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34747689A 1989-05-04 1989-05-04

Publications (2)

Publication Number Publication Date
DK0471036T3 DK0471036T3 (da) 1996-05-28
DK0471036T4 true DK0471036T4 (da) 2004-07-19

Family

ID=23363857

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90908830T DK0471036T4 (da) 1989-05-04 1990-05-02 Indkapslingsfremgangsmåde

Country Status (21)

Country Link
US (1) US5407609A (da)
EP (1) EP0471036B2 (da)
JP (1) JP2582186B2 (da)
KR (1) KR0162660B1 (da)
CN (1) CN1047223A (da)
AT (1) ATE133087T1 (da)
AU (1) AU5741590A (da)
CA (1) CA2050911C (da)
DE (1) DE69024953T3 (da)
DK (1) DK0471036T4 (da)
ES (1) ES2084698T5 (da)
FI (1) FI103183B1 (da)
GR (1) GR1000614B (da)
HK (1) HK30897A (da)
IE (1) IE69313B1 (da)
IL (1) IL94296A (da)
MX (1) MX20594A (da)
NO (1) NO302683B1 (da)
NZ (1) NZ233570A (da)
WO (1) WO1990013361A1 (da)
ZA (1) ZA903411B (da)

Families Citing this family (322)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693343A (en) 1984-03-16 1997-12-02 The United States Of America As Represented By The Secretary Of The Army Microparticle carriers of maximal uptake capacity by both M cells and non-M cells
US20030161889A1 (en) * 1984-03-16 2003-08-28 Reid Robert H. Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
USRE40786E1 (en) 1984-03-16 2009-06-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US5985354A (en) 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US5840293A (en) * 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
AU8303691A (en) 1991-04-24 1992-12-21 United States Of America, As Represented By The Secretary Of The Army, The Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ZA93929B (en) * 1992-02-18 1993-09-10 Akzo Nv A process for the preparation of biologically active materialcontaining polymeric microcapsules.
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5346738A (en) * 1992-11-04 1994-09-13 X-Cal Corporation Identification label with micro-encapsulated etchant
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6939546B2 (en) 1993-05-21 2005-09-06 The United States Of America As Represented By The Secretary Of The Army Model for testing immunogenicity of peptides
AU684324B2 (en) * 1993-11-19 1997-12-11 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
WO1995013814A1 (en) 1993-11-19 1995-05-26 Janssen Pharmaceutica N.V. Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IT1265290B1 (it) * 1993-12-17 1996-10-31 Dox Al Italia Spa Miscele ad elevato contenuto di sostanze attive idonee ad essere distribuite in modo omogeneo nei mangimi per animali.
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US5622723A (en) * 1995-02-03 1997-04-22 Eurand America, Incorporated Procedure for encapsulating chlorpheniramine
US7033608B1 (en) 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US5883103A (en) * 1995-06-07 1999-03-16 Shire Laboratories Inc. Oral acyclovir delivery
US5879712A (en) 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
US5942241A (en) 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
WO1997003702A1 (en) 1995-07-21 1997-02-06 Brown University Research Foundation A method for gene therapy using nucleic acid loaded polymeric microparticles
US6248720B1 (en) 1996-07-03 2001-06-19 Brown University Research Foundation Method for gene therapy using nucleic acid loaded polymeric microparticles
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
JP2000500744A (ja) 1995-11-09 2000-01-25 マイクロバイオロジカル リサーチ オーソリティー ワクチン接種および遺伝子治療のためのマイクロカプセル化ｄｎａ
GB9709900D0 (en) 1997-05-15 1997-07-09 Microbiological Res Authority Microencapsulated DNA for vaccination and gene therapy
JPH09169610A (ja) * 1995-12-20 1997-06-30 Sumitomo Chem Co Ltd マイクロカプセル化された有害生物防除剤組成物
WO1997022409A1 (en) * 1995-12-21 1997-06-26 Drexel University Hollow polymer microcapsules and method of producing
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
WO1997049391A1 (en) 1996-06-24 1997-12-31 Euro-Celtique, S.A. Methods for providing safe local anesthesia
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US7060277B2 (en) * 1996-12-30 2006-06-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins
IL119938A (en) * 1996-12-30 2005-08-31 Yissum Res Dev Co Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
ES2388248T3 (es) 1997-03-31 2012-10-11 Boston Scientific Scimed Limited Forma de dosificación que comprende taxol en forma cristalina
JP2000511941A (ja) 1997-07-02 2000-09-12 ユーロ−セルティーク エス．エイ． 関節間隙および身体間隙における持効性麻酔
KR100380856B1 (ko) * 1997-07-19 2003-10-10 주식회사 엘지화학 카본블랙의고분자에의한피낭화방법
BR9806238A (pt) * 1997-09-09 2005-07-12 Select Release L C Partìculas revestidas: processos de obtenção e uso
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
SE512663C2 (sv) * 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
FR2771824A1 (fr) * 1997-12-01 1999-06-04 Eastman Kodak Co Utilisation de microvesicules contenant un developpateur des halogenures d'argent pour former une image photographique
US6197229B1 (en) * 1997-12-12 2001-03-06 Massachusetts Institute Of Technology Method for high supercoiled DNA content microspheres
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
KR100797876B1 (ko) 1998-04-07 2008-01-24 코릭사 코포레이션 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6548302B1 (en) 1998-06-18 2003-04-15 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US6916490B1 (en) 1998-07-23 2005-07-12 UAB Research Center Controlled release of bioactive substances
US6264991B1 (en) 1998-08-18 2001-07-24 Southern Research Institute Compositions and methods for treating intracellular infections
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
US6306425B1 (en) 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US6387986B1 (en) * 1999-06-24 2002-05-14 Ahmad Moradi-Araghi Compositions and processes for oil field applications
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
CA2382821A1 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
CA2382577C (en) 1999-08-27 2008-01-22 Southern Research Institute Injectable buprenorphine microparticle compositions and their use
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6495166B1 (en) 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
US6705757B2 (en) 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
US6331317B1 (en) 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US7838037B2 (en) * 1999-11-17 2010-11-23 Tagra Biotechnologies Ltd. Method of microencapsulation
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
AU1956401A (en) * 1999-12-10 2001-06-18 Microban Products Company Antimicrobial synthetic ion exchange resins
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
IL151097A0 (en) 2000-02-23 2003-04-10 Smithkline Beecham Biolog Tumour-specific animal proteins
WO2001069245A2 (en) * 2000-03-14 2001-09-20 Trustees Of Tufts College Cross-reactive sensors
US6544646B2 (en) 2000-04-27 2003-04-08 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof
CN1189159C (zh) 2000-05-05 2005-02-16 欧莱雅 含水溶性美容活性组分水性核的微胶囊及含其的组合物
US6264987B1 (en) 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
WO2001093835A1 (en) * 2000-06-02 2001-12-13 Zycos Inc. Delivery systems for bioactive agents
EP1961819A3 (en) 2000-06-28 2008-11-12 Corixa Corporation Composition and methods for the therapy and diagnosis of lung cancer
CA2414926A1 (en) * 2000-07-07 2002-01-17 Corixa Corporation Microspheres and adjuvants for dna vaccine delivery
ES2294026T3 (es) * 2000-09-06 2008-04-01 Ap Pharma, Inc. Polimeros degradables de poliacetal.
MXPA03001997A (es) 2000-09-06 2004-10-15 Appleton Paper Inc Adhesivo microencapsulado in situ.
US6824822B2 (en) 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
US6471995B1 (en) 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
CA2423484A1 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
US6962716B1 (en) * 2000-09-27 2005-11-08 Board Of Regents, The University Of Texas System Compositions and methods for biodegradable microspheres as carriers of bioactive substances
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
SE517422C2 (sv) * 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
CA2424896A1 (en) 2000-10-06 2002-04-11 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation
EP1335661B1 (en) 2000-10-27 2009-05-06 Baxter Healthcare S.A. Production of microspheres
US6706289B2 (en) * 2000-10-31 2004-03-16 Pr Pharmaceuticals, Inc. Methods and compositions for enhanced delivery of bioactive molecules
SE518008C2 (sv) * 2000-11-16 2002-08-13 Bioglan Ab Parenteralt administrerbara mikropartiklar och förfarande för framställning av desamma
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US20020114843A1 (en) 2000-12-27 2002-08-22 Ramstack J. Michael Preparation of microparticles having improved flowability
JP2005504715A (ja) * 2000-12-29 2005-02-17 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続放出特性を有する吸入用粒子
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US20070142325A1 (en) * 2001-01-08 2007-06-21 Gustavsson Nils O Starch
WO2002062319A2 (en) * 2001-01-19 2002-08-15 Corixa Corporation Microsphere delivery of mucin peptides
JP2004521111A (ja) * 2001-01-25 2004-07-15 ユーロ−セルティーク，エス．エイ． 局所麻酔薬および使用法
JP2005504513A (ja) 2001-05-09 2005-02-17 コリクサ コーポレイション 前立腺癌の治療及び診断のための組成物及び方法
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
CA2452382A1 (en) 2001-07-10 2003-01-23 Corixa Corporation Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres
CA2456806C (en) * 2001-08-08 2011-10-18 Brown University Research Foundation Methods for micronization of hydrophobic drugs
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
US20030064033A1 (en) * 2001-08-16 2003-04-03 Brown Larry R. Propellant-based microparticle formulations
US7105181B2 (en) * 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
EP1455755B1 (en) * 2001-11-20 2013-04-17 Civitas Therapeutics, Inc. Improved particulate compositions for pulmonary delivery
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
US20030147965A1 (en) * 2001-12-10 2003-08-07 Spherics, Inc. Methods and products useful in the formation and isolation of microparticles
ES2405405T3 (es) 2001-12-17 2013-05-31 Corixa Corporation Composiciones y procedimientos para la terapia y el diagnóstico de enfermedad inflamatoria del intestino
US20060286356A1 (en) * 2002-02-27 2006-12-21 Thomas Toby R Web materials with active agent
US7497623B2 (en) * 2002-02-27 2009-03-03 Pactiv Corporation Packages with active agents
US20050220375A1 (en) * 2002-02-27 2005-10-06 Thomas Toby R Pakages with active agents
SE0201599D0 (sv) * 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
US7157102B1 (en) 2002-05-31 2007-01-02 Biotek, Inc. Multi-layered microcapsules and method of preparing same
US7041320B1 (en) 2002-05-31 2006-05-09 Biotek, Inc. High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
PL377591A1 (pl) * 2002-10-02 2006-02-06 Zealand Pharma A/S Stabilizowane związki eksendyny-4
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US7691296B2 (en) * 2002-11-25 2010-04-06 Amorepacific Corporation Method for stabilizing active components using polyol/polymer microcapsule, and cosmetic composition containing the microcapsule
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
CN101410174B (zh) 2003-04-10 2011-04-06 Pr药品有限公司 一种用于生产基于乳化的微观粒子的方法
US20060263403A1 (en) * 2003-04-24 2006-11-23 Essam Enan Compositions and methods for controlling insects involving the tyramine receptor
US7541155B2 (en) * 2003-04-24 2009-06-02 Tyratech, Inc. Methods of screening compositions for potential insect control activity
US7622269B2 (en) * 2004-03-19 2009-11-24 Tyratech, Inc. Methods of screening tyramine- and octopamine-expressing cells for compounds and compositions having potential insect control activity
US20040224030A1 (en) * 2003-05-06 2004-11-11 Shastri Venkatram R. Microsphere delivery systems
US7578916B2 (en) * 2004-05-25 2009-08-25 Applied Biosystems, Llc Emulsions of ionic liquids
CN1835974A (zh) 2003-06-16 2006-09-20 细胞技术研究与发展公司 对硬化素特异的抗体和用于增加骨矿化的方法
US7101617B2 (en) * 2003-07-10 2006-09-05 Motorola, Inc. Silicone dispensing with a conformal film
EP2462896A1 (en) * 2003-07-15 2012-06-13 PR Pharmaceuticals Inc. Method for the preparation of controlled release formulations
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
EP2462923A3 (en) 2003-07-18 2012-08-29 Oakwood Laboratories L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
CA2532837A1 (en) * 2003-07-18 2005-04-21 Baxter International, Inc. Method for preparing small spherical particles by controlled phase separation
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
WO2005009375A2 (en) * 2003-07-22 2005-02-03 Baxter International Inc. Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
WO2005009357A2 (en) * 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions
US20050245541A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
WO2005089926A1 (ja) * 2004-03-23 2005-09-29 Kyowa Hakko Kogyo Co., Ltd. 被覆微粒子の製造方法
DK1734971T3 (da) * 2004-04-15 2012-02-13 Alkermes Pharma Ireland Ltd Indretning på polymerbasis med forsinket frigivelse
US7919499B2 (en) 2004-04-22 2011-04-05 Alkermes, Inc. Naltrexone long acting formulations and methods of use
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
EP1758558B1 (en) * 2004-05-12 2013-10-16 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
ATE409025T1 (de) * 2004-05-12 2008-10-15 Baxter Int Nukleinsäure-mikrokügelchen, ihre herstellung und abgabe
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
JP5634009B2 (ja) 2004-05-12 2014-12-03 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ タンパク質を含み、そして高濃度のタンパク質で注射性能を示すミクロスフェア
US7740861B2 (en) * 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
EP2594259A1 (en) 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
KR101340946B1 (ko) * 2004-08-04 2013-12-13 알자 코포레이션 오름차 0차 방출 패턴을 나타내는 약물의 서방성 조성물,상기 조성물을 제조하는 방법
EP1802289B1 (en) * 2004-09-17 2011-12-07 University of Massachusetts Compositions and their uses for lysosomal enzyme deficiencies
US20060073208A1 (en) 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
CA2602246C (en) 2005-03-25 2013-09-10 Appleton Papers Inc. Activator means for pre-applied adhesives
JP2008539259A (ja) * 2005-04-27 2008-11-13 バクスター・インターナショナル・インコーポレイテッド 表面を修飾した微粒子およびその形成方法および使用
US7803422B2 (en) * 2005-05-23 2010-09-28 Appleton Papers Inc. Water-in-oil capsule manufacture process and microcapsules produced by such process
WO2007018736A2 (en) * 2005-07-22 2007-02-15 Appleton Papers Inc. Encapsulated structural adhesive
US9693967B2 (en) * 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
CA2622441A1 (en) * 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US20090209624A1 (en) * 2005-10-24 2009-08-20 University Of Massachusetts Compositions and their uses for gene therapy of bone conditions
US20070138671A1 (en) * 2005-12-15 2007-06-21 Anastasiou Theodore J Encapsulated active material with reduced formaldehyde potential
CA2634974A1 (en) 2005-12-30 2007-07-12 Zensun (Shanghai) Science & Technology, Ltd. Extended release of neuregulin for improved cardiac function
CA2648718A1 (en) 2006-04-07 2007-10-18 The Research Foundation Of State University Of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
CN100385063C (zh) * 2006-04-25 2008-04-30 中原工学院 具有持久抗菌芳香效果的纺织品纳米后整理试剂及其制作工艺
US7959940B2 (en) * 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
BRPI0708873A2 (pt) * 2006-06-27 2011-06-14 Tyratech Inc composiÇÕes e mÉtodos para tratar infecÇÕes parasÍticas
EP2048944A4 (en) * 2006-07-17 2012-06-27 Tyratech Inc COMPOSITIONS AND METHODS FOR CONTROLLING INSECTS
WO2008019346A2 (en) * 2006-08-04 2008-02-14 Baxter International Inc. Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
JP5048773B2 (ja) 2006-08-09 2012-10-17 インターシア セラピューティクス，インコーポレイティド 浸透圧式デリバリーシステム及びピストンアセンブリー
JP2010505882A (ja) * 2006-10-06 2010-02-25 バクスター・インターナショナル・インコーポレイテッド 表面改質微粒子を含むマイクロエンカプセルならびに、その形成および使用の方法
US20090099135A1 (en) * 2007-01-16 2009-04-16 Tyratech, Inc. Pest control compositions and methods
AU2008231093A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
ES2402172T3 (es) 2007-04-23 2013-04-29 Intarcia Therapeutics, Inc Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos
CN101678306A (zh) * 2007-05-21 2010-03-24 弗门尼舍有限公司 大型凝聚胶囊
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
WO2008157540A1 (en) * 2007-06-20 2008-12-24 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
MX2010001684A (es) * 2007-08-15 2010-04-21 Amunix Inc Composiciones y metodos para modificar propiedades de polipeptidos biologicamente activos.
WO2009058913A2 (en) * 2007-10-29 2009-05-07 University Of Massachusetts Encapsulated nanoparticles for nucleic acid delivery
CA2705520C (en) * 2007-11-13 2016-06-28 Surmodics Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
US8619257B2 (en) 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
ES2718612T3 (es) 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
WO2009086471A2 (en) * 2007-12-27 2009-07-09 Tyratech, Inc. Synergistic antiparasitic compositions and screening methods
CN101970558A (zh) * 2007-12-28 2011-02-09 陶氏环球技术公司 小尺寸功能材料
CN101960364A (zh) * 2007-12-28 2011-01-26 陶氏环球技术公司 包含吸收有液晶物质的聚合物纳米粒子的相位补偿膜
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
US8133861B2 (en) * 2008-02-29 2012-03-13 Alseres Pharmaceuticals, Inc. Systemic purine administration: modulating axonal outgrowth of central nervous system neurons
US8071214B2 (en) * 2008-05-01 2011-12-06 Appleton Papers Inc. Particle with selected permeance wall
US20090274906A1 (en) * 2008-05-01 2009-11-05 Appleton Papers Inc. Particle with low permeance wall
US8067089B2 (en) * 2008-05-01 2011-11-29 Appleton Papers Inc. Cationic microcapsule particles
JP5763525B2 (ja) * 2008-05-07 2015-08-12 サーモディクス，インコーポレイティド 粒子からの核酸複合体の送達
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
WO2010033776A1 (en) * 2008-09-18 2010-03-25 Surmodics Pharmaceuticals, Inc. Microencapsulation process with solvent and salt
WO2010033247A2 (en) 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Reduced size self-delivering rnai compounds
KR101820024B1 (ko) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
US20110224312A1 (en) * 2008-11-17 2011-09-15 Wayne State University Engineering porous particles of water soluble therapeutics for pressurized metered-dose inhaler formulations
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
CA2748296C (en) 2008-12-23 2017-03-21 Surmodics Pharmaceuticals, Inc. Implantable composites and compositions comprising releasable bioactive agents
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
JP2012515837A (ja) 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ， インコーポレイテッド 異なる非反復単位を有するポリマーを含むポリマー混合物、ならびにそれを作製および使用するための方法
CA2749993C (en) * 2009-01-23 2016-12-20 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
EP2389161A2 (en) * 2009-01-23 2011-11-30 Surmodics Pharmaceuticals, Inc. Controlled release systems from polymer blends
US20100196436A1 (en) * 2009-01-30 2010-08-05 Gooberman Lance L Implants containing disulfiram and an anti-inflammatory agent
EP3178835B1 (en) 2009-02-03 2019-04-10 Amunix Pharmaceuticals, Inc. Extended recombinant polypeptides and compositions comprising same
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
US8455098B2 (en) * 2009-04-07 2013-06-04 Appleton Papers Inc. Encapsulated solid hydrophilic particles
US8791093B2 (en) * 2009-05-29 2014-07-29 Lance L. Gooberman Pharmaceutical delivery systems for treatment of substance abuse and other addictions
US9062299B2 (en) 2009-08-24 2015-06-23 Amunix Operating Inc. Coagulation factor IX compositions and methods of making and using same
CA2775676C (en) 2009-09-28 2016-08-16 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
KR20120095371A (ko) 2009-10-01 2012-08-28 에보닉 데구사 코포레이션 노화 황반변성 치료용 극미립자 조성물들 및 노화 황반변성 치료방법
NZ599543A (en) 2009-10-30 2014-02-28 Ntf Therapeutics Inc Improved neurturin molecules
EP3831402A1 (de) 2009-11-13 2021-06-09 Sanofi-Aventis Deutschland GmbH Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
MX2012005184A (es) 2009-11-13 2012-06-08 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina.
US20110207653A1 (en) * 2009-12-21 2011-08-25 Adrian Raiche Microparticle Encapsulated Thiol-Containing Polypeptides Together with a Redox Reagent
US8715544B2 (en) * 2009-12-21 2014-05-06 Appvion, Inc. Hydrophilic liquid encapsulates
RU2562263C9 (ru) * 2009-12-22 2016-04-27 Евоник Корпорейшн Способ и рабочий узел для приготовления микрочастиц с использованием эмульсии
US9743688B2 (en) 2010-03-26 2017-08-29 Philip Morris Usa Inc. Emulsion/colloid mediated flavor encapsulation and delivery with tobacco-derived lipids
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
US20110269657A1 (en) 2010-04-28 2011-11-03 Jiten Odhavji Dihora Delivery particles
US9993793B2 (en) 2010-04-28 2018-06-12 The Procter & Gamble Company Delivery particles
US9186642B2 (en) 2010-04-28 2015-11-17 The Procter & Gamble Company Delivery particle
US20110319473A1 (en) 2010-06-29 2011-12-29 Surmodics, Inc. Compositions and methods for enhancement of nucleic acid delivery
WO2012024229A1 (en) 2010-08-14 2012-02-23 University Of Massachusetts Yeast cell wall particle for receptor-targeted nanoparticle delivery
CA2808901A1 (en) * 2010-08-20 2012-02-23 Cerulean Pharma Inc. Conjugates, particles, compositions, and related methods
CA2809825A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Biodegradable terpolymers and terpolymer blends as pressure-sensitive adhesives
RU2546520C2 (ru) 2010-08-30 2015-04-10 Санофи-Авентис Дойчланд Гмбх Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа
EP2621473A2 (en) 2010-09-30 2013-08-07 Evonik Corporation Method for removing residual organic solvent from microparticles
CN103298453A (zh) 2010-09-30 2013-09-11 赢创有限公司 制备低残留溶剂微粒的乳化法
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
WO2012109664A1 (en) 2011-02-11 2012-08-16 Edge Therapeutics Compositions and methods for improving prognosis of a human with subarachnoid hemorrhage
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
JP6336899B2 (ja) 2011-04-05 2018-06-06 エッジ セラピューティクス インコーポレイテッド 脳血流に影響する脳損傷後の結果を改善するための脳室内ドラッグデリバリーシステム
EP2694031B1 (en) 2011-04-07 2015-07-08 The Procter and Gamble Company Conditioner compositions with increased deposition of polyacrylate microcapsules
MX2013010980A (es) 2011-04-07 2013-10-30 Procter & Gamble Composiciones de limpieza personal con deposito mejorado de microcapsulas de poliacrilato.
MX2013010983A (es) 2011-04-07 2013-10-30 Procter & Gamble Composiciones de champu con deposito mejorado de microcapsulas de poliacrilato.
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012164480A1 (en) * 2011-05-30 2012-12-06 National Institute Of Immunology A vaccine composition capable of inducing memory antibody response from single point immunization
AU2012273153A1 (en) 2011-06-21 2013-05-02 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
SI2750699T1 (sl) 2011-08-29 2015-11-30 Sanofi-Aventis Deutschland Gmbh Farmacevtska kombinacija, za uporabo pri glikemični kontroli pri pacientih, ki imajo sladkorno bolezen tipa 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CA2855358C (en) 2011-11-11 2021-03-16 Fred Hutchinson Cancer Research Center Cyclin a1-targeted t-cell immunotherapy for cancer
HUE043537T2 (hu) 2012-02-15 2019-08-28 Bioverativ Therapeutics Inc Rekombináns VIII faktor fehérjék
CA2864904C (en) 2012-02-15 2023-04-25 Amunix Operating Inc. Factor viii compositions and methods of making and using same
US20130260040A1 (en) * 2012-02-28 2013-10-03 Neil Werde Microencapsulated catnip oil and methods of using the same
US9408419B2 (en) 2012-03-23 2016-08-09 Victoria's Secret Store Brand Management, Inc. Moisturizing fabric material, use thereof in moisturizing bras, and method of manufacture
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
WO2014022859A1 (en) 2012-08-03 2014-02-06 Essam Enan Antiparasitic compositions and methods
EP2916825A1 (en) 2012-11-09 2015-09-16 Evonik Corporation Drying methods for tuning microparticle properties
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
CN105960249B (zh) 2014-01-09 2021-03-16 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
RU2016132340A (ru) 2014-01-09 2018-02-14 Санофи Стабилизированные фармацевтические составы на основе инсулина аспарта
CN111658604A (zh) 2014-01-09 2020-09-15 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
WO2015150942A2 (en) 2014-03-29 2015-10-08 The WOCKHARDT LIMITED Improved process for preparing microparticles
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
ES2949095T3 (es) 2014-12-12 2023-09-25 Sanofi Aventis Deutschland Formulación de relación fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
WO2017024060A1 (en) 2015-08-03 2017-02-09 Biogen Ma Inc. Factor ix fusion proteins and methods of making and using same
EP3390483B1 (en) 2015-10-27 2022-05-18 The Procter & Gamble Company Encapsulation
BG112154A (bg) 2015-11-19 2017-05-31 СОФИЙСКИ УНИВЕРСИТЕТ "Св. Кл. Охридски" Метод за получаване на течни, полутечни и твърди органични частици с контролирана форма и/или размер
EP3419596A1 (en) 2016-02-23 2019-01-02 BioDelivery Sciences International, Inc. Sustained release buprenorphine microspheres (srbm) and methods of use thereof
EP3458084B1 (en) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Glucagon-receptor selective polypeptides and methods of use thereof
WO2017199123A1 (en) 2016-05-17 2017-11-23 Ecole Polytechnique Federale De Lausanne (Epfl) Device and methods for shell phase removal of core-shell capsules
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US10835580B2 (en) 2017-01-03 2020-11-17 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
CN110168042B (zh) 2017-01-27 2022-05-27 恩盖普有限公司 包封物
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
JP2021523878A (ja) 2018-05-18 2021-09-09 バイオベラティブ セラピューティクス インコーポレイテッド 血友病ａを処置する方法
WO2019236669A1 (en) * 2018-06-08 2019-12-12 The United States Of America, As Represented By The Secretary Of Agriculture Compositions containing microencapsulated organic compounds
WO2019240568A1 (es) 2018-06-14 2019-12-19 Centro De Investigación En Química Aplicada Método de obtención de partículas porosas mediante un proceso híbrido de pulverización por secado-enfriamiento
US11260359B2 (en) 2019-01-11 2022-03-01 Encapsys, Llc Incorporation of chitosan in microcapsule wall
CA3149494A1 (en) 2019-08-12 2021-02-18 Purinomia Biotech, Inc. Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
TW202332694A (zh) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 血清半衰期延長之ｐｄ－ｌ１結合多肽
EP4413038A1 (en) 2021-10-07 2024-08-14 Avacta Life Sciences Limited Pd-l1 binding affimers
WO2023153876A1 (ko) 2022-02-10 2023-08-17 주식회사 아피셀테라퓨틱스 Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도
WO2023218243A1 (en) 2022-05-12 2023-11-16 Avacta Life Sciences Limited Lag-3/pd-l1 binding fusion proteins
US20240147990A1 (en) 2022-10-21 2024-05-09 Encapsys, Llc Delivery Particles Based On Amine-Thiol-Ene Conjugates and Derivatives
WO2024118694A1 (en) 2022-12-01 2024-06-06 Encapsys, Llc Degradable delivery particles from mixed acid treated chitosan
WO2024118690A1 (en) 2022-12-01 2024-06-06 Encapsys, Llc Charge modified chitosan cross-linked encapsulate
WO2024118696A1 (en) 2022-12-01 2024-06-06 Encapsys, Llc Degradable delivery particles made from redox-initiator-modified chitosan

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572869A (en) * 1967-04-20 1986-02-25 Ppg Industries, Inc. Microcapsular opacifiers and method for their production
US3644963A (en) * 1969-07-24 1972-02-29 Federico Terranova Procedure for the removal of the bones from hams and similar cuts of meat
US3664963A (en) * 1969-10-22 1972-05-23 Balchem Corp Encapsulation process
US3780195A (en) * 1969-10-22 1973-12-18 Balchem Corp Encapsulation process
DE2059494B2 (de) * 1970-12-03 1972-03-16 Licentia Gmbh Biegsamer hohlleiter
US3790497A (en) * 1971-11-24 1974-02-05 Mitsubishi Rayon Co Method for producing water containing microcapsules
JPS528795B2 (da) * 1971-12-30 1977-03-11
US4089800A (en) * 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
JPS528795A (en) * 1975-07-10 1977-01-22 Kyocera Corp Selective indication circuit
DE2930248A1 (de) * 1979-07-26 1981-02-12 Bayer Ag Verfahren zur herstellung von mikrokapseln
US4933105A (en) * 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
JPS6048923A (ja) * 1983-08-25 1985-03-16 Mitsui Toatsu Chem Inc 微小粒子の製造方法
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
CA1287459C (en) * 1986-10-01 1991-08-13 Mukesh Jain Process for the preparation of hollow microspheres
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same

Also Published As

Publication number Publication date
IE901616L (en) 1990-11-04
DK0471036T3 (da) 1996-05-28
GR900100330A (en) 1991-10-10
AU5741590A (en) 1990-11-29
KR920700762A (ko) 1992-08-10
ES2084698T5 (es) 2005-03-01
ES2084698T3 (es) 1996-05-16
KR0162660B1 (en) 1998-11-16
CA2050911A1 (en) 1990-11-05
ZA903411B (en) 1991-02-27
IL94296A (en) 1995-10-31
EP0471036A4 (en) 1992-03-18
EP0471036B1 (en) 1996-01-17
NZ233570A (en) 1992-12-23
DE69024953T3 (de) 2005-01-27
US5407609A (en) 1995-04-18
ATE133087T1 (de) 1996-02-15
NO302683B1 (no) 1998-04-14
FI915129A0 (fi) 1991-10-30
IL94296A0 (en) 1991-03-10
MX20594A (es) 1994-03-31
NO914292L (no) 1991-11-01
HK30897A (en) 1997-03-21
DE69024953T2 (de) 1996-08-14
JP2582186B2 (ja) 1997-02-19
IE69313B1 (en) 1996-09-04
FI103183B (fi) 1999-05-14
CA2050911C (en) 1997-07-15
GR1000614B (el) 1992-08-31
DE69024953D1 (de) 1996-02-29
JPH04505454A (ja) 1992-09-24
WO1990013361A1 (en) 1990-11-15
CN1047223A (zh) 1990-11-28
EP0471036A1 (en) 1992-02-19
NO914292D0 (no) 1991-11-01
FI103183B1 (fi) 1999-05-14
EP0471036B2 (en) 2004-06-23

Similar Documents

Publication Publication Date Title
DK0471036T4 (da) Indkapslingsfremgangsmåde
ES8301663A1 (es) Un metodo de preparar microcapsulas cargadas con un agente activo, en particular con productos quimicos agricolas ,per- fumes,agentes de curado,colorantes-oxidantes y agentes biologicos activos.
ES8605983A1 (es) Un metodo de producir una microcapsula de liberacion prolongada de un farmaco soluble en agua
JPS5231981A (en) Microcapsule preparation method
ES2084171T3 (es) Sustitutivos de grasas y metodo de preparar microglobulos organicos.
JPS5430363A (en) Disc-brake apparatus
FR2548676B1 (fr) Compositions de biopolymeres et leur procede de preparation
JPS5222669A (en) Enclosed type reserver used in master cylinder
BR9406239A (pt) Método para encapsular substáncias em biocápsulas
JPS5215621A (en) Apparatus for producing pulp particles
GB1399292A (en) Stabilized pest-control composition
NL166258B (nl) Werkwijze voor de bereiding van verbindingen met werking tegen maagzweren, werkwijze voor de bereiding van preparaten die ze bevatten, en gevormde preparaten.
WO1990010436A3 (en) Membrane encapsulated essential oil
JPS529279A (en) Method of dividing a fluid containing a solid uniformly
JPS5266887A (en) Defoaming agent composition
JPS5456A (en) Organopolysiloxane emulsion
JPS51115915A (en) Method for preparing antimolds, antiseptics and substances preventing rancidity of higy purity
JPS51138055A (en) Separation method of oil and water
IT8120873A0 (it) Metodo per formare su un supporto quale un crosta di pelle un rivestimento finemente rugoso di elevata trasparenza e brillantezza,apparecchiatura per attuare tale metodo e manufatti cosi' ottenuti.
JPS529968A (en) Method for disposing of waste water containing surface-active agent
JPS51120894A (en) Method of removing rejected packages
JPS51138735A (en) Preparation of aqueous p olyolefin suspension
JPS53121699A (en) Separating column for chromatography
NL178251B (nl) 5-gesubstitueerde picolinezuren en derivaten daarvan met bloeddruk verlagende werking, werkwijze voor de bereiding daarvan en preparaten die ze bevatten.
JPS5278324A (en) Real time character recognition equipment of format discrimination typ e