DE69936285D1 - INDOLOi2,1-BöQUINAZOLIN-6,12-DIONE ANTIMALARIA DERIVATE UND METHODEN ZUR BEHANDLUNG VON MALARIA - Google Patents

INDOLOi2,1-BöQUINAZOLIN-6,12-DIONE ANTIMALARIA DERIVATE UND METHODEN ZUR BEHANDLUNG VON MALARIA

Info

Publication number
DE69936285D1
DE69936285D1 DE69936285T DE69936285T DE69936285D1 DE 69936285 D1 DE69936285 D1 DE 69936285D1 DE 69936285 T DE69936285 T DE 69936285T DE 69936285 T DE69936285 T DE 69936285T DE 69936285 D1 DE69936285 D1 DE 69936285D1
Authority
DE
Germany
Prior art keywords
indoloi2
boquinazoline
antimalaria
malaria
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69936285T
Other languages
English (en)
Inventor
Kevin K Pitzer
John P Scovill
Dennis E Kyle
Lucia Gerena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Army
Walter Reed Army Institute of Research
Original Assignee
US Department of Army
Walter Reed Army Institute of Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Army, Walter Reed Army Institute of Research filed Critical US Department of Army
Application granted granted Critical
Publication of DE69936285D1 publication Critical patent/DE69936285D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69936285T 1998-09-30 1999-09-28 INDOLOi2,1-BöQUINAZOLIN-6,12-DIONE ANTIMALARIA DERIVATE UND METHODEN ZUR BEHANDLUNG VON MALARIA Expired - Lifetime DE69936285D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10239998P 1998-09-30 1998-09-30
PCT/US1999/022569 WO2000018769A2 (en) 1998-09-30 1999-09-28 INDOLO[2,1-b]QUINAZOLE-6,12-DIONE ANTIMALARIAL COMPOUNDS AND METHODS OF TREATING MALARIA THEREWITH

Publications (1)

Publication Number Publication Date
DE69936285D1 true DE69936285D1 (de) 2007-07-26

Family

ID=22289636

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936285T Expired - Lifetime DE69936285D1 (de) 1998-09-30 1999-09-28 INDOLOi2,1-BöQUINAZOLIN-6,12-DIONE ANTIMALARIA DERIVATE UND METHODEN ZUR BEHANDLUNG VON MALARIA

Country Status (8)

Country Link
US (4) US6284772B1 (de)
EP (1) EP1032574B1 (de)
AP (1) AP1393A (de)
AU (1) AU765401B2 (de)
CA (1) CA2317711A1 (de)
DE (1) DE69936285D1 (de)
WO (1) WO2000018769A2 (de)
ZA (1) ZA200003315B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69936285D1 (de) * 1998-09-30 2007-07-26 Us Army INDOLOi2,1-BöQUINAZOLIN-6,12-DIONE ANTIMALARIA DERIVATE UND METHODEN ZUR BEHANDLUNG VON MALARIA
US20040242632A1 (en) * 2001-11-09 2004-12-02 Charous B. Lauren Method for treating inflammatory bowel disease
US7259167B2 (en) * 2002-02-09 2007-08-21 United States Of America As Represented By The Secretary Of The Army Antimalarial and antiproliferative pharmacophore models, novel tryptanthrin compounds having increased solubility, and methods of making and using thereof
CA2513655C (en) * 2003-01-21 2011-11-22 Chiron Corporation Use of tryptanthrin compounds for immune potentiation
WO2004087153A2 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
DE10315654A1 (de) * 2003-04-04 2004-11-04 Universitätsklinikum Charité an der Humboldt-Universität zu Berlin Technologietransferstelle 8-Nitro-Tryptanthrin und andere Tryptanthrin-Derivate zur Therapie von Erkrankungen, die durch hoch-proliferierende Zellen verursacht werden
US7256198B2 (en) 2004-02-18 2007-08-14 Wyeth Pyrimidoindolones and methods for using same
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
EP2277595A3 (de) 2004-06-24 2011-09-28 Novartis Vaccines and Diagnostics, Inc. Verbindungen zur Immunopotenzierung
US20080227730A1 (en) * 2005-01-14 2008-09-18 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9A-Carbamoyl and Thiocarbamoyl Azalides With Antimalarial Activity
WO2007036947A1 (en) * 2005-09-30 2007-04-05 Ipca Laboratories Limited Delayed release anti-malarial composition
ATE464301T1 (de) 2005-10-04 2010-04-15 Director General Defence Res & Aus gomphostemma niveum isolierte verbindung gegen malaria
EP2010537B1 (de) * 2006-03-23 2011-12-28 Novartis AG Imidazochinoxalinverbindungen als immunmodulatoren
CA2646891A1 (en) * 2006-03-23 2007-09-27 Novartis Ag Immunopotentiating compounds
EP2273974A2 (de) * 2008-05-09 2011-01-19 Tolmar, Inc. Proguanil zur behandlung von haut-/schleimhauterkrankungen
MX2011007897A (es) * 2009-01-30 2011-09-15 4Sc Ag Derivados de sulfamoil-fenil-ureido benzamidina como agentes contra la malaria.
CN103570726B (zh) * 2013-07-15 2016-04-06 上海天慈生物谷生物工程有限公司 N-烷基色胺酮衍生物及其制备方法和应用
CN103570727B (zh) 2013-11-12 2015-08-19 复旦大学 一种n-苄基色胺酮衍生物及其制备方法和应用
RU2694058C1 (ru) * 2019-04-08 2019-07-09 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Водорастворимое производное триптантрина, обладающее противоопухолевой, противовоспалительной и противомикробной активностью, и повышающее терапевтическую активность противоопухолевых антибиотиков
WO2021033159A1 (en) * 2019-08-20 2021-02-25 Ciimar - Centro Interdisciplinar De Investigação Marinha E Ambiental Pyrazino [1,2-b]quinazoline-3,6-diones derivatives, their production and uses thereof
CN114057760B (zh) * 2021-11-15 2023-10-20 成都大学 一种吲哚并喹唑啉酮螺1,3-二氧戊环化合物、制备方法及其用途
CN115197227A (zh) * 2022-08-09 2022-10-18 贵州大学 一类色胺酮1位或3位取代芳香硫醚衍生物、其制备方法及应用
CN115124531A (zh) * 2022-08-09 2022-09-30 贵州大学 一类4-氮杂色胺酮芳香硫醚衍生物、制备方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4114990A1 (de) * 1991-05-08 1992-11-12 Basf Ag Tryptanthrinderivate
US5441955A (en) 1993-11-19 1995-08-15 Pathogenesis Corporation Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof
US5616441A (en) * 1994-09-20 1997-04-01 Mita Industrial Co., Ltd. Tryptoanthorine derivative contained in electrophotosensitive material
JP3272189B2 (ja) * 1994-10-18 2002-04-08 京セラミタ株式会社 ナフチレンジアミン誘導体とそれを用いた電子写真感光体
EP0718298A1 (de) * 1994-11-29 1996-06-26 Mita Industrial Co. Ltd. Ladungstransportierende Tryptoanthrinimderivate
US5773613A (en) * 1994-11-29 1998-06-30 Mita Industrial Co., Ltd. Tryptoanthrinimine derivative and electrophotosensitive material using the same
JP3264618B2 (ja) * 1995-07-26 2002-03-11 京セラミタ株式会社 電子写真感光体
US5817810A (en) * 1995-07-26 1998-10-06 Mita Industrial Co., Ltd. Tryptanthrine compounds
DE69936285D1 (de) * 1998-09-30 2007-07-26 Us Army INDOLOi2,1-BöQUINAZOLIN-6,12-DIONE ANTIMALARIA DERIVATE UND METHODEN ZUR BEHANDLUNG VON MALARIA

Also Published As

Publication number Publication date
WO2000018769A3 (en) 2000-09-08
US6284772B1 (en) 2001-09-04
EP1032574B1 (de) 2007-06-13
CA2317711A1 (en) 2000-04-06
AP2000001855A0 (en) 2000-06-30
EP1032574A3 (de) 2000-12-20
US20010034350A1 (en) 2001-10-25
US8012987B2 (en) 2011-09-06
US20060160827A1 (en) 2006-07-20
EP1032574A2 (de) 2000-09-06
WO2000018769A2 (en) 2000-04-06
AU765401B2 (en) 2003-09-18
AU6502399A (en) 2000-04-17
AP1393A (en) 2005-04-19
ZA200003315B (en) 2001-07-11
US20030191138A1 (en) 2003-10-09
US6531487B2 (en) 2003-03-11

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