DE69627993D1 - Trycyclische derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen - Google Patents

Trycyclische derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen

Info

Publication number
DE69627993D1
DE69627993D1 DE69627993T DE69627993T DE69627993D1 DE 69627993 D1 DE69627993 D1 DE 69627993D1 DE 69627993 T DE69627993 T DE 69627993T DE 69627993 T DE69627993 T DE 69627993T DE 69627993 D1 DE69627993 D1 DE 69627993D1
Authority
DE
Germany
Prior art keywords
trycyclic
inhibiting
derivatives
proliferative diseases
protein function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69627993T
Other languages
English (en)
Other versions
DE69627993T2 (de
Inventor
Adriano Afonso
Joseph M Kelly
Ronald L Wolin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69627993D1 publication Critical patent/DE69627993D1/de
Application granted granted Critical
Publication of DE69627993T2 publication Critical patent/DE69627993T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69627993T 1995-03-24 1996-03-20 Trycyclische derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen Expired - Fee Related DE69627993T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/410,442 US5684013A (en) 1995-03-24 1995-03-24 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US410442 1995-03-24
PCT/US1996/003306 WO1996030017A1 (en) 1995-03-24 1996-03-20 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
DE69627993D1 true DE69627993D1 (de) 2003-06-12
DE69627993T2 DE69627993T2 (de) 2004-02-26

Family

ID=23624752

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69627993T Expired - Fee Related DE69627993T2 (de) 1995-03-24 1996-03-20 Trycyclische derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen

Country Status (15)

Country Link
US (3) US5684013A (de)
EP (1) EP0814807B1 (de)
JP (1) JP3001982B2 (de)
KR (1) KR19980703257A (de)
AR (1) AR003936A1 (de)
AT (1) ATE239472T1 (de)
AU (1) AU708244B2 (de)
CA (1) CA2216291C (de)
DE (1) DE69627993T2 (de)
ES (1) ES2198481T3 (de)
HU (1) HUP9801396A3 (de)
IL (1) IL117603A (de)
NZ (1) NZ305133A (de)
TW (1) TW473477B (de)
WO (1) WO1996030017A1 (de)

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US6727082B1 (en) 1996-04-11 2004-04-27 Gpc Biotech Inc. Assays and reagents for identifying anti-fungal agents, and uses related thereto
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Also Published As

Publication number Publication date
TW473477B (en) 2002-01-21
AU708244B2 (en) 1999-07-29
JP3001982B2 (ja) 2000-01-24
IL117603A0 (en) 1996-07-23
US5684013A (en) 1997-11-04
MX9707191A (es) 1997-11-29
HUP9801396A2 (hu) 1999-05-28
CA2216291C (en) 2001-06-05
AU5307296A (en) 1996-10-16
NZ305133A (en) 1999-11-29
ATE239472T1 (de) 2003-05-15
EP0814807B1 (de) 2003-05-07
HUP9801396A3 (en) 2000-03-28
JPH10505102A (ja) 1998-05-19
EP0814807A1 (de) 1998-01-07
KR19980703257A (ko) 1998-10-15
US5958939A (en) 1999-09-28
ES2198481T3 (es) 2004-02-01
DE69627993T2 (de) 2004-02-26
US5703090A (en) 1997-12-30
AR003936A1 (es) 1998-09-30
CA2216291A1 (en) 1996-10-03
WO1996030017A1 (en) 1996-10-03
IL117603A (en) 2001-01-28

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