DE69627183T2 - Verfahren zur automatischen bildanalyse biologischer proben - Google Patents

Verfahren zur automatischen bildanalyse biologischer proben Download PDF

Info

Publication number
DE69627183T2
DE69627183T2 DE69627183T DE69627183T DE69627183T2 DE 69627183 T2 DE69627183 T2 DE 69627183T2 DE 69627183 T DE69627183 T DE 69627183T DE 69627183 T DE69627183 T DE 69627183T DE 69627183 T2 DE69627183 T2 DE 69627183T2
Authority
DE
Germany
Prior art keywords
interest
objects
candidate
images
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69627183T
Other languages
English (en)
Other versions
DE69627183D1 (de
Inventor
W Douglass
J Riding
E Ring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ChromaVision Medical Systems Inc
Original Assignee
ChromaVision Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21833882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69627183(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ChromaVision Medical Systems Inc filed Critical ChromaVision Medical Systems Inc
Publication of DE69627183D1 publication Critical patent/DE69627183D1/de
Application granted granted Critical
Publication of DE69627183T2 publication Critical patent/DE69627183T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Multimedia (AREA)
  • Biochemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Theoretical Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Geometry (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Image Processing (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Image Analysis (AREA)
DE69627183T 1995-11-30 1996-11-27 Verfahren zur automatischen bildanalyse biologischer proben Expired - Lifetime DE69627183T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2680595P 1995-11-30 1995-11-30
PCT/US1996/019166 WO1997020198A2 (en) 1995-11-30 1996-11-27 Method and apparatus for automated image analysis of biological specimens

Publications (2)

Publication Number Publication Date
DE69627183D1 DE69627183D1 (de) 2003-05-08
DE69627183T2 true DE69627183T2 (de) 2004-01-29

Family

ID=21833882

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69627183T Expired - Lifetime DE69627183T2 (de) 1995-11-30 1996-11-27 Verfahren zur automatischen bildanalyse biologischer proben

Country Status (8)

Country Link
US (12) US6215892B1 (de)
EP (2) EP1300713A3 (de)
JP (1) JP2000501184A (de)
AT (1) ATE236386T1 (de)
AU (1) AU724393B2 (de)
CA (1) CA2236268A1 (de)
DE (1) DE69627183T2 (de)
WO (1) WO1997020198A2 (de)

Families Citing this family (407)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5161052B2 (ja) * 2008-12-04 2013-03-13 オリンパス株式会社 顕微鏡システム、標本観察方法およびプログラム
US6718053B1 (en) * 1996-11-27 2004-04-06 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
DE69627183T2 (de) * 1995-11-30 2004-01-29 Chromavision Med Sys Inc Verfahren zur automatischen bildanalyse biologischer proben
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
US6650357B1 (en) * 1997-04-09 2003-11-18 Richardson Technologies, Inc. Color translating UV microscope
EP1061127A4 (de) * 1998-02-03 2005-11-16 Hakuju Inst For Health Science Inspektionsverfahren für mikroorganismen und ähnliches und einheit dafür.
US6350613B1 (en) * 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts
US6373977B1 (en) * 1998-03-22 2002-04-16 Hewlett-Packard Company Methods and apparatus for constructing a 3D model of a scene and rendering new views of the scene
US20090111101A1 (en) * 1998-05-09 2009-04-30 Ikonisys, Inc. Automated Cancer Diagnostic Methods Using FISH
US7901887B2 (en) 1998-05-09 2011-03-08 Ikonisys, Inc. Automated cancer diagnostic methods using fish
KR100691043B1 (ko) * 1998-05-09 2007-03-09 아이코니시스 인코포레이티드 컴퓨터 제어된 태아 세포 포함 희귀 세포 진단 방법 및 장치
US20080241848A1 (en) * 1998-05-09 2008-10-02 Ikonisys, Inc. Methods for prenatal diagnosis of aneuploidy
US6606413B1 (en) * 1998-06-01 2003-08-12 Trestle Acquisition Corp. Compression packaged image transmission for telemicroscopy
US20040083085A1 (en) * 1998-06-01 2004-04-29 Zeineh Jack A. Integrated virtual slide and live microscope system
US6438261B1 (en) * 1998-09-03 2002-08-20 Green Vision Systems Ltd. Method of in-situ focus-fusion multi-layer spectral imaging and analysis of particulate samples
EP0990896B1 (de) * 1998-09-10 2012-01-25 Wallac Oy Analysegerät für ein grossflächiges Bild
CA2298192C (en) * 1999-02-08 2005-09-13 Seiko Epson Corporation Interface device, control method for the same, and data storage medium for recording the control method
US20040058401A1 (en) * 1999-04-13 2004-03-25 Blaise Bossy Method for detecting rare event
JP2002541494A (ja) * 1999-04-13 2002-12-03 クロマビジョン メディカル システムズ インコーポレイテッド 組織学的再構成と自動画像分析
US6847729B1 (en) 1999-04-21 2005-01-25 Fairfield Imaging Limited Microscopy
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US6453060B1 (en) 1999-06-29 2002-09-17 Tri Path Imaging, Inc. Method and apparatus for deriving separate images from multiple chromogens in a branched image analysis system
EP1203343A4 (de) * 1999-07-13 2006-08-23 Chromavision Med Sys Inc Automatische detektion von objekten in einem biologischen muster
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US6979425B1 (en) * 1999-10-04 2005-12-27 Robodesign International, Inc. High capacity microarray dispensing
US6558623B1 (en) * 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US7369304B2 (en) * 1999-10-29 2008-05-06 Cytyc Corporation Cytological autofocusing imaging systems and methods
US6483935B1 (en) * 1999-10-29 2002-11-19 Cognex Corporation System and method for counting parts in multiple fields of view using machine vision
US7346200B1 (en) 1999-11-18 2008-03-18 Ikonisys, Inc. Method and apparatus for computer controlled cell based diagnosis
US20060073509A1 (en) * 1999-11-18 2006-04-06 Michael Kilpatrick Method for detecting and quantitating multiple subcellular components
EP2281879B1 (de) * 1999-11-30 2016-01-27 Intrexon Corporation Vorrichtung zur Bestimmung eines morphologischen oder physiologischen Merkmals von individuellen Zellen in einer biologischen Probe
US6886168B2 (en) * 2000-01-20 2005-04-26 Q3Dm, Llc Method and system for extensible data processing
EP1154370B1 (de) * 2000-03-24 2008-01-23 LemnaTec GmbH Automatische Bonitierung von biologischen Objekten auf der Basis dynamischer Farbanalyse mit nachfolgender Grössen- und Formanalyse
US7518652B2 (en) * 2000-05-03 2009-04-14 Aperio Technologies, Inc. Method and apparatus for pre-focus in a linear array based slide scanner
US7738688B2 (en) 2000-05-03 2010-06-15 Aperio Technologies, Inc. System and method for viewing virtual slides
US6711283B1 (en) 2000-05-03 2004-03-23 Aperio Technologies, Inc. Fully automatic rapid microscope slide scanner
US7668362B2 (en) 2000-05-03 2010-02-23 Aperio Technologies, Inc. System and method for assessing virtual slide image quality
WO2001088850A2 (en) * 2000-05-17 2001-11-22 University Of South Florida Statistical image analysis
US6518554B1 (en) 2000-05-24 2003-02-11 Chromavision Medical Systems, Inc. Reverse focusing methods and systems
US7025933B2 (en) * 2000-07-06 2006-04-11 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US6498863B1 (en) * 2000-09-20 2002-12-24 Media Cybernetics Inc. Method, system, and product for analyzing a digitized image of an array to create an image of a grid overlay
AU2002232892B2 (en) 2000-10-24 2008-06-26 Intrexon Corporation Method and device for selectively targeting cells within a three -dimensional specimen
AU2002253796A1 (en) * 2000-10-30 2002-08-28 Robodesign International, Inc. High capacity microarray dispensing
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
AU2002217904A1 (en) * 2000-11-28 2002-06-11 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US6993169B2 (en) 2001-01-11 2006-01-31 Trestle Corporation System and method for finding regions of interest for microscopic digital montage imaging
US7155049B2 (en) 2001-01-11 2006-12-26 Trestle Acquisition Corp. System for creating microscopic digital montage images
CA2436448A1 (en) * 2001-02-02 2002-08-15 Dana-Farber Cancer Institute, Inc. Rare event detection system
US6922488B2 (en) * 2001-02-16 2005-07-26 International Business Machines Corporation Method and system for providing application launch by identifying a user via a digital camera, utilizing an edge detection algorithm
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US6943036B2 (en) * 2001-04-30 2005-09-13 Agilent Technologies, Inc. Error detection in chemical array fabrication
US6989276B2 (en) * 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US7695919B2 (en) * 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
CA2469843A1 (en) * 2001-06-04 2002-12-12 Ikonisys Inc. Method for detecting infectious agents using computer controlled automated image analysis
CA2469850A1 (en) * 2001-06-04 2002-12-12 Ikonisys Inc. Automated image analysis for detecting microalgae and other organisms in the environment
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US8722357B2 (en) * 2001-11-05 2014-05-13 Life Technologies Corporation Automated microdissection instrument
US10156501B2 (en) 2001-11-05 2018-12-18 Life Technologies Corporation Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area
WO2003042788A2 (en) * 2001-11-13 2003-05-22 Chromavision Medical Systems, Inc. A system for tracking biological samples
US7545949B2 (en) * 2004-06-09 2009-06-09 Cognex Technology And Investment Corporation Method for setting parameters of a vision detector using production line information
US9092841B2 (en) * 2004-06-09 2015-07-28 Cognex Technology And Investment Llc Method and apparatus for visual detection and inspection of objects
US20030165263A1 (en) * 2002-02-19 2003-09-04 Hamer Michael J. Histological assessment
WO2003095978A2 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
US7272252B2 (en) * 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
US20050037406A1 (en) * 2002-06-12 2005-02-17 De La Torre-Bueno Jose Methods and apparatus for analysis of a biological specimen
US6800249B2 (en) * 2002-06-14 2004-10-05 Chromavision Medical Systems, Inc. Automated slide staining apparatus
US7282723B2 (en) * 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US7309867B2 (en) * 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US20040208390A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for processing image data for use in tissue characterization
US20040209237A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
JP2005534912A (ja) * 2002-07-30 2005-11-17 ドイチェス クレブスフォルシュングスツェントルム 複数粒子を多重標識して検出および評価するための方法および装置
US20040021666A1 (en) * 2002-08-01 2004-02-05 University Of Iowa Research Foundation System and method for dynamically analyzing a mobile object
AU2003265414A1 (en) * 2002-08-09 2004-02-25 University Of Massachusetts Cancer diagnostics and prognostics
JPWO2004036283A1 (ja) * 2002-09-06 2006-02-16 セレスター・レキシコ・サイエンシズ株式会社 顕微鏡画像処理システム、顕微鏡画像処理方法、プログラム、および、記録媒体
JP2004101871A (ja) * 2002-09-10 2004-04-02 Olympus Corp 顕微鏡画像撮影装置
AU2003270687B2 (en) * 2002-09-13 2008-05-08 Life Technologies Corporation Interactive and automated tissue image analysis with global training database and variable-abstraction processing in cytological specimen classification and laser capture microdissection applications
US6884341B2 (en) * 2002-10-02 2005-04-26 G6 Science Corp. Filter device to capture a desired amount of material
US6905594B2 (en) * 2002-10-11 2005-06-14 G6 Science Corp. Filter apparatus and methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses
AU2006201607B2 (en) * 2002-10-28 2008-10-30 Ventana Medical Systems, Inc. Color space transformations for use in identifying objects of interest in biological specimens
US7200252B2 (en) * 2002-10-28 2007-04-03 Ventana Medical Systems, Inc. Color space transformations for use in identifying objects of interest in biological specimens
US7153691B2 (en) * 2002-11-13 2006-12-26 G6 Science Corp. Method of identifying and assessing DNA euchromatin in biological cells for detecting disease, monitoring wellness, assessing bio-activity, and screening pharmacological agents
GB0226787D0 (en) * 2002-11-18 2002-12-24 Qinetiq Ltd Measurement of mitotic activity
US20040105000A1 (en) * 2002-11-29 2004-06-03 Olymlpus Corporation Microscopic image capture apparatus
US7130463B1 (en) * 2002-12-04 2006-10-31 Foveon, Inc. Zoomed histogram display for a digital camera
GB0229734D0 (en) * 2002-12-23 2003-01-29 Qinetiq Ltd Grading oestrogen and progesterone receptors expression
US20040150217A1 (en) * 2003-01-23 2004-08-05 Heffelfinger David M. Identifying indicia and focusing target
US7116440B2 (en) 2003-02-28 2006-10-03 Aperio Technologies, Inc. Image processing and analysis framework
US8712118B2 (en) * 2003-04-10 2014-04-29 Carl Zeiss Microimaging Gmbh Automated measurement of concentration and/or amount in a biological sample
US20040202357A1 (en) * 2003-04-11 2004-10-14 Perz Cynthia B. Silhouette image acquisition
US6944333B2 (en) * 2003-04-30 2005-09-13 Ventana Medical Systems, Inc. Color image compression via spectral decorrelation and elimination of spatial redundancy
US7701489B1 (en) 2003-05-27 2010-04-20 Apple Inc. Method and apparatus for color correction
US20080235055A1 (en) * 2003-07-17 2008-09-25 Scott Mattingly Laboratory instrumentation information management and control network
US8719053B2 (en) * 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
GB2423988A (en) 2003-07-18 2006-09-13 Cytokinetics Inc Characterizing biological stimuli by response curves
WO2005010495A2 (en) * 2003-07-22 2005-02-03 Trestle Corporation System and method for generating digital images of a microscope slide
US7369699B1 (en) * 2003-08-29 2008-05-06 Apple Inc. Methods and apparatuses for restoring color and enhancing electronic images
US20050136549A1 (en) * 2003-10-30 2005-06-23 Bioimagene, Inc. Method and system for automatically determining diagnostic saliency of digital images
US8068988B2 (en) * 2003-09-08 2011-11-29 Ventana Medical Systems, Inc. Method for automated processing of digital images of tissue micro-arrays (TMA)
WO2005027015A2 (en) 2003-09-10 2005-03-24 Bioimagene, Inc. Method and system for quantitatively analyzing biological samples
US7760927B2 (en) * 2003-09-10 2010-07-20 Bioimagene, Inc. Method and system for digital image based tissue independent simultaneous nucleus cytoplasm and membrane quantitation
US7321791B2 (en) * 2003-09-23 2008-01-22 Cambridge Research And Instrumentation, Inc. Spectral imaging of deep tissue
US8634607B2 (en) * 2003-09-23 2014-01-21 Cambridge Research & Instrumentation, Inc. Spectral imaging of biological samples
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
EP1692292A1 (de) * 2003-11-14 2006-08-23 The State Of Israel-Ministry Of Agriculture & Rural Development Transgene krankheitsresistente banane
US20050154286A1 (en) * 2004-01-02 2005-07-14 Neason Curtis G. System and method for receiving and displaying information pertaining to a patient
US7425426B2 (en) * 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
US7423779B2 (en) * 2004-03-30 2008-09-09 Omnivision Technologies, Inc. Method and apparatus for automatic white balance
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP5134365B2 (ja) * 2004-05-27 2013-01-30 アペリオ・テクノロジーズ・インコーポレイテッド 三次元仮想スライドを生成しかつ可視化するためのシステム及び方法
US8243986B2 (en) 2004-06-09 2012-08-14 Cognex Technology And Investment Corporation Method and apparatus for automatic visual event detection
US20050276445A1 (en) * 2004-06-09 2005-12-15 Silver William M Method and apparatus for automatic visual detection, recording, and retrieval of events
US8127247B2 (en) 2004-06-09 2012-02-28 Cognex Corporation Human-machine-interface and method for manipulating data in a machine vision system
US8891852B2 (en) 2004-06-09 2014-11-18 Cognex Technology And Investment Corporation Method and apparatus for configuring and testing a machine vision detector
US7653260B2 (en) * 2004-06-17 2010-01-26 Carl Zeis MicroImaging GmbH System and method of registering field of view
EP1612537B1 (de) * 2004-06-30 2012-12-19 Sysmex Corporation Vorrichtung zur Vorbereitung von Proben, System zur Analyse von Proben und Probenplatte
US8582924B2 (en) * 2004-06-30 2013-11-12 Carl Zeiss Microimaging Gmbh Data structure of an image storage and retrieval system
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
HUP0401802A2 (en) * 2004-09-02 2006-03-28 3D Histech Kft Focusing method object carriers on fast-moving digitalization and object carrier moving mechanics, focusing optic, optical distance-measuring instrument
EP1787101B1 (de) 2004-09-09 2014-11-12 Life Technologies Corporation Vorrichtung und verfahren zur lasermikrodissektion
WO2006030367A1 (en) * 2004-09-16 2006-03-23 Philips Intellectual Property & Standards Gmbh An imaging method and apparatus for analysing objects
US8462384B2 (en) * 2004-09-29 2013-06-11 Apple Inc. Methods and apparatuses for aesthetically enhanced image conversion
US7113625B2 (en) * 2004-10-01 2006-09-26 U.S. Pathology Labs, Inc. System and method for image analysis of slides
KR100561872B1 (ko) * 2004-10-22 2006-03-17 삼성전자주식회사 미소 영역을 이용한 성분 분석 장치 및 방법
US7720315B2 (en) * 2004-11-12 2010-05-18 Cognex Technology And Investment Corporation System and method for displaying and using non-numeric graphic elements to control and monitor a vision system
US7636449B2 (en) 2004-11-12 2009-12-22 Cognex Technology And Investment Corporation System and method for assigning analysis parameters to vision detector using a graphical interface
US9292187B2 (en) 2004-11-12 2016-03-22 Cognex Corporation System, method and graphical user interface for displaying and controlling vision system operating parameters
EP2264512B1 (de) * 2004-11-24 2014-06-04 Battelle Memorial Institute Verfahren und Vorrichtung zur Detektion von seltenen Zellen
EP1846869B1 (de) * 2005-01-27 2011-10-05 Cambridge Research & Instrumentation, Inc. Klassifizierung der bildeigenschaften
US7907756B2 (en) * 2005-01-31 2011-03-15 Siemens Medical Solutions Usa, Inc. System and method for validating an image segmentation algorithm
US9910341B2 (en) 2005-01-31 2018-03-06 The Invention Science Fund I, Llc Shared image device designation
US7920169B2 (en) 2005-01-31 2011-04-05 Invention Science Fund I, Llc Proximity of shared image devices
US8606383B2 (en) 2005-01-31 2013-12-10 The Invention Science Fund I, Llc Audio sharing
US20060170956A1 (en) 2005-01-31 2006-08-03 Jung Edward K Shared image devices
US9124729B2 (en) 2005-01-31 2015-09-01 The Invention Science Fund I, Llc Shared image device synchronization or designation
US20060174203A1 (en) 2005-01-31 2006-08-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Viewfinder for shared image device
US7876357B2 (en) 2005-01-31 2011-01-25 The Invention Science Fund I, Llc Estimating shared image device operational capabilities or resources
US9489717B2 (en) 2005-01-31 2016-11-08 Invention Science Fund I, Llc Shared image device
US8902320B2 (en) 2005-01-31 2014-12-02 The Invention Science Fund I, Llc Shared image device synchronization or designation
US9325781B2 (en) 2005-01-31 2016-04-26 Invention Science Fund I, Llc Audio sharing
US9082456B2 (en) 2005-01-31 2015-07-14 The Invention Science Fund I Llc Shared image device designation
US20060221197A1 (en) * 2005-03-30 2006-10-05 Jung Edward K Image transformation estimator of an imaging device
GB0502511D0 (en) * 2005-02-08 2005-03-16 Medical Solutions Plc Apparatus and method for image processing of specimen images for use in computer analysis thereof
US9076208B2 (en) 2006-02-28 2015-07-07 The Invention Science Fund I, Llc Imagery processing
US9167195B2 (en) 2005-10-31 2015-10-20 Invention Science Fund I, Llc Preservation/degradation of video/audio aspects of a data stream
US8072501B2 (en) * 2005-10-31 2011-12-06 The Invention Science Fund I, Llc Preservation and/or degradation of a video/audio data stream
US7782365B2 (en) 2005-06-02 2010-08-24 Searete Llc Enhanced video/still image correlation
US9819490B2 (en) 2005-05-04 2017-11-14 Invention Science Fund I, Llc Regional proximity for shared image device(s)
US8233042B2 (en) * 2005-10-31 2012-07-31 The Invention Science Fund I, Llc Preservation and/or degradation of a video/audio data stream
US8681225B2 (en) 2005-06-02 2014-03-25 Royce A. Levien Storage access technique for captured data
US8253821B2 (en) * 2005-10-31 2012-08-28 The Invention Science Fund I, Llc Degradation/preservation management of captured data
US9967424B2 (en) 2005-06-02 2018-05-08 Invention Science Fund I, Llc Data storage usage protocol
US9451200B2 (en) 2005-06-02 2016-09-20 Invention Science Fund I, Llc Storage access technique for captured data
US9093121B2 (en) 2006-02-28 2015-07-28 The Invention Science Fund I, Llc Data management of an audio data stream
US9621749B2 (en) 2005-06-02 2017-04-11 Invention Science Fund I, Llc Capturing selected image objects
US7872675B2 (en) * 2005-06-02 2011-01-18 The Invention Science Fund I, Llc Saved-image management
US9001215B2 (en) 2005-06-02 2015-04-07 The Invention Science Fund I, Llc Estimating shared image device operational capabilities or resources
US9942511B2 (en) 2005-10-31 2018-04-10 Invention Science Fund I, Llc Preservation/degradation of video/audio aspects of a data stream
US8964054B2 (en) 2006-08-18 2015-02-24 The Invention Science Fund I, Llc Capturing selected image objects
US20070222865A1 (en) 2006-03-15 2007-09-27 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Enhanced video/still image correlation
US9191611B2 (en) 2005-06-02 2015-11-17 Invention Science Fund I, Llc Conditional alteration of a saved image
US10003762B2 (en) 2005-04-26 2018-06-19 Invention Science Fund I, Llc Shared image devices
US8164622B2 (en) 2005-07-01 2012-04-24 Aperio Technologies, Inc. System and method for single optical axis multi-detector microscope slide scanner
EP1912060A1 (de) * 2005-07-29 2008-04-16 Olympus Corporation Verfahren und vorrichtung zur messung von lichtintensität
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070031043A1 (en) * 2005-08-02 2007-02-08 Perz Cynthia B System for and method of intelligently directed segmentation analysis for automated microscope systems
US7627153B2 (en) * 2005-08-04 2009-12-01 Carl Zeiss Microimaging Gmbh Repositioning inaccuracies in an automated imaging system
US20070091109A1 (en) * 2005-09-13 2007-04-26 Roscoe Atkinson Image quality
JP4915071B2 (ja) * 2005-09-22 2012-04-11 株式会社ニコン 顕微鏡、およびバーチャルスライド作成システム
US7929738B2 (en) * 2005-10-11 2011-04-19 Olympus Corporation Microscope apparatus and microscope system
US20070120980A1 (en) * 2005-10-31 2007-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Preservation/degradation of video/audio aspects of a data stream
AT502855B1 (de) * 2005-11-30 2009-10-15 Oridis Biomed Forschungs Und E Verfahren und vorrichtung zur automatischen zerstörungsfreien analyse einer vielzahl von biologischen proben
US20070135999A1 (en) * 2005-12-13 2007-06-14 Applied Spectral Imaging Ltd. Method, apparatus and system for characterizing pathological specimen
WO2007080583A2 (en) * 2006-01-10 2007-07-19 Applied Spectral Imaging Ltd. Methods and systems for analyzing biological samples
US7526116B2 (en) * 2006-01-19 2009-04-28 Luigi Armogida Automated microscopic sperm identification
US7657070B2 (en) * 2006-01-20 2010-02-02 Sakura Finetek U.S.A., Inc. Automated system of processing biological specimens and method
US7844088B2 (en) * 2006-02-14 2010-11-30 Intelliscience Corporation Methods and systems for data analysis and feature recognition including detection of avian influenza virus
WO2007095330A2 (en) 2006-02-15 2007-08-23 Hologic Inc Breast biopsy and needle localization using tomosynthesis systems
JP4917331B2 (ja) * 2006-03-01 2012-04-18 浜松ホトニクス株式会社 画像取得装置、画像取得方法、及び画像取得プログラム
HUP0600177A2 (en) * 2006-03-03 2009-03-02 3D Histech Kft Equipment for and method of digitizing slides by automated digital image recording system
US20070244844A1 (en) * 2006-03-23 2007-10-18 Intelliscience Corporation Methods and systems for data analysis and feature recognition
US8625885B2 (en) 2006-03-23 2014-01-07 Intelliscience Corporation Methods and systems for data analysis and feature recognition
US8150163B2 (en) * 2006-04-12 2012-04-03 Scanbuy, Inc. System and method for recovering image detail from multiple image frames in real-time
US20070248943A1 (en) * 2006-04-21 2007-10-25 Beckman Coulter, Inc. Displaying cellular analysis result data using a template
US8367351B2 (en) 2006-05-05 2013-02-05 Historx, Inc. Methods for determining signal transduction activity in tumors
US7532767B2 (en) * 2006-05-31 2009-05-12 Xerox Corporation Removing ringing and blocking artifacts from JPEG compressed document images
WO2008111990A1 (en) * 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
JP4911172B2 (ja) * 2006-07-12 2012-04-04 東洋紡績株式会社 分析装置及びその利用
EP2047262A4 (de) * 2006-07-13 2011-03-16 Univ Yale Verfahren zur krebsprognose auf der basis subzellulärer lokalisierung von biomarkern
SE530750C2 (sv) * 2006-07-19 2008-09-02 Hemocue Ab En mätapparat, en metod och ett datorprogram
US8067245B2 (en) * 2006-07-24 2011-11-29 Medica Corporation Automated microscope for blood cell analysis
DE102006038335A1 (de) * 2006-08-15 2008-02-21 Böcking, Alfred, Prof. Dr. med. Verfahren zur Zellanalyse
US9262697B2 (en) * 2006-09-25 2016-02-16 Cambridge Research & Instrumentation, Inc. Sample imaging and classification
JP4938428B2 (ja) * 2006-12-01 2012-05-23 シスメックス株式会社 標本画像作成方法及び装置
KR100856411B1 (ko) * 2006-12-01 2008-09-04 삼성전자주식회사 조도 보상 방법 및 그 장치와 그 방법을 기록한 컴퓨터로 읽을 수 있는 기록매체
ITVA20060079A1 (it) * 2006-12-19 2008-06-20 St Microelectronics Srl Metodo di classificazione cromatica di pixel e metodo di miglioramento adattativo di un'immagine a colori
US9070006B2 (en) * 2006-12-19 2015-06-30 Hologic, Inc. Method and system for processing an image of a biological specimen
US8244021B2 (en) * 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US20080166036A1 (en) * 2007-01-05 2008-07-10 Carl Zeiss Microimaging Ais, Inc. System and method for analyzing tissue slides for observable pathologies
US7738094B2 (en) 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
US8126267B2 (en) * 2007-02-05 2012-02-28 Albany Medical College Methods and apparatuses for analyzing digital images to automatically select regions of interest thereof
JP5663873B2 (ja) * 2007-03-01 2015-02-04 日本電気株式会社 乳癌病理画像診断支援システム、乳癌病理画像診断支援方法、乳癌病理画像診断支援プログラム、及び、乳癌病理画像診断支援プログラムを記録した記録媒体
WO2008118886A1 (en) 2007-03-23 2008-10-02 Bioimagene, Inc. Digital microscope slide scanning system and methods
US7576307B2 (en) * 2007-04-30 2009-08-18 General Electric Company Microscope with dual image sensors for rapid autofocusing
US8179432B2 (en) * 2007-04-30 2012-05-15 General Electric Company Predictive autofocusing
US8165363B2 (en) 2007-05-04 2012-04-24 Aperio Technologies, Inc. System and method for quality assurance in pathology
US8494304B2 (en) * 2007-05-11 2013-07-23 Xerox Corporation Punched hole detection and removal
US20080286881A1 (en) * 2007-05-14 2008-11-20 Apel William A Compositions and methods for combining report antibodies
ES2374686T3 (es) 2007-05-14 2012-02-21 Historx, Inc. Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes.
US20080300796A1 (en) * 2007-05-31 2008-12-04 Lassahn Gordon D Biological analysis methods, biological analysis devices, and articles of manufacture
US8023714B2 (en) * 2007-06-06 2011-09-20 Aperio Technologies, Inc. System and method for assessing image interpretability in anatomic pathology
JP5153216B2 (ja) * 2007-06-08 2013-02-27 キヤノン株式会社 画像処理装置、画像処理方法
JP5593221B2 (ja) 2007-06-15 2014-09-17 ヒストロックス，インコーポレイテッド． 顕微鏡機器を標準化するための方法およびシステム
US8237099B2 (en) * 2007-06-15 2012-08-07 Cognex Corporation Method and system for optoelectronic detection and location of objects
WO2009005715A1 (en) * 2007-06-29 2009-01-08 Yale University Methods for a predictive diagnostic test for tamoxifen
WO2009009779A2 (en) * 2007-07-11 2009-01-15 Cualing Hernani D Automated bone marrow cellularity determination
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
US7936913B2 (en) * 2007-08-07 2011-05-03 Nextslide Imaging Llc Network image review in clinical hematology
WO2009029810A1 (en) * 2007-08-31 2009-03-05 Historx, Inc. Automatic exposure time selection for imaging tissue
JP5260919B2 (ja) * 2007-09-05 2013-08-14 浜松ホトニクス株式会社 血液検査装置
US20090067700A1 (en) * 2007-09-10 2009-03-12 Riverain Medical Group, Llc Presentation of computer-aided detection/diagnosis (CAD) results
US8103085B1 (en) 2007-09-25 2012-01-24 Cognex Corporation System and method for detecting flaws in objects using machine vision
US8330087B2 (en) * 2007-10-16 2012-12-11 Cambridge Research & Instrumentation, Inc. Spectral imaging system with dynamic optical correction
US8712116B2 (en) * 2007-10-17 2014-04-29 Ffei Limited Image generation based on a plurality of overlapped swathes
US8139831B2 (en) * 2007-12-06 2012-03-20 Siemens Aktiengesellschaft System and method for unsupervised detection and gleason grading of prostate cancer whole mounts using NIR fluorscence
US20090161930A1 (en) * 2007-12-19 2009-06-25 Cytyc Corporation System and method for processing and reading information on a biological specimen slide
JP4558047B2 (ja) * 2008-01-23 2010-10-06 オリンパス株式会社 顕微鏡システム、画像生成方法、及びプログラム
WO2009105530A2 (en) * 2008-02-19 2009-08-27 The Trustees Of The University Of Pennsylvania System and method for automated segmentation, characterization, and classification of possibly malignant lesions and stratification of malignant tumors
US9235887B2 (en) 2008-02-19 2016-01-12 Elucid Bioimaging, Inc. Classification of biological tissue by multi-mode data registration, segmentation and characterization
US8008032B2 (en) 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
WO2009106081A1 (en) 2008-02-29 2009-09-03 Dako Denmark A/S Systems and methods for tracking and providing workflow information
US8103081B2 (en) * 2008-03-10 2012-01-24 Cambridge Research & Instrumentation, Inc. Classification of samples
US8175992B2 (en) 2008-03-17 2012-05-08 Intelliscience Corporation Methods and systems for compound feature creation, processing, and identification in conjunction with a data analysis and feature recognition system wherein hit weights are summed
FI20085343A0 (fi) * 2008-04-22 2008-04-22 Wallac Oy Näytekorttien rei'ittämiseen liittyvä menetelmä ja laite
US9017610B2 (en) 2008-04-25 2015-04-28 Roche Diagnostics Hematology, Inc. Method of determining a complete blood count and a white blood cell differential count
US9602777B2 (en) * 2008-04-25 2017-03-21 Roche Diagnostics Hematology, Inc. Systems and methods for analyzing body fluids
US8199999B2 (en) 2008-06-17 2012-06-12 Cambridge Research & Instrumentation, Inc. Image classifier training
US20090324071A1 (en) * 2008-06-30 2009-12-31 Shengqi Yang Color enhancement for graphic images
US8644580B2 (en) * 2008-08-07 2014-02-04 Cambridge Research & Instrumentation, Inc. Detection of RNA in tissue samples
JP5269517B2 (ja) * 2008-08-14 2013-08-21 株式会社東芝 超音波診断装置、超音波画像処理装置及び超音波画像処理プログラム
US8446463B2 (en) 2008-08-22 2013-05-21 Genprime, Inc. Apparatus, method and article to perform assays using assay strips
US8041139B2 (en) * 2008-09-05 2011-10-18 The Neat Company, Inc. Method and apparatus for calculating the background color of an image
ES2573945T3 (es) * 2008-09-16 2016-06-13 Novartis Ag Cuantificación reproducible de expresión de biomarcadores
US8280134B2 (en) 2008-09-22 2012-10-02 Cambridge Research & Instrumentation, Inc. Multi-spectral imaging including at least one common stain
JP5301232B2 (ja) * 2008-09-30 2013-09-25 シスメックス株式会社 血球画像表示装置、検体分析システム、血球画像表示方法、及びコンピュータプログラム
TR201809167T4 (tr) * 2008-10-23 2018-07-23 Koninklijke Philips Nv Biyolojik örnekler için renk yönetimi.
WO2010048584A2 (en) 2008-10-24 2010-04-29 Aperio Technologies, Inc. Whole slide fluorescence scanner
US10928398B2 (en) * 2008-12-17 2021-02-23 Cornell University Method for double staining colocalized nuclear-markers in histological lymphoid or bone marrow tissue sample
JP2012514477A (ja) * 2009-01-09 2012-06-28 イントレクソン コーポレイション 細胞の遺伝学的解析
US8788213B2 (en) 2009-01-12 2014-07-22 Intrexon Corporation Laser mediated sectioning and transfer of cell colonies
US8049811B2 (en) * 2009-01-28 2011-11-01 Board Of Regents, The University Of Texas System Automatic focusing apparatus and method for digital images using automatic filter switching
US9567560B2 (en) * 2009-02-26 2017-02-14 National University Corporation Nagoya University Incubated state evaluating device, incubated state evaluating method, incubator, and program
JP5321145B2 (ja) 2009-03-04 2013-10-23 日本電気株式会社 画像診断支援装置、画像診断支援方法、画像診断支援プログラム、及びその記憶媒体
EP2406679B1 (de) 2009-03-11 2017-01-25 Sakura Finetek U.S.A., Inc. Autofokusverfahren und autofokuseinrichtung
WO2010111656A2 (en) 2009-03-27 2010-09-30 Life Technologies Corporation Systems and methods for assessing images
US8063385B2 (en) * 2009-05-29 2011-11-22 General Electric Company Method and apparatus for ultraviolet scan planning
WO2010151761A2 (en) * 2009-06-26 2010-12-29 Cim Software Corporation Method for identifying and tracking tissue samples and histological preparations
US20110029865A1 (en) * 2009-07-31 2011-02-03 Nellcor Puritan Bennett Llc Control Interface For A Medical Monitor
US9002077B2 (en) * 2009-08-10 2015-04-07 Cambridge Research & Instrumentation, Inc. Visualization of stained samples
US8463741B2 (en) * 2009-09-04 2013-06-11 Omnyx, LLC Digital pathology system
US9410965B2 (en) * 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US8969009B2 (en) * 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
EP2485651B1 (de) 2009-10-08 2020-12-23 Hologic, Inc. System für mammanadelbiopsie
JP5394887B2 (ja) 2009-10-29 2014-01-22 オリンパス株式会社 顕微鏡装置および顕微鏡観察方法
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
US10509216B2 (en) * 2012-12-26 2019-12-17 Ventana Medical Systems, Inc. Specimen processing systems and methods for aligning slides
WO2011072211A2 (en) 2009-12-11 2011-06-16 Aperio Technologies, Inc. Improved signal to noise ratio in digital pathology image analysis
US8765476B2 (en) * 2009-12-22 2014-07-01 Biocare Medical, Llc Methods and systems for efficient automatic slide staining in immunohistochemistry sample processing
US9001200B2 (en) * 2010-01-12 2015-04-07 Bio-Rad Laboratories, Inc. Cell characterization using multiple focus planes
US20110193950A1 (en) * 2010-02-09 2011-08-11 Stephen Liye Chen Application of microscopic linear array scanner for measuring rate of change of live organisms
CN102781305B (zh) * 2010-03-09 2015-06-03 奥林巴斯株式会社 荧光内窥镜装置
US8462981B2 (en) 2010-04-07 2013-06-11 Cambridge Research & Instrumentation, Inc. Spectral unmixing for visualization of samples
JP5622461B2 (ja) * 2010-07-07 2014-11-12 オリンパス株式会社 画像処理装置、画像処理方法、および画像処理プログラム
CA2805256C (en) * 2010-07-21 2019-03-05 Diopsys, Inc. Method and system for analyzing optical coherence tomography (oct) results using color reflectivity discrelization analysis
JP5324534B2 (ja) * 2010-07-29 2013-10-23 株式会社日立ハイテクノロジーズ 検査方法及び装置
EP2601513B1 (de) 2010-08-05 2014-05-14 Cambridge Research & Instrumentation, Inc. Verbesserte visuelle untersuchung von proben
US10139613B2 (en) 2010-08-20 2018-11-27 Sakura Finetek U.S.A., Inc. Digital microscope and method of sensing an image of a tissue sample
US8996570B2 (en) * 2010-09-16 2015-03-31 Omnyx, LLC Histology workflow management system
WO2012043498A1 (ja) * 2010-09-30 2012-04-05 日本電気株式会社 情報処理装置、情報処理システム、情報処理方法、プログラム及び記録媒体
CN103140757A (zh) * 2010-09-30 2013-06-05 日本电气株式会社 信息处理设备、信息处理系统、信息处理方法、程序和记录介质
EP2625502B1 (de) 2010-10-06 2018-09-05 Biocare Medical, LLC Verfahren und system zur effizienten verarbeitung biologischer proben
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
WO2012063107A1 (en) * 2010-11-08 2012-05-18 Manipal Institute Of Technology Automated tuberculosis screening
US9075903B2 (en) 2010-11-26 2015-07-07 Hologic, Inc. User interface for medical image review workstation
US8673643B2 (en) 2010-11-30 2014-03-18 General Electric Company Closed loop monitoring of automated molecular pathology system
EP2652537B1 (de) * 2010-12-15 2021-02-03 Carl Zeiss Microscopy GmbH Automatisierte abbildung vorbestimmter bereiche in schnittserien
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
AU2012225398B2 (en) 2011-03-08 2017-02-02 Hologic, Inc. System and method for dual energy and/or contrast enhanced breast imaging for screening, diagnosis and biopsy
WO2012142496A1 (en) 2011-04-15 2012-10-18 Constitution Medical, Inc. Measuring volume and constituents of cells
JP5372068B2 (ja) * 2011-05-20 2013-12-18 キヤノン株式会社 撮像システム、画像処理装置
JP2013011856A (ja) * 2011-06-01 2013-01-17 Canon Inc 撮像システムおよびその制御方法
AU2012271257B2 (en) 2011-06-17 2016-01-14 Roche Diagnostics Hematology, Inc. Systems and methods for sample display and review
US9958436B2 (en) 2011-06-17 2018-05-01 The Trustees Of Columbia University In The City Of New York Determination of cell chirality
WO2013003624A2 (en) 2011-06-29 2013-01-03 Academia Sinica The capture, purification and release of biological substance using a surface coating
JP5822345B2 (ja) * 2011-09-01 2015-11-24 島田　修 ホールスライドイメージ作成装置
US10001622B2 (en) * 2011-10-25 2018-06-19 Sanford Burnham Medical Research Institute Multifunction autofocus system and method for automated microscopy
EP2780705B1 (de) 2011-11-16 2018-09-19 Becton, Dickinson and Company Verfahren und systeme zum nachweis eines analyts in einer probe
JP2014534042A (ja) 2011-11-27 2014-12-18 ホロジック, インコーポレイテッドHologic, Inc. マンモグラフィーおよび／またはトモシンセシス画像データを使用して２ｄ画像を生成するためのシステムおよび方法
ES2405938B1 (es) * 2011-11-30 2014-09-24 Celeromics Technologies, S.L. Sistema de conteo de partículas adaptable a un instrumento óptico.
US9651499B2 (en) 2011-12-20 2017-05-16 Cognex Corporation Configurable image trigger for a vision system and method for using the same
US20130171642A1 (en) * 2011-12-30 2013-07-04 Ventana Medical Systems, Inc. Automated analysis of circulating tumor cells
JP6240097B2 (ja) 2012-02-13 2017-11-29 ホロジック インコーポレイティッド 合成画像データを使用してトモシンセシススタックをナビゲートする方法
US20130265411A1 (en) * 2012-04-09 2013-10-10 The Department Of Electrical Engineering, National Chang-Hua University Of Education System and method for inspecting scraped surface of a workpiece
DE13731071T1 (de) * 2012-06-14 2016-08-18 Assistance Publique Hôpitaux De Paris Verfahren zur Quantifizierung von Immunzellen in Tumorgewebe und dessen Anwendungen
US10955655B2 (en) * 2012-07-04 2021-03-23 Sony Corporation Stitching images based on presence of foreign matter
US9020221B2 (en) * 2012-07-13 2015-04-28 Sony Corporation Method and apparatus for automatic cancer diagnosis scoring of tissue samples
TW201404878A (zh) * 2012-07-27 2014-02-01 Hsian-Chang Chen 自動快速分析生物細胞的裝置和其相關的方法
US9285323B2 (en) 2012-08-08 2016-03-15 Scanadu Incorporated Quantifying color changes of chemical test pads induced concentrations of biological analytes under different lighting conditions
EP2883037B1 (de) 2012-08-08 2023-06-07 Healthy.io Ltd. Verfahren und vorrichtung zur durchführung und quantifizierung von farbveränderungen durch spezifische konzentrationen von biologischen analyten in einer automatisch kalibrierten umgebung
US9528941B2 (en) 2012-08-08 2016-12-27 Scanadu Incorporated Method and apparatus for determining analyte concentration by quantifying and interpreting color information captured in a continuous or periodic manner
CN102768271B (zh) * 2012-08-10 2014-06-04 爱威科技股份有限公司 样本分析方法及综合样本分析仪
JP2014048325A (ja) * 2012-08-29 2014-03-17 Sony Corp 情報処理装置、情報処理方法、および情報処理プログラム
US9881371B2 (en) 2012-10-24 2018-01-30 Sony Corporation System for visualization of a cancer diagnosis
US9739714B2 (en) 2012-10-29 2017-08-22 Mbio Diagnostics, Inc. Particle identification system, cartridge and associated methods
US8942447B2 (en) 2012-11-07 2015-01-27 Sony Corporation Method and apparatus for tissue region identification
US9678065B2 (en) 2013-01-11 2017-06-13 Becton, Dickinson And Company Low-cost point-of-care assay device
JP2014149381A (ja) * 2013-01-31 2014-08-21 Sony Corp 画像取得装置および画像取得方法
US10052631B2 (en) 2013-03-05 2018-08-21 Board Of Regents, The University Of Texas System Microfluidic devices for the rapid and automated processing of sample populations
US10624598B2 (en) 2013-03-15 2020-04-21 Hologic, Inc. System and method for navigating a tomosynthesis stack including automatic focusing
JP6388347B2 (ja) 2013-03-15 2018-09-12 ホロジック, インコーポレイテッドHologic, Inc. 腹臥位におけるトモシンセシス誘導生検
JP6453298B2 (ja) * 2013-03-15 2019-01-16 ホロジック, インコーポレイテッドHologic, Inc. 細胞診標本を観察および解析するためのシステムおよび方法
US9064304B2 (en) 2013-03-18 2015-06-23 General Electric Company Image quality assessment of microscopy images
US10088658B2 (en) 2013-03-18 2018-10-02 General Electric Company Referencing in multi-acquisition slide imaging
DE102013103971A1 (de) 2013-04-19 2014-11-06 Sensovation Ag Verfahren zum Erzeugen eines aus mehreren Teilbildern zusammengesetzten Gesamtbilds eines Objekts
US10376880B2 (en) 2013-07-30 2019-08-13 Carehealth America Corporation Lateral flow devices and methods of manufacture and use
WO2015016960A1 (en) * 2013-07-30 2015-02-05 Express Diagnostics Int'l., Inc. Universal assay reader
US9536304B2 (en) * 2013-08-30 2017-01-03 Dairy Quality Inc. Determining pathogens based on an image of somatic cells in a fluid sample
EP4278977A3 (de) 2013-10-24 2024-02-21 Hologic, Inc. System und methode zur röntgengestützen brust biopsie
CN113477149B (zh) 2013-11-06 2023-09-12 贝克顿·迪金森公司 微流体性装置和制造和使用其的方法
AU2014348910B2 (en) 2013-11-13 2017-04-20 Becton, Dickinson And Company Optical imaging system and methods for using the same
CA2930411C (en) 2013-11-15 2022-05-03 Mikroscan Technologies, Inc. Geological scanner
US10007102B2 (en) 2013-12-23 2018-06-26 Sakura Finetek U.S.A., Inc. Microscope with slide clamping assembly
JP6194791B2 (ja) 2013-12-27 2017-09-13 富士ゼロックス株式会社 画像処理装置及びプログラム
WO2015102919A2 (en) * 2013-12-30 2015-07-09 Clarient Diagnostic Services, Inc. Modular image analysis system and method
EP3110332B1 (de) 2014-02-28 2018-04-11 Hologic Inc. System und verfahren zur erzeugung und anzeige von tomosynthesebildplatten
JP2015169991A (ja) * 2014-03-05 2015-09-28 キヤノン株式会社 画像処理装置、画像処理方法
JP5768948B1 (ja) * 2014-03-27 2015-08-26 コニカミノルタ株式会社 画像処理装置および画像処理プログラム
WO2015153816A2 (en) 2014-04-01 2015-10-08 Academia Sinica Methods and systems for cancer diagnosis and prognosis
US20150286887A1 (en) 2014-04-07 2015-10-08 Massachusetts Institute Of Technology Use of Microparticle Additives to Simultaneously Enable Artifact-Free Image Registration, Auto-Focusing, and Chromatic Aberration Correction in Microscopy
EP3161449B1 (de) * 2014-06-30 2023-09-13 Ventana Medical Systems, Inc. Automatisierte probenverarbeitungssysteme und -verfahren
TWI533025B (zh) * 2014-07-07 2016-05-11 億觀生物科技股份有限公司 可攜式顯微鏡裝置
US9291576B2 (en) * 2014-07-11 2016-03-22 Intel Corporation Detection of defect in die
WO2016025935A2 (en) 2014-08-15 2016-02-18 Scanadu Incorporated Precision luxmeter methods for digital cameras to quantify colors in uncontrolled lighting environments
EP2998026B1 (de) 2014-08-26 2024-01-17 Academia Sinica Kollektorarchitektur-layoutdesign
WO2016030897A1 (en) * 2014-08-27 2016-03-03 S.D. Sight Diagnostics Ltd System and method for calculating focus variation for a digital microscope
CN105637852B (zh) * 2014-08-29 2019-03-01 华为技术有限公司 一种图像处理方法、装置及电子设备
AU2015334046B2 (en) 2014-10-14 2017-04-13 Becton, Dickinson And Company Blood sample management using open cell foam
BR122020024283B1 (pt) 2014-10-14 2023-02-23 Becton, Dickinson And Company Dispositivo de transferência de sangue adaptado para receber uma amostra de sangue
WO2016069794A1 (en) 2014-10-28 2016-05-06 Mikroscan Technologies, Inc. Microdissection viewing system
JP6448996B2 (ja) * 2014-11-25 2019-01-09 オリンパス株式会社 顕微鏡システム
EP3259553A4 (de) * 2015-02-18 2018-10-17 Abbott Laboratories Verfahren, systeme und vorrichtungen zum automatischen fokussieren eines mikroskops auf einem substrat
JP6759550B2 (ja) * 2015-03-04 2020-09-23 ソニー株式会社 情報処理装置、プログラム、情報処理方法及び観察システム
EP4350351A3 (de) 2015-03-10 2024-06-26 Becton, Dickinson and Company Mikroprobenverwaltungsvorrichtung für biologische flüssigkeiten
WO2016169807A1 (en) 2015-04-22 2016-10-27 Nestec S.A. Biomarkers for predicting degree of weight loss in female subjects
AU2016251446A1 (en) 2015-04-22 2017-09-07 Société des Produits Nestlé S.A. Biomarkers for predicting degree of weight loss in male subjects
WO2016179286A1 (en) 2015-05-05 2016-11-10 Massachusetts Institute Of Technology Substrate pre-scanning for high throughput microscopy
CA3109854C (en) 2015-09-01 2023-07-25 Becton, Dickinson And Company Depth filtration device for separating specimen phases
US10628736B2 (en) 2015-09-24 2020-04-21 Huron Technologies International Inc. Systems and methods for barcode annotations for digital images
WO2017066635A1 (en) * 2015-10-16 2017-04-20 Mikroscan Technologies, Inc. Systems, media, methods, and apparatus for enhanced digital microscopy
US9939623B2 (en) * 2015-10-19 2018-04-10 Molecular Devices, Llc Microscope system with transillumination-based autofocusing for photoluminescence imaging
WO2017070584A1 (en) * 2015-10-23 2017-04-27 Novartis Ag Computer processes behind an enhanced version of aqua
US9715721B2 (en) 2015-12-18 2017-07-25 Sony Corporation Focus detection
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
EP3440468B1 (de) 2016-04-06 2021-12-01 Nestle Sa Biomarker zur vorhersage des grads des gewichtsverlusts
USD808038S1 (en) * 2016-04-08 2018-01-16 Clever Culture Systems Ag Automated petri plate assessment system
CN114419114A (zh) 2016-04-20 2022-04-29 徕卡生物系统成像股份有限公司 用于数字病理学色彩校准的系统和方法
US20190346459A1 (en) 2016-06-28 2019-11-14 Nestec S.A. Biomarkers of blood-brain barrier dysfunction
EP3267394A1 (de) * 2016-07-04 2018-01-10 Centre National De La Recherche Scientifique Verfahren und vorrichtung zur echtzeitdetektion von polypen in optischer kolonoskopie
US11386552B2 (en) 2016-08-01 2022-07-12 Genprime, Inc. System and method to interpret tests that change color to indicate the presence or non-presence of a compound
US10576475B2 (en) 2016-09-15 2020-03-03 Genprime, Inc. Diagnostic assay strip cassette
JP7258354B2 (ja) 2016-10-20 2023-04-17 オプティナ ダイアグノスティクス，インコーポレイテッド 生体組織内の異常を検出するための方法及びシステム
US11280803B2 (en) 2016-11-22 2022-03-22 Sakura Finetek U.S.A., Inc. Slide management system
TWI756365B (zh) * 2017-02-15 2022-03-01 美商脫其泰有限責任公司 圖像分析系統及相關方法
CN110662489B (zh) 2017-03-30 2024-08-02 豪洛捷公司 用于靶向对象增强以生成合成乳房组织图像的系统和方法
JP7277053B2 (ja) 2017-03-30 2023-05-18 ホロジック， インコーポレイテッド 階層式マルチレベル特徴画像合成および提示のためのシステムおよび方法
CN110621233B (zh) 2017-03-30 2023-12-12 豪洛捷公司 用于处理乳房组织图像数据的方法
JP6543013B2 (ja) * 2017-06-13 2019-07-10 オリンパス株式会社 内視鏡装置
WO2018228875A1 (en) 2017-06-15 2018-12-20 Nestec S.A. Micro-rna biomarkers of blood-brain barrier dysfunction
EP3641635A4 (de) 2017-06-20 2021-04-07 Hologic, Inc. Dynamisches selbstlernendes medizinisches bildverfahren und -system
JP7009619B2 (ja) * 2017-09-29 2022-01-25 ライカ バイオシステムズ イメージング インコーポレイテッド ２回通過式マクロ画像
US20190042934A1 (en) 2017-12-01 2019-02-07 Meenakshi Arunachalam Methods and apparatus for distributed training of a neural network
EP3759540A4 (de) 2018-02-26 2022-03-16 Caliber Imaging & Diagnostics, Inc. System und verfahren zur makroskopischen und mikroskopischen abbildung von ex-vivo-gewebe
CA3118014C (en) * 2018-11-05 2024-06-11 Hamid Reza Tizhoosh Systems and methods of managing medical images
WO2020110072A1 (en) * 2018-11-29 2020-06-04 La Trobe University Automated method of identifying a structure
CN109709346B (zh) * 2018-12-07 2022-08-02 英华达（上海）科技有限公司 自动化细胞分析装置及其操作方法
DE102018133188A1 (de) * 2018-12-20 2020-06-25 Carl Zeiss Microscopy Gmbh Abstandbestimmung einer probenebene in einem mikroskopsystem
US10896316B2 (en) 2019-02-04 2021-01-19 Tokitae, LLC Automated microscopy scanning systems and methods
EP3757648B1 (de) * 2019-06-28 2023-08-30 Associação Fraunhofer Portugal An einer mobilen vorrichtung befestigbares optisches system zum scannen biologischer probenträger und betriebsverfahren dafür
US20210345955A1 (en) * 2020-05-05 2021-11-11 Dave Engineering Llc Portable real-time medical diagnostic device
CN114441512B (zh) * 2020-10-30 2024-02-23 深圳市瑞图生物技术有限公司 阴道分泌物检测仪、干化学检测装置和干化学检测方法
US11610395B2 (en) 2020-11-24 2023-03-21 Huron Technologies International Inc. Systems and methods for generating encoded representations for multiple magnifications of image data
CN112924382B (zh) * 2021-01-28 2024-02-23 内蒙古昆明卷烟有限责任公司 一种香烟条包质量检测装置
US11455724B1 (en) * 2021-05-12 2022-09-27 PAIGE.AI, Inc. Systems and methods to process electronic images to adjust attributes of the electronic images
CN118466001B (zh) * 2024-07-10 2024-10-11 武汉慧观生物科技有限公司 一种物镜切换原位映射显微成像方法及系统

Family Cites Families (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3072570A (en) * 1956-11-02 1963-01-08 Standard Oil Co Lubricating oil composition
US3805028A (en) * 1969-06-23 1974-04-16 Bausch & Lomb Methods of and apparatus for determining the quantity and physical parameters of objects
US3824393A (en) 1971-08-25 1974-07-16 American Express Invest System for differential particle counting
US4125828A (en) 1972-08-04 1978-11-14 Med-El Inc. Method and apparatus for automated classification and analysis of cells
US3851972A (en) * 1973-10-18 1974-12-03 Coulter Electronics Automatic method and system for analysis and review of a plurality of stored slides
US4011004A (en) * 1975-02-06 1977-03-08 Geometric Data Corporation Pivotable stage for microscope system
SE7705157L (sv) 1976-05-04 1977-11-05 Green James E Forfarande och apparat for analys
JPS5317081A (en) 1976-07-30 1978-02-16 Sharp Corp Production of i2l device
US4175860A (en) * 1977-05-31 1979-11-27 Rush-Presbyterian-St. Luke's Medical Center Dual resolution method and apparatus for use in automated classification of pap smear and other samples
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4210419A (en) 1978-02-17 1980-07-01 California Institute Of Technology Automated quantitative muscle biopsy analysis system
US4249825A (en) 1979-05-14 1981-02-10 The Trustees Of Boston University Method and apparatus suitable for ocular blood flow analysis
US4342905A (en) * 1979-08-31 1982-08-03 Nippon Kogaku K.K. Automatic focusing device of a microscope
JPS5672845A (en) * 1979-11-19 1981-06-17 Hitachi Ltd Detecting apparatus of examination position of sample
US4338024A (en) 1980-05-02 1982-07-06 International Remote Imaging Systems, Inc. Flow analyzer and system for analysis of fluids with particles
US4393466A (en) 1980-09-12 1983-07-12 International Remote Imaging Systems Method of analyzing particles in a dilute fluid sample
US4612614A (en) 1980-09-12 1986-09-16 International Remote Imaging Systems, Inc. Method of analyzing particles in a fluid sample
US4341802A (en) * 1980-10-24 1982-07-27 Provesto Corporation Production of protein with reduced nucleic acid
BR8107605A (pt) 1981-11-23 1983-07-05 Oce Nederland Bv Material de diazotipia
US4470043A (en) * 1982-03-01 1984-09-04 Squibb Vitatek Inc. Non-fade bouncing ball display
JPS58154064A (ja) * 1982-03-08 1983-09-13 Mitsubishi Rayon Co Ltd リンパ球ｔ細胞百分率測定方法
US4513438A (en) * 1982-04-15 1985-04-23 Coulter Electronics, Inc. Automated microscopy system and method for locating and re-locating objects in an image
DE3274009D1 (en) * 1982-08-13 1986-12-04 Ibm High-performance vibration filter
US4939240A (en) * 1983-03-04 1990-07-03 Health Research, Inc. Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy
DE3340647A1 (de) 1983-11-10 1985-05-23 Will Wetzlar Gmbh, 6330 Wetzlar Verfahren zur fokussierung eines mikroskopes sowie mikroskop zur durchfuehrung des verfahrens
JPH0616391B2 (ja) * 1984-07-13 1994-03-02 株式会社日立製作所 イオンビーム照射装置
US4700298A (en) * 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4673973A (en) * 1985-02-04 1987-06-16 National Biomedical Research Foundation Split-image, multi-power microscopic image display system and method
US4656594A (en) 1985-05-06 1987-04-07 National Biomedical Research Foundation Operator-interactive automated chromosome analysis system producing a karyotype
US4697594A (en) * 1985-08-21 1987-10-06 North American Philips Corporation Displaying a single parameter image
US4710472A (en) 1985-09-25 1987-12-01 The United States Of America As Represented By The Secretary Of The Navy Magnetic separation device
US4741043B1 (en) 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US5008185A (en) 1985-11-04 1991-04-16 Cell Analysis Systems, Inc. Methods and apparatus for the quantitation of nuclear proteins
US4777525A (en) * 1985-12-23 1988-10-11 Preston Jr Kendall Apparatus and method for a multi-resolution electro-optical imaging, display and storage/retrieval system
US4821205A (en) * 1986-05-30 1989-04-11 Eaton Corporation Seismic isolation system with reaction mass
JPH0774856B2 (ja) * 1986-10-16 1995-08-09 オリンパス光学工業株式会社 自動焦点調節方法
JPS63256916A (ja) * 1987-04-15 1988-10-24 Toshiba Corp 電子内視鏡装置
US5053344A (en) 1987-08-04 1991-10-01 Cleveland Clinic Foundation Magnetic field separation and analysis system
US5202931A (en) 1987-10-06 1993-04-13 Cell Analysis Systems, Inc. Methods and apparatus for the quantitation of nuclear protein
US5085325A (en) 1988-03-08 1992-02-04 Simco/Ramic Corporation Color sorting system and method
US5740270A (en) * 1988-04-08 1998-04-14 Neuromedical Systems, Inc. Automated cytological specimen classification system and method
US4965725B1 (en) 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
US4991223A (en) 1988-06-30 1991-02-05 American Innovision, Inc. Apparatus and method for recognizing image features using color elements
JP2622725B2 (ja) * 1988-07-25 1997-06-18 東亜医用電子株式会社 胃組織の腺腔を抽出するための画像処理方法
US6150089A (en) 1988-09-15 2000-11-21 New York University Method and characterizing polymer molecules or the like
FR2638240B1 (fr) * 1988-10-21 1991-10-18 Biocom Sa Platine pour l'analyse rapide et indexee sous microscope de filtres et d'autres supports porteurs d'echantillons multiples et procede d'analyse de ces echantillons utilisant cette platine
US4945220A (en) 1988-11-16 1990-07-31 Prometrix Corporation Autofocusing system for microscope having contrast detection means
US6099522A (en) * 1989-02-06 2000-08-08 Visx Inc. Automated laser workstation for high precision surgical and industrial interventions
US5726009A (en) 1989-03-20 1998-03-10 Anticancer, Inc. Native-state method and system for determining viability and proliferative capacity of tissues in vitro
US5016173A (en) * 1989-04-13 1991-05-14 Vanguard Imaging Ltd. Apparatus and method for monitoring visually accessible surfaces of the body
US5068909A (en) 1989-05-18 1991-11-26 Applied Imaging Corporation Method and apparatus for generating quantifiable video displays
US5003165A (en) 1989-05-25 1991-03-26 International Remote Imaging Systems, Inc. Method and an apparatus for selecting the best focal position from a plurality of focal positions
US4992660A (en) * 1989-06-26 1991-02-12 Jeol Ltd. Scanning tunneling microscope
US5087965A (en) 1989-06-28 1992-02-11 American Innovision, Inc. Recognition of image colors using arbitrary shapes in color space
US5123055A (en) 1989-08-10 1992-06-16 International Remote Imaging Systems, Inc. Method and an apparatus for differentiating a sample of biological cells
US5268966A (en) 1989-08-10 1993-12-07 International Remote Imaging Systems, Inc. Method of differentiating particles based upon a dynamically changing threshold
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5222205A (en) * 1990-03-16 1993-06-22 Hewlett-Packard Company Method for generating addresses to textured graphics primitives stored in rip maps
US5233684A (en) 1990-06-26 1993-08-03 Digital Equipment Corporation Method and apparatus for mapping a digital color image from a first color space to a second color space
JP2510771B2 (ja) 1990-07-25 1996-06-26 株式会社日立製作所 培養生体の活性診断方法及びシステム
US5235522A (en) 1990-10-10 1993-08-10 Cell Analysis Systems, Inc. Method and apparatus for automated analysis of biological specimens
US5051816A (en) * 1990-10-29 1991-09-24 At&T Bell Laboratories Pixel generator test set
US5655029A (en) * 1990-11-07 1997-08-05 Neuromedical Systems, Inc. Device and method for facilitating inspection of a specimen
EP0556286B1 (de) 1990-11-07 1999-04-07 Neuromedical Systems, Inc Untersuchungskontrollverfahren für bilder die auf einer anzeige gezeigt werden
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5784162A (en) 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US5991028A (en) 1991-02-22 1999-11-23 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for cell classification
US5231580A (en) * 1991-04-01 1993-07-27 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Automated method and apparatus for determining characteristics of nerve fibers
JP3324780B2 (ja) * 1991-05-16 2002-09-17 オリンパス光学工業株式会社 紫外線顕微鏡
CA2109943A1 (en) * 1991-06-13 1992-12-23 Herbert S. Chow Automated specimen analyzing apparatus and method
US5548661A (en) 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
JPH0560616A (ja) * 1991-09-05 1993-03-12 Matsushita Electric Ind Co Ltd 色識別方法および色識別装置
JP2714502B2 (ja) * 1991-09-18 1998-02-16 キヤノン株式会社 移動ステージ装置
US5428690A (en) * 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
CA2077781A1 (en) * 1991-09-23 1993-03-24 James W. Bacus Method and apparatus for automated assay of biological specimens
US5375177A (en) * 1991-09-27 1994-12-20 E. I. Du Pont De Nemours And Company Method of identifying and characterizing a valid object by color
US5463470A (en) * 1991-10-09 1995-10-31 Fuji Photo Film Co., Ltd. Methods of collecting photometric image data and determining light exposure by extracting feature image data from an original image
WO1993008302A1 (en) * 1991-10-25 1993-04-29 Itt Automotive Europe Gmbh Monoclonal antibodies directed against the microtubule-associated protein tau
US5371565A (en) * 1991-11-15 1994-12-06 Nikon Corporation Focal-plane shutter device
US5331275A (en) * 1991-12-09 1994-07-19 Fujitsu Limited Probing device and system for testing an integrated circuit
JP3030313B2 (ja) * 1992-02-12 2000-04-10 住特フェライト株式会社 連続超音波洗浄装置
US5635402A (en) 1992-03-05 1997-06-03 Alfano; Robert R. Technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy
US5533628A (en) 1992-03-06 1996-07-09 Agri Tech Incorporated Method and apparatus for sorting objects by color including stable color transformation
US6069242A (en) * 1992-03-11 2000-05-30 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
EP0567681B1 (de) 1992-04-30 1997-07-23 Becton, Dickinson and Company Verfahren und Vorrichtung zur Steuerung von Koordinatenverschiebungen einer Plattform
US5376851A (en) 1992-05-18 1994-12-27 Electric Power Research Institute, Inc. Variable reluctance motor with full and short pitch windings
JP3476482B2 (ja) * 1992-05-22 2003-12-10 株式会社トプコン 形態観察装置
US5384862A (en) 1992-05-29 1995-01-24 Cimpiter Corporation Radiographic image evaluation apparatus and method
US5338924A (en) 1992-08-11 1994-08-16 Lasa Industries, Inc. Apparatus and method for automatic focusing of light using a fringe plate
US5254845A (en) 1992-08-18 1993-10-19 Applied Imaging International Limited Automatic focusing system using focal length-changing element
US5889881A (en) 1992-10-14 1999-03-30 Oncometrics Imaging Corp. Method and apparatus for automatically detecting malignancy-associated changes
US5317140A (en) * 1992-11-24 1994-05-31 Dunthorn David I Diffusion-assisted position location particularly for visual pen detection
US5393976A (en) * 1992-11-26 1995-02-28 Kabushiki Kaisha Topcon Apparatus for displaying a sample image
DE69420874T2 (de) 1993-02-12 2000-05-04 Eastman Kodak Co., Rochester Verfahren zur geräteübergreifenden Farbbildkalibrierung und -verbesserung
JP3129015B2 (ja) 1993-02-16 2001-01-29 株式会社日立製作所 染色された粒子の検査方法及びその装置
US5602941A (en) 1993-05-21 1997-02-11 Digital Equipment Corporation Input modification system for multilevel dithering
FR2705655B1 (fr) * 1993-05-26 1995-08-25 Aerospatiale Machine pour le bobinage-déposé au contact simultané d'une pluralité de fils individuels.
US5356110A (en) * 1993-06-08 1994-10-18 Newport Corporation Pneumatic isolation systems for damping vertical, horizontal and rotational vibrations
US5483055A (en) 1994-01-18 1996-01-09 Thompson; Timothy V. Method and apparatus for performing an automatic focus operation for a microscope
US5587833A (en) 1993-07-09 1996-12-24 Compucyte Corporation Computerized microscope specimen encoder
US5515172A (en) 1993-07-19 1996-05-07 Xerox Corporation Apparatus and method for enhanced color to color conversion
US5432871A (en) 1993-08-04 1995-07-11 Universal Systems & Technology, Inc. Systems and methods for interactive image data acquisition and compression
US5514571A (en) * 1993-08-05 1996-05-07 University Technologies International Inc. Cyclin D1 negative regulatory activity
IL106691A (en) 1993-08-13 1998-02-08 Sophis View Tech Ltd System and method for diagnosis of living tissue diseases
US5352613A (en) 1993-10-07 1994-10-04 Tafas Triantafillos P Cytological screening method
US5450502A (en) * 1993-10-07 1995-09-12 Xerox Corporation Image-dependent luminance enhancement
JP3039594B2 (ja) 1993-10-08 2000-05-08 株式会社日立製作所 染色試薬およびその使用方法
US5544256A (en) * 1993-10-22 1996-08-06 International Business Machines Corporation Automated defect classification system
US5469353A (en) 1993-11-26 1995-11-21 Access Radiology Corp. Radiological image interpretation apparatus and method
US5409007A (en) 1993-11-26 1995-04-25 General Electric Company Filter to reduce speckle artifact in ultrasound imaging
JPH07212257A (ja) * 1994-01-21 1995-08-11 Uniden Corp 送信機の異常送信停止回路
JP3134660B2 (ja) 1994-04-14 2001-02-13 松下電器産業株式会社 色変換方法および色変換装置
US5795723A (en) 1994-05-06 1998-08-18 Fred Hutchinson Cancer Research Center Expression of neurogenic bHLH genes in primitive neuroectodermal tumors
US5595740A (en) * 1994-05-16 1997-01-21 University Of Florida Cloning of non-IgA FC binding forms of the group B streptococcal beta antigens
US5625705A (en) * 1994-06-03 1997-04-29 Neuromedical Systems, Inc. Intensity texture based classification system and method
US6463438B1 (en) * 1994-06-03 2002-10-08 Urocor, Inc. Neural network for cell image analysis for identification of abnormal cells
US6301025B1 (en) * 1994-06-24 2001-10-09 Mgi Software Corporation Method for performing a color space transformation
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
US5499097A (en) * 1994-09-19 1996-03-12 Neopath, Inc. Method and apparatus for checking automated optical system performance repeatability
US5647025A (en) * 1994-09-20 1997-07-08 Neopath, Inc. Automatic focusing of biomedical specimens apparatus
US5978497A (en) * 1994-09-20 1999-11-02 Neopath, Inc. Apparatus for the identification of free-lying cells
US5966465A (en) 1994-09-21 1999-10-12 Ricoh Corporation Compression/decompression using reversible embedded wavelets
US5846749A (en) 1994-10-12 1998-12-08 The Regents Of The University Of California Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination
JP2856386B2 (ja) * 1994-10-26 1999-02-10 松下電器産業株式会社 色彩調整装置及びその方法
EP0713086B1 (de) * 1994-11-17 1999-04-14 Chemunex Vorrichtung und Verfahren zum Erkennen und Zählen von selten vorkommenden Säugerzellen
US5625709A (en) 1994-12-23 1997-04-29 International Remote Imaging Systems, Inc. Method and apparatus for identifying characteristics of an object in a field of view
US5619032A (en) 1995-01-18 1997-04-08 International Remote Imaging Systems, Inc. Method and apparatus for automatically selecting the best focal position from a plurality of focal positions for a focusing apparatus
US5623415A (en) 1995-02-16 1997-04-22 Smithkline Beecham Corporation Automated sampling and testing of biological materials
US5646677A (en) 1995-02-23 1997-07-08 Motorola, Inc. Method and apparatus for interactively viewing wide-angle images from terrestrial, space, and underwater viewpoints
US5586160A (en) 1995-03-20 1996-12-17 The Regents Of The University Of California Automated analysis for microcalcifications in high resolution digital mammograms
US5671288A (en) * 1995-05-31 1997-09-23 Neopath, Inc. Method and apparatus for assessing slide and specimen preparation quality
US5773459A (en) * 1995-06-07 1998-06-30 Sugen, Inc. Urea- and thiourea-type compounds
US6252979B1 (en) * 1995-06-07 2001-06-26 Tripath Imaging, Inc. Interactive method and apparatus for sorting biological specimens
US5701172A (en) * 1995-06-07 1997-12-23 Gas Research Institute Optical flowmeter
US5925802A (en) * 1995-06-07 1999-07-20 Estes; Don Mark Functional reconstitution of SCID-bo mice with bovine fetal hematopoietic tissues
US6117985A (en) 1995-06-16 2000-09-12 Stemcell Technologies Inc. Antibody compositions for preparing enriched cell preparations
US5735387A (en) 1995-07-14 1998-04-07 Chiron Diagnostics Corporation Specimen rack handling system
US6091842A (en) * 1996-10-25 2000-07-18 Accumed International, Inc. Cytological specimen analysis system with slide mapping and generation of viewing path information
US5690892A (en) 1995-09-15 1997-11-25 Accumed, Inc. Cassette for use with automated specimen handling system
US6040139A (en) * 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
US5642441A (en) * 1995-10-24 1997-06-24 Neopath, Inc. Separation apparatus and method for measuring focal plane
US6718053B1 (en) * 1996-11-27 2004-04-06 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6418236B1 (en) * 1999-06-24 2002-07-09 Chromavision Medical Systems, Inc. Histological reconstruction and automated image analysis
US6330349B1 (en) 1995-11-30 2001-12-11 Chromavision Medical Systems, Inc. Automated method for image analysis of residual protein
US6151405A (en) 1996-11-27 2000-11-21 Chromavision Medical Systems, Inc. System and method for cellular specimen grading
DE69627183T2 (de) * 1995-11-30 2004-01-29 Chromavision Med Sys Inc Verfahren zur automatischen bildanalyse biologischer proben
JP3744989B2 (ja) 1995-12-05 2006-02-15 オリンパス株式会社 色分類装置及びその領域補正方法
US6125194A (en) 1996-02-06 2000-09-26 Caelum Research Corporation Method and system for re-screening nodules in radiological images using multi-resolution processing, neural network, and image processing
US5851186A (en) 1996-02-27 1998-12-22 Atl Ultrasound, Inc. Ultrasonic diagnostic imaging system with universal access to diagnostic information and images
JP2000508171A (ja) 1996-04-05 2000-07-04 ザ・ジョンズ・ホプキンス・ユニバーシティ・スクール・オブ・メディシン 希少細胞の富化方法
US5911003A (en) 1996-04-26 1999-06-08 Pressco Technology Inc. Color pattern evaluation system for randomly oriented articles
US6006191A (en) 1996-05-13 1999-12-21 Dirienzo; Andrew L. Remote access medical image exchange system and methods of operation therefor
US6031929A (en) 1996-07-18 2000-02-29 University Of Pittsburgh Image facsimile with real time image segmentation
US6272235B1 (en) * 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6404906B2 (en) * 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6396941B1 (en) * 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6031930A (en) * 1996-08-23 2000-02-29 Bacus Research Laboratories, Inc. Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing
US5867598A (en) 1996-09-26 1999-02-02 Xerox Corporation Method and apparatus for processing of a JPEG compressed image
US5911327A (en) 1996-10-02 1999-06-15 Nippon Steel Corporation Method of automatically discriminating and separating scraps containing copper from iron scraps
US5731156A (en) 1996-10-21 1998-03-24 Applied Imaging, Inc. Use of anti-embryonic hemoglobin antibodies to identify fetal cells
AU4920297A (en) * 1996-10-25 1998-05-15 Applied Imaging, Inc. Multifluor-fluorescence in situ hybridization (m-fish) imaging techniques using multiple multiband filters with image registration
US5880473A (en) 1997-07-28 1999-03-09 Applied Imaging, Inc. Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration
US6009192A (en) * 1996-12-19 1999-12-28 Xerox Corporation Color correction of a compressed image
US6259807B1 (en) 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6169816B1 (en) * 1997-05-14 2001-01-02 Applied Imaging, Inc. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6072570A (en) * 1997-07-24 2000-06-06 Innotech Image quality mapper for progressive eyeglasses
US6058322A (en) * 1997-07-25 2000-05-02 Arch Development Corporation Methods for improving the accuracy in differential diagnosis on radiologic examinations
US6040208A (en) * 1997-08-29 2000-03-21 Micron Technology, Inc. Angled ion implantation for selective doping
DK0902290T3 (da) * 1997-09-11 2009-02-09 Hitachi Ltd Et prövehåndteringssystem til automatiske analyseindretninger
US6011595A (en) 1997-09-19 2000-01-04 Eastman Kodak Company Method for segmenting a digital image into a foreground region and a key color region
US6141602A (en) 1997-09-25 2000-10-31 Hitachi, Ltd. Specimen processing system
US6122400A (en) 1997-09-26 2000-09-19 Sarnoff Corporation Compression encoder bit allocation utilizing colormetric-adaptive weighting as in flesh-tone weighting
US5920239A (en) 1997-10-07 1999-07-06 Scientific-Atlanta, Inc. Multiple dwelling unit tap off including an equalizer circuit
US5888742A (en) 1997-10-28 1999-03-30 Incyte Pharmaceuticals, Inc. Human phospholipid binding proteins
US6374989B1 (en) * 1997-11-14 2002-04-23 Bayer Corporation Conveyor system for clinical test apparatus
DE69941689D1 (de) * 1998-02-12 2010-01-07 Univ Texas Verfahren und reagenzien zur raschen und effizienten isolierung zirkulierender krebszellen
DE19819813C2 (de) 1998-05-04 2000-11-02 Olympus Diagnostica Gmbh Verwendung eines Laborprimärprobenverteilers zum Archivieren
US6313452B1 (en) 1998-06-10 2001-11-06 Sarnoff Corporation Microscopy system utilizing a plurality of images for enhanced image processing capabilities
US5978597A (en) 1998-08-04 1999-11-02 Eastman Kodak Company One-time-use camera with break-off protuberance for film ejection
US6281874B1 (en) * 1998-08-27 2001-08-28 International Business Machines Corporation Method and system for downloading graphic images on the internet
JP2000149283A (ja) * 1998-09-04 2000-05-30 Sony Corp 光学ヘッド及び記録再生装置
US6226636B1 (en) * 1998-11-20 2001-05-01 Philips Electronics North America Corp. System for retrieving images using a database
US6215894B1 (en) * 1999-02-26 2001-04-10 General Scanning, Incorporated Automatic imaging and analysis of microarray biochips
JP2002541494A (ja) * 1999-04-13 2002-12-03 クロマビジョン メディカル システムズ インコーポレイテッド 組織学的再構成と自動画像分析
EP1198956A1 (de) * 1999-07-13 2002-04-24 Chromavision Medical Systems, Inc. Gerät um genauefarbpegel in echtzeit anzuwenden
WO2001057785A1 (en) 2000-02-01 2001-08-09 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6518554B1 (en) * 2000-05-24 2003-02-11 Chromavision Medical Systems, Inc. Reverse focusing methods and systems
US6841388B2 (en) 2000-12-05 2005-01-11 Vysis, Inc. Method and system for diagnosing pathology in biological samples by detection of infrared spectral markers
US7050087B2 (en) * 2000-12-06 2006-05-23 Bioview Ltd. Data acquisition and display system and method
US6466690C1 (en) * 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US7141773B2 (en) 2001-08-06 2006-11-28 Bioview Ltd. Image focusing in fluorescent imaging
US6697509B2 (en) * 2001-10-04 2004-02-24 Chromavision Medical Systems, Inc. Method and apparatus for scoring the uptake of markers in cells
WO2003030620A2 (en) * 2001-10-12 2003-04-17 Vysis, Inc. Imaging microarrays
US7383134B2 (en) * 2002-01-15 2008-06-03 Piper James R Method and/or system for analyzing biological samples using a computer system

Also Published As

Publication number Publication date
US20070053569A1 (en) 2007-03-08
DE69627183D1 (de) 2003-05-08
US6920239B2 (en) 2005-07-19
EP0864082B1 (de) 2003-04-02
US7133545B2 (en) 2006-11-07
AU1086997A (en) 1997-06-19
US20080260233A1 (en) 2008-10-23
US20030228038A1 (en) 2003-12-11
WO1997020198A2 (en) 1997-06-05
US7359536B2 (en) 2008-04-15
US20040066960A1 (en) 2004-04-08
EP1300713A3 (de) 2004-11-03
EP0864082A2 (de) 1998-09-16
EP1300713A2 (de) 2003-04-09
US7558415B2 (en) 2009-07-07
US7783098B2 (en) 2010-08-24
US7359548B2 (en) 2008-04-15
CA2236268A1 (en) 1997-06-05
US6546123B1 (en) 2003-04-08
US20050185832A1 (en) 2005-08-25
JP2000501184A (ja) 2000-02-02
US20040120562A1 (en) 2004-06-24
AU724393B2 (en) 2000-09-21
ATE236386T1 (de) 2003-04-15
US20090060303A1 (en) 2009-03-05
US7660449B2 (en) 2010-02-09
WO1997020198A3 (en) 1997-08-28
US6553135B1 (en) 2003-04-22
US7177454B2 (en) 2007-02-13
US20080258061A1 (en) 2008-10-23
US20070140540A1 (en) 2007-06-21
US6215892B1 (en) 2001-04-10

Similar Documents

Publication Publication Date Title
DE69627183D1 (de) Verfahren zur automatischen bildanalyse biologischer proben
AU2003248207B2 (en) Color Space Transformations for Use in Identifying Objects of Interest in Biological Specimens
DE60226043T2 (de) Verfahren für quantitative video-mikroskopie und vorrichtung und programm zur durchführung des verfahrens
DE60316113T2 (de) Verfahren für quantitative video-mikroskopie und vorrichtung und computerprogramm zur durchführung des verfahrens
ATE245278T1 (de) Verfahren zur automatischen analyse von mikroskopaufnahmen
EP0468705A2 (de) Verfahren und Vorrichtung zum Untersuchen und Kontrollieren eines Objektes
AU2002334590A1 (en) Method quantitative video-microscopy and associated system and computer software program product
Pernthaler et al. In situ classification and image cytometry of pelagic bacteria from a high mountain lake (Gossenkollesee, Austria)
WO2004006985A3 (en) Assaying and imaging system identifying traits of biological specimens
US20040243318A1 (en) Microbe examining device and method
WO2003067256A3 (en) Systems for analyzing microtissue arrays
DE19801400C2 (de) Verfahren zur automatischen Erkennung, Eigenschaftsbeschreibung und Interpretation von Hep-2-Zellmustern
KR20060022266A (ko) 산점도 분포를 사용한 슬라이드를 분류하기 위한 시스템
CN116071367B (zh) 基于显微图像的粪便有形成分定量分析及控制方法和系统
EP3757872A1 (de) Abtastende/vorabtastende qualitätskontrolle von objektträgern
JPH0649195B2 (ja) 微生物検出装置
JPS6253792A (ja) 微生物相検出装置
US5874315A (en) Method for staining stool parasites
JPH1090163A (ja) 粒子分析装置
Netten et al. Automation of fluorescent dot counting in cell nuclei
Mantripragada et al. Image analysis of biological systems with microcomputers
EP4390376A1 (de) Verbessertes verfahren zur durchführung von fluoreszenzmessungen an einer probe
JP4344862B2 (ja) 観察対象の自動検出方法及び装置
EP1129337A1 (de) Anordnung und verfahren zur blutanalyse für die serodiagnostik
AU2006201607B2 (en) Color space transformations for use in identifying objects of interest in biological specimens

Legal Events

Date Code Title Description
8364 No opposition during term of opposition