DE69622992D1 - Substituierte heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Substituierte heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen

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Publication number
DE69622992D1
DE69622992D1 DE69622992T DE69622992T DE69622992D1 DE 69622992 D1 DE69622992 D1 DE 69622992D1 DE 69622992 T DE69622992 T DE 69622992T DE 69622992 T DE69622992 T DE 69622992T DE 69622992 D1 DE69622992 D1 DE 69622992D1
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production
same
pharmaceutical compositions
compositions containing
substituted heterocyclic
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DE69622992T
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DE69622992T2 (de
Inventor
Xavier Emonds-Alt
Isabelle Grossriether
Patrick Gueule
Vincenzo Proietto
Didier Van Broeck
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Sanofi Aventis France
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Sanofi Synthelabo SA
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Priority claimed from FR9501016A external-priority patent/FR2729952B1/fr
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Publication of DE69622992T2 publication Critical patent/DE69622992T2/de
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DE69622992T 1995-01-30 1996-01-30 Substituierte heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen Expired - Lifetime DE69622992T2 (de)

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FR9501016A FR2729952B1 (fr) 1995-01-30 1995-01-30 Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR9508046A FR2729953B1 (fr) 1995-01-30 1995-07-04 Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR9513005A FR2729954B1 (fr) 1995-01-30 1995-11-03 Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1996/000152 WO1996023787A1 (fr) 1995-01-30 1996-01-30 Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant

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DE69634806T Expired - Lifetime DE69634806T2 (de) 1995-01-30 1996-01-30 Substituierte heterocyclische Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751654B1 (fr) * 1996-07-26 1998-10-23 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9513972D0 (en) * 1995-07-08 1995-09-06 Merck Sharp & Dohme Pharmaceutical compositions
RU2135494C1 (ru) * 1995-12-01 1999-08-27 Санкио Компани Лимитед Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
GB9601680D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
FR2759585B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique
FR2759584B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire
KR100432210B1 (ko) 1997-05-30 2004-05-20 상꾜 가부시키가이샤 광학활성 술폭사이드 유도체의 염
CA2312770A1 (en) * 1997-12-04 1999-06-10 Takahide Nishi Alicyclic acylated heterocyclic derivatives
CA2342213A1 (en) * 1998-09-11 2000-03-23 Merck & Co., Inc. Process for the synthesis of n-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one
WO2000034274A1 (fr) * 1998-12-10 2000-06-15 Sankyo Company, Limited Derives de la cyclohexylpiperidine
FR2787790A1 (fr) 1998-12-23 2000-06-30 Sanofi Sa Procede de preparation du (r)-(+)-3-{1[2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates
FR2791346B3 (fr) * 1999-03-25 2001-04-27 Sanofi Sa Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2792199B3 (fr) * 1999-04-13 2001-05-18 Sanofi Sa Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur
FR2796069B3 (fr) 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
EP1377293B1 (de) * 2001-04-12 2010-03-10 Pharmacopeia, LLC Arly und diaryl piperidinderivate verwendbar als mch-hemmer
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
JP2006511555A (ja) * 2002-12-13 2006-04-06 スミスクライン ビーチャム コーポレーション Ｃｃｒ５拮抗剤としての複素環式化合物
TW200524868A (en) * 2003-07-31 2005-08-01 Zeria Pharm Co Ltd Benzylamine derivatives
WO2005080339A1 (ja) * 2004-02-25 2005-09-01 Sankyo Company, Limited スルホニルオキシ誘導体
US20080125461A1 (en) * 2004-04-05 2008-05-29 Sepracor Inc. (R,r)-Formoterol in Combination with Other Pharmacological Agents
US7955846B2 (en) * 2004-05-17 2011-06-07 The General Hospital Corporation Compositions comprising female germline stem cells and methods of use thereof
GB0412865D0 (en) * 2004-06-09 2004-07-14 Glaxo Group Ltd Chemical compounds
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
FR2873373B1 (fr) * 2004-07-23 2006-09-08 Sanofi Synthelabo Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
JP5486928B2 (ja) 2007-02-26 2014-05-07 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックウレアおよびカルバメートインヒビター
WO2009017671A1 (en) 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2252598A2 (de) 2008-02-11 2010-11-24 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-on und 1,3-diazepan-2-on als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
EP2254872A2 (de) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyllactamderivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
KR20110002492A (ko) 2008-05-01 2011-01-07 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
JP5451752B2 (ja) 2008-05-01 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
EP2291371B1 (de) 2008-05-01 2015-06-10 Vitae Pharmaceuticals, Inc. Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
CN102105454A (zh) 2008-07-25 2011-06-22 贝林格尔.英格海姆国际有限公司 合成1型11β-羟基类固醇脱氢酶的抑制剂
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
WO2010127237A2 (en) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN102119160B (zh) 2008-07-25 2014-11-05 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (de) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclische hemmer der 11beta-hydroxysteroiddehydrogenase 1 auf basis der 1,3 -oxazinan- 2 -on-struktur
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8552212B2 (en) 2009-11-05 2013-10-08 Boehringer Ingelheim International Gmbh Chiral phosphorus ligands
JP2013514982A (ja) * 2009-12-18 2013-05-02 イデニク プハルマセウティカルス，インコーポレイテッド ５，５−縮合アリーレン又はヘテロアリーレンｃ型肝炎ウイルス阻害剤
TWI475015B (zh) 2010-03-11 2015-03-01 Sumitomo Dainippon Pharma Co Ltd Ｎ－醯基環狀胺衍生物或其醫藥上容許之鹽
EP2576570A1 (de) 2010-05-26 2013-04-10 Boehringer Ingelheim International GmbH 2-oxo-1,2-dihydropyridin-4-ylborsäure-derivate
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
AU2011325286B2 (en) 2010-11-02 2015-04-16 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2398575A (en) * 1946-04-16 Theib manufacture
US2382285A (en) * 1941-11-19 1945-08-14 Roche Products Ltd Manufacture of arylacetonitrile derivatives
US2513346A (en) * 1948-12-21 1950-07-04 Parke Davis & Co Process for obtaining organic amino diols
US2689852A (en) * 1951-11-03 1954-09-21 Hoffmann La Roche Pyridine derivatives
US3112311A (en) * 1957-04-05 1963-11-26 Geigy Chem Corp 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines
GB1016828A (en) * 1961-11-13 1966-01-12 Mcneilab Inc Substituted morpholines and process for preparing same
GB8807921D0 (en) 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Ws-9326 & its derivatives
JP2865756B2 (ja) 1988-08-12 1999-03-08 フオルクスウアーゲン・アクチェンゲゼルシャフト 摩擦クラッチ
MX18467A (es) 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2654726B1 (fr) 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone et leur preparation.
UA41251C2 (uk) 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5332817A (en) * 1990-01-04 1994-07-26 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles
HUT62891A (en) 1990-06-01 1993-06-28 Pfizer Process for producing 3-amino-2-arylquinuclidine compounds and pharmaceuticql composition comprising such compounds
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
CA2099233A1 (en) * 1992-06-29 1993-12-30 Conrad P. Dorn Morpholine and thiomorpholine tachykinin receptor antagonists
FR2696178B1 (fr) * 1992-09-30 1994-12-30 Sanofi Elf Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.
AU678023B2 (en) * 1993-05-06 1997-05-15 Aventis Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists

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DK0807111T3 (da) 2002-12-16
ES2243373T3 (es) 2005-12-01
EP1688416A1 (de) 2006-08-09
FR2729954B1 (fr) 1997-08-01
SI1156049T1 (en) 2005-10-31
DE69634806D1 (de) 2005-07-07
CN1136189C (zh) 2004-01-28
MX9705590A (es) 1997-11-29
CN1179954C (zh) 2004-12-15
EP1156049B1 (de) 2005-06-01
DK1156049T3 (da) 2005-09-05
EP1923391A1 (de) 2008-05-21
CN1636983A (zh) 2005-07-13
NO973479D0 (no) 1997-07-29
CA2211668C (en) 2005-09-20
CA2211668A1 (en) 1996-08-08
IL116957A (en) 1999-06-20
CN1295221C (zh) 2007-01-17
JP3234228B2 (ja) 2001-12-04
CZ243697A3 (en) 1997-11-12
FI973148A (fi) 1997-09-29
SI0807111T1 (en) 2003-02-28
RU2157807C2 (ru) 2000-10-20
CN1321634A (zh) 2001-11-14
HUP9800295A3 (en) 2000-02-28
AU707901B2 (en) 1999-07-22
CY2537B1 (fr) 2006-06-28
DE69622992T2 (de) 2003-04-10
DE69634806T2 (de) 2006-04-27
AR036027A2 (es) 2004-08-04
HUP9800295A2 (hu) 1999-10-28
NO308795B1 (no) 2000-10-30
US5977359A (en) 1999-11-02
JP3357660B2 (ja) 2002-12-16
JP3943369B2 (ja) 2007-07-11
PL192164B1 (pl) 2006-09-29
ATE222251T1 (de) 2002-08-15
EP0807111A1 (de) 1997-11-19
NZ301285A (en) 2000-01-28
CN1202093C (zh) 2005-05-18
CN1321639A (zh) 2001-11-14
EP1156049A1 (de) 2001-11-21
US5869663A (en) 1999-02-09
CN1394855A (zh) 2003-02-05
JP2001131171A (ja) 2001-05-15
AR002955A1 (es) 1998-05-27
FR2729954A1 (fr) 1996-08-02
ES2181866T3 (es) 2003-03-01
IL116957A0 (en) 1996-05-14
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PT1156049E (pt) 2005-10-31
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ATE296823T1 (de) 2005-06-15
US5641777A (en) 1997-06-24
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