DE69430587D1 - Pyrimidin-acyclonukleosid-derivate - Google Patents

Pyrimidin-acyclonukleosid-derivate

Info

Publication number
DE69430587D1
DE69430587D1 DE69430587T DE69430587T DE69430587D1 DE 69430587 D1 DE69430587 D1 DE 69430587D1 DE 69430587 T DE69430587 T DE 69430587T DE 69430587 T DE69430587 T DE 69430587T DE 69430587 D1 DE69430587 D1 DE 69430587D1
Authority
DE
Germany
Prior art keywords
acyclonukleosid
pyrimidine
derivatives
acyclonukleosid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430587T
Other languages
English (en)
Other versions
DE69430587T2 (de
Inventor
Dae-Kee Kim
Jongsik Gam
Ganghyeok Kim
Young-Woo Kim
Namkyu Lee
Jinsoo Lim
Hun-Taek Kim
Hyup Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SK Discovery Co Ltd
Original Assignee
Sunkyung Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019940003794A external-priority patent/KR0128542B1/ko
Priority claimed from KR1019940018325A external-priority patent/KR0131391B1/ko
Priority claimed from KR1019940018324A external-priority patent/KR0140021B1/ko
Application filed by Sunkyung Industries Ltd filed Critical Sunkyung Industries Ltd
Publication of DE69430587D1 publication Critical patent/DE69430587D1/de
Application granted granted Critical
Publication of DE69430587T2 publication Critical patent/DE69430587T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Luminescent Compositions (AREA)
DE69430587T 1994-02-28 1994-07-29 Pyrimidin-acyclonukleosid-derivate Expired - Fee Related DE69430587T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1019940003794A KR0128542B1 (ko) 1994-02-28 1994-02-28 피리미딘 아사이클로뉴클레오시드 유도체
KR1019940018325A KR0131391B1 (ko) 1994-07-27 1994-07-27 피리미딘 아사이클로뉴클레오시드 유도체의 제조방법
KR1019940018324A KR0140021B1 (ko) 1994-07-27 1994-07-27 피리미딘 아사이클로뉴클레오시드 유도체
PCT/KR1994/000102 WO1995023138A1 (en) 1994-02-28 1994-07-29 Pyrimidine acyclonucleoside derivatives

Publications (2)

Publication Number Publication Date
DE69430587D1 true DE69430587D1 (de) 2002-06-13
DE69430587T2 DE69430587T2 (de) 2003-01-09

Family

ID=27349054

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430587T Expired - Fee Related DE69430587T2 (de) 1994-02-28 1994-07-29 Pyrimidin-acyclonukleosid-derivate

Country Status (8)

Country Link
US (1) US5889013A (de)
EP (1) EP0748316B1 (de)
JP (1) JP2683297B2 (de)
AU (1) AU693107B2 (de)
BR (1) BR9408370A (de)
CA (1) CA2159817C (de)
DE (1) DE69430587T2 (de)
WO (1) WO1995023138A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2264428B1 (de) 1997-01-31 2017-05-03 Xy, Llc Optisches Gerät mit fokussierendem Reflektor zur Konvergenz von Strahlung auf einen Partikelfluss
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
DK2275533T3 (en) 2002-08-01 2016-11-07 Xy Llc Sperm Cell Assessment Method
WO2004017041A2 (en) 2002-08-15 2004-02-26 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
DK2305832T3 (da) 2003-03-28 2022-05-23 Inguran Llc Fremgangsmåde til tilvejebringelse af kønssorteret dyresæd
CA2566749C (en) 2003-05-15 2017-02-21 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
NZ550198A (en) 2004-03-29 2009-12-24 Inguran Llc Sperm suspensions for use in insemination
WO2006012597A2 (en) 2004-07-22 2006-02-02 Monsanto Technology Llc Process for enriching a population of sperm cells
CN101495461A (zh) * 2006-07-24 2009-07-29 吉里德科学公司 新的hiv逆转录酶抑制剂
CA2692460A1 (en) * 2007-06-29 2009-01-08 Korea Research Institute Of Chemical Technology Hiv reverse transcriptase inhibitors
WO2009005693A1 (en) * 2007-06-29 2009-01-08 Gilead Sciences, Inc. Novel hiv reverse transcriptase inhibitors
US8119800B2 (en) * 2007-12-21 2012-02-21 Korea Research Institute Of Chemical Technology Processes for preparing HIV reverse transcriptase inhibitors
WO2009114325A2 (en) 2008-03-03 2009-09-17 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2781344A (en) * 1953-05-04 1957-02-12 Monsanto Chemicals Formylation of amino-pyrimidines
US3755295A (en) * 1969-10-24 1973-08-28 Syntex Corp 1-(2-amino-2-deoxy-{62 -d-ribofuranosyl) pyrimidines and derivatives thereof
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
JPS5738774A (en) * 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
US4868187A (en) * 1980-09-16 1989-09-19 Syntex (U.S.A.) Inc. Anti-viral N-substituted pyrimidines
US4613604A (en) * 1985-07-31 1986-09-23 Brown University Research Foundation Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
WO1989009213A1 (en) * 1988-03-31 1989-10-05 Mitsubishi Kasei Corporation 6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
KR0155168B1 (ko) * 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
HU205917B (en) * 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
FR2659656B1 (fr) * 1990-03-15 1994-09-09 Sanofi Sa Derives de pyrimidinedione-2,4 et medicaments les contenant.
DE69126469T2 (de) * 1990-03-29 1998-01-29 Mitsubishi Chem Corp Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten
US5141943A (en) * 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use

Also Published As

Publication number Publication date
DE69430587T2 (de) 2003-01-09
BR9408370A (pt) 1997-08-26
AU7351294A (en) 1995-09-11
CA2159817A1 (en) 1995-08-31
EP0748316A1 (de) 1996-12-18
CA2159817C (en) 2000-09-12
JPH08504833A (ja) 1996-05-28
JP2683297B2 (ja) 1997-11-26
WO1995023138A1 (en) 1995-08-31
EP0748316B1 (de) 2002-05-08
US5889013A (en) 1999-03-30
AU693107B2 (en) 1998-06-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee