DE69412534D1 - Piperazin-Derivate und ihre Verwendung als Calmodulin-Inhibitoren - Google Patents
Piperazin-Derivate und ihre Verwendung als Calmodulin-InhibitorenInfo
- Publication number
- DE69412534D1 DE69412534D1 DE69412534T DE69412534T DE69412534D1 DE 69412534 D1 DE69412534 D1 DE 69412534D1 DE 69412534 T DE69412534 T DE 69412534T DE 69412534 T DE69412534 T DE 69412534T DE 69412534 D1 DE69412534 D1 DE 69412534D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- substituted
- aryl
- alkylene
- nitrogen
- Prior art date
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- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11277193 | 1993-05-14 |
Publications (2)
Publication Number | Publication Date |
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DE69412534D1 true DE69412534D1 (de) | 1998-09-24 |
DE69412534T2 DE69412534T2 (de) | 1999-04-29 |
Family
ID=14595104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69412534T Expired - Fee Related DE69412534T2 (de) | 1993-05-14 | 1994-05-13 | Piperazin-Derivate und ihre Verwendung als Calmodulin-Inhibitoren |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0624584B1 (de) |
JP (2) | JP3220591B2 (de) |
KR (1) | KR100303737B1 (de) |
CN (1) | CN1049654C (de) |
AT (1) | ATE169914T1 (de) |
AU (2) | AU677644B2 (de) |
CA (1) | CA2123548C (de) |
DE (1) | DE69412534T2 (de) |
DK (1) | DK0624584T3 (de) |
EE (1) | EE03139B1 (de) |
ES (1) | ES2125372T3 (de) |
FI (1) | FI942252A (de) |
GR (1) | GR3027679T3 (de) |
HK (1) | HK1002221A1 (de) |
NO (1) | NO306901B1 (de) |
RU (1) | RU2124511C1 (de) |
SG (1) | SG48920A1 (de) |
SI (1) | SI0624584T1 (de) |
TW (1) | TW418198B (de) |
Families Citing this family (56)
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SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
JP3948744B2 (ja) * | 1994-11-04 | 2007-07-25 | 大日本住友製薬株式会社 | 新規なラクタム誘導体 |
ES2156605T3 (es) * | 1994-11-14 | 2001-07-01 | Daiichi Seiyaku Co | Procedimiento de preparacion de un 3,5-hidrato de dihidrocloruro de 3-(2-(4-(3-cloro-2-metilfenil)-1-piperazinil)etil)-5,6-dimetoxi-1-(4-imidazolilmetil)-1h-indazol. |
CA2180190A1 (en) * | 1995-07-10 | 1997-01-11 | Kazumi Ogata | Benzylpiperazine derivatives |
WO1997041108A1 (en) * | 1996-04-30 | 1997-11-06 | Warner-Lambert Company | Substituted piperazines and piperidines as central nervous system agents |
WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
US5859246A (en) * | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
JP3687899B2 (ja) * | 1997-09-29 | 2005-08-24 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | アミノアルキルフェノール誘導体および関連化合物 |
US6479495B1 (en) * | 1997-09-29 | 2002-11-12 | Aventis Pharmaceuticals Inc. | Aminoalkylphenol derivatives and related compounds |
WO1999024475A1 (fr) * | 1997-11-07 | 1999-05-20 | Daiichi Pharmaceutical Co., Ltd. | Complexes de piperazine et de cyclodextrine |
AR022303A1 (es) | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
GB9914371D0 (en) * | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
DE19934432A1 (de) | 1999-07-22 | 2001-02-01 | Merck Patent Gmbh | Indolderivate |
MXPA03000174A (es) | 2000-07-06 | 2003-09-22 | Neurogen Corp | Ligandos de receptor de hormona concentradora de melanina. |
SI1395567T1 (sl) | 2001-05-18 | 2009-04-30 | Astrazeneca Ab | 4-(fenil-piperazinil-metil)benzamidni derivati in njihova uporaba za zdravljenje bolečine, tesnobe ali gastrointestinalnih motenj |
BR0209932A (pt) | 2001-05-22 | 2004-10-13 | Neurogen Corp | Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, preparação farmacêutica embalada, métodos para modular ligação de mch a um receptor de mch e de mvc, para alterar a atividade de transdução de sinal de um receptor de mch em uma célula, para tratar uma doença ou distúrbio associado com a ativação de receptor de mch patogênico obesidade e para determinar a presença ou ausência de receptor de mch em uma amostra, e, uso de um composto |
CN1150176C (zh) * | 2002-05-22 | 2004-05-19 | 上海医药工业研究院 | 芳烷酮哌嗪衍生物及其应用 |
BRPI0315644B8 (pt) | 2002-10-23 | 2021-05-25 | Janssen Pharmaceutica Nv | compostos de piperazinil e diazapanil benzamidas e benzotioamidas, suas composições e respectivos usos |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
WO2005023261A1 (en) * | 2003-09-09 | 2005-03-17 | F. Hoffmann-La Roche Ag | 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
US7253168B2 (en) | 2004-04-07 | 2007-08-07 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US8013006B2 (en) | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
MX2007001240A (es) | 2004-08-02 | 2007-03-23 | Astrazeneca Ab | Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas. |
EP1805142A4 (de) | 2004-09-23 | 2009-06-10 | Reddy Us Therapeutics Inc | Neue pyridinverbindungen, verfahren zu ihrer herstellung und zusammensetzungen damit |
JP4762250B2 (ja) | 2004-12-09 | 2011-08-31 | エフ.ホフマン−ラ ロシュ アーゲー | フェニル−ピペラジンメタノン誘導体 |
CN100586951C (zh) | 2004-12-15 | 2010-02-03 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸转运体l(GlyT-1)抑制剂用于治疗阿尔茨海默氏病的二环和三环取代的苯甲酮化合物 |
US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
KR100895752B1 (ko) | 2005-01-07 | 2009-04-30 | 에프. 호프만-라 로슈 아게 | 신경 질환 및 신경정신 질환을 치료하기 위한 글라이신수송자 1(glyt-1) 저해제로서의[4-(헤테로아릴)피페라진-1-일]-(2,5-치환-페닐)메탄온유도체 |
ATE447572T1 (de) | 2005-01-26 | 2009-11-15 | Hoffmann La Roche | Phenylmethanonderivate und ihre verwendung als glycin-transporter-1-hemmer |
UA91536C2 (uk) | 2005-02-07 | 2010-08-10 | Ф. Хоффманн-Ля Рош Аг | Гетероциклічні заміщені фенілметанони як інгібітори переносника гліцину 1 |
WO2007021309A1 (en) * | 2005-08-12 | 2007-02-22 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
US7544685B2 (en) | 2005-08-17 | 2009-06-09 | H. Lundbeck A/S | 2,3-dihydroindole compounds |
US8003624B2 (en) * | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
PL1948607T3 (pl) | 2005-09-16 | 2010-09-30 | Janssen Pharmaceutica Nv | Cyklopropyloaminy jako modulatory receptora histaminowego H3 |
JP4783154B2 (ja) | 2006-01-11 | 2011-09-28 | 東芝モバイルディスプレイ株式会社 | 平面表示装置及びその駆動方法 |
TWI417100B (zh) * | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
JP5255994B2 (ja) * | 2008-11-04 | 2013-08-07 | 国立大学法人 岡山大学 | 核内受容体リガンド |
CN102260214B (zh) * | 2009-12-29 | 2013-12-04 | 浙江大学 | 一种吲唑化合物的制备方法 |
BR102012000187A2 (pt) * | 2012-01-05 | 2018-04-10 | Univ Rio De Janeiro | Derivados n-fenilpiperazínicos antagonistas de adrenoceptores a1a, a1d e de receptores 5-ht1a no tratamento da hiperplasia prostática benigna, composições farmacêuticas contendo os mesmos |
CN102653521B (zh) * | 2012-04-27 | 2014-08-06 | 首都师范大学 | 吲哚-2-酮的哌嗪硫代甲酰肼衍生物及其制备方法和用途 |
EA201590053A1 (ru) | 2012-06-20 | 2015-08-31 | Новартис Аг | Модуляторы пути системы комплемента и их применение |
EP3027607B1 (de) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Substituierte heteroarylverbindungen und verfahren zur verwendung davon |
CN104725359B (zh) | 2013-12-20 | 2017-05-03 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
CN105061317B (zh) * | 2015-08-26 | 2017-08-25 | 浙江大果生物医药科技有限公司 | 一类吲唑盐类化合物及其制备方法和应用 |
CN105078993B (zh) * | 2015-08-26 | 2019-02-22 | 浙江大果生物医药科技有限公司 | 一种吲唑类化合物组合物及其制备方法和应用 |
CN106632268A (zh) * | 2016-11-18 | 2017-05-10 | 河南师范大学 | 用于治疗脑源性疾病的钙调蛋白抑制剂的合成方法 |
CN110407752A (zh) * | 2019-08-22 | 2019-11-05 | 浙江大果生物医药科技有限公司 | 一种药物的草酸盐晶型及其制备方法 |
TWI749881B (zh) * | 2019-11-21 | 2021-12-11 | 大陸商深圳信立泰藥業股份有限公司 | 二氧代哌類衍生物、其製備方法及其在醫藥上的應用 |
CN112608303B (zh) * | 2020-12-25 | 2021-10-26 | 华南理工大学 | 一种哌嗪类中间体及其制备方法与应用 |
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US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
US4510307A (en) * | 1980-08-20 | 1985-04-09 | Asahi Kasei Kogyo Kabushiki Kaisha | 6-Quinazolinesulfonyl derivatives and process for preparation thereof |
US4544657A (en) * | 1983-05-19 | 1985-10-01 | Hoffmann-La Roche Inc. | Substituted isoquinolines |
GB9220735D0 (en) * | 1992-10-02 | 1992-11-18 | British Tech Group | Heterocyclic amines |
-
1994
- 1994-05-12 RU RU94016183/04A patent/RU2124511C1/ru not_active IP Right Cessation
- 1994-05-13 SI SI9430169T patent/SI0624584T1/xx not_active IP Right Cessation
- 1994-05-13 ES ES94107496T patent/ES2125372T3/es not_active Expired - Lifetime
- 1994-05-13 JP JP09939194A patent/JP3220591B2/ja not_active Expired - Fee Related
- 1994-05-13 AU AU63096/94A patent/AU677644B2/en not_active Ceased
- 1994-05-13 EP EP94107496A patent/EP0624584B1/de not_active Expired - Lifetime
- 1994-05-13 DK DK94107496T patent/DK0624584T3/da active
- 1994-05-13 SG SG1996003753A patent/SG48920A1/en unknown
- 1994-05-13 NO NO941802A patent/NO306901B1/no not_active IP Right Cessation
- 1994-05-13 CA CA002123548A patent/CA2123548C/en not_active Expired - Fee Related
- 1994-05-13 FI FI942252A patent/FI942252A/fi unknown
- 1994-05-13 DE DE69412534T patent/DE69412534T2/de not_active Expired - Fee Related
- 1994-05-13 AT AT94107496T patent/ATE169914T1/de not_active IP Right Cessation
- 1994-05-13 CN CN94105810A patent/CN1049654C/zh not_active Expired - Fee Related
- 1994-05-14 KR KR1019940010542A patent/KR100303737B1/ko not_active IP Right Cessation
- 1994-05-25 TW TW083104731A patent/TW418198B/zh not_active IP Right Cessation
- 1994-11-22 EE EE9400389A patent/EE03139B1/xx not_active IP Right Cessation
-
1997
- 1997-06-17 AU AU24952/97A patent/AU698486B2/en not_active Ceased
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1998
- 1998-01-21 HK HK98100555A patent/HK1002221A1/xx not_active IP Right Cessation
- 1998-08-20 GR GR980401824T patent/GR3027679T3/el unknown
-
2001
- 2001-06-13 JP JP2001178197A patent/JP2002053553A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TW418198B (en) | 2001-01-11 |
FI942252A (fi) | 1994-11-15 |
EP0624584A1 (de) | 1994-11-17 |
AU677644B2 (en) | 1997-05-01 |
SI0624584T1 (en) | 1998-10-31 |
AU6309694A (en) | 1994-11-17 |
DK0624584T3 (da) | 1999-05-25 |
GR3027679T3 (en) | 1998-11-30 |
NO306901B1 (no) | 2000-01-10 |
NO941802D0 (no) | 1994-05-13 |
JP3220591B2 (ja) | 2001-10-22 |
SG48920A1 (en) | 1998-05-18 |
JPH0797364A (ja) | 1995-04-11 |
KR100303737B1 (ko) | 2001-11-22 |
NO941802L (no) | 1994-11-15 |
AU698486B2 (en) | 1998-10-29 |
AU2495297A (en) | 1997-09-04 |
CA2123548A1 (en) | 1994-11-15 |
HK1002221A1 (en) | 1998-08-07 |
EP0624584B1 (de) | 1998-08-19 |
CA2123548C (en) | 2003-04-08 |
CN1101039A (zh) | 1995-04-05 |
CN1049654C (zh) | 2000-02-23 |
JP2002053553A (ja) | 2002-02-19 |
RU2124511C1 (ru) | 1999-01-10 |
ES2125372T3 (es) | 1999-03-01 |
FI942252A0 (fi) | 1994-05-13 |
ATE169914T1 (de) | 1998-09-15 |
DE69412534T2 (de) | 1999-04-29 |
RU94016183A (ru) | 1996-04-10 |
EE03139B1 (et) | 1998-12-15 |
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