DE69006052D1 - 19-Nor-Vitamin-D-Derivate. - Google Patents

19-Nor-Vitamin-D-Derivate.

Info

Publication number: DE69006052D1
Authority: DE; Germany
Prior art keywords: vitamin; undifferentiated cells; cells; malignant; treatment
Prior art date: 1989-03-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE90302521T

Other languages

English (en)

Other versions

DE122006000018I1 (de

DE69006052T2 (de

Inventor

Hector F Deluca

Heinrich K Schnoes

Kato L Perlman

Rafal R Sicinski

Jean Martin Prahl

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wisconsin Alumni Research Foundation

Original Assignee

Wisconsin Alumni Research Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-09

Filing date

1990-03-09

Publication date

1994-03-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26982778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69006052(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-02-16 Priority claimed from US07/481,354 external-priority patent/US5237110A/en

1990-03-09 Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation

1994-03-03 Publication of DE69006052D1 publication Critical patent/DE69006052D1/de

1994-05-05 Application granted granted Critical

1994-05-05 Publication of DE69006052T2 publication Critical patent/DE69006052T2/de

2010-03-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE90302521T 1989-03-09 1990-03-09 19-Nor-Vitamin-D-Derivate. Expired - Lifetime DE69006052T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32103089A	1989-03-09	1989-03-09
US07/481,354 US5237110A (en)	1989-03-09	1990-02-16	19-nor-vitamin d compounds

Publications (2)

Publication Number	Publication Date
DE69006052D1 true DE69006052D1 (de)	1994-03-03
DE69006052T2 DE69006052T2 (de)	1994-05-05

Family

ID=26982778

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE90302521T Expired - Lifetime DE69006052T2 (de)	1989-03-09	1990-03-09	19-Nor-Vitamin-D-Derivate.
DE1990606052 Pending DE122006000018I1 (de)	1989-03-09	1990-03-09	19-Nor-Vitamin-D-Derivate
DE122006000018C Active DE122006000018I2 (de)	1989-03-09	1990-03-09	19-Nor-Vitamin-D-Derivate.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DE1990606052 Pending DE122006000018I1 (de)	1989-03-09	1990-03-09	19-Nor-Vitamin-D-Derivate
DE122006000018C Active DE122006000018I2 (de)	1989-03-09	1990-03-09	19-Nor-Vitamin-D-Derivate.

Country Status (8)

Country	Link
EP (1)	EP0387077B1 (de)
CN (1)	CN1033857C (de)
AT (1)	ATE100447T1 (de)
DE (3)	DE69006052T2 (de)
ES (1)	ES2062334T3 (de)
IE (1)	IE64526B1 (de)
NL (1)	NL300228I1 (de)
NZ (1)	NZ232734A (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2229921B (en) *	1989-04-05	1992-12-16	Chugai Pharmaceutical Co Ltd	Treatment for hyperparathyroidism with use of vitamin d derivatives
US5459136A (en) *	1990-08-24	1995-10-17	Wisconsin Alumni Research Foundation	Methods using vitamin D compounds for improvement of skin conditions
AU649057B2 (en) *	1990-08-24	1994-05-12	Wisconsin Alumni Research Foundation	Methods and compositions containing vitamin D compounds for improvement of skin conditions
DE69130497T2 (de) *	1990-09-07	1999-04-22	Wisconsin Alumni Research Foundation, Madison, Wis.	Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis
AU650751B2 (en) *	1991-05-28	1994-06-30	Wisconsin Alumni Research Foundation	Novel synthesis of 19-nor vitamin D compounds
US5086191A (en) *	1991-05-28	1992-02-04	Wisconsin Alumni Research Foundation	Intermediates for the synthesis of 19-nor vitamin D compounds
ATE143007T1 (de) *	1991-07-05	1996-10-15	Duphar Int Res	Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür
AU682817B2 (en) *	1992-01-29	1997-10-23	Bone Care International, Inc.	1alpha-hydroxy-24-(epi)-vitamin D4
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
AU666563B2 (en) *	1992-08-07	1996-02-15	Wisconsin Alumni Research Foundation	Preparation of 19-nor-vitamin D compounds
CA2096105A1 (en) *	1992-10-07	1994-04-08	Enrico Giuseppe Baggiolini (Deceased)	Vitamin d3 fluorinated analogs
US5753638A (en) *	1992-10-07	1998-05-19	Hoffmann-La Roche Inc.	Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
TW267161B (de) *	1992-11-20	1996-01-01	Hoffmann La Roche
EP0619306B1 (de) *	1993-04-05	1996-09-11	Wisconsin Alumni Research Foundation	19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
US6017907A (en) *	1993-07-09	2000-01-25	Laboratoire Theramex S.A.	Structural analogues of vitamin D
ATE168367T1 (de) *	1994-01-20	1998-08-15	Duphar Int Res	Vitamin-d-derivate und verfahren zu deren herstellung
CA2206876A1 (en) *	1994-11-21	1996-05-30	Wisconsin Alumni Research Foundation	18,19-dinor-vitamin d compounds
DE69508895T2 (de) *	1994-12-14	1999-10-21	Duphar International Research B.V., Weesp	Vitamin-D-Derivate und Verfahren zur Herstellung dieser Verbindungen
US5597815A (en) *	1995-07-13	1997-01-28	Wisconsin Alumni Research Foundation	Prevention of hyperphosphatemia in kidney disorder patients
ATE290869T1 (de)	1995-12-28	2005-04-15	Chugai Pharmaceutical Co Ltd	Verwendung von vitamin d derivaten zur herstellung eines medikaments zur behandlung von bösartigen tumormetastase
US6869940B2 (en)	1995-12-28	2005-03-22	Chugai Seiyaku Kabushiki Kaisha	Malignant tumor metastasis inhibitors
US5891865A (en) *	1996-10-04	1999-04-06	Wisconsin Alumni Research Foundation	Treatment of arthritic disease induced by infectious agents
US6306844B1 (en)	1997-03-17	2001-10-23	Wisconsin Alumni Research Foundation	Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US6316642B1 (en)	1997-03-17	2001-11-13	Wisconsin Alumni Research Foundation	26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US5843928A (en) *	1997-03-17	1998-12-01	Wisconsin Alumni Research Foundation	2-alkylidene-19-nor-vitamin D compounds
US6392071B1 (en)	1997-03-17	2002-05-21	Wisconsin Alumni: Research Foundation	26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US5945410A (en) *	1997-03-17	1999-08-31	Wisconsin Alumni Research Foundation	2-alkyl-19-nor-vitamin D compounds
CA2288629A1 (en) *	1997-05-23	1998-11-26	F. Hoffmann-La Roche Ag	Cyclohexanediol derivatives
US5939406A (en) *	1997-07-21	1999-08-17	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
US6114317A (en)	1998-05-21	2000-09-05	Wisconsin Alumni Research Foundation	Method of locking 1α-OH of vitamin D compounds in axial orientation
EP1286962B1 (de)	2000-05-31	2008-06-25	Wisconsin Alumni Research Foundation	2-ethyl und 2-ethyliden-19-nor-vitamin d-verbindungen
KR20050120787A (ko)	2003-04-10	2005-12-23	위스콘신 얼럼나이 리서어치 화운데이션	2-프로필리덴-19-노르-비타민 ｄ 화합물
US6894037B2 (en)	2003-07-03	2005-05-17	Wisconsin Alumni Research Foundation	2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en)	2004-04-09	2010-05-11	Wisconsin Alumni Research Foundation	2-alkylidene-18,19-dinor-vitamin D compounds
CA2612604A1 (en) *	2005-07-18	2007-01-25	Anchel Schwartz	Purification of paricalcitol
NZ571896A (en)	2006-04-05	2011-09-30	Wisconsin Alumni Res Found	1-Alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and use thereof
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
US7491712B1 (en)	2007-12-10	2009-02-17	Formosa Laboratories, Inc.	Process for preparation of paricalcitol and intermediates thereof
CN102131773B (zh)	2008-07-22	2014-09-24	Azad药物成分股份公司	生产帕立骨化醇的方法
PL216135B1 (pl)	2009-08-07	2014-03-31	Inst Farmaceutyczny	Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D
EP2545940A1 (de)	2011-07-14	2013-01-16	hameln rds gmbh	Parenterale Zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4448726A (en) *	1983-05-11	1984-05-15	Wisconsin Alumni Research Foundation	Ring A- and triene-modified vitamin D compounds
JPS61501147A (ja) *	1984-01-30	1986-06-12	ウイスコンシン　アラムナイ　リサ−チ　フォンデ−ション	１α，２５−ジヒドロキシ−２２Ｚ−デヒドロビタミンＤ化合物
US4555364A (en) *	1984-11-01	1985-11-26	Wisconsin Alumni Research Foundation	Method for preparing 1-hydroxyvitamin D compounds
CA1314872C (en) *	1986-04-25	1993-03-23	Toshio Nishizawa	Fluorine derivatives of vitamin d _and process for producing the same

1990
- 1990-02-28 NZ NZ232734A patent/NZ232734A/xx unknown
- 1990-03-09 AT AT90302521T patent/ATE100447T1/de not_active IP Right Cessation
- 1990-03-09 DE DE90302521T patent/DE69006052T2/de not_active Expired - Lifetime
- 1990-03-09 EP EP90302521A patent/EP0387077B1/de not_active Expired - Lifetime
- 1990-03-09 ES ES90302521T patent/ES2062334T3/es not_active Expired - Lifetime
- 1990-03-09 DE DE1990606052 patent/DE122006000018I1/de active Pending
- 1990-03-09 DE DE122006000018C patent/DE122006000018I2/de active Active
- 1990-03-09 CN CN90101777.9A patent/CN1033857C/zh not_active Expired - Lifetime
- 1990-03-09 IE IE84090A patent/IE64526B1/en not_active IP Right Cessation
2006
- 2006-04-07 NL NL300228C patent/NL300228I1/nl unknown

Also Published As

Publication number	Publication date
NL300228I1 (nl)	2006-06-01
DE122006000018I1 (de)	2006-06-29
IE64526B1 (en)	1995-08-09
DE122006000018I2 (de)	2008-05-08
NZ232734A (en)	1991-11-26
ES2062334T3 (es)	1994-12-16
CN1046155A (zh)	1990-10-17
EP0387077A1 (de)	1990-09-12
DE69006052T2 (de)	1994-05-05
ATE100447T1 (de)	1994-02-15
IE900840L (en)	1990-09-09
CN1033857C (zh)	1997-01-22
EP0387077B1 (de)	1994-01-19

Publication	Publication Date	Title
DE69006052D1 (de)	1994-03-03	19-Nor-Vitamin-D-Derivate.
GR3019450T3 (en)	1996-06-30	Azaheterocyclylmethyl-chromans as agents for the treatment of diseases of the central nervous system
YU29099A (sh)	2002-06-19	Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola
AU549481B2 (en)	1986-01-30	Hair growing agent
AP2000001881A0 (en)	2000-09-30	2-(Purine-9-YL)-tetrahydrofuran-3,4 4-diol derivatives.
HUT52769A (en)	1990-08-28	Process for producing pyrimidine derivatives and pharmaceutical compositions containing them
BG104729A (en)	2001-04-30	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
ATE90342T1 (de)	1993-06-15	1-hydroxyvitamin d2-epimer und dessen derivate.
AU4204389A (en)	1990-03-23	3-(aminopropyl)methyl phosphinic acid as a therapeutic agent and intermediates in its synthesis
EP0363415A4 (en)	1993-03-17	Compounds for the treatment of alzheimer's disease
NO902800L (no)	1990-12-27	Fremgangsmaate for fremstilling av 11beta-aryl-4-oestrener.
PL293065A1 (en)	1992-08-10	Method of obtaining novel derivatives of chromane and thiochromane
EP0412554A3 (en)	1991-09-25	Sustained-release preparation for administration into brain
TR199700711T1 (xx)	1998-01-21	Ciltten ge�erek v�cuda giren form�lasyon.
IL68456A (en)	1989-09-28	Pharmaceutical compositions comprising perfluoro-substituted compounds as vehicles
DE3681581D1 (de)	1991-10-24	4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamine und 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamine.
EP0328634A4 (en)	1991-08-21	Pharmaceutical compositions for the treatment of psoriasis
ATE528279T1 (de)	2011-10-15	3-butenyl-1-aminederivate und ihre verwendung als ih modulatoren von therapie für psychiatrische erkrankungen
ATE239470T1 (de)	2003-05-15	Melatonin-derivate zur verwendung in der behandlung von desynchronisierungs-erkankungen
IE891407L (en)	1989-10-29	Side chain unsaturated 1-ó-hydroxyvitamin d homologs
MY103593A (en)	1993-08-28	Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
ES466795A1 (es)	1979-01-16	Un procedimiento para la produccion de imidazo(1,5-b)pirida-zinas
JPS5753475A (en)	1982-03-30	Novel thiazolyl-2-oxamic acid derivative, manufacture and medicine containing same
EP0301449A3 (en)	1990-03-21	Enantiomers of propafenone-containing therapeutic agents
DK0486586T3 (da)	1994-10-24	Kynurensyrederivater, fremstilling deraf og farmaceutiske præparater, der indeholder dem