DE69001839D1 - 1-hydroxyvitamin d2-epimer und dessen derivate. - Google Patents

1-hydroxyvitamin d2-epimer und dessen derivate.

Info

Publication number
DE69001839D1
DE69001839D1 DE9090104564T DE69001839T DE69001839D1 DE 69001839 D1 DE69001839 D1 DE 69001839D1 DE 9090104564 T DE9090104564 T DE 9090104564T DE 69001839 T DE69001839 T DE 69001839T DE 69001839 D1 DE69001839 D1 DE 69001839D1
Authority
DE
Germany
Prior art keywords
vitamin
hydroxy
derivatives
hydroxyvitamin
epimer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE9090104564T
Other languages
English (en)
Other versions
DE69001839T2 (de
Inventor
Hector F Deluca Hector Deluca
Heinrich K Schnoes Hei Schnoes
Kato L Perlman Kato L Perlman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE69001839D1 publication Critical patent/DE69001839D1/de
Publication of DE69001839T2 publication Critical patent/DE69001839T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE9090104564T 1989-03-09 1990-03-09 1-hydroxyvitamin d2-epimer und dessen derivate. Expired - Fee Related DE69001839T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/321,254 US4973584A (en) 1989-03-09 1989-03-09 Novel 1α-hydroxyvitamin D2 epimer and derivatives

Publications (2)

Publication Number Publication Date
DE69001839D1 true DE69001839D1 (de) 1993-07-15
DE69001839T2 DE69001839T2 (de) 1993-09-16

Family

ID=23249837

Family Applications (1)

Application Number Title Priority Date Filing Date
DE9090104564T Expired - Fee Related DE69001839T2 (de) 1989-03-09 1990-03-09 1-hydroxyvitamin d2-epimer und dessen derivate.

Country Status (15)

Country Link
US (1) US4973584A (de)
EP (1) EP0386793B1 (de)
JP (1) JPH0737443B2 (de)
KR (1) KR950005776B1 (de)
AT (1) ATE90342T1 (de)
AU (1) AU631618B2 (de)
CA (1) CA1335105C (de)
DE (1) DE69001839T2 (de)
DK (1) DK0386793T3 (de)
ES (1) ES2055193T3 (de)
HU (1) HU207040B (de)
IL (1) IL93456A (de)
NZ (1) NZ232735A (de)
RU (1) RU2065851C1 (de)
WO (1) WO1990010619A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
US6251883B1 (en) 1991-01-08 2001-06-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
US5789397A (en) * 1991-01-08 1998-08-04 Bone Care International, Inc. Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US5182396A (en) * 1991-03-29 1993-01-26 Nisshin Flour Milling Co., Ltd. 1-hydroxyvitamin d derivatives
IL104201A0 (en) * 1991-12-26 1993-05-13 Wisconsin Alumni Res Found 26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them
AU682817B2 (en) * 1992-01-29 1997-10-23 Bone Care International, Inc. 1alpha-hydroxy-24-(epi)-vitamin D4
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
CA2121689C (en) * 1992-08-28 2008-03-18 Ronald L. Horst 1.alpha.,24(s)-dihydroxy vitamin d2, its formation and use
TW267161B (de) * 1992-11-20 1996-01-01 Hoffmann La Roche
JPH0753384A (ja) * 1993-07-13 1995-02-28 Wisconsin Alumni Res Found ２４−エピ−１α−ヒドロキシビタミンＤ２ を含んでなる骨粗鬆症治療剤
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5373004A (en) * 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
AU1525700A (en) 1998-11-19 2000-06-05 Board Of Trustees Of The University Of Arkansas, The Increasing bone strength with selected bisphosphonates
CA2366586C (en) * 1999-04-01 2004-06-22 Johns Hopkins University Non-calcemic, antiproliferative, transcriptionally active sulfur-containing analogs of 1.alpha., 25-dihydroxy vitamin d3
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
WO2003018545A1 (en) * 2001-08-22 2003-03-06 Johns Hopkins University 24-sulfur-substituted analogs of 1α,25-dihydroxy vitamin d¿3?
US7101865B2 (en) 2002-06-13 2006-09-05 Cytochroma Inc. 24-sulfoximine vitamin D3 compounds
CA2510228C (en) 2002-12-18 2012-10-30 Johns Hopkins University 25-so2-substituted analogs of 1.alpha.,25-dihydroxyvitamin d3
US7232810B2 (en) * 2003-08-20 2007-06-19 Wisconsin Alumni Research Foundation 2-methylene-19-nor-vitamin D2 compounds
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
JP6608810B2 (ja) 2013-05-29 2019-11-20 バーグ エルエルシー ビタミンｄを使用する化学療法誘発性脱毛症の予防又は軽減

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
NL193245C (nl) * 1983-05-09 1999-04-02 Wisconsin Alumni Res Found Aan 1Ó,25-dihydroxyvitamine D2 verwante verbinding en farmaceutisch preparaat met een het calciummetabolisme regulerende werking dat een dergelijke verbinding bevat.
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity

Also Published As

Publication number Publication date
AU631618B2 (en) 1992-12-03
ES2055193T3 (es) 1994-08-16
IL93456A (en) 1994-02-27
JPH03504508A (ja) 1991-10-03
WO1990010619A1 (en) 1990-09-20
AU5192590A (en) 1990-10-09
KR950005776B1 (ko) 1995-05-30
KR920700201A (ko) 1992-02-19
DK0386793T3 (da) 1993-08-02
JPH0737443B2 (ja) 1995-04-26
EP0386793B1 (de) 1993-06-09
RU2065851C1 (ru) 1996-08-27
US4973584A (en) 1990-11-27
EP0386793A1 (de) 1990-09-12
ATE90342T1 (de) 1993-06-15
NZ232735A (en) 1992-07-28
DE69001839T2 (de) 1993-09-16
HU207040B (en) 1993-03-01
CA1335105C (en) 1995-04-04
HU902288D0 (en) 1991-07-29
IL93456A0 (en) 1990-11-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee