DE60327936D1 - Modulatoren von ship-1 - Google Patents

Modulatoren von ship-1

Info

Publication number
DE60327936D1
DE60327936D1 DE60327936T DE60327936T DE60327936D1 DE 60327936 D1 DE60327936 D1 DE 60327936D1 DE 60327936 T DE60327936 T DE 60327936T DE 60327936 T DE60327936 T DE 60327936T DE 60327936 D1 DE60327936 D1 DE 60327936D1
Authority
DE
Germany
Prior art keywords
ship
modulators
activity
pelorol
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327936T
Other languages
English (en)
Inventor
Raymond Andersen
David E Williams
Alice Mui
Christopher Ong
Gerald Krystal
Lu San Diego Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2002/001550 external-priority patent/WO2003033517A1/en
Application filed by University of British Columbia filed Critical University of British Columbia
Application granted granted Critical
Publication of DE60327936D1 publication Critical patent/DE60327936D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Amplitude Modulation (AREA)
DE60327936T 2002-10-17 2003-04-23 Modulatoren von ship-1 Expired - Lifetime DE60327936D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CA2002/001550 WO2003033517A1 (en) 2001-10-17 2002-10-17 Ship 1 modulators
PCT/CA2003/000571 WO2004035601A1 (en) 2002-10-17 2003-04-23 Ship 1 modulators

Publications (1)

Publication Number Publication Date
DE60327936D1 true DE60327936D1 (de) 2009-07-23

Family

ID=32097361

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327936T Expired - Lifetime DE60327936D1 (de) 2002-10-17 2003-04-23 Modulatoren von ship-1

Country Status (7)

Country Link
EP (1) EP1554304B1 (de)
JP (1) JP4753581B2 (de)
AT (1) ATE433458T1 (de)
CA (1) CA2502293C (de)
DE (1) DE60327936D1 (de)
ES (1) ES2327829T3 (de)
WO (1) WO2004035601A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009541224A (ja) * 2006-06-21 2009-11-26 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア Ｓｈｉｐ１モジュレーター化合物
US8101605B2 (en) 2009-12-04 2012-01-24 Aquinox Pharmaceuticals Inc. SHIP1 modulators and methods related thereto
US8697644B2 (en) 2011-03-10 2014-04-15 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of peptide drugs
US9125805B2 (en) * 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
WO2014110036A1 (en) * 2013-01-09 2014-07-17 Aquinox Pharmaceuticals Inc. Ship1 modulators and methods related thereto
JP6407951B2 (ja) 2013-03-14 2018-10-17 アクイノックス ファーマシューティカルズ （カナダ） インコーポレイテッド Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法
EP2970100A1 (de) 2013-03-14 2016-01-20 Aquinox Pharmaceuticals (Canada) Inc. Ship1-modulatoren und zugehörige verfahren
CA2957399C (en) 2014-08-06 2023-09-26 Xeris Pharmaceuticals, Inc. Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
JP2018518494A (ja) 2015-06-26 2018-07-12 アクイノックス ファーマシューティカルズ （カナダ） インコーポレイテッド （１Ｓ，３Ｓ，４Ｒ）−４−（（３ａＳ，４Ｒ，５Ｓ，７ａＳ）−４−（アミノメチル）−７ａ−メチル−１−メチレンオクタヒドロ−１Ｈ−インデン−５−イル）−３−（ヒドロキシメチル）−４−メチルシクロヘキサノールの酢酸塩の結晶固体形態
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2018126040A1 (en) 2016-12-28 2018-07-05 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol
BR112019024987A2 (pt) 2017-06-02 2020-06-16 Xeris Pharmaceuticals, Inc. Formulações de fármaco de molécula pequena resistente à precipitação
CN115955970A (zh) * 2020-04-20 2023-04-11 斑马药研公司 使用Pelorol衍生物治疗SHIP1介导的疾病的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033517A1 (en) * 2001-10-17 2003-04-24 The University Of British Columbia Ship 1 modulators

Also Published As

Publication number Publication date
CA2502293A1 (en) 2004-04-29
EP1554304B1 (de) 2009-06-10
JP2006506363A (ja) 2006-02-23
ATE433458T1 (de) 2009-06-15
JP4753581B2 (ja) 2011-08-24
EP1554304A1 (de) 2005-07-20
CA2502293C (en) 2011-09-06
ES2327829T3 (es) 2009-11-04
WO2004035601A1 (en) 2004-04-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition