DE60220422D1 - Substituierte pyrazoloverbindungen zur behandlung von entzündungen - Google Patents
Substituierte pyrazoloverbindungen zur behandlung von entzündungenInfo
- Publication number
- DE60220422D1 DE60220422D1 DE60220422T DE60220422T DE60220422D1 DE 60220422 D1 DE60220422 D1 DE 60220422D1 DE 60220422 T DE60220422 T DE 60220422T DE 60220422 T DE60220422 T DE 60220422T DE 60220422 D1 DE60220422 D1 DE 60220422D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- sup
- compounds
- inflammation
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 206010061218 Inflammation Diseases 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32329701P | 2001-09-19 | 2001-09-19 | |
| US323297P | 2001-09-19 | ||
| US38322602P | 2002-05-24 | 2002-05-24 | |
| US383226P | 2002-05-24 | ||
| PCT/US2002/029625 WO2003024936A1 (en) | 2001-09-19 | 2002-09-19 | Substituted pyrazolo compounds for the treatment of inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60220422D1 true DE60220422D1 (de) | 2007-07-12 |
| DE60220422T2 DE60220422T2 (de) | 2008-02-07 |
Family
ID=26983875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60220422T Expired - Fee Related DE60220422T2 (de) | 2001-09-19 | 2002-09-19 | Substituierte pyrazol-verbindungen zur behandlung von entzündungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7211597B2 (de) |
| EP (1) | EP1427706B1 (de) |
| JP (1) | JP2005510466A (de) |
| AT (1) | ATE363473T1 (de) |
| BR (1) | BR0212617A (de) |
| CA (1) | CA2460939C (de) |
| DE (1) | DE60220422T2 (de) |
| ES (1) | ES2286275T3 (de) |
| MX (1) | MXPA04002682A (de) |
| WO (1) | WO2003024936A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10229762A1 (de) | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase |
| WO2004041285A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
| AU2004230952A1 (en) | 2003-04-09 | 2004-10-28 | Millenium Pharmaceuticals, Inc. | Beta-carbolines useful for treating inflammatory disease |
| AU2003304380A1 (en) * | 2003-07-03 | 2005-02-15 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivatives as kinase inhibitors |
| US7132428B2 (en) | 2003-07-03 | 2006-11-07 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders |
| EP1694686A1 (de) * | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinaseinhibitoren |
| CA2561859A1 (en) | 2004-04-09 | 2005-11-24 | Millennium Pharmaceuticals, Inc. | Beta-carbolines useful for treating inflammatory disease |
| JP2007533753A (ja) * | 2004-04-23 | 2007-11-22 | タケダ サン ディエゴ インコーポレイテッド | インドール誘導体及びキナーゼ阻害剤としてのその使用 |
| AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
| WO2006023931A2 (en) * | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| EP1781667B1 (de) * | 2004-08-18 | 2010-11-03 | 4Sc Ag | Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin |
| TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
| EP1812439B2 (de) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinaseinhibitoren |
| JP2008528552A (ja) * | 2005-01-27 | 2008-07-31 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のインドロピリジン、ベンゾフラノピリジン及びベンゾチエノピリジン |
| EP1856117A1 (de) * | 2005-01-28 | 2007-11-21 | Nycomed GmbH | Indolopyridine, benzofuranopyridine und benzothienopyridine |
| TW200738638A (en) * | 2005-06-23 | 2007-10-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
| CN101203495B (zh) * | 2005-06-23 | 2013-07-17 | 默沙东公司 | 作为受体酪氨酸激酶met抑制剂的苯并环庚三烯并吡啶化合物 |
| ATE524445T1 (de) * | 2005-06-23 | 2011-09-15 | Merck Sharp & Dohme | Benzocycloheptapyridine als inhibitoren der tyrosinkinase met |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| WO2007005534A2 (en) | 2005-06-30 | 2007-01-11 | Smithkline Beecham Corporation | Chemical compounds |
| US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| WO2007050383A2 (en) * | 2005-10-21 | 2007-05-03 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US7790739B2 (en) * | 2005-10-21 | 2010-09-07 | Merck & Co., Inc. and Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| KR101415354B1 (ko) * | 2006-02-22 | 2014-07-04 | 4에스체 악티엔게젤샤프트 | Ｅｇ5 키네신 조절제로서의 인돌로피리딘 |
| JP2009527534A (ja) * | 2006-02-22 | 2009-07-30 | ４エスツェー アクチェンゲゼルシャフト | Ｅｇ５キネシン・モジュレータとしてのインドロピリジン |
| UY30377A1 (es) | 2006-06-02 | 2008-01-02 | Elan Pharm Inc | Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa |
| TW200813021A (en) * | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
| EP2041141A2 (de) * | 2006-07-13 | 2009-04-01 | 4Sc Ag | Benzopyranopyrazole |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| EP2223925A1 (de) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase-Inhibitoren |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| EP2278999A4 (de) | 2008-04-21 | 2015-04-22 | Otonomy Inc | Ohrbehandlungsformulierungen zur behandlung von ohrenerkrankungen und -leiden |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
| JP2012506848A (ja) * | 2008-10-27 | 2012-03-22 | グラクソ グループ リミテッド | グルタミン酸受容体モジュレーターとしての三環式化合物 |
| JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ｉｋｋ２阻害剤としてのインドール誘導体 |
| EP2904119B1 (de) | 2012-10-02 | 2020-06-17 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Verfahren für mit dem dna-erfassungspfad assoziierten leiden |
| RU2663898C2 (ru) | 2013-06-24 | 2018-08-13 | Мерк Патент Гмбх | Пиразольные соединения в качестве модуляторов fshr и их применение |
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| KR20190024983A (ko) | 2016-06-29 | 2019-03-08 | 오토노미, 인코포레이티드 | 트리글리세라이드 귀 제제 및 이의 용도 |
| US11345710B2 (en) * | 2017-07-10 | 2022-05-31 | Impact Therapeutics (Shanghai), Inc | Imidazo[1,2-b]pyrimido[4,5-d]pyridazin-5(6H)-ones and the use thereof |
| WO2024044778A2 (en) * | 2022-08-26 | 2024-02-29 | Celmatix Inc. | Novel modulators of fshr and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940418A (en) * | 1972-04-07 | 1976-02-24 | G. D. Searle & Co. | Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds |
| US4678499A (en) * | 1985-03-11 | 1987-07-07 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
| JPS63166588A (ja) * | 1986-12-27 | 1988-07-09 | Kanzaki Paper Mfg Co Ltd | クロメノ化合物およびクロメノ化合物を用いた感熱記録体 |
| US4816467A (en) * | 1987-01-09 | 1989-03-28 | Farmitalia Carlo Erba S.R.L | Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use |
| GB8814587D0 (en) | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation |
| GB2227741B (en) | 1989-02-06 | 1992-08-05 | Erba Carlo Spa | Condensed 3-oxo-propanenitrile derivatives and process for their preparation |
| GB8907799D0 (en) * | 1989-04-06 | 1989-05-17 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases |
| US5260328A (en) * | 1989-04-06 | 1993-11-09 | Farmitalia Carlo Erba Srl | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis |
| GB8916290D0 (en) * | 1989-07-17 | 1989-08-31 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5547975A (en) * | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5696143A (en) | 1994-09-20 | 1997-12-09 | Talley; John J. | Benz G! indazolyl derivatives for the treatment of inflammation |
| US5886016A (en) * | 1995-09-15 | 1999-03-23 | G.D. Searle & Co. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| US5756529A (en) | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| ES2194195T3 (es) | 1996-04-12 | 2003-11-16 | Searle & Co | N-((4-(5-metil-3-fenililxazol-4-il)fenil)sulfonilpropanamida y su sal sodica como profarmacos de inhibnidores de cox-2. |
| EP1073435B1 (de) | 1998-04-30 | 2004-07-07 | Abbott GmbH & Co. KG | Substituierte trizyklische pyrazolderivate mit protein kinase aktivität |
| EP1142889A1 (de) | 2000-04-03 | 2001-10-10 | Pfizer Products Inc. | Pyrazolderivate als entzündungs-/schmerzhemmende Mittel |
-
2002
- 2002-09-19 US US10/247,028 patent/US7211597B2/en not_active Expired - Fee Related
- 2002-09-19 JP JP2003528784A patent/JP2005510466A/ja active Pending
- 2002-09-19 CA CA002460939A patent/CA2460939C/en not_active Expired - Fee Related
- 2002-09-19 AT AT02763656T patent/ATE363473T1/de not_active IP Right Cessation
- 2002-09-19 ES ES02763656T patent/ES2286275T3/es not_active Expired - Lifetime
- 2002-09-19 EP EP02763656A patent/EP1427706B1/de not_active Expired - Lifetime
- 2002-09-19 BR BR0212617-6A patent/BR0212617A/pt not_active IP Right Cessation
- 2002-09-19 DE DE60220422T patent/DE60220422T2/de not_active Expired - Fee Related
- 2002-09-19 MX MXPA04002682A patent/MXPA04002682A/es active IP Right Grant
- 2002-09-19 WO PCT/US2002/029625 patent/WO2003024936A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2460939C (en) | 2008-07-29 |
| EP1427706B1 (de) | 2007-05-30 |
| WO2003024936A1 (en) | 2003-03-27 |
| ES2286275T3 (es) | 2007-12-01 |
| US20030114432A1 (en) | 2003-06-19 |
| DE60220422T2 (de) | 2008-02-07 |
| US7211597B2 (en) | 2007-05-01 |
| ATE363473T1 (de) | 2007-06-15 |
| BR0212617A (pt) | 2005-02-09 |
| JP2005510466A (ja) | 2005-04-21 |
| CA2460939A1 (en) | 2003-03-27 |
| MXPA04002682A (es) | 2004-06-18 |
| EP1427706A1 (de) | 2004-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |