DE60143363D1 - Pharmazeutische zusammensetzungen, die die immunogenität von schwach immunogenen antigenen fördern - Google Patents

Pharmazeutische zusammensetzungen, die die immunogenität von schwach immunogenen antigenen fördern

Info

Publication number
DE60143363D1
DE60143363D1 DE60143363T DE60143363T DE60143363D1 DE 60143363 D1 DE60143363 D1 DE 60143363D1 DE 60143363 T DE60143363 T DE 60143363T DE 60143363 T DE60143363 T DE 60143363T DE 60143363 D1 DE60143363 D1 DE 60143363D1
Authority
DE
Germany
Prior art keywords
antigenes
immunogenicity
promote
pharmaceutical compositions
weak immunogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60143363T
Other languages
English (en)
Inventor
Molina Luis Enrique Fernandez
Ramirez Belinda Sanchez
Pestana Eduardo Raul Suarez
La Barrera Aira Anabel De
Pardillo Circe Mesa
Leon Delgado Joel De
Rodriguez Yildian Diaz
Rodriguez Rolando Perez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro de Immunologia Molecular
Original Assignee
Centro de Immunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CU20000285A external-priority patent/CU23000A1/es
Priority claimed from CU20010167A external-priority patent/CU23009A1/es
Application filed by Centro de Immunologia Molecular filed Critical Centro de Immunologia Molecular
Application granted granted Critical
Publication of DE60143363D1 publication Critical patent/DE60143363D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DE60143363T 2000-12-06 2001-12-06 Pharmazeutische zusammensetzungen, die die immunogenität von schwach immunogenen antigenen fördern Expired - Lifetime DE60143363D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CU20000285A CU23000A1 (es) 2000-12-06 2000-12-06 Composiciones vacunales para la inmunoterapia activa específica del cáncer
CU20010167A CU23009A1 (es) 2001-07-12 2001-07-12 Preparaciones para potenciar la inmunogenicidad depreparaciones para potenciar la inmunogenicidad de antígenos poco inmunogénicos antígenos poco inmunogénicos
PCT/CU2001/000010 WO2002045746A2 (es) 2000-12-06 2001-12-06 Composiciones farmaceuticas para potenciar la inmunogenicidad de antigenos poco inmunogenicos

Publications (1)

Publication Number Publication Date
DE60143363D1 true DE60143363D1 (de) 2010-12-09

Family

ID=38812545

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60143363T Expired - Lifetime DE60143363D1 (de) 2000-12-06 2001-12-06 Pharmazeutische zusammensetzungen, die die immunogenität von schwach immunogenen antigenen fördern

Country Status (20)

Country Link
US (1) US7776342B2 (de)
EP (1) EP1356822B1 (de)
JP (1) JP4210519B2 (de)
KR (1) KR100850473B1 (de)
CN (1) CN1291755C (de)
AR (1) AR031638A1 (de)
AT (1) ATE485833T1 (de)
AU (2) AU2002221519B2 (de)
BR (1) BRPI0116013B8 (de)
CA (1) CA2431188C (de)
DE (1) DE60143363D1 (de)
DK (1) DK1356822T3 (de)
EA (1) EA005138B1 (de)
HK (1) HK1063726A1 (de)
MX (1) MXPA03005032A (de)
NZ (1) NZ526282A (de)
PE (1) PE20020572A1 (de)
UY (1) UY27059A1 (de)
WO (1) WO2002045746A2 (de)
ZA (1) ZA200304411B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1367395A1 (de) * 2002-05-02 2003-12-03 B.R.A.H.M.S Aktiengesellschaft Diagnose von Neoplasmen mit Hilfe von anti-Gangliosid-Antikörpern
EP1358910A1 (de) * 2002-05-02 2003-11-05 B.R.A.H.M.S Aktiengesellschaft Verfahren und Mittel zur Prävention, Hemmung und Therapie von Krebserkrankungen
CU23257A1 (es) * 2003-02-27 2008-01-24 Centro Inmunologia Molecular COMPOSICIONES VACUNALES A BASE DE GANGLIOSIDOS PARA LA ADMINISTRACION SUBCUTáNEA
AR045815A1 (es) * 2003-10-09 2005-11-16 Ct Ingenieria Genetica Biotech Composiciones farmaceuticas que contienen antigenos del virus de papiloma humano
US8147840B2 (en) * 2004-05-14 2012-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human immunodeficiency virus (HIV) immunization strategies employing conformationally-stabilized, surface-occluded peptides comprising a gp41 2F5 epitope in association with lipid
WO2010003219A1 (en) * 2008-06-17 2010-01-14 Universite Laval Compositions comprising salmonella porins and uses thereof as adjuvants and vaccines
HUE043473T4 (hu) * 2010-12-22 2019-12-30 Bayer Ip Gmbh Fokozott immunválasz szarvasmarha fajokban
KR101323845B1 (ko) * 2011-01-21 2013-10-31 광주과학기술원 외막소포체를 유효성분으로 포함하는 항암용 약제학적 조성물
CU24070B1 (es) * 2011-12-27 2015-01-29 Ct De Inmunología Molecular Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3)
CN105209481B (zh) * 2013-03-15 2020-08-25 因斯瑞拜奥有限公司 自组装合成蛋白
CU24299B1 (es) * 2013-08-02 2017-12-08 Centro De Inmunología Molecular Composiciones vacunales bivalentes basadas en los receptores de tipo 1 y 2 del factor de crecimiento epidérmico
US10105306B2 (en) * 2013-09-17 2018-10-23 Bestop Group Holdings Limited Method of preparing a growth factor concentrate
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
CA2941416C (en) * 2014-03-11 2022-10-18 Universite D'aix-Marseille A chimeric peptide that interacts with cell membrane gangliosides
EP3597214A1 (de) 2017-03-15 2020-01-22 Centro de Inmunologia Molecular Verfahren zur behandlung von patienten mit karzinomen
US12019073B2 (en) * 2017-03-15 2024-06-25 Centro De Inmunologia Molecular Method for the treatment of patients with carcinomas
US11890335B2 (en) * 2017-09-27 2024-02-06 L2 Diagnostics, Llc ErbB peptide pharmaceutical and vaccine compositions and therapeutic uses thereof for cancer
CU24534B1 (es) * 2017-11-06 2021-07-02 Ct Inmunologia Molecular Adyuvantes nano-particulados que contienen variantes sintéticas del gangliósido gm3
CU20170173A7 (es) * 2017-12-27 2019-11-04 Ct Inmunologia Molecular Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras
CN109865137A (zh) * 2019-01-23 2019-06-11 天德悦（北京）生物科技有限责任公司 经碘代乙酰基活化的琼脂糖微球在提高多肽或蛋白类免疫原免疫原性中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857637A (en) * 1986-05-07 1989-08-15 Genentech, Inc. Methods and compositions for immunologically modulating growth hormone receptor activity
IT1206250B (it) * 1987-02-18 1989-04-14 Ist Farmacoterapico It Spa Stiche umane e relativi prodotti metodo per l'estrazione di antigeni di membrana aventi proprieta' immunogene a partire da cellule neopla-
US5726292A (en) * 1987-06-23 1998-03-10 Lowell; George H. Immuno-potentiating systems for preparation of immunogenic materials
JPH07504683A (ja) 1992-07-08 1995-05-25 シェリング・コーポレーション Ｇｍ−ｃｓｆのワクチンアジュバントとしての利用
DE69428763T2 (de) * 1993-12-09 2002-08-01 Centro De Inmunologia Molecular, Ciudad De La Habana Monoklonale Antikörper gegen Ganglioside und deren Verwendung in der spezifischen, aktiven Immuntherapie gegen bösartige Tumoren
CU22420A1 (es) * 1993-12-29 1996-01-31 Centro Inmunologia Molecular Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer
US6149921A (en) * 1993-12-29 2000-11-21 Centro De Inmunologia Molecular Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
JP2002509114A (ja) * 1998-01-16 2002-03-26 バイオミラ・ユーエスエイ・インコーポレイテッド 膜プロテオリポソームから作製される患者特異的白血球悪性腫瘍ワクチン

Also Published As

Publication number Publication date
BRPI0116013B1 (pt) 2018-07-24
WO2002045746A3 (es) 2002-12-27
PE20020572A1 (es) 2002-07-31
EA005138B1 (ru) 2004-12-30
KR20030061838A (ko) 2003-07-22
BRPI0116013B8 (pt) 2021-05-25
CN1484532A (zh) 2004-03-24
CN1291755C (zh) 2006-12-27
CA2431188A1 (en) 2002-06-13
BR0116013A (pt) 2004-01-06
EP1356822A2 (de) 2003-10-29
NZ526282A (en) 2005-01-28
DK1356822T3 (da) 2011-02-07
WO2002045746A2 (es) 2002-06-13
AR031638A1 (es) 2003-09-24
HK1063726A1 (en) 2005-01-14
US7776342B2 (en) 2010-08-17
UY27059A1 (es) 2002-04-26
EP1356822B1 (de) 2010-10-27
KR100850473B1 (ko) 2008-08-07
JP4210519B2 (ja) 2009-01-21
CA2431188C (en) 2010-09-07
ATE485833T1 (de) 2010-11-15
MXPA03005032A (es) 2004-09-10
AU2002221519B2 (en) 2006-11-23
AU2151902A (en) 2002-06-18
JP2004523494A (ja) 2004-08-05
US20020136735A1 (en) 2002-09-26
EA200300640A1 (ru) 2003-12-25
ZA200304411B (en) 2004-07-29

Similar Documents

Publication Publication Date Title
DE60143363D1 (de) Pharmazeutische zusammensetzungen, die die immunogenität von schwach immunogenen antigenen fördern
ITTO20010005A0 (it) Formulazione farmaceutica.
BR0115810B1 (pt) composições cosméticas, dermatológicas e farmacêuticas isentas de tensoativos.
ITTO20000779A0 (it) Composizioni farmaceutiche.
IT1318649B1 (it) Composizioni farmaceutiche per il trattamento di mucositi e stomatiti.
ATE468324T1 (de) Pharmazeutische zusammensetzung
NO20030713D0 (no) Oral faststoffdose vaksine
NO20033556L (no) Farmasöytiske formuleringer
NO20026175L (no) Vaksinesammensetning
NO20030627D0 (no) Hydrogel-drevet medikament doseringsform
ITMI20010748A0 (it) Composizioni farmaceutiche
ITFI20000154A0 (it) Convogliatore radioelettrico asimmetrico terapeutico.
ATE320244T1 (de) Pharmazeutische zusammensetzungen mit amlodipinmaleat
EE05020B1 (et) Glburiidi ravimkoostis
AU2002221519A1 (en) Pharmaceutical compositions enhancing the immunogenicity of poorly immunogenic antigens
NO20026123L (no) Farmasöytiske sammensetninger
DE60217390D1 (de) Bicalutamid enthaltende pharmazeutische zusammensetzung
ATE366128T1 (de) Pharmazeutische zusammensetzung
FR2831442B1 (fr) Composition cosmetique mimant le sebum, et utilisations
ITMI20001695A0 (it) Procedimento per la preparazione di composizioni organico-sili-coniche.
DE10291905D2 (de) Pharmazeutische Zusammensetzung
NO20032957L (no) Farmasöytisk emulsjonspreparat
MXPA03001857A (es) Composicones medicinales.
DE10107261B4 (de) Pharmazeutische Zusammensetzung
IT1317818B1 (it) Procedimento per la produzione di componenti per integratorialimentari, formulazioni dietetiche, cosmetiche e farmaceutiche,