DE60003949D1 - 5-aryl-1h-1,2,4 triazolverbindungen als cyclooxygenase -2 inhibitoren und dieseenthaltende pharmazeutische zusammensetzungen - Google Patents

5-aryl-1h-1,2,4 triazolverbindungen als cyclooxygenase -2 inhibitoren und dieseenthaltende pharmazeutische zusammensetzungen

Info

Publication number
DE60003949D1
DE60003949D1 DE60003949T DE60003949T DE60003949D1 DE 60003949 D1 DE60003949 D1 DE 60003949D1 DE 60003949 T DE60003949 T DE 60003949T DE 60003949 T DE60003949 T DE 60003949T DE 60003949 D1 DE60003949 D1 DE 60003949D1
Authority
DE
Germany
Prior art keywords
inhibitors
aryl
pharmaceutical compositions
cyclooxygenase
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60003949T
Other languages
English (en)
Other versions
DE60003949T2 (de
Inventor
Jean-Claude Pascal
Denis Carniato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Theramex SAM
Original Assignee
Laboratoire Theramex SAM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex SAM filed Critical Laboratoire Theramex SAM
Publication of DE60003949D1 publication Critical patent/DE60003949D1/de
Application granted granted Critical
Publication of DE60003949T2 publication Critical patent/DE60003949T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60003949T 1999-11-09 2000-11-06 5-aryl-1h-1,2,4 triazolverbindungen als cyclooxygenase -2 inhibitoren und dieseenthaltende pharmazeutische zusammensetzungen Expired - Lifetime DE60003949T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99402784 1999-11-09
EP99402784A EP1099695A1 (de) 1999-11-09 1999-11-09 5-Aryl-1H-1,2,4-triazolverbindungen als Cyclooxygenase-2 Inhibitoren und diese enthaltende pharmazeutische Zusammensetzungen
PCT/EP2000/010956 WO2001034577A1 (en) 1999-11-09 2000-11-06 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
DE60003949D1 true DE60003949D1 (de) 2003-08-21
DE60003949T2 DE60003949T2 (de) 2004-05-27

Family

ID=8242172

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60003949T Expired - Lifetime DE60003949T2 (de) 1999-11-09 2000-11-06 5-aryl-1h-1,2,4 triazolverbindungen als cyclooxygenase -2 inhibitoren und dieseenthaltende pharmazeutische zusammensetzungen

Country Status (24)

Country Link
US (1) US6803380B1 (de)
EP (2) EP1099695A1 (de)
JP (1) JP4786846B2 (de)
CN (1) CN1198807C (de)
AT (1) ATE245148T1 (de)
AU (1) AU778819B2 (de)
BR (1) BR0015440A (de)
CA (1) CA2390649C (de)
CZ (1) CZ20021591A3 (de)
DE (1) DE60003949T2 (de)
DK (1) DK1246809T3 (de)
ES (1) ES2203538T3 (de)
HU (1) HUP0203376A3 (de)
IL (2) IL149370A0 (de)
MX (1) MXPA01012903A (de)
NO (1) NO328008B1 (de)
NZ (1) NZ518682A (de)
PL (1) PL204230B1 (de)
PT (1) PT1246809E (de)
RU (1) RU2249588C2 (de)
SI (1) SI1246809T1 (de)
TW (1) TWI268925B (de)
WO (1) WO2001034577A1 (de)
ZA (1) ZA200203165B (de)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
DE60204823T2 (de) 2001-07-05 2005-12-29 Pfizer Products Inc., Groton Heterocyclo-alkylsulfonyl Pyrazole als entzündungshemmende/analgetische Mittel
ES2240661T3 (es) 2001-07-05 2005-10-16 Pfizer Products Inc. Sulfonil-heteroaril-triazoles como agentes antiinflamatorios y analgesicos.
CA2390181A1 (en) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
KR100824233B1 (ko) * 2001-10-10 2008-04-24 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
AUPR878201A0 (en) 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds
KR100686537B1 (ko) * 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004060367A1 (en) * 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
US9113536B2 (en) 2005-04-28 2015-08-18 Basf Se Electroluminescent device
CA2660261A1 (en) * 2006-08-09 2008-02-14 Pfizer Products Inc. Heterocycles useful as inhibitors of carbonic anhydrase
CN103347886A (zh) * 2010-11-26 2013-10-09 株式会社半导体能源研究所 有机金属配合物、发光元件、发光装置、电子设备以及照明装置
WO2012170839A2 (en) * 2011-06-09 2012-12-13 Cardeus Pharmaceuticals, Inc. Treatment of neuroinflammatory disease with selective cox1 inhibitors
US8853248B2 (en) * 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
CN104693133A (zh) * 2015-02-16 2015-06-10 广州市盈宇医药科技有限公司 一种环氧化酶-2选择性抑制剂及其制备方法和应用
KR20200129128A (ko) 2018-03-08 2020-11-17 바이엘 악티엔게젤샤프트 식물 보호에서 살충제로서의 헤테로아릴-트리아졸 및 헤테로아릴-테트라졸 화합물의 용도
ES2965494T3 (es) 2018-04-12 2024-04-15 Bayer Ag Derivados de N-(ciclopropilmetil)-5-(metilsulfonil)-n-{1-[1-(pirimidin-2-il)-1H-1,2,4-triazol-5-il]etil}benzamida y los correspondientes derivados de piridina-carboxamida como plaguicidas
EP3784661B1 (de) 2018-04-25 2023-11-22 Bayer Aktiengesellschaft Neuartige heteroaryl-triazol- und heteroaryl-tetrazol-verbindungen als pestizide
MX2022000951A (es) 2019-07-23 2022-02-14 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas.
WO2021013719A1 (en) 2019-07-23 2021-01-28 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
JP2022551309A (ja) 2019-10-09 2022-12-08 バイエル・アクチエンゲゼルシヤフト 殺有害生物剤としての新規ヘテロアリール－トリアゾール化合物
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
KR20220143072A (ko) 2020-02-18 2022-10-24 바이엘 악티엔게젤샤프트 살충제로서의 헤테로아릴-트리아졸 화합물
TWI754474B (zh) * 2020-11-30 2022-02-01 翁豐富 具選擇性第二型環氧合酶抑制活性之1,2,4-三氮唑衍生物及其用途
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW226993B (de) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
JPH0776577A (ja) * 1993-07-14 1995-03-20 Kumiai Chem Ind Co Ltd ジフェニルトリアゾール誘導体及び殺虫、殺ダニ剤
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

Also Published As

Publication number Publication date
AU1998501A (en) 2001-06-06
NO20022202D0 (no) 2002-05-08
NO328008B1 (no) 2009-11-09
CZ20021591A3 (cs) 2002-07-17
EP1099695A1 (de) 2001-05-16
BR0015440A (pt) 2002-07-02
WO2001034577A1 (en) 2001-05-17
EP1246809B1 (de) 2003-07-16
CN1198807C (zh) 2005-04-27
IL149370A (en) 2007-06-17
EP1246809A1 (de) 2002-10-09
NO20022202L (no) 2002-05-08
SI1246809T1 (en) 2004-02-29
CA2390649C (en) 2008-05-06
NZ518682A (en) 2003-07-25
CA2390649A1 (en) 2001-05-17
HUP0203376A2 (hu) 2003-01-28
TWI268925B (en) 2006-12-21
ATE245148T1 (de) 2003-08-15
PT1246809E (pt) 2003-11-28
JP4786846B2 (ja) 2011-10-05
RU2249588C2 (ru) 2005-04-10
US6803380B1 (en) 2004-10-12
DK1246809T3 (da) 2003-10-20
JP2003513961A (ja) 2003-04-15
ZA200203165B (en) 2003-06-25
CN1387517A (zh) 2002-12-25
PL356120A1 (en) 2004-06-14
DE60003949T2 (de) 2004-05-27
HUP0203376A3 (en) 2004-12-28
AU778819B2 (en) 2004-12-23
ES2203538T3 (es) 2004-04-16
PL204230B1 (pl) 2009-12-31
IL149370A0 (en) 2002-11-10
MXPA01012903A (es) 2002-11-07

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