DE50107204D1 - 8beta-substituierte-11beta-pentyl-und 11beta-hexyl-estra-1,3,5(10)-trienderivate - Google Patents

8beta-substituierte-11beta-pentyl-und 11beta-hexyl-estra-1,3,5(10)-trienderivate

Info

Publication number: DE50107204D1
Authority: DE; Germany
Prior art keywords: 11beta; trienderivate; 8beta; estra; pentyl
Prior art date: 2000-04-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE50107204T

Other languages

English (en)

Inventor

Olaf Peters

Nico Braeuer

Alexander Hillisch

Christa Hegele-Hartung

Karl-Heinrich Fritzemeier

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-12

Filing date

2001-04-12

Publication date

2005-09-29

2001-04-12 Application filed by Schering AG filed Critical Schering AG

2001-04-12 Priority to DE50107204T priority Critical patent/DE50107204D1/de

2001-04-12 Priority claimed from PCT/EP2001/004289 external-priority patent/WO2001077138A1/de

2005-09-29 Application granted granted Critical

2005-09-29 Publication of DE50107204D1 publication Critical patent/DE50107204D1/de

2021-04-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/18—Feminine contraceptives
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pregnancy & Childbirth (AREA)
Toxicology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE50107204T 2000-04-12 2001-04-12 8beta-substituierte-11beta-pentyl-und 11beta-hexyl-estra-1,3,5(10)-trienderivate Expired - Fee Related DE50107204D1 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE50107204T DE50107204D1 (de)	2000-04-12	2001-04-12	8beta-substituierte-11beta-pentyl-und 11beta-hexyl-estra-1,3,5(10)-trienderivate

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE10019167A DE10019167A1 (de)	2000-04-12	2000-04-12	Substituierte Estratriene als selektiv wirksame Estrogene
US20737000P	2000-05-26	2000-05-26
DE50107204T DE50107204D1 (de)	2000-04-12	2001-04-12	8beta-substituierte-11beta-pentyl-und 11beta-hexyl-estra-1,3,5(10)-trienderivate
PCT/EP2001/004289 WO2001077138A1 (de)	2000-04-12	2001-04-12	8β-SUBSTITUIERTE-11β-PENTYL-UND 11β-HEXYL-ESTRA-1,3,5(10)-TRIENDERIVATE

Publications (1)

Publication Number	Publication Date
DE50107204D1 true DE50107204D1 (de)	2005-09-29

Family

ID=7639163

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE10019167A Withdrawn DE10019167A1 (de)	2000-04-12	2000-04-12	Substituierte Estratriene als selektiv wirksame Estrogene
DE50107204T Expired - Fee Related DE50107204D1 (de)	2000-04-12	2001-04-12	8beta-substituierte-11beta-pentyl-und 11beta-hexyl-estra-1,3,5(10)-trienderivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE10019167A Withdrawn DE10019167A1 (de)	2000-04-12	2000-04-12	Substituierte Estratriene als selektiv wirksame Estrogene

Country Status (11)

Country	Link
JP (1)	JP4860880B2 (de)
KR (1)	KR100825534B1 (de)
AR (1)	AR028329A1 (de)
DE (2)	DE10019167A1 (de)
PE (1)	PE20011215A1 (de)
SI (1)	SI1272504T1 (de)
TW (1)	TWI288138B (de)
UA (1)	UA79073C2 (de)
UY (1)	UY26665A1 (de)
YU (1)	YU77302A (de)
ZA (1)	ZA200209149B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ543724A (en) *	2000-04-12	2007-07-27	Schering Ag	8beta-hydrocarbyl-substituted estratrienes as selectively active estrogens
DE10151114A1 (de) *	2001-10-15	2003-04-17	Schering Ag	8ß-Substituierte-11ß-aryl-estra-2,3,5(10)-trienderivate
WO2005051401A2 (en) *	2003-11-26	2005-06-09	Schering Aktiengesellschaft	Prevention and treatment of hypertensive heart diseases by the selective estrogens 8beta-vinyl-estra-1,3,5(10)-trien-3,17beta-diol and 17beta-fluor-9alpha-vinyl-estra-1,3,5(10)-trien-3,16alpha-diol
EP2094651A1 (de) *	2006-11-17	2009-09-02	Trustees Of Dartmouth College	Synthese und biologische wirkungen neuer tricyclischer bis-enone (tbes)
EP2014672A1 (de) *	2007-07-12	2009-01-14	Bayer Schering Pharma Aktiengesellschaft	8-Beta-substituierte Estratriene als selektiv aktive Östrogene
EP2358351A1 (de) *	2008-11-21	2011-08-24	Bayer Pharma Aktiengesellschaft	Arzneimittelabgabesystem

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3681407A (en)	1969-06-18	1972-08-01	American Cyanamid Co	3-methoxy 8{62 -methylestra 1,3,5(10),9(11)-tetraene-17{62 -carboxylic acid lower alkyl ester and intermediates in the preparation thereof
US3806546A (en)	1969-06-18	1974-04-23	American Cyanamid Co	Steroid-like compounds and method of synthesis
US3736345A (en)	1971-05-18	1973-05-29	American Cyanamid Co	Steroid-like compounds and method of synthesis

2000
- 2000-04-12 DE DE10019167A patent/DE10019167A1/de not_active Withdrawn
2001
- 2001-04-11 UY UY26665A patent/UY26665A1/es not_active Application Discontinuation
- 2001-04-11 PE PE2001000335A patent/PE20011215A1/es not_active Application Discontinuation
- 2001-04-11 AR ARP010101730A patent/AR028329A1/es active IP Right Grant
- 2001-04-12 JP JP2001575609A patent/JP4860880B2/ja not_active Expired - Fee Related
- 2001-04-12 TW TW090108786A patent/TWI288138B/zh not_active IP Right Cessation
- 2001-04-12 SI SI200130752T patent/SI1272504T1/sl unknown
- 2001-04-12 YU YU77302A patent/YU77302A/sh unknown
- 2001-04-12 DE DE50107204T patent/DE50107204D1/de not_active Expired - Fee Related
- 2001-04-12 KR KR1020027013665A patent/KR100825534B1/ko not_active IP Right Cessation
- 2001-12-04 UA UA2002118922A patent/UA79073C2/uk unknown
2002
- 2002-11-11 ZA ZA200209149A patent/ZA200209149B/en unknown

Also Published As

Publication number	Publication date
ZA200209149B (en)	2007-10-31
SI1272504T1 (sl)	2007-10-31
JP2003534248A (ja)	2003-11-18
DE10019167A1 (de)	2001-10-18
PE20011215A1 (es)	2001-11-29
UA79073C2 (en)	2007-05-25
JP4860880B2 (ja)	2012-01-25
KR100825534B1 (ko)	2008-04-25
KR20030028734A (ko)	2003-04-10
AR028329A1 (es)	2003-05-07
YU77302A (sh)	2005-11-28
TWI288138B (en)	2007-10-11
UY26665A1 (es)	2001-11-30

Legal Events

Date	Code	Title	Description
2006-09-14	8364	No opposition during term of opposition
2007-05-31	8327	Change in the person/name/address of the patent owner	Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE
2008-03-27	8327	Change in the person/name/address of the patent owner	Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE
2009-02-19	8339	Ceased/non-payment of the annual fee

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