DE3863908D1 - Stabilisierung von antikoerpern. - Google Patents

Stabilisierung von antikoerpern.

Info

Publication number
DE3863908D1
DE3863908D1 DE8888202555T DE3863908T DE3863908D1 DE 3863908 D1 DE3863908 D1 DE 3863908D1 DE 8888202555 T DE8888202555 T DE 8888202555T DE 3863908 T DE3863908 T DE 3863908T DE 3863908 D1 DE3863908 D1 DE 3863908D1
Authority
DE
Germany
Prior art keywords
stabilization
antibody
pluronic
phospholipid
polyoxypropylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888202555T
Other languages
English (en)
Inventor
Theodorus Jansen
Engelbertus Johannes M Janssen
Lammert Cornelius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of DE3863908D1 publication Critical patent/DE3863908D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8888202555T 1987-11-27 1988-11-16 Stabilisierung von antikoerpern. Expired - Fee Related DE3863908D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8702848 1987-11-27

Publications (1)

Publication Number Publication Date
DE3863908D1 true DE3863908D1 (de) 1991-08-29

Family

ID=19850988

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888202555T Expired - Fee Related DE3863908D1 (de) 1987-11-27 1988-11-16 Stabilisierung von antikoerpern.

Country Status (15)

Country Link
US (1) US4902500A (de)
EP (1) EP0318081B1 (de)
JP (1) JPH01168624A (de)
KR (1) KR890007754A (de)
AT (1) ATE65410T1 (de)
AU (1) AU612430B2 (de)
CA (1) CA1317899C (de)
DE (1) DE3863908D1 (de)
DK (1) DK648088A (de)
ES (1) ES2051830T3 (de)
GR (1) GR3002971T3 (de)
IE (1) IE60719B1 (de)
MX (1) MX165991B (de)
NZ (1) NZ227088A (de)
ZA (1) ZA888577B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417821A1 (de) * 1989-09-13 1991-03-20 Duphar International Research B.V Verfahren zur Stabilisierung von Kolostrum für immunochemische Untersuchung
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
US20020123476A1 (en) * 1991-03-19 2002-09-05 Emanuele R. Martin Therapeutic delivery compositions and methods of use thereof
US6933286B2 (en) * 1991-03-19 2005-08-23 R. Martin Emanuele Therapeutic delivery compositions and methods of use thereof
JP3388894B2 (ja) * 1994-07-27 2003-03-24 富士写真フイルム株式会社 固体微粒子分散物とその製造方法
US5981296A (en) * 1997-02-18 1999-11-09 Dade Behring Inc. Stabilization of particle reagents
AU6914998A (en) * 1997-04-07 1998-10-30 Cangene Corporation Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties
US6066602A (en) * 1997-08-07 2000-05-23 Becton Dickinson And Company Waterborne non-silicone lubricant comprising phospholipid and polyether
EP0917879B1 (de) 1997-11-22 2002-07-17 Boehringer Mannheim Gmbh Verbessertes Verfahren zur Stabilisierung von Proteinen
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
JP2005500340A (ja) * 2001-07-31 2005-01-06 シーワイアールエックス コーポレイション 治療のための送達用組成物およびその使用方法
CA2517310C (en) * 2003-02-28 2015-11-24 Chugai Seiyaku Kabushiki Kaisha Stabilized protein-containing formulations comprising a poloxamer
PT1610822E (pt) * 2003-04-02 2011-01-05 Ares Trading Sa Formulações farmacêuticas líquidas ou liofilizadas de fsh e/ou lh em conjunto com o surfactante não iónico poloxâmero 188 e um agente bacteriostático
DK1638595T3 (da) 2003-06-20 2013-04-08 Ares Trading Sa Frysetørrede FSH-/LH-formuleringer
CN106959367B (zh) 2009-10-30 2019-06-14 协和梅迪克斯株式会社 用于测定样本中的待测定成分的方法和试剂盒
RU2584232C2 (ru) 2010-03-22 2016-05-20 Дженентек, Инк. Композиции и способы, используемые для стабилизации белоксодержащих готовых форм
CA3020477A1 (en) * 2016-09-01 2018-03-08 Romeo BEBEACHIBULI Food factor-based formulation, products produced using said formulation and methods for producing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3271181D1 (en) * 1982-02-08 1986-06-19 Schweiz Serum & Impfinst Intravenously administrable human immunoglobuline and process for its preparation
JPS58206513A (ja) * 1982-05-28 1983-12-01 Eisai Co Ltd セクレチン吸着防止組成物および方法
US4397870A (en) * 1982-07-27 1983-08-09 The University Of Pennsylvania Process for prolonging retention of emulsion particles in the bloodstream
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4707441A (en) * 1984-08-06 1987-11-17 Technicon Instruments Corp. Binding assays in automated apparatus with liposome compatible surfactants
ES2039229T3 (es) * 1986-01-14 1993-09-16 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Procedimiento para la preparacion de complejos inmunogenicos y composiciones farmaceuticas que contienen estos complejos.

Also Published As

Publication number Publication date
AU2579188A (en) 1989-06-01
DK648088D0 (da) 1988-11-18
ATE65410T1 (de) 1991-08-15
IE883445L (en) 1989-05-27
IE60719B1 (en) 1994-08-10
US4902500A (en) 1990-02-20
NZ227088A (en) 1990-07-26
KR890007754A (ko) 1989-07-05
DK648088A (da) 1989-05-28
AU612430B2 (en) 1991-07-11
GR3002971T3 (en) 1993-01-25
JPH01168624A (ja) 1989-07-04
EP0318081B1 (de) 1991-07-24
ES2051830T3 (es) 1994-07-01
EP0318081A1 (de) 1989-05-31
MX165991B (es) 1992-12-14
CA1317899C (en) 1993-05-18
ZA888577B (en) 1989-08-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL

8339 Ceased/non-payment of the annual fee