DE3480923D1 - Verfahren zur c-methylierung von 2-methylbutyraten. - Google Patents

Verfahren zur c-methylierung von 2-methylbutyraten.

Info

Publication number: DE3480923D1
Authority: DE; Germany
Prior art keywords: methylbutyrates; methylation
Prior art date: 1983-10-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE8484111760T

Other languages

English (en)

Inventor

Meyer Sletzinger

Thomas R Verhoeven

Ralph P Volante

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-11

Filing date

1984-10-02

Publication date

1990-02-08

1984-10-02 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1990-02-08 Application granted granted Critical

1990-02-08 Publication of DE3480923D1 publication Critical patent/DE3480923D1/de

2004-10-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE8484111760T 1983-10-11 1984-10-02 Verfahren zur c-methylierung von 2-methylbutyraten. Expired - Lifetime DE3480923D1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US54095483A	1983-10-11	1983-10-11

Publications (1)

Publication Number	Publication Date
DE3480923D1 true DE3480923D1 (de)	1990-02-08

Family

ID=24157590

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE8484111760T Expired - Lifetime DE3480923D1 (de)	1983-10-11	1984-10-02	Verfahren zur c-methylierung von 2-methylbutyraten.

Country Status (6)

Country	Link
EP (1)	EP0137445B1 (de)
JP (1)	JPS6097973A (de)
DE (1)	DE3480923D1 (de)
HK (1)	HK104590A (de)
IE (1)	IE57686B1 (de)
SG (1)	SG88790G (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668699A (en) *	1985-08-05	1987-05-26	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
US4820850A (en) *	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4866068A (en) *	1988-02-01	1989-09-12	Merck & Co., Inc.	Novel HMG-CoA reductase inhibitors
US5112857A (en) *	1990-09-04	1992-05-12	Merck & Co., Inc.	Hmg-coa reductase inhibitor metabolites
US5223415A (en) *	1990-10-15	1993-06-29	Merck & Co., Inc.	Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
JPH0722806U (ja) *	1993-09-30	1995-04-25	株式会社ゼクセル	ヒータユニット
JPH0969862A (ja) *	1995-08-31	1997-03-11	Mitsubishi Electric Corp	ディジタル無線通信受信機
US5763646A (en) *	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Process for manufacturing simvastatin from lovastatin or mevinolinic acid
SI9800057A (sl) *	1998-02-26	1999-08-31	Krka, Tovarna Zdravil, D.D.	Postopek za pripravo simvastatina in njegovih derivatov
CA2240983A1 (en) *	1998-06-18	1999-12-18	Yong Tao	Process to manufacture simvastatin and intermediates
JP4853987B2 (ja) *	2001-07-09	2012-01-11	日本曹達株式会社	α−置換化合物の製造方法
US6472542B1 (en)	2001-11-29	2002-10-29	Fermic S.A. De C.V.	Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
SI21187A (sl)	2002-03-26	2003-10-31	Krka, Tovarna Zdravil D.D., Novo Mesto	Postopek za pripravo 4-oksitetrahidropiran-2-onov

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (de) *	1974-06-07	1981-03-18
FR2470758A1 (fr) *	1979-12-07	1981-06-12	Sanofi Sa	Procede pour la fixation de groupes alkyles sur une chaine carbonee portant un groupe fonctionnel
AU548996B2 (en) *	1980-02-04	1986-01-09	Merck & Co., Inc.	Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) *	1980-02-04	1982-09-06	Merck & Co Inc	Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
EP0094443A1 (de) *	1982-05-17	1983-11-23	Merck & Co. Inc.	6(R)-(2-(8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S))ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-Pyran-2-on, Verfahren zur Herstellung und diese enthaltende pharmazeutische Zusammenstellung

1984
- 1984-10-02 EP EP84111760A patent/EP0137445B1/de not_active Expired - Lifetime
- 1984-10-02 DE DE8484111760T patent/DE3480923D1/de not_active Expired - Lifetime
- 1984-10-09 JP JP59210622A patent/JPS6097973A/ja active Granted
- 1984-10-10 IE IE2592/84A patent/IE57686B1/en not_active IP Right Cessation
1990
- 1990-10-27 SG SG887/90A patent/SG88790G/en unknown
- 1990-12-13 HK HK1045/90A patent/HK104590A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0137445A2 (de)	1985-04-17
EP0137445A3 (en)	1986-01-29
HK104590A (en)	1990-12-21
JPH0528714B2 (de)	1993-04-27
EP0137445B1 (de)	1990-01-03
IE842592L (en)	1985-04-11
IE57686B1 (en)	1993-02-24
JPS6097973A (ja)	1985-05-31
SG88790G (en)	1990-12-21

Similar Documents

Publication	Publication Date	Title
DE3485206D1 (de)	1991-11-28	Verfahren zur hydroraffination von kohlenwasserstoff-einsatzmaterial.
DE3583050D1 (de)	1991-07-11	Verfahren zur mikrophotometrie von mikroskopischen prueflingen.
DE3481453D1 (de)	1990-04-05	Verfahren zur platzierung von elementen.
DE3679815D1 (de)	1991-07-18	Verfahren zur innenauskleidung von leitungen.
DE3585147D1 (de)	1992-02-20	Verfahren zur reinigung von proteinen.
DE3486229D1 (de)	1993-11-18	Verfahren zur Herstellung von L-Phenylalanin.
DE3578698D1 (de)	1990-08-23	Verfahren zur behandlung von aluminiumoberflaechen.
DE58900407D1 (de)	1991-12-05	Verfahren zur reinigung von rohargon.
DE3874028D1 (de)	1992-10-01	Verfahren zur justierung von photomasken.
DE3483958D1 (de)	1991-02-21	Verfahren zur nutzung von betriebsmitteln zwischen mehreren arbeitsplaetzen.
DE68903992D1 (de)	1993-02-04	Verfahren zur aenderung der schattierung von bildern.
PT74887B (de)	1986-01-27	Verfahren zur verbesserung der fullfahigkeit von tabaken
DE3483344D1 (de)	1990-11-08	Verfahren zur reinigung von lpf-ha.
DE3774360D1 (de)	1991-12-12	Verfahren zur hydroraffinierung von kohlenwasserstoff enthaltenden einsaetzen.
DE3681034D1 (de)	1991-09-26	Verfahren zur oxydehydrierung von ethan.
DE3481609D1 (de)	1990-04-19	Verfahren zur reinigung von polyisocyanaten.
DE3486207D1 (de)	1993-10-07	Verfahren zur Abtrennung von 2-Chlor-m-xylol.
DE3484959D1 (de)	1991-09-26	Verfahren zur bearbeitung von oberflaechen.
DE3480923D1 (de)	1990-02-08	Verfahren zur c-methylierung von 2-methylbutyraten.
DE58901598D1 (de)	1992-07-09	Verfahren zur gewinnung von rohargon.
DE3482449D1 (de)	1990-07-19	Verfahren zur trennung von borisotopen.
DE3576148D1 (de)	1990-04-05	Verfahren zur trennung von racematen.
DE3481320D1 (de)	1990-03-15	Verfahren zur herstellung von protease-inhibitoren.
DE3763468D1 (de)	1990-08-02	Verfahren zur feinreinigung von spaltmolybdaen.
DE3874510D1 (de)	1992-10-15	Verfahren zur stabilisierung von hydroisomeraten.

Legal Events

Date	Code	Title	Description
1991-01-24	8364	No opposition during term of opposition