DE102004018276A1 - Imaging the stomach and/or duodenum for e.g. diagnosis of gastroduodenal diseases, comprises using a contrast agent, performing magnetic resonance tomography and computing a three-dimensional model - Google Patents
Imaging the stomach and/or duodenum for e.g. diagnosis of gastroduodenal diseases, comprises using a contrast agent, performing magnetic resonance tomography and computing a three-dimensional model Download PDFInfo
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- DE102004018276A1 DE102004018276A1 DE102004018276A DE102004018276A DE102004018276A1 DE 102004018276 A1 DE102004018276 A1 DE 102004018276A1 DE 102004018276 A DE102004018276 A DE 102004018276A DE 102004018276 A DE102004018276 A DE 102004018276A DE 102004018276 A1 DE102004018276 A1 DE 102004018276A1
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- stomach
- duodenum
- patient
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- 210000002784 stomach Anatomy 0.000 title claims abstract description 18
- 210000001198 duodenum Anatomy 0.000 title claims abstract description 16
- 239000002872 contrast media Substances 0.000 title claims abstract description 15
- 238000003384 imaging method Methods 0.000 title abstract description 3
- 238000003325 tomography Methods 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 3
- 238000003745 diagnosis Methods 0.000 title description 2
- 238000000034 method Methods 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 238000012805 post-processing Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- HOZOZZFCZRXYEK-GSWUYBTGSA-M butylscopolamine bromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CCCC)=CC=CC=C1 HOZOZZFCZRXYEK-GSWUYBTGSA-M 0.000 claims description 3
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 3
- 238000009877 rendering Methods 0.000 claims description 3
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 2
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 2
- 102000003898 interleukin-24 Human genes 0.000 claims description 2
- 108090000237 interleukin-24 Proteins 0.000 claims description 2
- 229950009846 scopolamine butylbromide Drugs 0.000 claims description 2
- 239000000932 sedative agent Substances 0.000 claims 1
- 238000011835 investigation Methods 0.000 abstract description 3
- 210000003238 esophagus Anatomy 0.000 description 5
- 238000001839 endoscopy Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229940088506 buscopan Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4238—Evaluating particular parts, e.g. particular organs stomach
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Signal Processing (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Die Erfindung betrifft ein Verfahren zur Erzeugung eines Untersuchungsbilds des Magens und/oder des Duodenums eines Patienten.The The invention relates to a method for generating an examination image of the stomach and / or duodenum of a patient.
Zur Untersuchung des Magens oder des Duodenums (Zwölffingerdarm) sind bereits invasive Verfahren wie die Endoskopie bekannt, die zur Diagnose von gastroduodenalen Krankheiten eingesetzt werden.to Examination of the stomach or duodenum (duodenum) are already Invasive procedures known as endoscopy are used to diagnose Gastroduodenal diseases are used.
Die Endoskopie ermöglicht es einem Arzt, die Beschaffenheit der Innenseite des Ösophagus (Speiseröhre), des Magens und des Duodenums mittels eines Endoskops zu betrachten. Das Endoskop ist ein dünnes, flexibles Instrument, das durch den Mund eingeführt und dann langsam über die Kehle und den Ösophagus in den Magen und den oberen Bereich des Dünndarms, das Duodenum, eingebracht wird. Durch die Endoskopie können Krankheitsbilder wie Geschwüre, Entzündungen, Tumore, Infektionen oder Blutungen erkannt werden. Allerdings besteht bei endoskopischen Eingriffen zumindest ein geringes Risiko für den Patienten. Bei einem von 1000 Patienten treten Komplikationen auf, bei einem von 3000 Patienten kann es zur Verletzung des Ösophagus, des Magens oder des oberen Bereichs des Dünndarms kommen.The Endoscopy allows a doctor, the nature of the inside of the esophagus (esophagus), the Stomach and duodenum using an endoscope. The endoscope is a thin, flexible instrument that is inserted through the mouth and then slowly over the Throat and the esophagus into the stomach and upper part of the small intestine, the duodenum becomes. Through endoscopy can Diseases such as ulcers, inflammation, Tumors, infections or bleeding are detected. However, there is at least a low risk for the patient during endoscopic procedures. Complications occur in one out of 1000 patients, at one Out of 3,000 patients, it may cause injury to the esophagus, stomach or stomach upper area of the small intestine come.
Der Erfindung liegt daher das Problem zugrunde, ein Verfahren zur Erzeugung eines Untersuchungsbilds des Magens und/oder des Duodenums anzugeben, das für den Patienten ungefährlich ist.Of the The invention is therefore based on the problem of a method for generating indicate an examination image of the stomach and / or duodenum, that for harmless to the patient is.
Zur Lösung dieses Problems ist ein Verfahren der eingangs genannten Art mit den folgenden Schritten vorgesehen:
- – Verabreichen eines Kontrastmittels;
- – Durchführen wenigstens einer Magnetresonanztomographieuntersuchung;
- – rechnerisches Erzeugen eines dreidimensionalen Modells des Untersuchungsbereichs.
- - administering a contrast agent;
- Performing at least one magnetic resonance imaging study;
- - computationally generating a three-dimensional model of the examination area.
Erfindungsgemäß wird anstelle einer invasiven Untersuchung eine Magnetresonanzuntersuchung (MR) durchgeführt, bei der die Gefahr innerer Verletzungen nicht besteht. Dementsprechend ist das erfindungsgemäße Verfahren wesentlich schonender für den Patienten. Vor der Durchführung der Magnetresonanzuntersuchung wird dem Patienten ein Kontrastmittel verabreicht. Die durch die MR-Untersuchung erfassten Daten werden rechnerisch weiterverarbeitet, um daraus ein dreidimensionales Modell des Untersuchungsbereichs zu erzeugen. Das erfindungsgemäße Verfahren kann daher als „virtuelle Gastroskopie„ bezeichnet werden. Anschließend kann das auf diese Weise erzeugte Untersuchungsbild von einem Arzt ausgewertet werden.According to the invention instead an invasive examination a magnetic resonance examination (MR) carried out, where the risk of internal injury does not exist. Accordingly is the inventive method much gentler for the patient. Before the implementation The magnetic resonance examination becomes a contrast agent for the patient administered. The data collected by the MRI will become computationally processed to make it a three-dimensional model of the examination area. The inventive method can therefore be called "virtual Gastroscopy " become. Then you can the examination image generated in this way is evaluated by a doctor become.
Gemäß einer ersten Variante des Verfahrens kann es vorgesehen sein, dass der Patient eine Mischung aus Wasser und dem Kontrastmittel trinkt. Diese Mischung gelangt durch die Speiseröhre in den Magen und allmählich in das Duodenum. Durch die Verwendung des Kontrastmittels ergeben sich besonders aussagekräftige MR-Untersuchungsbilder.According to one In the first variant of the method, it may be provided that the Patient drinks a mixture of water and the contrast agent. These Mixture passes through the esophagus into the stomach and gradually into the duodenum. By using the contrast agent arise particularly meaningful MR examination images.
Gemäß einer zweiten, alternativen Variante des Verfahrens kann es vorgesehen sein, dass der Patient Wasser trinkt und ihm ein Kontrastmittel intravenös verabreicht wird. Das Kontrastmittel gelangt durch die Blutbahn des Patienten in die Wände des Magens und des Duodenums, so dass dieser Untersuchungsbereich auf dem erzeugten Untersuchungsbild besonders gut zu erkennen ist. Da der Magen und anschließend auch das Duodenum bei der MR-Untersuchung mit Wasser gefüllt sind, werden Artefakte vermieden, die ansonsten durch Luftblasen verursacht werden könnten.According to one second, alternative variant of the method can be provided be that the patient drinks water and gives him a contrast agent intravenous is administered. The contrast medium passes through the bloodstream of the patient in the walls of the stomach and duodenum, leaving this area of investigation is particularly well recognized on the generated examination image. As the stomach and then also the duodenum are filled with water during the MR examination, avoid artifacts that are otherwise caused by air bubbles could become.
Eine weitere Verbesserung lässt sich erzielen, wenn dem Patienten ein den Magen und/oder das Duodenum ruhigstellendes Medikament verabreicht wird. Dadurch werden Bewegungen dieser Organe während der Durchführung der MR-Untersuchung weitgehend vermieden, die die Bildqualität beeinträchtigen könnten. Besonders geeignet ist dazu ein Skopolamin-butylbromid enthaltendes Medikament wie Buscopan (eingetragene Marke), das die Entleerung des Magens verzögert, ferner werden die Gefäßwände des Untersuchungsbereichs erweitert, wodurch Einzelheiten besser erkennbar werden.A further improvement leaves achieve if the patient has a stomach and / or duodenum sedating drug is administered. This will make movements these organs during the implementation MR imaging, which affects image quality, is largely avoided could. Particularly suitable for this purpose is a scopolamine-butylbromide-containing Drug like Buscopan (registered trademark), which is emptying the stomach is delayed, Furthermore, the vessel walls of Scope extended, making details more recognizable become.
Bei dem erfindungsgemäßen Verfahren kann eine 3D-T1-Gradientenechosequenz zur Magnetresonanzuntersuchung verwendet werden, wobei insbesondere eine 3D-FLASH-Gradientenechosequenz eingesetzt werden kann.In the method according to the invention, a 3D T 1 gradient echo sequence can be used for the magnetic resonance examination, wherein in particular a 3D FLASH gradient echo sequence can be used.
Alternativ ist es auch möglich, eine FISP- oder TrueFISP-Gradientenechosequenz zu verwenden.alternative it is also possible a FISP or TrueFISP gradient echo sequence to use.
Um sämtliche Gefäßwände des Untersuchungsbereichs zu erfassen, können Magnetresonanzuntersuchungen in Bauchlage und in Rückenlage des Patienten durchgeführt werden. Die Daten dieser Untersuchungen können anschließend rechnerisch zu einem dreidimensionalen Modell des Untersuchungsbereichs zusammengeführt werden.Around all Vessel walls of the To capture the examination area, magnetic resonance examinations in prone and supine position Patients performed become. The data of these investigations can then be calculated be merged into a three-dimensional model of the examination area.
Es wird besonders bevorzugt, dass die Erstellung des Untersuchungsbilds durch ein Post-Processing-Verfahren erfolgt, bei dem die bei der Magnetresonanzuntersuchung erfassten Daten verarbeitet werden. Durch dieses Post-Processing-Verfahren kann ein dreidimensionales Modell des Untersuchungsbereichs erzeugt werden, so dass ein virtuelles Abbild des zu untersuchenden Körperteils entsteht. Anschließend kann dieses virtuelle Modell für die Diagnose durch einen Arzt verwendet werden.It is particularly preferred that the examination image is generated by a post-processing method in which the data acquired in the magnetic resonance examination are processed be. By means of this post-processing method, a three-dimensional model of the examination area can be generated so that a virtual image of the body part to be examined is produced. Subsequently, this virtual model can be used for diagnosis by a physician.
Weitere Vorteile und Einzelheiten der Erfindung werden anhand von zwei Ausführungsbeispielen unter Bezugnahme auf die Figuren erläutert. Die Figuren zeigen:Further Advantages and details of the invention will be apparent from two embodiments explained with reference to the figures. The figures show:
Zur
Erzeugung des Untersuchungsbilds wird eine Mischung aus Wasser und
einem Kontrastmittel hergestellt, wobei Gadolinium als Kontrastmittel
verwendet wird. Im Schritt
Im
Verfahrensschritt
Anschließend ist
der Patient bereit für
die MR-Untersuchung
Die
bei der MR-Untersuchung erfassten Daten werden in einem Post-Processing-Verfahren
Das beschriebene Verfahren kann von einer Fachkraft für Röntgenuntersuchungen durchgeführt werden, die Mitwirkung eines Arztes ist dabei nicht erforderlich.The The procedure described may be carried out by a specialist in X-ray examinations be performed, the participation of a doctor is not required.
Dem
Patienten wird im Schritt
Claims (11)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004018276A DE102004018276A1 (en) | 2004-04-15 | 2004-04-15 | Imaging the stomach and/or duodenum for e.g. diagnosis of gastroduodenal diseases, comprises using a contrast agent, performing magnetic resonance tomography and computing a three-dimensional model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004018276A DE102004018276A1 (en) | 2004-04-15 | 2004-04-15 | Imaging the stomach and/or duodenum for e.g. diagnosis of gastroduodenal diseases, comprises using a contrast agent, performing magnetic resonance tomography and computing a three-dimensional model |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102004018276A1 true DE102004018276A1 (en) | 2005-11-17 |
Family
ID=35160161
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102004018276A Ceased DE102004018276A1 (en) | 2004-04-15 | 2004-04-15 | Imaging the stomach and/or duodenum for e.g. diagnosis of gastroduodenal diseases, comprises using a contrast agent, performing magnetic resonance tomography and computing a three-dimensional model |
Country Status (1)
| Country | Link |
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| DE (1) | DE102004018276A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2761722C1 (en) * | 2021-07-03 | 2021-12-13 | федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации | Method for diagnosing disorders of accommodation of the stomach |
-
2004
- 2004-04-15 DE DE102004018276A patent/DE102004018276A1/en not_active Ceased
Non-Patent Citations (8)
| Title |
|---|
| IN: Magnetic resonance imaging. UNITED STATES, 1994, Vol.12, Nr.5, S.719-726 |
| Knopp M V, Giesel F L, Radleff J, Von Tengg- Kobligk H.: Bile-tagged 3d magnetic resonance colonography after exclusive intravenous administration of gadobenate dimeglumine, a contrast agent with partial hepatobillary excre- tion". IN: Investigative radiology, United States, Okt.2001, Vol.36, Nr.10, S.619-623 |
| Laghi Andrea, Paolatonio Pascuale, lafrate Franco , Borrelli Osvaldo, Dito Lucia, Tomei Ernesto, Cucchiara Salvatore, Passariello Roberto: MR of the small bowel with a biphasic oral contrast ag- ent (polyethylene glycol): technical aspects and findings in patients affected by Chron's disease", IN: La Radiologia medica. Italy, Juli/Aug. 2003, Vol.106, Nr.1-2, S.18-27 |
| Laghi Andrea, Paolatonio Pascuale, lafrate Franco , Borrelli Osvaldo, Dito Lucia, Tomei Ernesto, Cucchiara Salvatore, Passariello Roberto: MR of the small bowel with a biphasic oral contrast ag- ent (polyethylene glycol): technical aspects and findings in patients affected by Chron's disease",IN: La Radiologia medica. Italy, Juli/Aug. 2003, Vol.106, Nr.1-2, S.18-27 * |
| Patak M A, Weißhaupt D, Fröhlich J M, Debatin J F: "Sequential fast 3D MRI following oral ingestion of Gd-DOTA: A new means to assess in intestinal transit time". IN: Jouranl of magnetic resonance imaging: JMRI, UNITED STATES, Sep 1999, Vol.10, Nr.3. S.474-476 |
| Patak M A, Weißhaupt D, Fröhlich J M, Debatin J F:"Sequential fast 3D MRI following oral ingestion of Gd-DOTA: A new means to assess in intestinal transit time". IN: Jouranl of magnetic resonance imaging: JMRI, UNITED STATES, Sep 1999, Vol.10, Nr.3. S.474-476 * |
| Vlahos L., Gouliamos A, Athanasopoulou A, Kotoulas G, Claus W, Hatziioannou A, Kalovidouris A, Papa- vasilliou C:"A comparative study between Gd-DTPA and oral magnetic particles (OMP) as gastrointest- tinal (GI) contrast agents for the abdomen" |
| Vlahos L., Gouliamos A, Athanasopoulou A, KotoulasG, Claus W, Hatziioannou A, Kalovidouris A, Papa- vasilliou C:"A comparative study between Gd-DTPA and oral magnetic particles (OMP) as gastrointest-tinal (GI) contrast agents for the abdomen" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2761722C1 (en) * | 2021-07-03 | 2021-12-13 | федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации | Method for diagnosing disorders of accommodation of the stomach |
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