DE10119608A1 - Hair treatment or post-treatment compositions for preventing or repairing damage caused by chemical treatment, e.g. perming or bleaching, containing creatine or its derivative as hair strengthening agent - Google Patents

Abstract

The use of creatine compounds (I) in hair treatment or post-treatment compositions (A) for preventing damage caused by chemical treatments and repairing already damaged hair is new. The use of creatine and/or its derivatives is claimed in hair treatment or post-treatment compositions (A) for preventing damage caused by chemical treatments and repairing already damaged hair, where the active agents are one or more of compounds of formula (I) and their salts and/or hydrates. R1 = H; or alkyl, hydroxyalkyl or carboxyalkyl of 2-30C; R2 = OR4 and R'2 = H; or R2 + R'2 = direct bond; R3, R4 = H; or optionally branched 1-30C hydrocarbyl (optionally containing double bonds). An Independent claim is included for the compositions (A), comprising (I) (or their salts and/or hydrates), together with conventional auxiliaries and/or additives.

Description

Human hair has a wide variety of influences every day exposed. In addition to mechanical stresses from brushing, Combing, pinning up or tying back, the hair too due to environmental influences such as B. strong UV radiation, cold, wind and water attacked.

In particular, however, treatment with chemical agents changes the structure and surface properties of the hair. me methods such as B. the perm, bleaching, dyeing, tinting, smoothing etc., but also frequent washing with aggressive surfactants contribute to more or less severe damage to the Hair structure caused. So z. B. for a duration wave both the cortex and the cuticle of the hair attacked. The disulfide bridges of the cystine are replaced by the Re Production step broken up and in the subsequent oxidation partially oxidized to cysteic acid.

When bleaching, not only the melanin is destroyed, but it 15 to 25 wt .-% of the disulfide bonds of the Cystine oxidized during mild bleaching. With an excessive Bleaching can even be up to 45% by weight (K.F. de Polo, A Short Textbook of Cosmetology, 2000, Verlag für chemische In dustrie, H. Ziolkowsky GmbH).

The hair is treated frequently by chemical treatments or UV radiation brittle, dry, lackluster, porous and  difficult to comb. It loses moisture, elasticity and before mechanical resistance and tear resistance. This is shown by a significant decrease in tensile strain forces and tear strength when the hair is wet. Besides, it is against further damage from chemicals, surfactants and environmental influences less resistant than healthy hair.

There are special ones for the repair of such damaged hair Preparations such as B. hair rinses, hair treatments, shampoos, Leave-in conditioners etc., but most of all the combable improve the feel, feel and shine of damaged hair can.

The special problem that the hair is damaged by damage mechanical resistance is greatly reduced has been paying great attention to for a long time.

The use of Protein hydrolyzates known. So in WO-A-9005521 Methods for the production of protein extracts described wel obtained from wheat gluten in a multi-stage process are and can be used in hair care products. such Protein hydrolyzates are said to be able to be preventive Care effect in largely undamaged hair. These protein hydrolyzates are ever for damaged hair but less suitable because of their high Molecular weight only act non-specifically and not in the Are able to counteract the effects of the damage.

There is therefore still a need for active ingredients for hair treatment agents and hair aftertreatment agents that the mecha niche resistance of the hair improve, the hair before protect further damage to the hair structure and the, turned puts in a permanent wave solution, a bleaching solution or a hair dye  or hair tint, the structural damage of hair that occurs through these treatments.

Such an active ingredient should preferably already be present in small amounts Use concentrations have a clear effect, be non-toxic, preferably of natural origin, very well tolerated by the hair and scalp, high Have compatibility with other ingredients and yourself can be easily incorporated into hair treatment products. Beson it is also desirable if this active ingredient in addition can also perform the function of certain components that up forth used for hair treatment, such as Conditioning.

It is an object of the invention to provide such an active ingredient To be able to provide both the mecha resistance of damaged hair to verbes as well as the hair from damage from a chemical To protect treatment.

It has now surprisingly been found that creatine and / or creatine derivatives in preparations for treatment and After-treatment of the hair all these desired criteria to fill.

The invention therefore relates to the use of creatine and / or creatine derivatives in hair treatment agents and hair aftertreatment agents to prevent damage caused by chemical treatment agents and to repair hair that has already been damaged, which is characterized in that at least one of the compounds of the general formulas ( III) and (IV)

and / or their salts or hydrates, in which
R ¹ = H, alkyl, hydroxyalkyl, carboxyalkyl radical with 2 to 30 C atoms;
R ² = -OR ⁴ with
R ⁴ = H or an optionally branched hydrocarbon radical having 1 to 30 C atoms and possibly containing double bonds,
preferably 2 to 20 carbon atoms;
R ³ = H or an optionally branched hydrocarbon radical with 1 to 30 C atoms, preferably 2 to 20 C atoms, which may contain double bonds, may also be used.

Further objects of the invention are set out in the claims characterized.

According to the invention, creatine is a preferred or used shared connection.

Creatine is a natural substance in the body, which in the Body from among other things in the liver or also in the kidneys synthesized the amino acids glycine, arginine and methionine will or will be ingested through meat foods can. Creatine is mainly found in muscle tissue and is involved in energy storage and transmission there. has  the body has adequate adenosine triphosphate (ATP) reserves ven, such as B. at rest, then creatine is in a rever sible reaction by the enzyme creatine kinase from Adeno sintriphosphate (ATP) phosphorylated to creatine phosphate. at a muscle load, the ATP is broken down quickly, and the Reaction runs in the other direction, i.e. i.e., creatine phosphate reacts with ADP to creatine and ATP (see also M. Wyss and T. Wallimann, "Creatine metabolism and the consequences of crea tine depletion in muscle "in Mol. and Cell. Biochem. 133/134, 51-66 (1994)).

Chemically, creatine belongs to the N-formamidinyl class amino acid derivatives and is represented by the following formula (I) characterized.

The IUPAC name is N- (aminoiminomethyl) -N-methyl glycine.

Industrial processes for creatine production are known, so can large-scale creation z. B. by the reaction of Sarcosinate salts can be synthesized with cyanamide, as in the DE-A-195 26 236 (SKW Trostberg). By full Drying with creatine (CAS No. 57-00-1) as a white powder the formula C4H9N3O2 and a molecular weight of 131.31 g / mol receive. If the drying process starts with a residual water content of 12.1% by weight, creatine monohydrate (CAS No. 6020-87-7) with the empirical formula C4H9N3O2 × H2O and ei nem molecular weight of 149.15 g / mol obtained as a product.  

According to the invention, creatinine is another preferred one or connection used.

Creatinine (CAS # 60-27-5) is the common name for that 2-imino-N-methylhydantoin, a cyclic condensation product, which is caused by intramolecular elimination of water from creatine can be obtained (Formula II).

Because of its special physiological importance, Kreati tin already with great success as a dietary supplement u. a. used in sports. In addition, applications from Creatine and creatinine proposed in human medicine. For example, US-5 576 316 describes the use of Creatine and creatine derivatives to inhibit tumor wax tums.

More recently, a few patent applications have been filed published in which the use of creatine in skin care products is described.

So from WO-0015187 (SKW Trostberg) the use of Creatine as a humectant in cosmetic preparations known. The use of creatine or its suitable derivatives is said to be symptoms of dry skin such as cracks and flaking eliminate sustainably.

JP-0247866 (Lion Corporation) also only uses skin cosmetics described, which have an excellent care effect  have and creatine and / or creatinine in connection with egg nem another pharmaceutical active ingredient and / or a bioakti contain substance.

Another application is WO-0100203 (Avicena), which the Use of creatine and creatine derivatives as antioxidants and used to regenerate stressed skin.

The literature therefore cannot say anything about the use of Creatine or its derivatives in hair treatment products for Purpose of protecting the hair from damage caused by chemical loading agent or for repairing damaged hair in hair care products.

As particularly suitable in the sense of the present invention ha creatine and creatinine have been proven and are therefore before Trains t. But also creatine derivatives such as creatine monohydrate or Salts with preferably organic mono- or polybasic acid such as acetic acid, glycolic acid, lactic acid, Citric acid, malic acid, salicylic acid or sorbic acid and their mixtures or like creatine pyruvate are very suitable. In the context of the present invention, it is also possible to mix suitable creatine derivatives with one another turn.

The creatine derivatives of the general formulas (III) and (IV) can after conventional esterification and alkylation or Addition process or based on these processes getting produced.

As cosmetic preparations according to the invention for aftertreatment The styling, shaping and care of the hair are especially such Hair treatment agents understood that after a chemical loading hair treatment can be used (hair treatment agent)  and chemical hair treatment agents, through which the hair structure is damaged and in which the damage by the addition of creatine and creatine derivatives can be minimized (Haarbe treatment agents).

Creatine and its derivatives can generally be used in one Concentration of 0.1 to 10.0 wt .-%, preferably in a con concentration of 0.1 to 5.0 wt .-%, especially in one Concentration of 0.1 to 1.0 wt .-%, may be included.

The hair aftertreatment agents are e.g. B. um Hair rinses, hair treatments, conditioners, leave-in conditioners rer, hair shampoos, two-in-one shampoos, setting formulations such as foaming agents, hair sprays or hair lotions, hair lotions, Hair end fluids. They can be used as a gel, emulsion, solution, Aerosol spray or foam, non-aerosol spray or foam lie.

The cosmetic preparations according to the invention for treatment the hair after a chemical treatment have a pH value from 3 to 7 and therefore preferably contain one suitable for this nete water-soluble acid or a buffer mixture that this pH stabilized. Suitable acids are, in particular low molecular weight organic acids, such as vinegar acid, glycolic acid, lactic acid, citric acid, malic acid, Salicylic acid or sorbic acid and mixtures of these acids with their alkali salts.

The cosmetic preparations according to the invention for treatment hair after a chemical treatment can be next Creatine and its derivatives still contain components, the advantageous for the respective application and / or are.  

So shampoos z. B. 3 to 30 wt .-% foaming anionic, zwitterionic, ampholytic and nonionic surfactants hold. Hair conditioners and hair treatments contain 0 to 10% by weight, preferably 0.5 to 5% by weight, emulsifiers, 0 to 10% by weight, preferably 0.5 to 5 wt .-%, consistency and 0 to 20% by weight of cosmetic oils of vegetable and synthetic Origin, emollients, vitamin preparations and proteins. shampoos, Hair rinses, hair treatments and conditioners also contain preferably 0 to 8% by weight, preferably 0.1 to 5% by weight, cationic surfactants and water-soluble polymers with quaternary Ammonium groups to reduce the static chargeability and to improve combability, grip and shine.

The cationic surfactants are usually

• - To quaternary ammonium compounds, such as. B. Alkyltri methyl ammonium salts, dialkyldimethyl ammonium salts, trial kylmethylammonium salts and imidazolinium compounds. The long alkyl chains consist of a carbon chain with 10 to 22 carbon atoms, the counterions to the quaternary Nitrogen are e.g. B. halides, sulfate, acetate, lactate, Glycolate, nitrate or phosphate. Products can be found at the designation Varisoft® 300, 432 CG, 442-100 P, BT 85 from Goldschmidt-Rewo, Dehyquart® A from Henkel in stores;
• - Ester quats, such as those known as Dehyquart® F75 from Henkel or Armocare® VGH-70 from Akzo the;
• - Alkylamidoquats, such as z. B. under the name Vari soft® PATC and RTM 50 from Goldschmidt-Rewo are on the market.

The water-soluble polymers with quaternary ammonium groups are e.g. B.

• - To cationic cellulose derivatives, as described under the Be drawing Celquat® H 100 and L 200 from National Starch or Polymer JR® 400 are commercially available from Amerchol,
• - polymeric dimethyldiallylammonium salts and their copolymers with esters and amides of acrylic acid and methacrylic acid. The Merguat® 100 or Merquat® 550 Commercial products from Calgon are examples for such cationic polymers,
• - Copolymers of vinyl pyrrolidone with quaternized derivatives of dialkylaminoacrylate and methacrylate. Such ver Binding are under the names Gafquat® 735 and Gaf quat® 744 commercially available from ISP,
• - vinylpyrrolidone vinylimidazoliummethochloride copolymers, as they are called Luviquat® FC 370, FC 550, FC 905 and HM-552 are offered by BASF
• - quaternized polyvinyl alcohol,
• - quaternized protein hydrolysates from animals or plants origin based on keratin, collagen, elastin, white zen, rice, soy, milk, silk, corn. Such products will be z. B. under the name Croquat® Wheat and Silk from Croda, Promois® W-32CAQ, Silk CAQ, WG CAQ from Seiwa Kasei or Quat-Coll® CDMA sold by Brooks,
• - Guarhydroxypropyltrimethylammoniumchlorid,
• - amino-functional polydimethylsiloxanes or hydroxylamino modified silicones, such as the commercial products ABIL® Quat 3272 and ABIL® Quat 3474 from Goldschmidt, Dow Corning® 929 Emulsion, Dow Corning® 939 from Dow Corning.

Fixer formulations and other hair styling preparations usually contain 0.1 to 5 wt .-% film-forming, in aq polymers soluble in aqueous or alcoholic media, optionally together with cationic surfactants or cationic polymers. Examples of film formers are Homopolymers of vinyl pyrrolidone, homopolymers of  N-vinylformamids, copolymers of vinylpyrrolidone and Vi nyl acetate, terpolymers of vinyl pyrrolidone, vinyl acetate and Vi nylpropionate, polyacrylamides, polyvinyl alcohols, high molecular weight res polyethylene glycol or high molecular copolymers of Ethy lenglycol with propylene glycol, chitosan. Find these products one under the name Luviskol® K30, K60, K80, VA37E from BASF or PVP / VA E335 and PVP K30 from ISP in stores.

Typical framework formulations for the respective applications are known prior art and are for example in the Bro stoke the manufacturer of the respective basic and active ingredients contain. These existing phrases can usually unchanged. If necessary, you can adjust solution and optimization simple experiments can be carried out without complications.

A typical formulation for a hair conditioner contains:
0.1 to 2% by weight of at least one of the compounds of the general formulas (III) and (IV),
0.1 to 5% by weight of emulsifier,
0.1 to 5% by weight of a consistency agent,
0.1 to 5% by weight of cationic surfactants and / or water-soluble polymers with quaternary ammonium groups,
0 to 10% by weight of other cosmetic active ingredients, preservatives and customary additives and auxiliaries,
ad 100 wt .-% water.

A typical formulation for a hair shampoo contains, for example:

• a) 0.1 to 2 wt .-% of at least one of the compounds of gen my formula (III) and (IV),
• b) 3 to 30 wt .-% foaming anionic, amphoteric, ampholy table or non-ionic surfactants,  
• c) 0.1 to 5.0 wt .-% cationic surfactants and / or water-soluble liche polymers with quaternary ammonium groups,
• d) 0.1 to 6.0% by weight of thickener,
• e) 0 to 10% by weight of other cosmetic active ingredients, Opacifiers, solvents and usual additives and excipients
• f) ad 100% by weight of water.

In the preparations for chemical hair treatment according to the invention action is a means of permanent deformation of the hair like permanent wave and fixative, color changing mit such as bleaching agents, oxidation colorants and tinting agents and shampoos based on direct dyes.

The preparations for chemical treatment according to the invention the hair contains creatine and its derivatives other components, usually for the respective application be used.

These are with a permanent wave solution such. B. 1 to 10% by weight Thioglycolic acid, thioglycolic acid salts or esters. permanent wave Fixing agents or bleaching agents preferably contain 2 to 10% by weight Oxidizing agents, such as. B. potassium bromate, sodium bromate or hydrogen peroxide. Hair dyes contain directly pulling hair dye or oxidation dye precursors.

Finally, the preparations according to the invention can be further cosmetic auxiliaries and additives used in such preparations gene are included. Such additives are e.g. B. Solubilizers such as ethanol, isopropanol, ethylene glycol; Propylene glycol, glycerin and diethylene glycol, complexing agents such as EDTA, NTA, β-alaninediacetic acid and phosphonic acid, Konser Curing agents, antioxidants, fragrances, coloring agents coloring of the cosmetic preparation, opacifiers such as latex,  Styrene / PVP and styrene-acrylamide copolymers, pearlescent agents such as Ethylene glycol mono- and distearate and PEG-3 distearate, Pig elements, light stabilizers, thickeners or blowing agents.

The creatine and the creatine derivatives can in the Invention moderate, cosmetic preparations also with other hair cosms table active ingredients, such as. B. ceramides, Pseudoceramides, protein hydrolyzates vegetable or tieri origin based on keratin, collagen, elastin, wheat, Rice, soy, milk, silk, corn, anti-dandruff agents such as pi roctone olamine, zinc omadine and climbazole, sebostat, vita mines, panthenol, pyrrolidone carboxylic acid, bisabolol, plants zen extracts can be combined.

The production of the hair treatment agent according to the invention follows in the usual way, with the creatine and its deri vate preferably dissolved in the aqueous phase of the formulation become. The pH is preferably set last by adding the intended acid and / or the buffer mixture used. For better solubility of creatine and its De The preparation according to the invention can derivative before use be slightly warmed on the hair.

The following examples are intended to be the subject of the invention explain in more detail:  

recipes Application engineering review Hair used

Euro hair (European hair), natural, bundled up Strands of hair weighing 2 g.

Pre-damaged hair

1 × perm and bleaching each with commercially available products.

Treatment of damaged hair

The damaged hair is 5 × with the sample form treated.

Table 1

A treatment cycle consists of two steps:

• 1. Wash with 8% by weight sodium lauryl ether sulfate solution (0.25 ml / g hair, lather for 1 minute, rinse out for 1 minute).
• 2. 1 ml formulation / g hair is massaged into the hair (Massage in 1 min., 4 min. Exposure time) and then Rinsed under running water for 1 min.

After each treatment cycle, the hair is left in the air dry.

After 5 treatment cycles, the forces required for a 15 or 25% stretch of the treated hair is required (name in Table 2: DW + Bl + 5 × hair conditioner). to in addition, the forces of 15 or 25% elongation of un damaged hair (name in table 2: undamaged) and damaged hair before treatment with the sample formu Measurements A and B measured (designation in Table 2: DW + Bl). 55 individual hairs were used for each series of measurements. For measurement the tensile forces became the company's fully automatic Mtt670 Dia Stron used. To reduce the spread of the Forces became her cross before the tensile strain measurement of the hair cut using a Dia Stron laser scan micrometer determined and the quotient of force / cross-sectional area of the Haa res (FQ) calculated.

To evaluate the measured values, the t-test is used to compare mean values (Kaiser, Mühlbauer: Elementary tests for evaluating measured data). The mean values of the stresses at 15% and 25% elongation of the damaged, untreated hair are compared with those of the treated hair. The repair effect is also calculated:

Repair effect = (FQ _treated - FQ _damaged ) .100 / (FQ _undamaged - FQ _damaged ) [%].

Table 2

Hair conditioner A with the active ingredient creatine is therefore in the Location, 28% and 26% of the damage to the hair caused by the Damage caused by perms and bleaching, undo (repair effect), with hair conditioner B it is 20.8% and 25.2%. Hair conditioner C shows no repair Effect.  

Protection of the hair from damage by chemical agents

To clarify the effect, the hair is pre-damaged. For this purpose, the hair is permanently waved and bleached once.

Part of the damaged hair is left unchanged, the the second part is treated 5 times with the leave-in conditioner.

Table 3

A treatment cycle with the leave-in conditioner consists of the following steps:

• 1. Wash with 8% sodium lauryl ether sulfate solution (0.25 ml / g hair, lather for 1 minute, rinse out for 1 minute).
• 2. 1 ml leave-in conditioner formulation / g hair is in massaged the hair (1 min.).

After each treatment cycle, the hair is left in the air dry.

Then both leave-in Conditioner treated hair as well as the pre-damaged, untreated hair, a second chemical Subjected to hair treatment. Part of this hair becomes a permed a second time, another part becomes a second time bleached.  

Then the hair cross sections and the forces that required for 15% or 25% stretching of the hair are measured. In addition, the forces become 15% and 25% Stretching and the hair cross-section of damaged hair measured.

The following Table 4 serves to explain the results in Tables 5a and 5b.

Table 4

The protective effect is calculated using the following formula:

Protection effect = 100. (FQ _{DW + Bl + 5 × LiC + DW} - FQ _{DW + Bl + DW} ) / (FQ _{DW + BL} - FQ _{DW + Bl + DW} ).

Table 5a

Those treated with the leave-in conditioner with creatine Hair is also damaged by the second perm, however, the damage is 40% and 37.6% less than for hair that is not before the second perm with the Leave-in conditioners had been treated.

Table 5b

Between the forces at 15 and 25% elongation pre-damaged hair (DW + Bl) and the hair with the Leave-in conditioners were treated and subsequently were bleached again (DW + BL + 5 × LiK + Bl; Table 5b) there is no difference, even statistically. The train- Elongation forces of the hair that are not with the leave-in Conditioners have been treated (DW + Bl + Bl), take however, by the second bleaching significantly. The leave-in Conditioner with creatine thus brings about an almost 100% Protection of hair from damage caused by bleaching.

Claims (9)

1. Use of creatine and / or creatine derivatives in hair treatment agents and hair aftertreatment agents to prevent damage caused by chemical treatment agents and to repair damaged hair, characterized in that at least one of the compounds of the general formulas (III) and (IV)
and / or their salts and / or hydrates in those
R ¹ = H, alkyl, hydroxyalkyl, carboxyalkyl radical with 2 to 30 C atoms;
R ² = -OR ⁴ with
R ⁴ = H or an optionally branched hydrocarbon radical having 1 to 30 C atoms and possibly containing double bonds,
R ³ = H or an optionally branched hydrocarbon radical with 1 to 30 C atoms, optionally containing double bonds, can also be used. 2. Use of creatine and / or creatine derivatives in hair treatment agents and hair aftertreatment agents according to an Proof 1, characterized in that as active substances Use creatine and / or creatinine and / or their salts be det.   3. Hair aftertreatment agent for repairing hair already damaged by chemical agents, containing an effective amount of creatine and / or creatine derivatives of the general formulas (III) and / or (IV)
and / or their salts and / or hydrates, in which
R ¹ = H, alkyl, hydroxyalkyl, carboxyalkyl radical with 2 to 30 C atoms;
R ² = -OR ⁴ with
R ⁴ = H or an optionally branched hydrocarbon radical having 1 to 30 C atoms and possibly containing double bonds,
R ³ = H or an optionally branched hydrocarbon radical with 1 to 30 carbon atoms, optionally containing double bonds, and optionally conventional auxiliaries and additives. 4. Hair treatment agent for preventing damage caused by chemical agents, containing an effective amount of creatine and / or creatine derivatives of the general formulas (III) and / or (IV)
and / or their salts and / or hydrates, in which
R ¹ = H, alkyl, hydroxyalkyl, carboxyalkyl radical with 2 to 30 C atoms;
R ² = -OR ⁴ with
R ⁴ = H or an optionally branched hydrocarbon radical having 1 to 30 C atoms and possibly containing double bonds,
R ³ = H or an optionally branched hydrocarbon radical with 1 to 30 carbon atoms, optionally containing double bonds, and optionally conventional auxiliaries and additives. 5. Hair treatment agent and hair treatment agent according to Claims 3 and 4, characterized in that they 0.1 to 10.0% by weight of the compounds of the general form meln (III) and / or (IV) and / or their salts and / or de contain hydrates. 6. Hair conditioner containing 0 to 10 wt .-% of one or several emulsifiers, 0 to 10% by weight of one or more Consistency generator, 0 to 10 wt .-% of one or more cationic surfactants, 0 to 20% by weight of one or more cosmetic oils or emollients as well as usual auxiliary and Additives in usual concentrations, characterized records that they 0.1 to 10.0 wt .-% of the compounds of general formulas (III) and / or (IV) and / or their Contain salts and / or their hydrates. 7. Hair shampoo containing 3 to 30 wt .-% of a foaming anionic, zwitterionic, ampholytic and / or nonionic surfactants, 0 to 10% by weight of one or more rer cationic surfactants and / or polymers with cationi ammonium groups and usual auxiliaries and additives in usual concentrations, characterized in that  they 0.1 to 10.0% by weight of the compounds of the general Formulas (III) and / or (IV) and / or their salts and / or whose hydrates contain. 8. Leave-in conditioner, to remain on the hair after the Application containing 0 to 10 wt .-% of one or more cationic surfactants and / or polymers with cationic Ammonium groups and usual auxiliaries and additives in usual concentrations, characterized in that they 0.1 to 10.0% by weight of the compounds of the general Formulas (III) and / or (IV) and / or their salts and / or whose hydrates contain. 9. Hair treatment agents and hair treatment agents, ent holding 0.1 to 10.0% by weight of the compounds of the general NEN formulas (III) and / or (IV) and / or their salts and / or their hydrates in combination with hair cosmetics Active ingredients such as B. protein or vegetable hydrolysates animal origin based on keratin, collagen, elastin, Wheat, rice, soy, milk, silk, corn, anti-dandruff substances such as piroctone olamine, zinc omadine and climbazole, Sebostats, vitamins, panthenol, pyrrolidone carboxylic acid, Bisabolol, plant extracts, ceramides.