CY1123456T1 - Μεθοδος παρασκευης οπτικως καθαρων και προαιρετικως υποκατεστημενων παραγωγων 2-(1-υδροξυ-αλκυλ)-χρωμεν-4-ονης και χρηση αυτων στην παρασκευη φαρμακευτικων ουσιων - Google Patents
Μεθοδος παρασκευης οπτικως καθαρων και προαιρετικως υποκατεστημενων παραγωγων 2-(1-υδροξυ-αλκυλ)-χρωμεν-4-ονης και χρηση αυτων στην παρασκευη φαρμακευτικων ουσιωνInfo
- Publication number
- CY1123456T1 CY1123456T1 CY20201100974T CY201100974T CY1123456T1 CY 1123456 T1 CY1123456 T1 CY 1123456T1 CY 20201100974 T CY20201100974 T CY 20201100974T CY 201100974 T CY201100974 T CY 201100974T CY 1123456 T1 CY1123456 T1 CY 1123456T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- hydroxy
- alkyl
- derivatives
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε ενώσεις χρήσιμες ως φαρμακευτικά ενδιάμεσα, σε μεθόδους παρασκευής των ενδιαμέσων, σε ενδιάμεσα που χρησιμοποιούνται στις μεθόδους και στη χρήση των ενδιαμέσων στην παρασκευή φαρμακευτικών ουσιών. Ιδιαιτέρως, η παρούσα εφεύρεση αφορά εναντιομερικώς καθαρά προαιρετικώς υποκατεστημένα παράγωγα 2-(1-υδροξυ-αλκυλ)-χρωμεν-4-όνης που αντιπροσωπεύονται με τον τύπο (ΙΑ) και (IB), μεθόδους για παρασκευή των παραγώγων αλκοόλης και χρήση αυτών στην παρασκευή φαρμακευτικών ουσιών.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1737CH2012 | 2012-05-04 | ||
| US201261671956P | 2012-07-16 | 2012-07-16 | |
| PCT/IB2013/053544 WO2013164801A1 (en) | 2012-05-04 | 2013-05-03 | Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123456T1 true CY1123456T1 (el) | 2022-03-24 |
Family
ID=54193684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100974T CY1123456T1 (el) | 2012-05-04 | 2020-10-15 | Μεθοδος παρασκευης οπτικως καθαρων και προαιρετικως υποκατεστημενων παραγωγων 2-(1-υδροξυ-αλκυλ)-χρωμεν-4-ονης και χρηση αυτων στην παρασκευη φαρμακευτικων ουσιων |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9309216B2 (el) |
| EP (1) | EP2844647B1 (el) |
| JP (2) | JP6290186B2 (el) |
| KR (1) | KR102073181B1 (el) |
| CN (2) | CN104507922B (el) |
| AP (1) | AP3547A (el) |
| AU (1) | AU2013255469B2 (el) |
| BR (1) | BR112014027470A2 (el) |
| CA (1) | CA2871000C (el) |
| CL (1) | CL2014002986A1 (el) |
| CO (1) | CO7141413A2 (el) |
| CY (1) | CY1123456T1 (el) |
| EA (1) | EA032812B1 (el) |
| HK (1) | HK1203964A1 (el) |
| IL (1) | IL235181A (el) |
| MX (1) | MX365250B (el) |
| MY (1) | MY171207A (el) |
| NZ (1) | NZ701198A (el) |
| PH (1) | PH12014502453B1 (el) |
| PL (1) | PL2844647T3 (el) |
| RS (1) | RS61035B1 (el) |
| SG (1) | SG11201407184PA (el) |
| SI (1) | SI2844647T1 (el) |
| WO (1) | WO2013164801A1 (el) |
| ZA (1) | ZA201407769B (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012010640A2 (pt) | 2009-11-05 | 2016-11-22 | Rhizen Pharmaceuticals S A | novos moduladores de quinase |
| MX365250B (es) * | 2012-05-04 | 2019-05-28 | Rhizen Pharmaceuticals Sa | Procedimiento para la preparación de derivados de 2- (1-hidroxi-alquil)-cromen-4-ona ópticamente pura y opcionalmente sustituida y su uso en la preparación de productos farmacéuticos. |
| US10130635B2 (en) * | 2012-05-04 | 2018-11-20 | Rhizen Pharmaceuticals Sa | Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals |
| BR112015030385B1 (pt) | 2013-06-07 | 2020-08-18 | Rhizen Pharmaceuticals S.A. | Composto, composto para uso e composição farmacêutica |
| KR20170016489A (ko) * | 2014-06-27 | 2017-02-13 | 리젠 파마슈티컬스 소시에떼 아노님 | Pi3 델타 및 감마 단백질 키나제의 선택적 이중 저해제로서 치환된 크로멘 유도체 |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| EP3325462A4 (en) * | 2015-07-23 | 2019-06-19 | Pharmakea, Inc. | INHIBITORS OF LYSYL OXIDASE-LIKE 2 AND USES OF SAID INHIBITORS |
| CN108884049A (zh) | 2016-02-09 | 2018-11-23 | 法玛克亚公司 | 喹啉酮赖氨酰氧化酶样2抑制剂及其用途 |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2023130334A1 (zh) * | 2022-01-07 | 2023-07-13 | 同润生物医药(上海)有限公司 | 一种色烯-4-酮化合物及其中间体的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62201882A (ja) * | 1985-11-18 | 1987-09-05 | Yamanouchi Pharmaceut Co Ltd | イソフラボン誘導体 |
| PE20060426A1 (es) * | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| BR112012010640A2 (pt) | 2009-11-05 | 2016-11-22 | Rhizen Pharmaceuticals S A | novos moduladores de quinase |
| ES2710874T3 (es) | 2011-05-04 | 2019-04-29 | Rhizen Pharmaceuticals S A | Compuestos novedosos como moduladores de proteína cinasas |
| MX365250B (es) * | 2012-05-04 | 2019-05-28 | Rhizen Pharmaceuticals Sa | Procedimiento para la preparación de derivados de 2- (1-hidroxi-alquil)-cromen-4-ona ópticamente pura y opcionalmente sustituida y su uso en la preparación de productos farmacéuticos. |
| EP2870157B1 (en) * | 2012-07-04 | 2017-08-30 | Rhizen Pharmaceuticals S.A. | Selective pi3k delta inhibitors |
-
2013
- 2013-05-03 MX MX2014013426A patent/MX365250B/es active IP Right Grant
- 2013-05-03 WO PCT/IB2013/053544 patent/WO2013164801A1/en active Application Filing
- 2013-05-03 KR KR1020147034065A patent/KR102073181B1/ko active IP Right Grant
- 2013-05-03 BR BR112014027470A patent/BR112014027470A2/pt not_active Application Discontinuation
- 2013-05-03 CN CN201380023361.1A patent/CN104507922B/zh not_active Expired - Fee Related
- 2013-05-03 CA CA2871000A patent/CA2871000C/en not_active Expired - Fee Related
- 2013-05-03 US US14/398,902 patent/US9309216B2/en not_active Expired - Fee Related
- 2013-05-03 CN CN201810028555.5A patent/CN108084138A/zh active Pending
- 2013-05-03 EP EP13729095.3A patent/EP2844647B1/en active Active
- 2013-05-03 SG SG11201407184PA patent/SG11201407184PA/en unknown
- 2013-05-03 RS RS20201267A patent/RS61035B1/sr unknown
- 2013-05-03 EA EA201491818A patent/EA032812B1/ru unknown
- 2013-05-03 SI SI201331803T patent/SI2844647T1/sl unknown
- 2013-05-03 PL PL13729095T patent/PL2844647T3/pl unknown
- 2013-05-03 NZ NZ701198A patent/NZ701198A/en not_active IP Right Cessation
- 2013-05-03 AU AU2013255469A patent/AU2013255469B2/en not_active Ceased
- 2013-05-03 JP JP2015509560A patent/JP6290186B2/ja not_active Expired - Fee Related
- 2013-05-03 AP AP2014008087A patent/AP3547A/xx active
- 2013-05-03 MY MYPI2014003098A patent/MY171207A/en unknown
-
2014
- 2014-10-19 IL IL235181A patent/IL235181A/en active IP Right Grant
- 2014-10-24 ZA ZA2014/07769A patent/ZA201407769B/en unknown
- 2014-11-03 PH PH12014502453A patent/PH12014502453B1/en unknown
- 2014-11-04 CL CL2014002986A patent/CL2014002986A1/es unknown
- 2014-12-03 CO CO14266920A patent/CO7141413A2/es unknown
-
2015
- 2015-05-19 HK HK15104774.7A patent/HK1203964A1/xx unknown
-
2017
- 2017-12-14 JP JP2017239643A patent/JP2018039849A/ja active Pending
-
2020
- 2020-10-15 CY CY20201100974T patent/CY1123456T1/el unknown
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