CY1123415T1 - Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων - Google Patents

Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων

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Publication number
CY1123415T1
CY1123415T1 CY20201100811T CY201100811T CY1123415T1 CY 1123415 T1 CY1123415 T1 CY 1123415T1 CY 20201100811 T CY20201100811 T CY 20201100811T CY 201100811 T CY201100811 T CY 201100811T CY 1123415 T1 CY1123415 T1 CY 1123415T1
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CY
Cyprus
Prior art keywords
polykinase
methods
gene expression
inhibitors
expression signatures
Prior art date
Application number
CY20201100811T
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English (en)
Inventor
Sheng Guo
Dawei Chen
Juan Zhang
Jie Cai
Henry Qixiang LI
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Crown Bioscience, Inc. (Taicang)
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Filing date
Publication date
Application filed by Crown Bioscience, Inc. (Taicang) filed Critical Crown Bioscience, Inc. (Taicang)
Publication of CY1123415T1 publication Critical patent/CY1123415T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Γνωστοποιείται η υπογραφή της έκφρασης γονιδίων προγνωστική της απόκρισης ασθενών με καρκίνο στον αναστολέα πολυκινάσης. Επίσης, γνωστοποιούνται μέθοδοι προγνωστικές της αποτελεσματικότητας του αναστολέα, πολυκινάσης στη θεραπευτική αντιμετώπιση του καρκίνου σε έναν ασθενή. Επίσης, γνωστοποιούνται μέθοδοι για τη διάκριση των αποκρινόμενων από τους μη αποκρινόμενους σε έναν αναστολέα πολυκινάσης στη θεραπευτική αντιμετώπιση του καρκίνου. Επίσης, γνωστοποιούνται μέθοδοι θεραπευτικής αγωγής ενός καρκινοπαθούς με έναν αναστολέα πολυκινάσης.
CY20201100811T 2013-08-28 2020-08-28 Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων CY1123415T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013082487 2013-08-28
PCT/US2014/053142 WO2015031604A1 (en) 2013-08-28 2014-08-28 Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same

Publications (1)

Publication Number Publication Date
CY1123415T1 true CY1123415T1 (el) 2021-12-31

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CY20201100811T CY1123415T1 (el) 2013-08-28 2020-08-28 Υπογραφες εκφρασης γονιδιων προγνωστικες της αποκρισης υποκειμενου σε αναστολεα πολυκινασης και μεθοδοι χρησεως αυτων

Country Status (9)

Country Link
US (1) US11136625B2 (el)
EP (1) EP3039424B1 (el)
JP (1) JP6612232B2 (el)
CN (1) CN105659085B (el)
CY (1) CY1123415T1 (el)
DK (1) DK3039424T3 (el)
ES (1) ES2813877T3 (el)
PT (1) PT3039424T (el)
WO (1) WO2015031604A1 (el)

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WO2017110764A1 (ja) * 2015-12-24 2017-06-29 公益財団法人がん研究会 マルチキナーゼ阻害剤の有効性と安全性を予測する検査方法、検査キット、及びバイオマーカー
WO2020085936A1 (ru) * 2018-10-24 2020-04-30 Общество С Ограниченной Ответственностью "Онкобокс" Тест-классификатор клинического ответа на лечение сорафенибом индивидуальных пациентов с раком почки
US20220088016A1 (en) * 2019-01-02 2022-03-24 Zhejiang Crownmab Biotech Co. Ltd. Cancer treatment using multi-targeted kinase inhibitor in combination of protein kinase biomarkers
CN111521810B (zh) * 2019-02-02 2024-06-21 中国科学院上海药物研究所 癌症患者根据脾酪氨酸激酶进行分层
CN111693707A (zh) * 2020-07-16 2020-09-22 首都医科大学附属北京朝阳医院 Rock激酶活性在辅助诊断血管炎患者中的应用
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ES2813877T3 (es) 2021-03-25
WO2015031604A1 (en) 2015-03-05
DK3039424T3 (da) 2020-08-31
CN105659085A (zh) 2016-06-08
JP2016528914A (ja) 2016-09-23
EP3039424A1 (en) 2016-07-06
CN105659085B (zh) 2018-12-07
US11136625B2 (en) 2021-10-05
EP3039424B1 (en) 2020-07-29
PT3039424T (pt) 2020-09-03
US20160208328A1 (en) 2016-07-21
EP3039424A4 (en) 2017-03-29
JP6612232B2 (ja) 2019-11-27

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