CY1120424T1 - Πεπτιδια λαμβανομενα απο ανθρωπινη bplp πρωτεϊνη, πολυνουκλεοτιδια που κωδικοποιουν τα εν λογω πεπτιδια και αντισωματα κατευθυνομενα εναντι των εν λογω πεπτιδιων - Google Patents

Πεπτιδια λαμβανομενα απο ανθρωπινη bplp πρωτεϊνη, πολυνουκλεοτιδια που κωδικοποιουν τα εν λογω πεπτιδια και αντισωματα κατευθυνομενα εναντι των εν λογω πεπτιδιων

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Publication number
CY1120424T1
CY1120424T1 CY20181100725T CY181100725T CY1120424T1 CY 1120424 T1 CY1120424 T1 CY 1120424T1 CY 20181100725 T CY20181100725 T CY 20181100725T CY 181100725 T CY181100725 T CY 181100725T CY 1120424 T1 CY1120424 T1 CY 1120424T1
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Cyprus
Prior art keywords
polynucleotices
polynectors
peptides
coding
human
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Application number
CY20181100725T
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English (en)
Inventor
Catherine Rougeot
Jean-François HUAULME
Marie-Noëlle UNGEHEUER
Anne Wisner
Evelyne Dufour
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Institut Pasteur
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Application filed by Institut Pasteur filed Critical Institut Pasteur
Publication of CY1120424T1 publication Critical patent/CY1120424T1/el

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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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Abstract

Η εφεύρεση αφορά σε ένα μιμητικό ενός πεπτιδίου το οποίο είναι προϊόν ωρίμανσης της Βασικής πλούσιας σε Προλίνη Δακρυϊκής Πρωτεΐνης (BPLP) ή παράγωγο πεπτιδίου του εν λόγω προϊόντος ωρίμανσης.
CY20181100725T 2004-03-19 2018-07-11 Πεπτιδια λαμβανομενα απο ανθρωπινη bplp πρωτεϊνη, πολυνουκλεοτιδια που κωδικοποιουν τα εν λογω πεπτιδια και αντισωματα κατευθυνομενα εναντι των εν λογω πεπτιδιων CY1120424T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04290754A EP1577320B1 (en) 2004-03-19 2004-03-19 Peptides derived from human BPLP protein, polynucleotides coding for said peptides and antibodies directed against said peptides
EP05708768.6A EP1725579B1 (en) 2004-03-19 2005-03-18 Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides
EP14191558.7A EP2952521B1 (en) 2004-03-19 2005-03-18 Peptides derived from human BPLP protein, polynucleotides coding for said peptides and antibodies directed against said peptides

Publications (1)

Publication Number Publication Date
CY1120424T1 true CY1120424T1 (el) 2019-07-10

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Family Applications (2)

Application Number Title Priority Date Filing Date
CY20151100154T CY1116087T1 (el) 2004-03-19 2015-02-13 Πεπτιδια λαμβανομενα απο ανθρωπινη bplp πρωτεϊνη, πολυνουκλεοτιδια που κωδικοποιουν τα εν λογω πεπτιδια και αντισωματα κατευθυνομενα εναντι των εν λογω πεπτιδιων
CY20181100725T CY1120424T1 (el) 2004-03-19 2018-07-11 Πεπτιδια λαμβανομενα απο ανθρωπινη bplp πρωτεϊνη, πολυνουκλεοτιδια που κωδικοποιουν τα εν λογω πεπτιδια και αντισωματα κατευθυνομενα εναντι των εν λογω πεπτιδιων

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CY20151100154T CY1116087T1 (el) 2004-03-19 2015-02-13 Πεπτιδια λαμβανομενα απο ανθρωπινη bplp πρωτεϊνη, πολυνουκλεοτιδια που κωδικοποιουν τα εν λογω πεπτιδια και αντισωματα κατευθυνομενα εναντι των εν λογω πεπτιδιων

Country Status (17)

Country Link
US (4) US8017571B2 (el)
EP (3) EP1577320B1 (el)
JP (3) JP5049776B2 (el)
CN (2) CN1953988B (el)
AU (1) AU2005223492B2 (el)
CA (1) CA2559215C (el)
CY (2) CY1116087T1 (el)
DK (3) DK1577320T3 (el)
ES (3) ES2390075T3 (el)
HK (1) HK1185894A1 (el)
HU (2) HUE016435T4 (el)
LT (1) LT2952521T (el)
PL (3) PL1577320T3 (el)
PT (3) PT1577320E (el)
SI (2) SI1725579T1 (el)
TR (1) TR201809994T4 (el)
WO (1) WO2005090386A1 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2390075T3 (es) 2004-03-19 2012-11-06 Institut Pasteur Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos
WO2008096276A2 (en) 2007-02-02 2008-08-14 Greenpharma Peptide inhibitors of metallo- ectopeptidases, compositions comprising said compounds and their pharmaceutical and cosmetic uses
WO2009090265A1 (en) * 2008-01-18 2009-07-23 Institut Pasteur Method for identifying bplp and opiorphin agonists or antagonists
PT2274321T (pt) 2008-04-07 2019-03-21 Pasteur Institut Derivados do péptido opiorfina como inibidores potentes da encefalina ¿ degradação de ectopeptidades
FR2931362B1 (fr) * 2008-05-26 2017-08-18 Pasteur Institut L'opiorphine pour une utilisation en tant que psychostimulant.
WO2010028671A1 (en) * 2008-09-09 2010-03-18 Mondobiotech Laboratories Ag Use of opiorphin as a therapeutic agent
WO2010038228A2 (en) * 2008-10-02 2010-04-08 Ramot At Tel Aviv University Ltd. Method and system for emitting light
CA2645452A1 (en) * 2008-11-28 2010-05-28 Institut Pasteur Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker
FR2968560A1 (fr) * 2010-12-13 2012-06-15 Oreal Utilisation de l'ide comme biomarqueur d'un etat du cuir chevelu
KR102422174B1 (ko) * 2016-08-16 2022-07-18 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 악성 종양 표적 펩티드
CN113284553B (zh) * 2021-05-28 2023-01-10 南昌大学 一种用于治疗药物成瘾的药物靶点结合能力测试方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2637600B1 (fr) 1988-10-11 1992-03-06 Pasteur Institut Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques
FR2707169B1 (fr) 1993-06-04 1995-09-01 Pasteur Institut Antigène cellulaire CD26 impliqué dans l'infection par un rétrovirus hiv. nouveaux inhibiteurs de l'infection par HIV. * (Dipeptidyl-peptidase IV).
EP0753069A1 (en) 1994-04-15 1997-01-15 Targeted Genetics Corporation Gene delivery fusion proteins
EP0930831B1 (en) 1996-09-20 2003-07-23 The Howard Foundation Flavonol containing food supplements
US6589750B2 (en) 1997-02-20 2003-07-08 Institut Pasteur Therapeutic use of the SMR1 protein, the SMR1 maturation products, specifically the QHNPR pentapeptide as well as its biologically active derivatives
IT1291113B1 (it) 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
DK1593387T3 (da) 1999-06-23 2009-03-02 Pasteur Institut Sammensætninger for behandling af uhæmmede interpersonelle og adfærdsmæssige forstyrrelser
US6812248B2 (en) 2000-07-05 2004-11-02 John Hopkins University School Of Medicine Prevention and treatment of degenerative diseases by glutathione and phase II detoxification enzymes
EP1216707B1 (en) 2000-12-22 2005-02-09 Institut Pasteur Process for screening ligand molecules that specifically bind to the NEP binding site for the QHNPR pentapeptide
US7119110B2 (en) 2001-10-05 2006-10-10 Interhealth Nutraceuticals Incorporated Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
ES2390075T3 (es) 2004-03-19 2012-11-06 Institut Pasteur Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos
WO2009090265A1 (en) 2008-01-18 2009-07-23 Institut Pasteur Method for identifying bplp and opiorphin agonists or antagonists
PT2274321T (pt) 2008-04-07 2019-03-21 Pasteur Institut Derivados do péptido opiorfina como inibidores potentes da encefalina ¿ degradação de ectopeptidades
FR2931362B1 (fr) 2008-05-26 2017-08-18 Pasteur Institut L'opiorphine pour une utilisation en tant que psychostimulant.
CA2645452A1 (en) 2008-11-28 2010-05-28 Institut Pasteur Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker

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