CY1118046T1 - Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου - Google Patents

Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου

Info

Publication number
CY1118046T1
CY1118046T1 CY20161100950T CY161100950T CY1118046T1 CY 1118046 T1 CY1118046 T1 CY 1118046T1 CY 20161100950 T CY20161100950 T CY 20161100950T CY 161100950 T CY161100950 T CY 161100950T CY 1118046 T1 CY1118046 T1 CY 1118046T1
Authority
CY
Cyprus
Prior art keywords
binding proteins
antigen
antigen specific
amyloid component
amyloid
Prior art date
Application number
CY20161100950T
Other languages
English (en)
Inventor
Tejinder Kaur Bhinder
Susannah Karen Ford
Volker Germaschewski
Alan Peter Lewis
Mark Brian Pepys
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43881068&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118046(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of CY1118046T1 publication Critical patent/CY1118046T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε πρωτεΐνες δέσμευσης με αντιγόνο, όπως αντισώματα, που δεσμεύονται με το συστατικό Ρ αμυλοειδούς ορού (SAP), πολυνουκλεοτίδια που κωδικοποιούν τέτοιες πρωτεΐνες σύνδεσης με αντιγόνο, σε φαρμακευτικές συνθέσεις που περιέχουν τις εν λόγω πρωτεΐνες δέσμευσης με αντιγόνο και σε μεθόδους παραγωγής. Η παρούσα εφεύρεση αφορά επίσης τη χρήση τέτοιων πρωτεϊνών δέσμευσης με αντιγόνο στη θεραπεία ή προφύλαξη νόσων συνδεόμενων με την εναπόθεση αμυλοειδούς όπου περιλαμβάνονται η συστημική αμυλοείδωση, τοπική αμυλοείδωση, νόσος Alzheimer, και διαβήτης τύπου 2.
CY20161100950T 2010-03-03 2016-09-23 Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου CY1118046T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30995710P 2010-03-03 2010-03-03
PCT/EP2011/053038 WO2011107480A1 (en) 2010-03-03 2011-03-01 Antigen binding proteins specific for serum amyloid p component

Publications (1)

Publication Number Publication Date
CY1118046T1 true CY1118046T1 (el) 2017-05-17

Family

ID=43881068

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100950T CY1118046T1 (el) 2010-03-03 2016-09-23 Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου
CY181101126T CY1120803T1 (el) 2010-03-03 2018-10-31 Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY181101126T CY1120803T1 (el) 2010-03-03 2018-10-31 Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου

Country Status (39)

Country Link
EP (2) EP3025729B1 (el)
JP (2) JP5922592B2 (el)
KR (1) KR101817265B1 (el)
CN (1) CN102858371B (el)
AR (1) AR080432A1 (el)
AU (1) AU2011223048C1 (el)
BR (1) BR112012021926A2 (el)
CA (1) CA2789557A1 (el)
CL (1) CL2012002418A1 (el)
CO (1) CO6602134A2 (el)
CR (1) CR20120491A (el)
CY (2) CY1118046T1 (el)
DK (2) DK2542261T3 (el)
DO (1) DOP2012000232A (el)
EA (1) EA026375B1 (el)
ES (2) ES2593454T3 (el)
HK (2) HK1173959A1 (el)
HR (2) HRP20161096T1 (el)
HU (1) HUE028960T2 (el)
IL (2) IL221418A (el)
JO (1) JO3188B1 (el)
LT (2) LT3025729T (el)
MA (1) MA34135B1 (el)
ME (1) ME02491B (el)
MX (1) MX340350B (el)
MY (1) MY159255A (el)
NZ (1) NZ601763A (el)
PE (1) PE20130040A1 (el)
PL (2) PL2542261T3 (el)
PT (2) PT2542261T (el)
RS (2) RS57708B1 (el)
SG (2) SG10201500382SA (el)
SI (2) SI2542261T1 (el)
SM (1) SMT201600337B (el)
TW (1) TWI558409B (el)
UA (1) UA108227C2 (el)
UY (1) UY33258A (el)
WO (1) WO2011107480A1 (el)
ZA (1) ZA201206529B (el)

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SG183316A1 (en) 2012-09-27
MX2012010129A (es) 2012-09-12
EP2542261B1 (en) 2016-07-06
HRP20161096T1 (hr) 2016-11-04
PL3025729T3 (pl) 2019-02-28
UY33258A (es) 2011-09-30
IL251031A0 (en) 2017-04-30
EA201290671A1 (ru) 2013-05-30
EP2542261A1 (en) 2013-01-09
PT2542261T (pt) 2016-09-27
IL221418A (en) 2017-03-30
BR112012021926A2 (pt) 2020-08-25
ES2699078T3 (es) 2019-02-07
ME02491B (me) 2017-02-20
TW201143789A (en) 2011-12-16
CN102858371B (zh) 2017-03-01
LT3025729T (lt) 2018-12-10
EP3025729B1 (en) 2018-09-12
CR20120491A (es) 2013-02-20
WO2011107480A1 (en) 2011-09-09
CY1120803T1 (el) 2019-12-11
HK1223292A1 (zh) 2017-07-28
EA026375B1 (ru) 2017-04-28
NZ601763A (en) 2014-08-29
CO6602134A2 (es) 2013-01-18
SMT201600337B (it) 2016-11-10
EP3025729A1 (en) 2016-06-01
MX340350B (es) 2016-07-06
JP6236478B2 (ja) 2017-11-22
IL221418A0 (en) 2012-10-31
RS57708B1 (sr) 2018-12-31
HK1173959A1 (zh) 2013-05-31
AU2011223048C1 (en) 2018-06-21
AR080432A1 (es) 2012-04-11
LT2542261T (lt) 2016-09-26
PL2542261T3 (pl) 2016-12-30
TWI558409B (zh) 2016-11-21
KR20130027483A (ko) 2013-03-15
SG10201500382SA (en) 2015-03-30
CN102858371A (zh) 2013-01-02
UA108227C2 (xx) 2015-04-10
JP5922592B2 (ja) 2016-05-24
SI2542261T1 (sl) 2016-11-30
DK3025729T3 (en) 2018-11-26
JP2016154535A (ja) 2016-09-01
ZA201206529B (en) 2018-12-19
CL2012002418A1 (es) 2013-03-08
HUE028960T2 (en) 2017-01-30
KR101817265B1 (ko) 2018-01-10
AU2011223048B2 (en) 2013-12-19
PE20130040A1 (es) 2013-02-09
SI3025729T1 (sl) 2018-11-30
HRP20181666T1 (hr) 2018-12-14
ES2593454T3 (es) 2016-12-09
JO3188B1 (ar) 2018-03-08
CA2789557A1 (en) 2011-09-09
PT3025729T (pt) 2018-11-30
AU2011223048A1 (en) 2012-10-04
RS55133B1 (sr) 2016-12-30
DOP2012000232A (es) 2013-01-15
MY159255A (en) 2016-12-30
JP2013521252A (ja) 2013-06-10
MA34135B1 (fr) 2013-04-03
DK2542261T3 (en) 2016-09-19
IL251031A (en) 2017-11-30

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