CY1117688T1 - Ενωσεις τετραϋδροπυρρολοθειαζινης - Google Patents
Ενωσεις τετραϋδροπυρρολοθειαζινηςInfo
- Publication number
- CY1117688T1 CY1117688T1 CY20161100566T CY161100566T CY1117688T1 CY 1117688 T1 CY1117688 T1 CY 1117688T1 CY 20161100566 T CY20161100566 T CY 20161100566T CY 161100566 T CY161100566 T CY 161100566T CY 1117688 T1 CY1117688 T1 CY 1117688T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- tetrahydropyrrolothiazine
- tetrahydropyrrolothiazine compounds
- ch2oh
- och3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ενώσεις του Τύπου I: όπου Α επιλέγεται από την ομάδα που αποτελείται από· (a), (b), (c) και (d), R1 είναι Η ή F· R2 είναι Η, -CH2OH, C1-C3 αλκύλ, (e) ή (f), R3 είναι Η, F, ή CN· R4 είναι Η, F· ή CN· και R5 είναι Η, -CH3, ή -OCH3· ή φαρμακευτικώς αποδεκτό άλας αυτών.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619460P | 2012-04-03 | 2012-04-03 | |
| US201261700960P | 2012-09-14 | 2012-09-14 | |
| US201361758798P | 2013-01-31 | 2013-01-31 | |
| PCT/US2013/033959 WO2013151832A1 (en) | 2012-04-03 | 2013-03-27 | Tetrahydropyrrolothiazine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117688T1 true CY1117688T1 (el) | 2017-05-17 |
Family
ID=48083661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100566T CY1117688T1 (el) | 2012-04-03 | 2016-06-24 | Ενωσεις τετραϋδροπυρρολοθειαζινης |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8629270B2 (el) |
| EP (1) | EP2836495B1 (el) |
| JP (1) | JP6067099B2 (el) |
| CN (1) | CN104185635B (el) |
| AR (1) | AR090474A1 (el) |
| CA (1) | CA2866201C (el) |
| CY (1) | CY1117688T1 (el) |
| DK (1) | DK2836495T3 (el) |
| ES (1) | ES2584827T3 (el) |
| HR (1) | HRP20160674T1 (el) |
| HU (1) | HUE030097T2 (el) |
| JO (1) | JO3143B1 (el) |
| ME (1) | ME02404B (el) |
| PL (1) | PL2836495T3 (el) |
| PT (1) | PT2836495T (el) |
| RS (1) | RS54899B1 (el) |
| SI (1) | SI2836495T1 (el) |
| TW (1) | TWI572610B (el) |
| WO (1) | WO2013151832A1 (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2548774T3 (es) | 2008-01-18 | 2015-10-20 | Eisai R&D Management Co., Ltd. | Derivado de aminodihidrotiazina condensado |
| EP2912041B1 (en) | 2012-10-26 | 2016-12-14 | Eli Lilly and Company | Tetrahydropyrrolothiazine derivatives as bace inhibitors |
| TWI593692B (zh) * | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
| TWI684452B (zh) * | 2014-03-14 | 2020-02-11 | 美國禮來大藥廠 | 胺基噻嗪化合物 |
| TWI570127B (zh) * | 2014-09-15 | 2017-02-11 | 美國禮來大藥廠 | 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物 |
| US20210355138A1 (en) * | 2016-08-11 | 2021-11-18 | Eli Lilly And Company | Aminothiazinies and their use as bace1 inhibitors |
| TWI726329B (zh) | 2018-06-22 | 2021-05-01 | 美商美國禮來大藥廠 | 2,3-二氫呋喃并[2,3-b]吡啶化合物 |
| CN111184725B (zh) * | 2020-02-27 | 2020-12-01 | 慈溪市人民医院医疗健康集团(慈溪市人民医院) | 一种防治脑梗塞的药物制剂及其制备方法 |
| CN111675659B (zh) * | 2020-06-16 | 2022-03-11 | 阿里生物新材料（常州）有限公司 | 一种（5-氟嘧啶-4-基）甲醇的合成方法 |
| CN112263583B (zh) * | 2020-11-23 | 2021-10-22 | 诸城市精神卫生中心 | 一种治疗帕金森疾病的药物及其制备方法 |
| CN113666878A (zh) * | 2021-08-27 | 2021-11-19 | 宁夏常晟药业有限公司 | 一种5-溴-2-氯嘧啶-4-羧酸甲酯的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI332005B (en) | 2005-06-14 | 2010-10-21 | Schering Corp | Aspartyl protease inhibitors |
| JP5383483B2 (ja) * | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| ES2548774T3 (es) | 2008-01-18 | 2015-10-20 | Eisai R&D Management Co., Ltd. | Derivado de aminodihidrotiazina condensado |
| AU2009239536C1 (en) | 2008-04-22 | 2012-12-13 | Merck Sharp & Dohme Corp. | Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use |
| TW201016708A (en) | 2008-09-30 | 2010-05-01 | Eisai R&D Man Co Ltd | Novel fused aminodihydrothiazine derivative |
| AR077277A1 (es) | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
| GB0912778D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| US7964594B1 (en) * | 2009-12-10 | 2011-06-21 | Hoffmann-La Roche Inc. | Amino oxazine derivatives |
| EP2511269A4 (en) | 2009-12-11 | 2013-04-24 | Shionogi & Co | FUSED HETEROCYCLIC COMPOUND HAVING AN AMINO GROUP |
| WO2012162334A1 (en) | 2011-05-24 | 2012-11-29 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| WO2013030713A1 (en) | 2011-08-31 | 2013-03-07 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds |
-
2013
- 2013-03-21 JO JOP/2013/0080A patent/JO3143B1/ar active
- 2013-03-22 AR ARP130100947A patent/AR090474A1/es unknown
- 2013-03-22 TW TW102110358A patent/TWI572610B/zh not_active IP Right Cessation
- 2013-03-27 HU HUE13715556A patent/HUE030097T2/en unknown
- 2013-03-27 PL PL13715556.0T patent/PL2836495T3/pl unknown
- 2013-03-27 DK DK13715556.0T patent/DK2836495T3/en active
- 2013-03-27 CN CN201380017730.6A patent/CN104185635B/zh not_active Expired - Fee Related
- 2013-03-27 PT PT137155560T patent/PT2836495T/pt unknown
- 2013-03-27 ME MEP-2016-117A patent/ME02404B/me unknown
- 2013-03-27 ES ES13715556.0T patent/ES2584827T3/es active Active
- 2013-03-27 SI SI201330189A patent/SI2836495T1/sl unknown
- 2013-03-27 RS RS20160505A patent/RS54899B1/sr unknown
- 2013-03-27 WO PCT/US2013/033959 patent/WO2013151832A1/en active Application Filing
- 2013-03-27 US US13/851,116 patent/US8629270B2/en not_active Expired - Fee Related
- 2013-03-27 CA CA2866201A patent/CA2866201C/en not_active Expired - Fee Related
- 2013-03-27 EP EP13715556.0A patent/EP2836495B1/en active Active
- 2013-03-27 JP JP2015504623A patent/JP6067099B2/ja not_active Expired - Fee Related
- 2013-12-04 US US14/096,443 patent/US8772282B2/en not_active Expired - Fee Related
-
2014
- 2014-05-22 US US14/284,452 patent/US8889856B2/en not_active Expired - Fee Related
-
2016
- 2016-06-14 HR HRP20160674TT patent/HRP20160674T1/hr unknown
- 2016-06-24 CY CY20161100566T patent/CY1117688T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2866201A1 (en) | 2013-10-10 |
| CN104185635B (zh) | 2016-03-09 |
| HUE030097T2 (en) | 2017-04-28 |
| RS54899B1 (sr) | 2016-10-31 |
| JP2015512445A (ja) | 2015-04-27 |
| ES2584827T3 (es) | 2016-09-29 |
| EP2836495B1 (en) | 2016-05-18 |
| SI2836495T1 (sl) | 2016-06-30 |
| JP6067099B2 (ja) | 2017-01-25 |
| EP2836495A1 (en) | 2015-02-18 |
| AR090474A1 (es) | 2014-11-12 |
| JO3143B1 (ar) | 2017-09-20 |
| US8772282B2 (en) | 2014-07-08 |
| WO2013151832A1 (en) | 2013-10-10 |
| TW201400491A (zh) | 2014-01-01 |
| PT2836495T (pt) | 2016-07-18 |
| US20140256933A1 (en) | 2014-09-11 |
| US20130261111A1 (en) | 2013-10-03 |
| CN104185635A (zh) | 2014-12-03 |
| DK2836495T3 (en) | 2016-08-15 |
| ME02404B (me) | 2016-09-20 |
| CA2866201C (en) | 2016-09-20 |
| US20140094454A1 (en) | 2014-04-03 |
| US8629270B2 (en) | 2014-01-14 |
| US8889856B2 (en) | 2014-11-18 |
| PL2836495T3 (pl) | 2016-11-30 |
| TWI572610B (zh) | 2017-03-01 |
| HRP20160674T1 (hr) | 2016-07-15 |
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