CS202591B2 - Process for preparing derivatives of 9-fluorprednisolone - Google Patents

Process for preparing derivatives of 9-fluorprednisolone Download PDF

Info

Publication number: CS202591B2
Authority: CS; Czechoslovakia
Prior art keywords: dione; fluoro; pregnadien; hydroxy; acetone
Prior art date: 1977-03-21

Application number

CS781785A

Other languages

Czech (cs)

English (en)

Inventor

Klaus Annen

Henry Laurent

Helmut Hofmeister

Rudolf Wiechert

Hans Wendt

Joachim-Friedrich Kapp

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-21

Filing date

1978-03-21

Publication date

1981-01-30

1977-03-21 Priority claimed from DE2712862A external-priority patent/DE2712862C2/de

1978-03-03 Priority claimed from DE19782809732 external-priority patent/DE2809732C2/de

1978-03-21 Application filed by Schering Ag filed Critical Schering Ag

1979-03-06 Priority to CS791500A priority Critical patent/CS202592B2/cs

1979-03-06 Priority to CS791501A priority patent/CS202593B2/cs

1981-01-30 Publication of CS202591B2 publication Critical patent/CS202591B2/cs

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CS781785A 1977-03-21 1978-03-21 Process for preparing derivatives of 9-fluorprednisolone CS202591B2 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
CS791500A CS202592B2 (cs)	1977-03-21	1979-03-06	Způsob výroby derivátů 9-fluorprednisolonu
CS791501A CS202593B2 (cs)	1977-03-21	1979-03-06	Způsob výroby derivátů 9-fluorprednisolonu

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2712862A DE2712862C2 (de)	1977-03-21	1977-03-21	Derivate des 9-Fluorprednisolons, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE19782809732 DE2809732C2 (de)	1978-03-03	1978-03-03	Derivate des 9-Fluorprednisolons, Verfahren zu ihrer Herstellung, und pharmazeutische Präparate, die diese Wirkstoffe enthalten

Publications (1)

Publication Number	Publication Date
CS202591B2 true CS202591B2 (en)	1981-01-30

Family

ID=25771793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS781785A CS202591B2 (en)	1977-03-21	1978-03-21	Process for preparing derivatives of 9-fluorprednisolone

Country Status (20)

Country	Link
JP (1)	JPS53130651A (ro)
AT (1)	AT365203B (ro)
AU (1)	AU525614B2 (ro)
CA (1)	CA1104124A (ro)
CH (1)	CH638226A5 (ro)
CS (1)	CS202591B2 (ro)
DD (1)	DD134955A5 (ro)
DK (1)	DK126378A (ro)
ES (1)	ES468107A1 (ro)
FR (1)	FR2384792A1 (ro)
GB (1)	GB1603281A (ro)
GR (1)	GR70385B (ro)
IE (1)	IE46584B1 (ro)
IL (1)	IL54308A (ro)
IT (1)	IT1095477B (ro)
LU (1)	LU79271A1 (ro)
NO (1)	NO151043C (ro)
NZ (1)	NZ186735A (ro)
RO (1)	RO81525B (ro)
SE (1)	SE431656B (ro)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2853785A1 (de) *	1978-12-11	1980-06-19	Schering Ag	Neue prednison-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische praeparate und deren verwendung
JPH07116215B2 (ja) *	1989-04-19	1995-12-13	エスエス製薬株式会社	新規なステロイド化合物
JPH07213320A (ja) *	1994-02-04	1995-08-15	Daiwa:Kk	長尺物用バック

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2055221A1 (en) *	1970-11-10	1972-05-18	Laboratorio Chimico Farmaceutico Dr. P. Blasina S.R.L., Mailand (Italien)	17-acyloxy-3-keto-pregn-4-enes prepn - by acylating 17-hydroxy steroids in presence ofstannic chloride
CH529739A (fr) *	1972-02-28	1972-10-31	Sdc Steroidi Dev Co	Procédé pour la préparation d'un stéroïde de la série des prégnadiènes
US3832366A (en) *	1973-07-30	1974-08-27	Squibb & Sons Inc	Process for preparing 21-chloro-17-acyloxy-20-ketosteroids

1978
- 1978-03-17 CH CH296278A patent/CH638226A5/de not_active IP Right Cessation
- 1978-03-17 DD DD78204259A patent/DD134955A5/xx unknown
- 1978-03-18 RO RO93558A patent/RO81525B/ro unknown
- 1978-03-20 NO NO780984A patent/NO151043C/no unknown
- 1978-03-20 JP JP3225378A patent/JPS53130651A/ja active Granted
- 1978-03-20 SE SE7803168A patent/SE431656B/sv not_active IP Right Cessation
- 1978-03-20 AT AT0195978A patent/AT365203B/de not_active IP Right Cessation
- 1978-03-20 NZ NZ186735A patent/NZ186735A/xx unknown
- 1978-03-20 LU LU79271A patent/LU79271A1/de unknown
- 1978-03-20 GR GR55756A patent/GR70385B/el unknown
- 1978-03-20 GB GB10925/78A patent/GB1603281A/en not_active Expired
- 1978-03-20 IT IT21364/78A patent/IT1095477B/it active
- 1978-03-20 CA CA299,299A patent/CA1104124A/en not_active Expired
- 1978-03-20 IE IE545/78A patent/IE46584B1/en unknown
- 1978-03-20 IL IL54308A patent/IL54308A/xx unknown
- 1978-03-21 CS CS781785A patent/CS202591B2/cs unknown
- 1978-03-21 ES ES468107A patent/ES468107A1/es not_active Expired
- 1978-03-21 AU AU34346/78A patent/AU525614B2/en not_active Expired
- 1978-03-21 FR FR7808099A patent/FR2384792A1/fr active Granted
- 1978-03-21 DK DK126378A patent/DK126378A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
AT365203B (de)	1981-12-28
LU79271A1 (de)	1978-06-29
IE780545L (en)	1978-09-21
IT1095477B (it)	1985-08-10
DD134955A5 (de)	1979-04-04
FR2384792A1 (fr)	1978-10-20
IE46584B1 (en)	1983-07-27
AU525614B2 (en)	1982-11-18
IL54308A0 (en)	1978-06-15
RO81525A (ro)	1983-04-29
JPS6131116B2 (ro)	1986-07-17
GR70385B (ro)	1982-10-05
NO151043C (no)	1985-01-30
SE7803168L (sv)	1978-09-22
AU3434678A (en)	1979-09-27
RO81525B (ro)	1983-04-30
GB1603281A (en)	1981-11-25
NZ186735A (en)	1980-10-24
DK126378A (da)	1978-09-22
NO780984L (no)	1978-09-22
CH638226A5 (en)	1983-09-15
ES468107A1 (es)	1979-07-01
FR2384792B1 (ro)	1980-04-04
IL54308A (en)	1984-03-30
SE431656B (sv)	1984-02-20
JPS53130651A (en)	1978-11-14
NO151043B (no)	1984-10-22
ATA195978A (de)	1981-05-15
IT7821364A0 (it)	1978-03-20
CA1104124A (en)	1981-06-30

Publication	Publication Date	Title
JP3333210B2 (ja)	2002-10-15	新規プレドニソロン誘導体および該化合物を含有する薬剤
JPS6040439B2 (ja)	1985-09-11	ヒドロコルチゾン誘導体
NO156203B (no)	1987-05-04	Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive 6alfa-methylprednisolon-derivater.
HU191539B (en)	1987-03-30	Process for producing new 6,16-dimethyl-corticoides and pharmaceutical compositions containing them
EP0072546B1 (de)	1985-10-09	Neue Hydrocortison-Derivate, ihre Herstellung und Verwendung
HU190746B (en)	1986-10-28	Process for producing 6-alpha-methyl-corticoides and pharmaceutical compositions containing them
US4777165A (en)	1988-10-11	6α, 16β-dimethyl corticoids and their anti-inflammatory use
CS202591B2 (en)	1981-01-30	Process for preparing derivatives of 9-fluorprednisolone
US4243664A (en)	1981-01-06	Novel corticoids
EP0072268B1 (fr)	1985-10-16	Stéroides estérifiés en la position 17 et thioestérifiés en la position 21, leur procédé de préparation et leur application comme médicament
EP0141684B1 (fr)	1987-09-30	17-oxo-21-thioesters d'hydrocortisone, leur préparation et leurs applications comme médicament
JPH0412279B2 (ro)	1992-03-04
US3899581A (en)	1975-08-12	Triamcinolone acetonide derivative
CS231199B2 (en)	1984-10-15	Processing method of derivative of 6alpha-methylhydrokortisone
JPS6129960B2 (ro)	1986-07-10
CS202593B2 (cs)	1981-01-30	Způsob výroby derivátů 9-fluorprednisolonu
DE2809732C2 (de)	1986-04-24	Derivate des 9-Fluorprednisolons, Verfahren zu ihrer Herstellung, und pharmazeutische Präparate, die diese Wirkstoffe enthalten
JPS6150960B2 (ro)	1986-11-06
HU181970B (en)	1983-11-28	Process for preparing new derivatives of 9alpha-fluoro-prednisolone
EP0000609B1 (en)	1981-09-23	Novel 19-nor-pregnahexaenes, process for the preparation thereof, and pharmaceutical compositions containing them
CS244662B2 (cs)	1986-08-14	Způsob výroby nových derivátů 9-chlorprednisolonu
DE2645105A1 (de)	1978-04-06	Neue derivate des 9-chlorprednisolons
CS244663B2 (cs)	1986-08-14	Způsob výroby nových derivátů 9-chlorprednisolonu
CS248730B2 (cs)	1987-02-12	Způsob výroby derivátů Ba-methylkortikoidu
CS199512B2 (cs)	1980-07-31	Způsob výroby kortikoidfi