CR20230235A - Construcciones polipeptídicas que se unen selectivamente a cldn6 y cd3 - Google Patents

Construcciones polipeptídicas que se unen selectivamente a cldn6 y cd3

Info

Publication number
CR20230235A
CR20230235A CR20230235A CR20230235A CR20230235A CR 20230235 A CR20230235 A CR 20230235A CR 20230235 A CR20230235 A CR 20230235A CR 20230235 A CR20230235 A CR 20230235A CR 20230235 A CR20230235 A CR 20230235A
Authority
CR
Costa Rica
Prior art keywords
polypeptide
selectively bind
polynucleotide
construction
cldn6
Prior art date
Application number
CR20230235A
Other languages
English (en)
Inventor
Christoph Dahlhoff
Lars Gaedtke
Silke Quaglia
Jonas Anlahr
Tobias Raum
Julie Bailis
Benjamin M Alba
Elizabeth Dang Pham
Claudia Bluemel
Jonas Honer
Christopher M Murawsky
Original Assignee
Amgen Res Munich Gmbh
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh, Amgen Inc filed Critical Amgen Res Munich Gmbh
Publication of CR20230235A publication Critical patent/CR20230235A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un polipéptido o a una construcción polipeptídica que comprende un dominio que se une a la claudina 6 (CLDN6) y otro dominio que se une a CD3. Así mismo, la invención proporciona un polinucleótido que codifica la construcción, un vector que comprende dicho polinucleótido y una célula huésped transformada o transfectada con dicho polinucleótido o vector. Además, la invención proporciona un procedimiento para producir la construcción de la invención, un uso médico de dicha construcción y un kit que comprende dicha construcción.
CR20230235A 2020-11-06 2021-11-08 Construcciones polipeptídicas que se unen selectivamente a cldn6 y cd3 CR20230235A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063110817P 2020-11-06 2020-11-06
US202163139419P 2021-01-20 2021-01-20
PCT/EP2021/080863 WO2022096700A1 (en) 2020-11-06 2021-11-08 Polypeptide constructs selectively binding to cldn6 and cd3

Publications (1)

Publication Number Publication Date
CR20230235A true CR20230235A (es) 2023-10-05

Family

ID=78820148

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230235A CR20230235A (es) 2020-11-06 2021-11-08 Construcciones polipeptídicas que se unen selectivamente a cldn6 y cd3

Country Status (15)

Country Link
EP (1) EP4240770A1 (es)
JP (1) JP2023547662A (es)
KR (1) KR20230098334A (es)
AU (1) AU2021374036A1 (es)
BR (1) BR112023008629A2 (es)
CA (1) CA3199976A1 (es)
CL (1) CL2023001310A1 (es)
CO (1) CO2023006677A2 (es)
CR (1) CR20230235A (es)
IL (1) IL302586A (es)
MX (1) MX2023005343A (es)
PE (1) PE20231516A1 (es)
TW (1) TW202233679A (es)
UY (1) UY39507A (es)
WO (1) WO2022096700A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024118771A1 (en) 2022-11-30 2024-06-06 Integral Molecular, Inc. Antibodies directed to claudin 6, including bispecific formats thereof

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