CO6630162A2 - Derivados del ácido 1-amino -2-ciclopropiletilboronico - Google Patents
Derivados del ácido 1-amino -2-ciclopropiletilboronicoInfo
- Publication number
- CO6630162A2 CO6630162A2 CO12195461A CO12195461A CO6630162A2 CO 6630162 A2 CO6630162 A2 CO 6630162A2 CO 12195461 A CO12195461 A CO 12195461A CO 12195461 A CO12195461 A CO 12195461A CO 6630162 A2 CO6630162 A2 CO 6630162A2
- Authority
- CO
- Colombia
- Prior art keywords
- cyclopropylethylboronic
- amino
- acid derivatives
- compositions
- treatment
- Prior art date
Links
- MRSJTEYJBNWEFR-UHFFFAOYSA-N (1-amino-2-cyclopropylethyl)boronic acid Chemical class OB(O)C(N)CC1CC1 MRSJTEYJBNWEFR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079156 Proteasome inhibitor Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003207 proteasome inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención proporciona nuevos compuestos útiles como inhibidores de proteasoma. La invención también proporciona composiciones farmacéuticas que comprenden los compuestos de la invención y métodos para usar las composiciones en el tratamiento de diferentes enfermedades.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31946410P | 2010-03-31 | 2010-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6630162A2 true CO6630162A2 (es) | 2013-03-01 |
Family
ID=44710349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12195461A CO6630162A2 (es) | 2010-03-31 | 2012-10-30 | Derivados del ácido 1-amino -2-ciclopropiletilboronico |
Country Status (25)
Country | Link |
---|---|
US (3) | US8513218B2 (es) |
EP (1) | EP2552216B1 (es) |
JP (1) | JP5933523B2 (es) |
KR (1) | KR20130036228A (es) |
CN (3) | CN107266485A (es) |
AR (1) | AR080863A1 (es) |
AU (1) | AU2011235227B2 (es) |
CA (1) | CA2794334C (es) |
CL (1) | CL2012002733A1 (es) |
CO (1) | CO6630162A2 (es) |
CR (1) | CR20120529A (es) |
DO (1) | DOP2012000257A (es) |
EA (1) | EA029521B1 (es) |
EC (1) | ECSP12012249A (es) |
MA (1) | MA34169B1 (es) |
MX (1) | MX2012011298A (es) |
NZ (1) | NZ602622A (es) |
PE (1) | PE20130383A1 (es) |
RU (1) | RU2012146101A (es) |
SG (1) | SG184222A1 (es) |
TN (1) | TN2012000465A1 (es) |
UA (1) | UA110612C2 (es) |
UY (1) | UY33314A (es) |
WO (1) | WO2011123502A1 (es) |
ZA (2) | ZA201207406B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2453556C2 (ru) | 2005-11-09 | 2012-06-20 | Протеоликс, Инк. | Соединения для ингибирования фермента |
NZ613252A (en) | 2006-06-19 | 2015-01-30 | Onyx Therapeutics Inc | Peptide epoxyketones for proteasome inhibition |
CN101883779B (zh) | 2007-10-04 | 2014-08-06 | 欧尼斯治疗公司 | 结晶肽环氧酮蛋白酶抑制剂和氨基酸酮-环氧化物的合成 |
BRPI0915300C1 (pt) | 2008-06-17 | 2021-05-25 | Millennium Pharm Inc | compostos de éster boronato e composições farmacêuticas dos mesmos |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
PE20120059A1 (es) | 2008-10-21 | 2012-02-27 | Onyx Therapeutics Inc | Combinaciones farmaceuticas con epoxicetonas peptidicas |
AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
SG183843A1 (en) | 2010-03-01 | 2012-10-30 | Onyx Therapeutics Inc | Compounds for immunoproteasome inhibition |
JP5933523B2 (ja) | 2010-03-31 | 2016-06-08 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 1−アミノ−2−シクロプロピルエチルボロン酸の誘導体 |
ES2691468T3 (es) | 2010-08-10 | 2018-11-27 | Rempex Pharmaceuticals, Inc. | Derivados de éster del ácido borónico cíclicos y usos terapéuticos de los mismos |
CN104039328B (zh) | 2011-11-11 | 2018-10-09 | 米伦纽姆医药公司 | 对蛋白酶体抑制剂的反应的生物标记 |
US20150184246A1 (en) | 2011-11-11 | 2015-07-02 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
KR20140114391A (ko) | 2011-12-22 | 2014-09-26 | 아레스 트레이딩 에스.에이. | 알파-아미노 보론산 유도체, 선택적 면역프로테아좀 저해인자 |
CA2862492A1 (en) | 2012-01-24 | 2013-08-01 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
JP2015524394A (ja) | 2012-07-09 | 2015-08-24 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ |
CN109096370B (zh) * | 2012-07-26 | 2022-03-18 | 圣特莱国际公司 | 多肽环氧酮化合物 |
EA201591003A1 (ru) | 2013-01-04 | 2015-12-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
BR112016007237A2 (pt) | 2013-10-03 | 2017-09-12 | Millennium Pharm Inc | método para a profilaxia ou tratamento do lúpus eritematoso sistêmico e/ou nefrite lúpica |
EP3092244B1 (en) | 2014-01-10 | 2019-08-14 | Cornell University | Dipeptides as inhibitors of human immunoproteasomes |
WO2015171398A1 (en) | 2014-05-05 | 2015-11-12 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
ES2972939T3 (es) | 2014-05-05 | 2024-06-17 | Melinta Therapeutics Inc | Síntesis de sales de boronato |
EP3145936B1 (en) | 2014-05-19 | 2020-09-30 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
SG10202003693RA (en) | 2014-05-20 | 2020-05-28 | Millennium Pharm Inc | Boron-containing proteasome inhibitors for use after primary cancer therapy |
MX2016016666A (es) * | 2014-07-01 | 2017-08-08 | Rempex Pharmaceuticals Inc | Derivados de acido boronico y usos terapeuticos de los mismos. |
WO2016022955A1 (en) | 2014-08-07 | 2016-02-11 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
EP3193904A4 (en) | 2014-08-18 | 2018-04-11 | Cornell University | Dipeptidomimetics as inhibitors of human immunoproteasomes |
WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
EP4006012A1 (en) | 2015-10-15 | 2022-06-01 | Cornell University | Proteasome inhibitors and uses thereof |
SG11201811549UA (en) | 2016-06-30 | 2019-01-30 | Qpex Biopharma Inc | Boronic acid derivatives and therapeutic uses thereof |
WO2018160717A1 (en) | 2017-02-28 | 2018-09-07 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
WO2019075252A1 (en) | 2017-10-11 | 2019-04-18 | Cornell University | PEPTIDOMIMETIC INHIBITORS OF PROTEASOME |
WO2019075084A1 (en) | 2017-10-11 | 2019-04-18 | Qpex Biopharma, Inc. | BORONIC ACID DERIVATIVES AND SYNTHESIS THEREOF |
US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
EP3781576B1 (en) | 2018-04-20 | 2024-06-12 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ203706A (en) | 1982-04-22 | 1986-03-14 | Squibb & Sons Inc | Occlusive multi-layer wound dressing and hydrocolloidal granules for wound treatment |
US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
US5106948A (en) | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
US5159060A (en) | 1988-05-27 | 1992-10-27 | Mayo Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
DE3827340A1 (de) | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
ATE149563T1 (de) | 1992-08-14 | 1997-03-15 | Procter & Gamble | Alpha-aminoborsäurehaltige flüssige waschmittel |
US5492900A (en) | 1993-09-10 | 1996-02-20 | Neutron Technology Corporation | Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA) |
US6060462A (en) | 1993-10-20 | 2000-05-09 | Dupont Pharmaceuticals Company | Electrophilic peptide analogs as inhibitors of trypsin-like enzymes |
US5574017A (en) | 1994-07-05 | 1996-11-12 | Gutheil; William G. | Antibacterial agents |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5614649A (en) | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
DE69814618T2 (de) | 1997-02-15 | 2004-03-25 | Millenium Pharmaceuticals, Inc., Cambridge | Behandlung von infarkten durch inhibierung von nf-kappab |
EP1017398A1 (en) | 1997-09-25 | 2000-07-12 | Proscript, Inc. | Proteasome inhibitors, ubiquitin pathway inhibitors or agents that interfere with the activation of nf-kb via the ubiquitin proteasome pathway to treat inflammatory and autoimmune diseases |
EP1037626A1 (en) | 1997-12-16 | 2000-09-27 | Cephalon, Inc. | Multicatalytic protease inhibitors for use as anti-tumor agents |
US6169076B1 (en) | 1999-03-31 | 2001-01-02 | Glcosyn Pharmaceuticals, Inc. | P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols |
EP1196436A2 (en) | 1999-07-07 | 2002-04-17 | Bristol-Myers Squibb Pharma Company | Peptide boronic acid inhibitors of hepatitis c virus protease |
US7122627B2 (en) * | 1999-07-26 | 2006-10-17 | Bristol-Myers Squibb Company | Lactam inhibitors of Hepatitis C virus NS3 protease |
PL201411B1 (pl) | 2000-02-29 | 2009-04-30 | Bristol Myers Squibb Co | Zastosowanie entekawiru do wytwarzania kompozycji farmaceutycznej |
US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
EP1355910B1 (en) | 2001-01-25 | 2011-03-09 | The United States of America, represented by the Secretary, Department of Health and Human Services | Formulation of boronic acid compounds |
WO2003033507A1 (fr) | 2001-10-12 | 2003-04-24 | Kyorin Pharmaceutical Co., Ltd. | Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant |
EP1463719A2 (en) | 2002-01-08 | 2004-10-06 | Eisai Co., Ltd | Eponemycin and epoxomicin analogs and uses thereof |
US20060084592A1 (en) | 2002-09-09 | 2006-04-20 | Trigen Limited | Peptide boronic acid inhibitors |
TW200418791A (en) * | 2003-01-23 | 2004-10-01 | Bristol Myers Squibb Co | Pharmaceutical compositions for inhibiting proteasome |
MY162518A (en) * | 2003-08-14 | 2017-06-15 | Cephalon Inc | Proteasome inhibitors and methods of using the same |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
ES2899606T3 (es) | 2004-03-30 | 2022-03-14 | Millennium Pharm Inc | Síntesis de compuestos de ésteres y ácidos borónicos |
BRPI0612607A2 (pt) | 2005-07-05 | 2010-12-07 | Tufts College | inibidores de alfa proteìna de ativação de fibroblasto |
WO2007089618A2 (en) | 2006-01-27 | 2007-08-09 | Phenomix Corporation | Hepatitis c serine protease inhibitors and uses therefor |
WO2009006473A2 (en) | 2007-07-05 | 2009-01-08 | Trustees Of Tufts College | Pro-soft polypeptide proteasome inhibitors, and methods of use thereof |
KR20160040735A (ko) | 2007-08-06 | 2016-04-14 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아좀 억제제 |
US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
BRPI0915300C1 (pt) * | 2008-06-17 | 2021-05-25 | Millennium Pharm Inc | compostos de éster boronato e composições farmacêuticas dos mesmos |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
JP5933523B2 (ja) | 2010-03-31 | 2016-06-08 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 1−アミノ−2−シクロプロピルエチルボロン酸の誘導体 |
-
2011
- 2011-03-30 JP JP2013502789A patent/JP5933523B2/ja not_active Expired - Fee Related
- 2011-03-30 KR KR1020127028506A patent/KR20130036228A/ko not_active Application Discontinuation
- 2011-03-30 CA CA2794334A patent/CA2794334C/en not_active Expired - Fee Related
- 2011-03-30 US US13/075,306 patent/US8513218B2/en not_active Expired - Fee Related
- 2011-03-30 UA UAA201212379A patent/UA110612C2/uk unknown
- 2011-03-30 CN CN201710639537.6A patent/CN107266485A/zh active Pending
- 2011-03-30 MA MA35323A patent/MA34169B1/fr unknown
- 2011-03-30 RU RU2012146101/04A patent/RU2012146101A/ru not_active Application Discontinuation
- 2011-03-30 AU AU2011235227A patent/AU2011235227B2/en not_active Ceased
- 2011-03-30 SG SG2012070595A patent/SG184222A1/en unknown
- 2011-03-30 AR ARP110101066A patent/AR080863A1/es unknown
- 2011-03-30 EP EP11763354.5A patent/EP2552216B1/en active Active
- 2011-03-30 NZ NZ602622A patent/NZ602622A/en not_active IP Right Cessation
- 2011-03-30 CN CN2011800240565A patent/CN102892291A/zh active Pending
- 2011-03-30 EA EA201290980A patent/EA029521B1/ru not_active IP Right Cessation
- 2011-03-30 PE PE2012001810A patent/PE20130383A1/es not_active Application Discontinuation
- 2011-03-30 WO PCT/US2011/030455 patent/WO2011123502A1/en active Application Filing
- 2011-03-30 CN CN201610326909.5A patent/CN106008570A/zh active Pending
- 2011-03-30 MX MX2012011298A patent/MX2012011298A/es unknown
- 2011-03-31 UY UY0001033314A patent/UY33314A/es not_active Application Discontinuation
-
2012
- 2012-09-26 TN TNP2012000465A patent/TN2012000465A1/en unknown
- 2012-09-28 CL CL2012002733A patent/CL2012002733A1/es unknown
- 2012-09-28 DO DO2012000257A patent/DOP2012000257A/es unknown
- 2012-10-03 ZA ZA2012/07406A patent/ZA201207406B/en unknown
- 2012-10-11 EC ECSP12012249 patent/ECSP12012249A/es unknown
- 2012-10-17 CR CR20120529A patent/CR20120529A/es unknown
- 2012-10-30 CO CO12195461A patent/CO6630162A2/es active IP Right Grant
-
2013
- 2013-07-03 US US13/934,989 patent/US8703743B2/en not_active Expired - Fee Related
- 2013-10-30 ZA ZA2013/08086A patent/ZA201308086B/en unknown
-
2014
- 2014-02-25 US US14/189,303 patent/US9023832B2/en active Active
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