CO6321192A2 - Moduladores de diamino-piridina pirimidina y piridazina del receptor h4 de histamina - Google Patents

Moduladores de diamino-piridina pirimidina y piridazina del receptor h4 de histamina

Info

Publication number
CO6321192A2
CO6321192A2 CO10156304A CO10156304A CO6321192A2 CO 6321192 A2 CO6321192 A2 CO 6321192A2 CO 10156304 A CO10156304 A CO 10156304A CO 10156304 A CO10156304 A CO 10156304A CO 6321192 A2 CO6321192 A2 CO 6321192A2
Authority
CO
Colombia
Prior art keywords
diamino
modulators
piridazina
pirimidina
piridina
Prior art date
Application number
CO10156304A
Other languages
English (en)
Inventor
Hui Cai
Frank Chavez
Paul Dunford
Andrew Greenspan
Steven Meduna
Jorge Alfredo Quiroz
Brad M Savall
Kevin L Tays
Robin Thurmond
Jianmei Wei
Ronald L Wolin
Xiaohu Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41417123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6321192(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CO6321192A2 publication Critical patent/CO6321192A2/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Compuestos de diamino-piridina, pirimidina y piridazina que se pueden usar como moduladores del receptor H4, y en composiciones farmacéuticas y métodos para el tratamiento de estados de enfermedad, trastornos, y afecciones mediadas por la actividad del receptor H4, tales como alergia, asma, enfermedades autoinmunes, y prurito.
CO10156304A 2008-06-12 2010-12-13 Moduladores de diamino-piridina pirimidina y piridazina del receptor h4 de histamina CO6321192A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6103908P 2008-06-12 2008-06-12
US11441608P 2008-11-13 2008-11-13
US11442508P 2008-11-13 2008-11-13

Publications (1)

Publication Number Publication Date
CO6321192A2 true CO6321192A2 (es) 2011-09-20

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CO10156304A CO6321192A2 (es) 2008-06-12 2010-12-13 Moduladores de diamino-piridina pirimidina y piridazina del receptor h4 de histamina

Country Status (21)

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US (3) US8841287B2 (es)
EP (1) EP2315521B1 (es)
JP (1) JP5658662B2 (es)
KR (1) KR101600278B1 (es)
CN (1) CN102118969B (es)
AU (1) AU2009257434B2 (es)
BR (1) BRPI0915720A2 (es)
CA (1) CA2727684C (es)
CO (1) CO6321192A2 (es)
CR (1) CR20110029A (es)
EA (1) EA018198B1 (es)
EC (1) ECSP10010675A (es)
HK (1) HK1157569A1 (es)
IL (1) IL209593A (es)
MX (1) MX2010013726A (es)
MY (1) MY158927A (es)
NI (1) NI201000214A (es)
NZ (1) NZ589532A (es)
PE (1) PE20110061A1 (es)
WO (1) WO2009152325A1 (es)
ZA (1) ZA201100298B (es)

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KR101054325B1 (ko) 2006-03-31 2011-08-04 얀센 파마슈티카 엔.브이. 히스타민 ｈ４ 수용체 조절제로서의 벤조이미다졸―２―일 피리미딘 및 피라진
EA019143B1 (ru) * 2008-06-12 2014-01-30 Янссен Фармацевтика Нв Использование антагонистов н4-гистаминовых рецепторов для лечения послеоперационных спаек
MY158927A (en) 2008-06-12 2016-11-30 Janssen Pharmaceutica Nv Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
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