CO4820396A1 - DERIVATIVES OF 1,25-DIHIDROXI-16,22,23-TRISDEHIDRO-COLECALCI- FEROL - Google Patents
DERIVATIVES OF 1,25-DIHIDROXI-16,22,23-TRISDEHIDRO-COLECALCI- FEROLInfo
- Publication number
- CO4820396A1 CO4820396A1 CO97015089A CO97015089A CO4820396A1 CO 4820396 A1 CO4820396 A1 CO 4820396A1 CO 97015089 A CO97015089 A CO 97015089A CO 97015089 A CO97015089 A CO 97015089A CO 4820396 A1 CO4820396 A1 CO 4820396A1
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- lower alkyl
- trisdehidro
- colecalci
- dihidroxi
- Prior art date
Links
- 239000011647 vitamin D3 Substances 0.000 title 1
- 229940021056 vitamin d3 Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 150000002221 fluorine Chemical class 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Liquid Crystal Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto de fórmulaen donde R es hidroxilo y R1 es H2 ó CH2 , ó R es hidrógeno ó flúor y R1 es CH2 . Un procedimiento para la preparación de un compuesto de fórmula I, como se ha descrito en la reivindicación 1, el cual comprende la eliminación de los grupos protectores sililo de un diol o triol correspondientemente sililados, de fórmula I, siendo de preferencia los grupos sililados protectores Si (R4 , R5 R6 ), en donde R4 y R6 son alquilo inferior y R5 es alquilo inferior, arilo o aril-alquilo inferior, y la eliminación del grupo sililo protector se efectúa convenientemente mediante la reacción con una sal de flúor en un disolvente orgánico polar.A compound of formula where R is hydroxyl and R1 is H2 or CH2, or R is hydrogen or fluorine and R1 is CH2. A process for the preparation of a compound of formula I, as described in claim 1, which comprises the removal of the silyl protecting groups from a correspondingly silylated diol or triol, of formula I, the silylated protecting groups being preferably Si (R4, R5 R6), wherein R4 and R6 are lower alkyl and R5 is lower alkyl, aryl or aryl-lower alkyl, and the removal of the protective silyl group is conveniently effected by reaction with a fluorine salt in a solvent organic polar.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1380996P | 1996-03-21 | 1996-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4820396A1 true CO4820396A1 (en) | 1999-07-28 |
Family
ID=21761865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97015089A CO4820396A1 (en) | 1996-03-21 | 1997-03-20 | DERIVATIVES OF 1,25-DIHIDROXI-16,22,23-TRISDEHIDRO-COLECALCI- FEROL |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP0796843B1 (en) |
| JP (1) | JP2801587B2 (en) |
| KR (1) | KR100240541B1 (en) |
| CN (1) | CN1110477C (en) |
| AR (1) | AR006315A1 (en) |
| AT (1) | ATE240941T1 (en) |
| AU (1) | AU708679B2 (en) |
| BR (1) | BR9701404A (en) |
| CA (1) | CA2199893C (en) |
| CO (1) | CO4820396A1 (en) |
| CZ (1) | CZ85897A3 (en) |
| DE (1) | DE69722064T2 (en) |
| DK (1) | DK0796843T3 (en) |
| ES (1) | ES2198512T3 (en) |
| HR (1) | HRP970162A2 (en) |
| HU (1) | HUP9700609A3 (en) |
| ID (1) | ID16285A (en) |
| IL (1) | IL120469A0 (en) |
| MA (1) | MA26423A1 (en) |
| MX (1) | MX9702139A (en) |
| NO (1) | NO971217L (en) |
| NZ (1) | NZ314424A (en) |
| PE (1) | PE42998A1 (en) |
| PL (1) | PL319070A1 (en) |
| PT (1) | PT796843E (en) |
| SG (1) | SG70589A1 (en) |
| TR (1) | TR199700219A2 (en) |
| TW (1) | TW444001B (en) |
| YU (1) | YU10397A (en) |
| ZA (1) | ZA972302B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9625271D0 (en) * | 1996-12-04 | 1997-01-22 | Leo Pharm Prod Ltd | Chemical compounds |
| US6331642B1 (en) * | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| KR101285720B1 (en) * | 2012-03-02 | 2013-07-19 | 주식회사 유니크메디케어 | Composition for improving acne |
| KR102493627B1 (en) | 2015-11-26 | 2023-01-31 | 코웨이 주식회사 | Pharmaceutical Composition Comprising Hordenine as Active Ingredient for Preventing or Treating Skin Cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA8923B (en) * | 1988-01-20 | 1989-09-27 | Hoffmann La Roche | 16-dehydro-vitamin d3-derivatives |
| DE69005897D1 (en) * | 1989-05-18 | 1994-02-24 | Hoffmann La Roche | Dehydrocholecalciferol derivatives. |
-
1997
- 1997-03-06 AU AU15135/97A patent/AU708679B2/en not_active Ceased
- 1997-03-11 SG SG1997000771A patent/SG70589A1/en unknown
- 1997-03-12 PE PE1997000190A patent/PE42998A1/en not_active Application Discontinuation
- 1997-03-13 TW TW086103109A patent/TW444001B/en active
- 1997-03-13 CA CA002199893A patent/CA2199893C/en not_active Expired - Fee Related
- 1997-03-14 DK DK97104387T patent/DK0796843T3/en active
- 1997-03-14 AT AT97104387T patent/ATE240941T1/en not_active IP Right Cessation
- 1997-03-14 DE DE69722064T patent/DE69722064T2/en not_active Expired - Fee Related
- 1997-03-14 EP EP97104387A patent/EP0796843B1/en not_active Expired - Lifetime
- 1997-03-14 PT PT97104387T patent/PT796843E/en unknown
- 1997-03-14 ES ES97104387T patent/ES2198512T3/en not_active Expired - Lifetime
- 1997-03-17 NO NO971217A patent/NO971217L/en not_active Application Discontinuation
- 1997-03-17 NZ NZ314424A patent/NZ314424A/en unknown
- 1997-03-17 ZA ZA9702302A patent/ZA972302B/en unknown
- 1997-03-17 IL IL12046997A patent/IL120469A0/en unknown
- 1997-03-18 JP JP9064030A patent/JP2801587B2/en not_active Expired - Fee Related
- 1997-03-19 HU HU9700609A patent/HUP9700609A3/en unknown
- 1997-03-19 YU YU10397A patent/YU10397A/en unknown
- 1997-03-19 AR ARP970101091A patent/AR006315A1/en not_active Application Discontinuation
- 1997-03-19 HR HR60/013,809A patent/HRP970162A2/en not_active Application Discontinuation
- 1997-03-19 ID IDP970894A patent/ID16285A/en unknown
- 1997-03-20 CZ CZ97858A patent/CZ85897A3/en unknown
- 1997-03-20 PL PL97319070A patent/PL319070A1/en unknown
- 1997-03-20 KR KR1019970009478A patent/KR100240541B1/en not_active IP Right Cessation
- 1997-03-20 CN CN97103358A patent/CN1110477C/en not_active Expired - Fee Related
- 1997-03-20 MX MX9702139A patent/MX9702139A/en not_active IP Right Cessation
- 1997-03-20 BR BR9701404A patent/BR9701404A/en not_active IP Right Cessation
- 1997-03-20 TR TR97/00219A patent/TR199700219A2/en unknown
- 1997-03-20 CO CO97015089A patent/CO4820396A1/en unknown
- 1997-03-21 MA MA24528A patent/MA26423A1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR910007525A (en) | Wool | |
| KR930703317A (en) | Method for preparing imidazo [4,5-c] quinolin-4-amine | |
| ES2191005T3 (en) | SUBSTITUTED TAXANS AS ANTITUMOR AGENTS. | |
| ES8307763A1 (en) | Novel N-aryl-piperazinealkanamides. | |
| CO4700455A1 (en) | TETRACYCLIC DERIVATIVES AND THE PROCESS FOR THEIR PREPARATION | |
| ES2051693T3 (en) | PROCEDURE FOR PREPARING SULFONAMIDE BICYCLE COMPOUNDS. | |
| CA2420996A1 (en) | Substituted heterocyclic compounds for treating multidrug resistance | |
| ES2221440T3 (en) | AMINOPHENOXYACETIC ACID DERIVATIVES AS NEUROPROTECTORS. | |
| ES2101044T3 (en) | ALCOXY TAXANES SUBSTITUTED AS ANTITUMORAL AGENTS. | |
| FI956270A0 (en) | Piperine derivatives and process for their preparation | |
| CO5170498A1 (en) | BIARIL SULFONAMIDS ARE USEFUL AS CELL PROLIFERATION INHIBITORS | |
| ATE180258T1 (en) | METHOD FOR PRODUCING TAXAND DERIVATIVES | |
| KR950702976A (en) | Benzopyrans and benzoxazine derivatives [BENZOPYRAN AND BENZOXAZINE DERIVATIVES] | |
| EP0761759A3 (en) | Curable silicon compositions, process for their preparation and their use | |
| ATE377593T1 (en) | 9,10-ALPHA,ALPHA-OH-TAXANE ANALOGUE AND METHOD FOR THE PRODUCTION THEREOF | |
| CO4820396A1 (en) | DERIVATIVES OF 1,25-DIHIDROXI-16,22,23-TRISDEHIDRO-COLECALCI- FEROL | |
| KR950014125A (en) | Process for preparing 2,2-difluoroketen silyl acetal and α, α-difluoro-β-silyloxy-1,3-dioxolane-4-propanoic acid ester | |
| KR840005464A (en) | Process for preparing phospholipid derivative | |
| PE25998A1 (en) | DERIVATIVES OF OCTAHIDRO-PIRROLO (1,2-a) -PIRAZINA 2,7-SUBSTITUTED | |
| HUP9802455A2 (en) | Use of piperidine compounds for producing polypropylene | |
| EP0139221A3 (en) | Substituted dihydroazepines useful as calcium channel blockers, methods for preparing and compositions containing the same | |
| KR840006233A (en) | Method for preparing thiophene derivative | |
| DE69820481D1 (en) | METHOD FOR PRODUCING CHOLECALCIFEROL DERIVATIVES AND INTERMEDIATE COMPOUNDS | |
| ES2195815T3 (en) | PROCEDURE TO PURIFY ORGANIC ISOCIANATES. | |
| ES2073153T3 (en) | PHOSPHORUS COMPOUNDS. |