CN2382019Y

CN2382019Y - Bioreagent plate

Info

Publication number: CN2382019Y
Application number: CN99217522U
Authority: CN
Inventors: 牛刚; 张扬; 高德禄
Original assignee: Individual
Current assignee: Individual
Priority date: 1999-08-03
Filing date: 1999-08-03
Publication date: 2000-06-07
Anticipated expiration: 2009-08-03
Also published as: AU6257900A; WO2001009619A1

Abstract

The utility model relates to a disposable biochemical reagent plate which is exclusively used for a full automatic biochemical analyzer and is used for replacing a cuvette to detect samples. The biochemical reagent plate is characterized in that the biochemical reagent plate forms a plate-shaped body, the center of the plate-shaped body 2 is provided with a through hole 3, biochemical reagents are previously injected into the through hole and both ends of the through hole are sealed by transparent materials. The biochemical reagents which are previously injected into the through hole are standard liquid, or reaction reagents with accurate quantities, or reaction solutions. The plate-shaped body is made of plastic. The disposable biochemical reagent plate can enhance the detection speed and the detection precision of a biochemical analyzer, and simplify the detection working procedures.

Description

Biochemical reagent plate

The utility model relates to a kind of disposable biochemical reagent plate that is exclusively used in automatic clinical chemistry analyzer, is used to replace cuvette sample is detected.

Biochemical Analyzer has developed extremely rapidly since 1950's end emerges, and it can be applicable to numerous areas such as medicine, food, environment, clinical medicine.Particularly in clinical medicine, use quite extensive, because its effect mainly is that the various biochemical indicators in the blood of human body are carried out assay determination, instruct the clinician that the patient is made diagnosis accurately, it has been an exhausted indispensable detecting instrument in the hospital work.The development of Biochemical Analyzer is to have passed through original manual operations equally, and the index that can detect is less, progressively develops into semi-automatic biochemical analyzer and present most widely used automatic clinical chemistry analyzer.The index that detects also present can be carried out the detection of more than 60 project by original several developing into.The for example detection of the biochemical indicator that changes of three, five of blood fat (cholesterol, glycerine three refer to, lipoprotein or the like), reflecting myocardiums.

At present, most widely used automatic clinical chemistry analyzer is to adopt double reagent, two reaction principle, detects and analyzes with colourimetry.The testing process is: earlier the blood serum sample with the experimenter quantitatively adds cuvette, adds in the same cuvette after quantitatively drawing reaction reagent and dilution with full-automatic syringe, mixes with the method for colorimetric and measures.Before carrying out next sample detection, need to clean all used motoring syringe and cuvettes; Also want the bubble supervisor in the discharge line.Because its is multiple functional, speed is fast, and advantage is to have given prominence to, and needs solution and improved part also just to display more highlightedly.Such as: it has complicated structure, and it costs an arm and a leg; Repeatedly the probability of sampling error appearance is big; Purging system is huge, increases the expense that detects; The use of standard items is check and correction of carrying out self relatively, and expensive or the like.Even like this, because the rigorous and years of development that it designs self has been tending towards perfect.

At adopting the existing deficiency of cuvette, the purpose of this utility model in the above-mentioned existing Biochemical Analyzer is a kind of disposable biochemical reagent plate of design, improves the detection speed and the precision of Biochemical Analyzer, simplifies and detects operation.

The main technical schemes that realizes above-mentioned purpose is: this biochemical reagent plate, it is characterized in that it is tabular body, and have a through hole 3 in the central authorities of tabular body 2, in through hole 3, be injected with biochemical reagents in advance, the two ends of through hole 3 seal with transparent material.Also the biochemical reagents that inject in advance in through hole 3 are titers.Perhaps the biochemical reagents that inject in advance in through hole 3 are reaction reagent or reaction solutions of accurately amount, the upper end of a snorkel 7 to tabular body 2 drawn in the top of through hole 3, have a hole 5 in the upper end of tabular body 2, this hole is with sealing the film sealing, the lower end in hole is an inner chamber 6 in tabular body, inject thinning agent in the inner chamber 6 in advance, inner chamber 6 is connected with snorkel 7 by a groove, air hole and groove connecting place be provided with can the controlling liquid directed flow control device 8.Perhaps also be provided with inner chamber 9 in tabular body 3, inject the another kind of accurately reaction reagent or the reaction dissolvent of amount in the inner chamber 9 in advance, inner chamber 9 also is connected with snorkel 7 by control device 8.Described control device 8 is snap switch, mechanical three-way, rotary switch, move horizontally switch or electromagnetic switch.This tabular body adopts the plastics manufacturing.

The utility model has the advantages that: 1. owing to the biochemical reagents and the dilution that participate in reaction all quantitatively add at workshop, sampling, the inaccurate problem of application of sample dosage of having avoided general Biochemical Analyzer to occur, the testing result favorable reproducibility, be easy to carry out large-scale quality control, the testing result comparability of different instruments is strong.2. stay-in-grade biochemical reagents on-gauge plate can be demarcated, proofread and correct instrument at any time, compares more accurately and reliably with demarcation, the trimming process of traditional Biochemical Analyzer, operates simplyr, has saved the titer as consumables.3. in the sensitivity that guarantees test sample, greatly reduce manufacturing, the maintenance cost of instrument, make hospital and patient all reduce expenditure.4. board-like wet type automatic clinical chemistry analyzer does not need consumables and supporting with it equipment such as dilution, cleaning fluid, deionized water, not only saved expense, and reduced the chance that pollution takes place with sample room between reagent, and saved the time that is used to clean, improved detection speed.5. the biochemical reagent plate after detecting is easy to handle as solid waste.6. a plurality of reactors can be installed, make it to carry out the continuous detecting of agent plate, detection speed is accelerated.

Below in conjunction with accompanying drawing the utility model is described in further detail:

Fig. 1 is the structural representation of standard biochemical reagent plate.

Fig. 2 is the structural representation of single reagent biochemical reagent plate.

Fig. 3 is the structural representation of double reagent biochemical reagent plate.

The standard biochemical reagent plate sees also Fig. 1, can complete the biochemical reagent plate of standard to demarcation, the correction of instrument at workshop.The titer of Packed concentration known in the standard biochemical reagent plate can repeatedly use in the quite long term of validity, and deviation should not appear in the accuracy height.And the demarcation of traditional Biochemical Analyzer, proofread and correct and to need quota of expenditure liquid, also need cleaning process, what carry out is the correction of self, deviation very easily takes place in Quality Control on a large scale.Standard biochemical reagent plate 1 tabular body 2 made of plastic, its length * wide * thick size can be: 40mm * 25mm * 4mm, central authorities at tabular body 2 open a through hole 3, inject titer in advance, and the two ends that the through hole 3 of titer will be housed with transparent material are sealed again.

Consult Fig. 1, Fig. 2, Fig. 3, three kinds of designed biochemical reagents of the utility model all have common feature, promptly integral body is tabular body, central authorities at tabular body have a through hole 3, be injected with biochemical reagents in through hole 3 in advance, said here biochemical reagents can be titers, also can be reaction reagent or reaction dissolvent, two ends with through hole 3 seal with transparent material then, so that observe the color of biochemical reagents from external energy.When its during as single reagent or double reagent biochemical reagent plate, its inner structure need make the following changes:

As shown in Figure 2, the specification of single reagent biochemical reagent plate 4 is with standard biochemical reagent plate 1, also adopt plastics to make, central authorities at tabular body 2 open a through hole 3, inject the accurately reaction reagent or the reaction dissolvent of amount in advance, seal with transparent material again, form a reactive tank, these reactive tank 3 tops are provided with the upper end of a snorkel 7 straight-through tabular bodys 2, a side has hole 5 in the upper end of tabular body 2, and these hole 5 usefulness are sealed the film sealing, and 5 belows, hole are inner chambers 6, inject dilution in inner chamber 6 in advance, inner chamber 6 links to each other with snorkel 7 by control device 8.During use, seal film and be pierced back adding sample, as blood serum sample, sample injects in the inner chamber 6 diluted, operating control device 8 makes diluted sample mix with reaction reagent by flowing in the reactive tank 3 in the inner chamber 6, when reaction finishes, again liquid color in the reactive tank and standard biochemical reagent plate are compared, can obtain accurate data.

The detection of some sample needs two kinds of reagent just can finish, designed double reagent biochemical reagent plate 10 shown in Figure 3 for this reason, its shape and structure and Fig. 2 are basic identical, difference is also to be provided with an inner chamber 9 in tabular body 2, inject second kind of reaction reagent in advance, inner chamber 9 communicates with control device 8.

Above-mentioned control device is meant the device of the directed flow that all can controlling liquid, for example snap switch, mechanical three-way, rotary switch, move horizontally switch, electromagnetic switch, gas switch etc.

The utility model is produced disposable reagent plate by injection moulding, and the reagent that will participate in reaction in workshop is packed in the agent plate ground reactive tank in advance quantitatively, by the control device on control and the adjusting agent plate, make it when detection is subjected to the sample product, only need quantitatively to add sample in the biochemical reagent plate, the quantitative reaction reagent and the dilution that seal in advance in the biochemical reagent plate are mixed with the reactive tank of sample on biochemical reagent plate, inner chamber 6 on the agent plate or 9 flows into next reactive tank through the passage orientation under the control of control device, finish next step reaction, question response finishes, carry out colorimetric estimation again, colorimetric estimation is finished by Biochemical Analyzer.

Claims

1. a biochemical reagent plate is characterized in that it is tabular body, has a through hole (3) in the central authorities of tabular body (2), is injected with biochemical reagents in advance in through hole (3), and the two ends of through hole (3) seal with transparent material.

2. biochemical reagent plate according to claim 1 is characterized in that the biochemical reagents that inject in advance are titers in through hole (3).

3. biochemical reagent plate according to claim 1, it is characterized in that the biochemical reagents that inject in advance are reaction reagent or reaction solutions of accurately amount in through hole (3), the upper end of a snorkel (7) to tabular body (2) drawn in the top of through hole (3), have a hole (5) in the upper end of tabular body (2), this hole is with sealing the film sealing, the lower end in hole is an inner chamber (6) in tabular body, inner chamber injects thinning agent in (6) in advance, inner chamber (6) is connected with snorkel (7) by a groove, air hole and groove connecting place be provided with can the controlling liquid directed flow control device (8).

4. biochemical reagent plate according to claim 3, it is characterized in that in tabular body (3), also being provided with inner chamber (9), inject the another kind of accurately reaction reagent or the reaction dissolvent of amount in the inner chamber (9) in advance, inner chamber (9) also is connected with snorkel (7) by control device (8).

5. according to claim 3 or 4 described biochemical reagent plates, it is characterized in that control device (8) is snap switch, mechanical three-way, rotary switch, moves horizontally switch or electromagnetic switch.

6. according to claim 1 or 2 or 3 or 4 described biochemical reagent plates, it is characterized in that tabular body adopts the plastics manufacturing.