CN209966387U

CN209966387U - Trace sample collecting tube for automatic sample introduction

Info

Publication number: CN209966387U
Application number: CN201821970111.5U
Authority: CN
Inventors: 胡力坚
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2018-05-31
Filing date: 2018-11-27
Publication date: 2020-01-21
Anticipated expiration: 2028-11-27
Also published as: CN110553877A

Abstract

A micro sample collecting tube for automatic sample introduction comprises a tube body and a closing body. The tube body is provided with a containing cavity for containing a blood sample and a supporting part for inserting into a sample rack of the sample rack for supporting. Accept chamber one end opening and form the import, the supporting part extends the setting to one side of keeping away from the opening from the outside diapire of accepting the chamber. The length of the trace sample collecting tube is increased by the supporting part, so that the trace sample collecting tube can be suitable for a conventional sample rack, and a bar code can be conveniently adhered to the trace sample collecting tube. Moreover, the closing body is provided with a puncture structure which can enable the sampling device to pass through and be inserted into the containing cavity, so that the sampling device can pass through the closing body and enter the containing cavity, manual opening of the closing body is not needed, and the micro sample collecting tube can be suitable for automatic sample feeding operation in large batch.

Description

Trace sample collecting tube for automatic sample introduction

Technical Field

The application relates to a medical instrument, in particular to a trace sample collecting tube for automatic sample introduction.

Background

During sample analysis, a sample is first collected. For example, blood sample testing requires the collection of a certain amount of sample from a patient. Two common blood sampling methods are available: venous blood and peripheral blood were collected. The venous blood sampling mode is suitable for adult patients; in the case of infants, children, or critically ill patients, it is sometimes difficult to collect blood by intravenous means, and in such cases, peripheral blood is often collected. There are two ways to collect peripheral blood: (1) sucking peripheral blood into the capillary tube by using the capillary tube, and then pumping the blood sample into the micro blood collection tube; (2) scraping peripheral blood into the blood collecting tube by using the blood collecting tube with a blood scraping end.

The most of the closures of the micro blood collection tubes on the market at present are made of hard materials such as plastics, and the closures are connected with the tube bodies through threads (air release is facilitated). The micro blood collection tube structure is not suitable for being punctured by a sample sucking needle when blood is collected, the sample sucking needle can be directly damaged by the sample sucking needle due to the fact that the sample sucking needle is punctured by a hard material or the service life of the sample sucking needle is seriously influenced, and blood samples can be polluted by chips generated by the puncture hard material falling into the blood collection tube. Therefore, the enclosure is generally required to be opened, and the operation needs to be performed manually, which is not favorable for a large-batch automatic sample feeding mode. Moreover, this trace heparin tube is short and small usually, inconvenient pasting the bar code, the difference is great for the height of the relative trace heparin tube of the degree of depth that conventional sample frame was used for placing the chamber of placing the heparin tube, make the trace heparin tube hardly carry out batch sample introduction through conventional sample frame, and the specially-made sample frame to this kind of trace heparin tube generally does the fastener on heparin tube hole upper portion or the protruding portion is done to the tube hole lower part so that rise the high convenient appearance of introducing of trace heparin tube, but the inconvenient problem of posting the bar code of trace heparin tube can not be solved to these two kinds of modes, thereby probably lead to heparin tube bar code information can't be by automatic identification.

Disclosure of Invention

The application provides a neotype a trace sample collection pipe for autoinjection.

According to an aspect of the present application, there is provided in one embodiment a micro sample collection tube for autosampling, comprising:

the blood sample collecting device comprises a tube body and a blood sample collecting device, wherein the tube body is provided with a containing cavity for containing a blood sample and a supporting part for supporting when being inserted into a sample rack, an inlet is formed in one end of the containing cavity through an opening, and the supporting part extends from the bottom wall of the outer side of the containing cavity to one side far away from the opening;

and a closure for closing the inlet, the closure having a piercing structure for enabling a sampling device to be inserted through and into the receiving cavity.

As a further improvement of the micro sample collecting tube, the supporting part comprises a supporting side wall formed by extending downwards from the edge of the bottom wall outside the containing cavity, and the supporting side wall is enclosed into a cylindrical structure.

As a further improvement of the micro sample collecting tube, the puncture structure comprises a puncture area corresponding to the inlet of the accommodating cavity, and at least the puncture area in the closing body is made of a flexible material which can be penetrated by a sampling device.

As a further improvement of the micro sample collection tube, the closing body comprises a cap body and a cover film, the cap body is connected with the tube body, the cap body is provided with an annular top wall, the cover film is hermetically installed on the inner ring of the annular top wall, and at least one part of the cover film is a puncture area.

As a further improvement of the micro sample collecting tube, the closing body adopts a cover sealing film, the cover sealing film is covered on the inlet of the tube body in a sealing mode, and the hanging part of the cover sealing film is a puncture area.

As a further improvement of the micro sample collection tube, the micro sample collection tube further comprises a cover body which covers the closing body so as to prevent external contamination, such as dust.

As a further improvement of the micro sample collecting tube, the micro sample collecting tube further comprises a cover body, wherein the cover body covers the cover sealing film and the tube body, and the cover sealing film is provided with a reserved opening for the capillary tube to enter and exit.

As a further improvement of the trace sample collecting tube, the flexible material for manufacturing the puncture area has elasticity, the side part of the puncture area is provided with a through exhaust notch, and the exhaust notch is communicated with the accommodating cavity and used for exhausting when the air pressure in the accommodating cavity is too high.

As a further improvement of the trace sample collecting tube, a cut mark which is convenient for puncturing the puncture area is arranged in the puncture area.

As a further improvement of the trace sample collection tube, the puncture structure comprises a puncture area corresponding to the inlet of the accommodating cavity, at least the puncture area in the closing body is made of elastic flexible material, and a through notch is formed in the puncture area and leads to the accommodating cavity for enabling the sampling device to pass in and out of the accommodating cavity through the notch.

As a further improvement of the trace sample collecting tube, the whole closing body is made of elastic materials, and the tube body is tightly matched or clamped and fixed with the closing body.

As a further improvement of the micro sample collecting tube, the closing body is made of rubber or rubber compound.

As a further improvement of the micro sample collecting tube, the closing body is provided with a connecting cylinder body used for being matched with the side wall of the containing cavity and a transverse partition body used for closing the interior of the connecting cylinder body, and at least one part of the transverse partition body is a puncture area.

As a further improvement of the trace sample collection tube, a through cut is arranged in the puncture area of the transverse partition body, and the connecting cylinder body has a radial size larger than that of the accommodating cavity, so that the connecting cylinder body can be squeezed after being accommodated in the accommodating cavity and the cut is urged to be kept closed after puncture.

As a further improvement of the micro sample collecting tube, the closing body further comprises an outer cylinder body and a top cover, the outer cylinder body is sleeved outside the connecting cylinder body and forms a clamping cavity capable of clamping the side wall of the tube body with the connecting cylinder body, the upper end of the outer cylinder body is communicated with the upper end of the connecting cylinder body through the top cover, and the top cover is provided with an opening leading to the transverse partition body.

As a further improvement of the micro sample collecting tube, the closing body is provided with an outer cylinder body, a connecting cylinder body and a transverse partition body, the connecting cylinder body is used for being matched with the side wall of the containing cavity, at least one part of the transverse partition body is a puncture area, the outer cylinder body is positioned on the outer side of the connecting cylinder body and is connected with the connecting cylinder body to form a clamping cavity capable of clamping the side wall of the tube body, the upper end of the outer cylinder body is higher than the upper end of the connecting cylinder body, and the part of the outer cylinder body higher than the upper end of the connecting cylinder body forms a receiving cavity for receiving the transverse partition body.

As a further improvement of the trace sample collecting tube, the inner cavity wall of the receiving cavity is provided with a mounting groove or a mounting protrusion, and the transverse partition body is clamped in the mounting groove or provided with a clamping groove matched with the mounting protrusion.

As a further improvement of the micro sample collection tube, the mounting grooves or the mounting protrusions are annularly distributed on the inner cavity wall of the receiving cavity.

As a further improvement of the micro sample collecting tube, the inner diameter of the mounting groove is smaller than the outer diameter of the transverse partition body, so that the groove wall of the mounting groove can extrude the transverse partition body.

As a further improvement of the micro sample collecting tube, the mounting groove is provided with an upper side wall and a lower side wall, and the upper side wall and the lower side wall clamp the transverse partition body from the upper side and the lower side of the transverse partition body so as to fix the transverse partition body in the mounting groove.

As a further improvement of the micro sample collecting tube, the micro sample collecting tube comprises a pressing member for pressing the cross spacer in the mounting groove, the mounting groove has an upper side wall and a lower side wall, the lower side of the cross spacer is placed on the lower side wall, the pressing member abuts against the upper side of the cross spacer, and the upper side wall presses the pressing member to fix the cross spacer in the mounting groove.

As a further improvement of the micro sample collection tube, the compression member has an opening leading to the cross-partition.

As a further improvement of the micro sample collection tube, the micro sample collection tube further comprises a cover body covering the closing body.

As a further improvement of the micro sample collecting tube, the accommodating cavity is provided with a bottom in the shape of a paraboloid of revolution, a semiellipsoid, a hemisphere or an inverted cone.

As a further improvement of the trace sample collecting tube, the tube body further comprises a blood scraping plate for scraping blood, and the blood scraping plate is convexly arranged at the inlet of the accommodating cavity.

As a further improvement of the trace sample collecting tube, the length A of the tube body has the following value range: a is more than or equal to 45mm and less than or equal to 90 mm.

As a further improvement of the trace sample collection tube, the volume V of the accommodating cavity ranges from: v is more than or equal to 0.2ml and less than or equal to 2 ml.

and the closing body is detachably connected with the opening of the pipe body, the closing body is made of rubber or rubber compound, and the closing body comprises a transverse partition body which is radially arranged in the accommodating cavity of the pipe body.

As a further improvement of the micro sample collection tube, the transverse partition body is provided with a through cut.

As a further improvement of the micro sample collection tube, the notch is formed by two intersecting elongated slits, and the intersection point of the two intersecting elongated slits is located in the center of the transverse partition.

As a further improvement of the micro sample collection tube, the notch is arranged at the side of the transverse partition body.

As a further improvement of the micro sample collection tube, the closing body is provided with a connecting cylinder body used for being matched with the side wall of the containing cavity, the transverse partition body is used for closing the inside of the connecting cylinder body, and the connecting cylinder body is provided with a radial size larger than the containing cavity, so that the connecting cylinder body can be squeezed after being loaded into the containing cavity and the cut opening can be kept closed after puncture.

As a further improvement of the micro sample collecting tube, a part of the opening of the tube body forms a plate-shaped bulge. As a further improvement of the micro sample collecting tube, the length a of the micro sample collecting tube has a value range of: a is more than or equal to 45mm and less than or equal to 90 mm; the volume V of the accommodating cavity is in the range: v is more than or equal to 0.5ml and less than or equal to 1.5 ml.

The micro sample collection tube according to the above embodiment includes a tube body and a sealing body. The tube body is provided with a containing cavity for containing a blood sample and a supporting part for inserting into a sample rack of the sample rack for supporting. Accept chamber one end opening and form the import, the supporting part extends the setting to one side of keeping away from the opening from the outside diapire of accepting the chamber. The length of the trace sample collecting tube is increased by the supporting part, so that the trace sample collecting tube can be suitable for a conventional sample rack, and a bar code can be conveniently adhered to the trace sample collecting tube. Moreover, the closing body is provided with a puncture structure which can enable the sampling device to pass through and be inserted into the containing cavity, so that the sampling device can pass through the closing body and enter the containing cavity, manual opening of the closing body is not needed, and the micro sample collecting tube can be suitable for automatic sample feeding operation in large batch.

Drawings

FIGS. 1 and 2 are schematic views of a micro sample collection tube in both closed and open states according to one embodiment of the present disclosure;

FIG. 3 is a cross-sectional view of a micro sample collection tube in a closed position according to one embodiment of the present disclosure;

FIG. 4 is a cross-sectional view of a closure in one embodiment of the present application;

FIG. 5 is a schematic view of a cross-cut in the closure according to one embodiment of the present application;

FIG. 6 is a schematic view of an in-line vent in an enclosure according to an embodiment of the present application;

FIG. 7 is a schematic view of a sampling needle inserted into the closure of FIG. 6 in one embodiment of the present application;

FIGS. 8a and 8b are schematic views of a split design of a cap and a lidding film in a closure according to an embodiment of the present application;

FIGS. 9 and 10 are schematic illustrations of an embodiment of the present application in which the closure utilizes a lidding film;

FIGS. 11 and 12 are schematic views of the structure of cuts in a lidding film according to one embodiment of the present application;

FIG. 13 is a schematic view of a capillary blood collection configuration employing the closure of FIGS. 11 and 12;

FIGS. 14 and 15 are schematic illustrations of an embodiment of the present application in which the closure utilizes a lidding film with a cut-out;

FIG. 16 is a schematic view of a micro sample collection tube according to an embodiment of the present disclosure;

FIG. 17 is an exploded view of the micro sample collection tube of FIG. 16;

FIG. 18 is a cross-sectional view of the micro sample collection tube of FIG. 16;

FIG. 19 is a cross-sectional view of the outer barrel and the connecting barrel of the micro sample collection tube;

FIG. 20 is a schematic view of a septum in a microsample collection tube;

FIG. 21 is an exploded view of a micro sample collection tube according to an embodiment of the present application;

FIG. 22 is a cross-sectional view of the micro sample collection tube of FIG. 21.

Detailed Description

Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.

Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).

The present embodiment provides a micro sample collection tube applicable to an automatic sample introduction type sample analyzer, and more particularly to a micro sample collection tube applicable to a blood analyzer.

The micro sample collecting tube comprises a tube body and a closing body for closing the tube body. The tube body is provided with an accommodating cavity for accommodating a blood sample and a supporting part for supporting when the tube body is inserted into the sample rack, an inlet is formed at one end opening of the accommodating cavity, and the supporting part extends from the outer bottom wall of the accommodating cavity to one side far away from the opening. The closure member may be removably or non-removably secured to the tube and has a piercing structure for allowing the sampling device to be inserted through and into the receiving cavity.

Wherein, the puncture structure that can make the sampling device pass and insert and accept the chamber can be realized through setting up the material that can be punctured by the sampling device or setting up the opening that can supply the sampling device to pass through.

The length of the trace sample collecting tube is increased by the supporting part of the trace sample collecting tube, so that the trace sample collecting tube is suitable for a conventional sample rack and is convenient for the trace sample collecting tube to be adhered with a bar code. Moreover, the closing body is provided with a puncture structure which can enable the sampling device to pass through and be inserted into the containing cavity, so that the sampling device can pass through the closing body and enter the containing cavity, manual opening of the closing body is not needed, and the micro sample collecting tube can be suitable for automatic sample feeding operation in large batch.

The present invention will be described in further detail with reference to the following detailed description and accompanying drawings.

The first embodiment is as follows:

the present embodiments provide a micro sample collection tube.

Referring to fig. 1-3, the micro sample collection tube 1 includes a tube body 2 and a closure body 3.

The tube 2 has a chamber 21 for receiving a blood sample and a support 23 for inserting into a sample holder for supporting. The receiving chamber 21 is open at one end to form an inlet. The supporting portion 23 extends from the outer bottom wall of the containing cavity 21 to a side away from the opening, and the collected peripheral blood can be contained in the containing cavity 21 through the inlet for standby.

The closing body 3 is detachably connected with the tube body 2 to enclose the containing cavity 21 into a closed cavity. Referring to fig. 3, in an embodiment, the puncturing structure includes a puncturing area 31 corresponding to the inlet of the receiving cavity 21, and at least the puncturing area 31 of the closing body 3 is made of a flexible material that can be punctured by a sampling device, for example, the flexible material can be various film-shaped covering films such as a paper film, a plastic film, and a tin film, and can also be a flexible material with elasticity such as silicon gel, rubber, and the like, so that the sampling device (for example, a sampling needle of the sampling device) can puncture the puncturing area 31 and enter the receiving cavity 21.

Referring to fig. 3-5, in one embodiment, the piercing area 31 is made of a flexible material, such as a rubber material. The puncturing area 31 is provided with a through-going cut-out 311, which cut-out 311 communicates with the receiving chamber 21 for passing the sampling device through the closing body 3 into the receiving chamber 21.

The incision 311 can be in a closed state during the non-sampling period, and when the automatic sampling is performed, the incision 311 is deformed and cracked under the action of the sampling needle, so that the sampling needle can pass through the incision 311, and the sampling is completed. After sampling is completed, the sampling needle is retracted, and the side walls on the two sides of the notch 311 are returned to a closed state under the action of material characteristics.

Moreover, when the notch 311 is provided in the elastic flexible material, the notch 311 is opened to release the gas in the housing cavity 21 when the pressure in the housing cavity 21 is higher than the outside, so that the pressure in the housing cavity 21 is close to or balanced with the outside pressure, thereby preventing the sealing member 3 from falling off from the tube body due to the difference between the inside pressure and the outside pressure. That is, the notch 311 may have both a function of inserting the sampling device into the housing cavity 21 and a function of exhausting air to the outside.

Specifically, referring to fig. 3 and 4, when the closing body 3 is applied to the tubular body 2, the piercing area 31 is gradually inserted into the entrance of the housing cavity 21, and during this process, the air pressure in the housing cavity 21 is continuously increased. When the closing body 3 is deformed in the direction Z1 by the difference in the outside air pressure in the housing cavity 21 to a certain extent, the sealing effect of the notch 311 is broken, air escapes from the housing cavity 21 out of the housing cavity 21, and the air pressure in the housing cavity 21 is reduced. Finally, when the internal and external pressure differences are equal or close to each other, the closing body 3 is deformed back towards the direction Z2 by the elastic restoring force, and the sealing effect is formed again by the notch 311.

The above process of deforming the closing body 3 toward the Z1 direction and then restoring the deformation toward the Z2 direction by the elastic restoring force may be repeated several times during the process of continuously entering the closing body 3 into the receiving cavity 21. Finally, when the closing body 3 stops entering the housing cavity 21, the remaining air pressure in the housing cavity 21 may still be greater than the air pressure outside the housing cavity 21, but the remaining air pressure difference cannot overcome the fixing action between the closing body 3 and the tube body 2, and therefore the closing body 3 cannot be pushed in the direction of collapsing from the tube body 2.

The notch 311 may have various shapes such as a long and narrow shape, a crescent shape, a wavy shape, a door shape, a flat oval shape, or an i-shape. The notches 311 may be more than one, may be arranged in a cross shape or in a line shape, and may be arranged in other ways.

Preferably, as shown in fig. 5, in one embodiment, the incision 311 comprises two intersecting elongated slits, and the intersection point is formed at the center of the puncture area 31, so as to facilitate the penetration of the sampling needle, reduce the resistance, and further facilitate the balance of the internal pressure and the external pressure when the sampling needle is used for sampling.

In addition, referring to fig. 6 and 7, in other embodiments, the middle of the puncturing area 31 can be completely closed, and the sampling needle 4 of the sampling device can directly puncture the middle of the puncturing area 31 and enter the receiving cavity 21 to complete sampling, instead of being inserted into the receiving cavity 21 through the incision 311.

With reference to fig. 6, a through exhaust slit 312 is further disposed at a side portion of the puncturing area 31, and the exhaust slit 312 is communicated with the accommodating cavity 21 for exhausting when the air pressure in the accommodating cavity 21 is too high. In this case, this venting slit 312 does not serve as a passage for the sampling device through the closure body 3, which serves primarily for venting.

As shown in fig. 6 and 7, the vent slits 312, which are primarily used for venting air, may be arranged in line on more than one side of the puncturing area 31. The advantage of the air vent 312 avoiding the center of the puncture area 31 is to prevent external impurities from falling into the tube 2 along with the gap formed in the sampling process of the sampling needle 4.

Of course, in the case where the puncturing area 31 is not provided with the notch 311 for the entrance and exit of the sampling device, the puncturing area 31 may be provided with a cut for puncturing the puncturing area 31. The cut does not penetrate the puncture area 31, which not only ensures the sealing of the puncture area 31, but also facilitates the puncture of the sampling device.

After the blood is collected, the closure body 3 is covered on the trace sample collecting tube 1, and in the sample sucking operation, the sampling device automatically penetrates through the puncture area 31 and enters the collecting cavity 21, so that the closure body 3 does not need to be manually opened, and the trace sample collecting tube 1 can be suitable for automatic sample feeding operation in large batch.

Furthermore, the closing body 3 and the tube body 2 can be fixed by tight fit, clamping or other various detachable fixing modes.

Referring to fig. 3 and 4, in one embodiment, the closing body 3 has a connecting cylinder 32 for engaging with a side wall of the receiving cavity 21 and a cross-piece 33 for closing the inside of the connecting cylinder 32. At least a portion of the septum 33 is the puncturing area 31, i.e., the septum 33 may partially or entirely correspond to the opening of the receiving cavity 21, and the portion corresponding to the opening serves as the puncturing area 31 for the sampling device to puncture or pass through.

Specifically, referring to fig. 3-5, the slit 311 is disposed through the cross partition 33, and the connecting cylinder 32 has a radial dimension d slightly larger than the receiving cavity 21, so that the connecting cylinder 32 can be pressed after being received in the receiving cavity 21 and the slit 311 is kept closed. The closing body 3 can be fixedly connected by means of the tight fit of the connecting cylinder 32 with the wall of the receiving chamber 21.

After the connection cylinder 32 is placed into the accommodation cavity 21, the wall of the accommodation cavity 21 presses the connection cylinder 32, so that the connection cylinder 32 is contracted, the transverse partition 33 connected with the connection cylinder 32 is pressed and deformed to enable the notch 311 to be kept closed, the sealing effect at the notch 311 is improved, and the problems of leakage and blood sample pollution caused by poor sealing of the notch 311 are solved. In general, in this way of screwing and fixing the closing body 3 and the pipe body, the notch 311 is closed only by the material restoring force of the side walls at the two sides of the notch 311, in contrast, in this embodiment, by designing the size of the connecting cylinder 32, a pre-tightening force can be given to the connecting cylinder 32, and the pre-tightening force is transmitted to the cross partition 33 through the connecting cylinder 32, so that the cross partition 33 deforms to apply a closing force to the notch 311, which not only can improve the sealing effect at the notch 311, but also can simplify the structure of the closing body 3, so that the closing body 3 can be fixed with the pipe body 2 and simultaneously complete the sealing to the notch 311.

With this sealing method, even when the micro sample collection tube 1 is inverted, the blood sample in the housing chamber 21 does not easily flow out of the housing chamber 21. The sealing effect formed by the extrusion of the notch 311 can also isolate the environment inside and outside the micro sample collection tube 1, so that the sample is not polluted, the moisture in the sample is not volatilized, and the measurement result is not distorted due to the volatilization of the moisture in the plasma stored for a long time.

Referring to fig. 4, in one embodiment, the transverse partition 33 is disposed along the radial direction of the connecting cylinder 32. In other embodiments, the diaphragm 33 may be slightly inclined with respect to the nozzle. The connecting cylinder 32 may be a cylindrical or cubic cylinder structure, and the cross-partitions 33 are correspondingly circular or square. In addition, referring to fig. 4, the horizontal partition 33 may be disposed at the bottom of the connection cylinder 32.

The transverse spacers 33 can be designed as a sheet-like structure. The diaphragm 33 and the connecting cylinder 32 may be integrally formed or fixedly connected by a separate structure.

Further, in one embodiment, at least the spacers 33 are made of a reversibly deformable polymeric elastic material (also referred to as a polymer material). In other embodiments, the whole of the closing body 3 can be made of a high molecular elastic material (also referred to as a polymer material).

Further, in one embodiment, at least the spacers 33 are made of rubber or a rubber compound. The material has good deformation capability and recovery capability. In other embodiments, the closure body 3 may be made entirely of rubber or a rubber compound.

The tubular body 2 itself may be made of an inelastic polymer compound such as plastic.

Further, referring to fig. 3 and 4, in one embodiment, the closing body 3 further comprises an outer cylinder 34 and a top cover 35, the outer cylinder 34 is sleeved outside the connection cylinder 32, and forms a clamping cavity 36 with the connection cylinder 32, which can clamp the side wall of the tube body 2, thereby improving the fixing effect of the closing body 3 and the tube body 2, and preventing the closing body 3 from being squeezed into the accommodating cavity 21 out of the nozzle when the sampling needle passes through the closing body 3. The upper end of the outer cylinder 34 and the upper end of the connecting cylinder 32 communicate with each other through a top cover 35, and the top cover 35 has an opening leading to the cross spacer 33. This structural closure 3 can be fitted better to the tubular body 2 without being easily detached.

Referring to fig. 3, in an embodiment, the receiving cavity 21 has a bottom 211 with a shape of a paraboloid of revolution, a semi-ellipsoid, a hemisphere, or an inverted cone, and the blood sample can slide down along the wall of the receiving cavity 21 to the bottom 211 of the receiving cavity 21.

Referring to fig. 2 and 3, in one embodiment, the supporting portion 23 includes a supporting sidewall extending downward from an edge of the bottom wall outside the receiving cavity 21, and the supporting sidewall forms a cylindrical structure. Such a cylindrical structure is more easily realized from the viewpoint of the injection mold opening.

Further, in an embodiment, the length a of the pipe body 2 ranges as follows: a is more than or equal to 45mm and less than or equal to 90 mm. In one embodiment, the volume V of the receiving cavity 21 can be selected from the following range: v is more than or equal to 0.2ml and less than or equal to 2 ml. Preferably, in an embodiment, the volume V of the receiving cavity ranges from: v is more than or equal to 0.5ml and less than or equal to 1.5 ml.

On the other hand, referring to fig. 2, in an embodiment, the tube 2 further includes a blood scraping plate 22 for scraping blood, and the blood scraping plate 22 is convexly disposed at the inlet of the receiving cavity 21. The use of the scraping blade 22 may assist in scraping the tip into the micro sample collection tube 1. Of course, in other embodiments, the scraping plate 22 may not be provided, and a capillary glass tube may be used for blood collection.

Example two

The present embodiments also provide a micro sample collection tube that can be applied to an autosampler type sample analyzer.

Referring to fig. 8a and 8b, fig. 8a shows a cross-sectional view of the micro sample collection tube 1 in a disassembled state, and fig. 8b shows a cross-sectional view of the micro sample collection tube 1 in an assembled state, wherein the micro sample collection tube 1 comprises a tube body 2 and a closing body 3. The construction shown in this embodiment differs from that of the first embodiment in that the closure body 3 includes a cap body 37 and a cover film 38 connected to the tubular body 2. The cap body 37 has an annular top wall, and the cover film 38 is sealingly mounted on an inner ring of the annular top wall, for example by adhesive bonding.

The portion of the cover film 38 corresponding to the opening of the receiving cavity 21 of the tube 2 is a piercing area 31, and the piercing area 31 may be a part or all of the cover film 38. The puncture area 31 allows the sampling device to pass through and aspirate a sample.

With continued reference to fig. 8a and 8b, the cap body 37 and the cover film 38 are designed separately and fixedly connected by a fixing structure. This construction allows the cap 37 to be made of other materials, such as plastic. The cover film 38 may be formed of various films such as a paper film, a plastic film, and a tin film. The cover 38 may be a closed structure or may be provided with a slit to facilitate access to the sampling device. A cut may also be provided in the lidding film 38 of the closure structure to facilitate puncturing of the lidding film 38 by the sampling device. The cap body 37 and the tube body 2 are detachably fixed, and the fixing mode can adopt a tight fit or clamping mode and the like.

Taking a blood sample as an example, the micro sample collecting tube can open the closing body 3 first in the blood collecting process, put the blood sample into the containing cavity 21, and then cover the closing body 3. Thereafter, the sampling needle of the sampling device can directly puncture the puncture area 31 of the cap film 38, thereby realizing the sample suction.

EXAMPLE III

Referring to fig. 9 and 10, the micro sample collection tube 1 includes a tube body 2 and a closure body 3. This embodiment differs from the first embodiment in that the closure body 3 employs a lidding film 38. The cover film 38 is sealed to cover the inlet of the tube body 2, and encloses the receiving cavity 21 as a sealed cavity. Wherein the free portion of the cover film 38 is the puncturing area 31.

The cover film 38 may be made of a flexible material that can be pierced by the capillary tubes, for example, various films such as a paper film, a plastic film, and a tin film may be used.

In the case of a blood sample, since the micro sample collection tube 1 can be pierced by a capillary, peripheral blood can be drawn into the capillary by the capillary first in the blood collection process, and then the blood sample can be injected into the micro sample collection tube 1 by the capillary 5 as shown in fig. 10. When the capillary 5 is removed, an opening is left in the cover film 38, and the opening can be used for the sampling needle of the sampling device to enter and exit, so as to realize sample suction.

Further, in order to improve the efficiency of the capillary 5 to pierce the cover film 38, referring to fig. 11 and 12, in one embodiment, the cut 39 is provided in the piercing region 31 of the cover film 38 for facilitating the piercing of the piercing region 31. As shown in fig. 12 and 13, the cut 39 does not extend through the lidding film 38, but it reduces the thickness of the lidding film 38 to facilitate rapid puncture of the puncture region 31 by the capillary 5.

Example four

The present embodiment provides another micro sample collection tube that can be applied to an autosampler sample analyzer.

The difference between this embodiment and the third embodiment is that referring to fig. 14 and 15, the micro sample collection tube 1 includes a tube body 2, a closing body and a cover body 6.

The closure also employs a lidding film 38, as shown in example three. The cover film 38 covers the opening of the receiving cavity 21 of the tube body 2. The cover film 38 has a pre-formed opening 310, and the opening 310 is communicated with the receiving cavity 21 for the entrance and exit of the capillary 5 and the sampling device. At this moment, in the blood collection process and the sample suction process of the sampling device, the capillary tube 5 and the sampling device do not need to pierce the sealing cover film 38, and the accommodating cavity 21 can be directly accessed from the reserved opening 310, so that the working efficiency is improved.

This lid 6 shroud is on closing cap membrane 38 and body 2, and it can form detachable the connection with body 2 for seal reservation trompil 310, play dustproof and prevent the function that the sample revealed.

EXAMPLE five

The difference between this embodiment and the first embodiment is that referring to fig. 16-19, the micro sample collection tube 1 comprises a tube body 2 and a closure body 3. The closure body 3 has an outer cylinder 34, a connecting cylinder 32 for engaging with a side wall of the receiving space 21, and a transverse partition 33. At least a portion of the diaphragm 33 is a puncturing area 31, the structure of the puncturing area 31 can refer to the structure shown in any of the above embodiments, for example, the puncturing area 31 can be made of a flexible material or a flexible material with elasticity. The piercing area 31 can also be provided with venting slits for facilitating, among other things, venting of gas from the interior of the tube body 2 when the closure body 3 is installed.

Referring to fig. 19, the outer cylinder 34 is located outside the connecting cylinder 32 and connected to the connecting cylinder 32 to form a clamping chamber 36 capable of clamping the sidewall of the tube. The clamping cavity 36 can clamp the tube 2 from the inner side and the outer side of the side wall of the tube 2, so as to improve the fixing effect of the sealing body 33 and the tube 2, and prevent the sealing body 33 from being extruded into the accommodating cavity 2121 from the tube opening when the sampling needle passes through the sealing body 33.

The upper end of the outer cylinder 34 is higher than the upper end of the connection cylinder 32, and a portion of the outer cylinder 34 higher than the upper end of the connection cylinder 32 forms a receiving cavity 341 for receiving the cross partition 33, and the cross partition 33 is installed in the inner cavity 3412 of the receiving cavity 341. The diaphragm 33 may be fixedly mounted within the interior 3412 of the receiving chamber 341 or may be removably mounted within the interior 3412 of the receiving chamber 341.

The split construction allows the outer cylinder 34 and the connector cylinder 32 to be made of a different material than the cross-over member 33, for example, the outer cylinder 34 and the connector cylinder 32 are made of plastic. The capping film 38 may be made of rubber or a rubber compound, etc.

Further, referring to fig. 19, in an embodiment, the inner cavity wall of the receiving cavity 341 has a mounting groove 3411, and the cross partition 33 is clamped in the mounting groove 3411. The cross partition 33 may be made of an elastic and flexible material, and may be elastically deformed when being pressed, so that the cross partition 33 may be inserted into the mounting groove 3411. After the lateral spacers 33 are inserted into the mounting grooves 3411, the lateral spacers 33 are restored to their original shapes and held by the groove walls of the mounting grooves 3411 to prevent the lateral spacers from falling off. In an alternative embodiment, not shown, the inner cavity wall of the receiving cavity 341 has a mounting projection, and the crosspiece 33 has a snap-in recess cooperating with the mounting projection.

In one embodiment, the mounting grooves 3411 are annularly distributed on the inner cavity wall of the receiving cavity 341, such that the edges of the cross partition 33 are all received in the mounting grooves 3411. In some embodiments, the mounting groove 3411 may be in the form of a plurality of grooves distributed at a plurality of positions on the inner cavity wall of the receiving cavity 341, and the edge of the cross partition 33 corresponding to the plurality of grooves is protruded toward the mounting groove 3411, thereby achieving the fixed connection.

Preferably, in one embodiment, the transverse partitions 33 are made of rubber or a rubber compound. The inner diameter of mounting groove 3411 is preferably smaller than the outer diameter of cross-spacers 33 so that the walls of mounting groove 3411 can press against the edges of cross-spacers 33 to cause cross-spacers 33 to collapse toward the middle. The inner diameter of the mounting groove 3411 is defined as the diameter of the annulus formed by the bottom wall of the mounting groove 3411. Referring to fig. 20, especially when the diaphragm 33 has a through notch 311, the groove wall of the mounting groove 3411 presses the diaphragm 33 to seal the notch 311.

Referring to fig. 20, in one embodiment, the piercing area 31 of the diaphragm 33 is provided with a through-cut 311. The notch 311 may be a cross-shaped slot and may be disposed in the middle of the puncturing area 31. Of course, the notch 311 may also be disposed at the edge of the puncturing area 31, and the shape thereof may be a slender shape, a crescent shape, a wave shape, a door shape, a flat oval shape, an i-shape, or other shapes. The notches 311 may be more than one, may be arranged in a cross shape or in a line shape, and may be arranged in other ways.

Further, referring to fig. 18 and 19, the mounting groove 3411 has an upper side wall 3413 and a lower side wall 3414, and the upper side wall 3413 and the lower side wall 3414 sandwich the cross partition 33 from both upper and lower sides of the cross partition 33, so that the cross partition 33 is fixed in the mounting groove 3411.

Referring to fig. 21 and 22, in one embodiment, the micro sample collection tube 1 further comprises a pressing member 320 for pressing the cross spacer 33 into the mounting groove 3411. To facilitate the entry and exit of the sampling device, the compression member 320 has an opening to the septum 33. The mounting groove 3411 has an upper side wall 3413 and a lower side wall 3414, the lower side of the diaphragm 33 is placed on the lower side wall 3414, the pressing member 320 abuts against the upper side of the diaphragm 33, and the upper side wall 3413 presses the pressing member 320, so that the diaphragm 33 is fixed in the mounting groove 3411. The pressing member 320 may be made of an elastic material, such as plastic, and has a certain amount of elasticity.

The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For a person skilled in the art to which the invention pertains, several simple deductions, modifications or substitutions may be made according to the idea of the invention.

Claims

1. A micro sample collection tube for automatic sample introduction, comprising:

2. The micro sample collection tube of claim 1, wherein the support portion comprises a support sidewall extending downward from an edge of the bottom wall outside the receiving cavity, and the support sidewall forms a cylindrical structure.

3. The micro sample collection tube of claim 1, wherein the piercing structure comprises a piercing region corresponding to the inlet of the receiving cavity, and wherein at least the piercing region of the closure is made of a flexible material that is capable of being passed through by a sampling device.

4. The micro sample collection tube of claim 3, wherein the closure body comprises a cap body coupled to the tube body, the cap body having an annular top wall, and a cover film sealingly mounted to an inner ring of the annular top wall, the cover film having at least a portion that is a puncture area.

5. The micro sample collection tube of claim 3, wherein the closure member comprises a cover film, the cover film is sealed and covers the inlet of the tube body, and the hanging portion of the cover film is the puncture area.

6. The micro sample collection tube of any one of claims 1-5, further comprising a cap that caps the closure.

7. The micro sample collection tube of claim 5, further comprising a cap covering the capping film and the tube body, the capping film having a pre-formed opening for capillary access.

8. The micro sample collection tube of claim 3, wherein the flexible material forming the piercing area is elastic, and the piercing area is provided at a side thereof with a vent slit extending therethrough, the vent slit communicating with the receiving cavity for venting air when the air pressure in the receiving cavity is too high.

9. A micro sample collection tube according to any of claims 3 to 5, wherein the piercing area is provided with a cut facilitating piercing of the piercing area.

10. The micro sample collection tube of claim 1, wherein the piercing structure comprises a piercing region corresponding to the inlet of the receiving cavity, at least the piercing region of the closure body is made of a flexible material having elasticity, and the piercing region is provided with a through-cut opening leading to the receiving cavity for allowing a sampling device to enter and exit the receiving cavity through the cut opening.

11. The micro sample collection tube of claim 3, 8 or 10, wherein the closure is integrally formed of a resilient material, and the tube is tightly or snap-fit to the closure.

12. The micro sample collection tube of claim 11, wherein the closure is made of rubber or a rubber compound.

13. The micro sample collection tube of claim 3, 8 or 10, wherein the closure body has a connector body for engaging a sidewall of the receiving chamber and a septum for sealing an interior of the connector body, at least a portion of the septum being a puncture area.

14. The micro sample collection tube of claim 13, wherein the septum has a cut-out formed therethrough in the piercing region, and wherein the connector body has a radial dimension greater than the receiving cavity such that the connector body can be squeezed when received in the receiving cavity and urge the cut-out to remain closed after piercing.

15. The micro sample collection tube according to claim 13, wherein the closure further comprises an outer barrel that fits over the outer side of the connector barrel and forms a clamping cavity with the connector barrel that clamps the sidewall of the tube body, wherein the upper end of the outer barrel and the upper end of the connector barrel communicate through the cap, and wherein the cap has an opening to the septum.

16. The micro sample collection tube according to claim 3, 8 or 10, wherein the closure body comprises an outer barrel, a connecting barrel for engaging with the sidewall of the receiving cavity, and a cross-partition, at least a portion of the cross-partition is a piercing region, the outer barrel is located outside the connecting barrel and connected with the connecting barrel to form a clamping cavity capable of clamping the sidewall of the tube body, the upper end of the outer barrel is higher than the upper end of the connecting barrel, and the portion of the outer barrel higher than the upper end of the connecting barrel forms a receiving cavity for receiving the cross-partition.

17. The micro sample collection tube of claim 16, wherein the inner cavity wall of the receiving cavity has a mounting groove or a mounting protrusion, and the cross partition is snapped into the mounting groove or the cross partition is provided with a snapping groove matching with the mounting protrusion.

18. The micro sample collection tube of claim 17, wherein the mounting recesses or projections are annularly distributed on the inner lumen wall of the receiving cavity.

19. The micro sample collection tube of claim 17 or 18, wherein the mounting groove has an inner diameter smaller than an outer diameter of the septum to allow a groove wall of the mounting groove to compress the septum.

20. The micro sample collection tube of claim 17 or 18, wherein the mounting recess has upper and lower sidewalls that sandwich the septum from both the upper and lower sides of the septum for securing the septum within the mounting recess.

21. The micro sample collection tube of claim 17 or 18, wherein the micro sample collection tube comprises a compression member for compressing the septum in the mounting groove, the mounting groove having an upper sidewall and a lower sidewall, the lower side of the septum resting on the lower sidewall, the compression member abutting against the upper side of the septum, the upper sidewall compressing the compression member to secure the septum within the mounting groove.

22. The micro sample collection tube of claim 21, wherein the constriction has an opening to the septum.

23. The micro sample collection tube of claim 17 or 18, further comprising a cap that caps the closure.

24. The micro sample collection tube according to any one of claims 1 to 5, wherein the receiving cavity has a bottom in the shape of a paraboloid of revolution, a semi-ellipsoid, a hemisphere, or an inverted cone.

25. The micro sample collection tube according to any one of claims 1 to 5, wherein the tube body further comprises a scraping plate for scraping blood, the scraping plate protrusion being provided at an inlet of the receiving cavity.

26. The micro sample collection tube according to any one of claims 1 to 5, wherein the length A of the tube body ranges from: a is more than or equal to 45mm and less than or equal to 90 mm.

27. A micro sample collection tube according to any of claims 1 to 5, wherein the volume V of the receiving cavity is in the range: v is more than or equal to 0.2ml and less than or equal to 2 ml.

28. A micro sample collection tube for automatic sample introduction, characterized in that it comprises:

29. The micro sample collection tube of claim 28, wherein the septum has a cut therethrough.

30. The micro sample collection tube of claim 29, wherein the slit is two intersecting elongated slits, the intersection point of which is located at the center of the septum.

31. The micro sample collection tube of claim 29, wherein the notch is disposed on a side of the septum.

32. The micro sample collection tube according to any one of claims 29-31, wherein the closure body comprises a connector body for engaging a sidewall of the receiving cavity, wherein the septum seals the interior of the connector body, and wherein the connector body has a radial dimension greater than the receiving cavity such that the connector body can be compressed when received in the receiving cavity and urge the slit to remain closed after piercing.

33. The micro sample collection tube according to claim 32, wherein the closure further comprises an outer barrel that fits over the outer side of the connector barrel and forms a clamping cavity with the connector barrel that clamps the sidewall of the tube body, wherein the upper end of the outer barrel and the upper end of the connector barrel communicate through the cap, and wherein the cap has an opening to the septum.

34. The micro sample collection tube of claim 28, wherein a portion of the opening of the tube body forms a plate-like protrusion.

35. A micro sample collection tube according to any of claims 28 to 31, wherein the length a of the micro sample collection tube is in the range: a is more than or equal to 45mm and less than or equal to 90 mm; the volume V of the accommodating cavity is in the range: v is more than or equal to 0.5ml and less than or equal to 1.5 ml.