CN202471710U

CN202471710U - Quantitative detection electronic pen for disposal in-vitro diagnostic reagent

Info

Publication number: CN202471710U
Application number: CN2012200637529U
Authority: CN
Inventors: 张国华
Original assignee: SHANGHAI CHEMTRON BIOTECH CO Ltd
Current assignee: SHANGHAI CHEMTRON BIOTECH CO Ltd
Priority date: 2012-02-24
Filing date: 2012-02-24
Publication date: 2012-10-03
Anticipated expiration: 2022-02-24

Abstract

The utility model relates to the field of quantitative detection electronic pens, and in particular discloses a quantitative detection electronic pen for a disposal in-vitro diagnostic reagent. The quantitative detection electronic pen comprises a pen body, a test paper strip, iron sheets, a power supply, an LED (Light Emitting Diode), a photoelectric sensor, a power amplifier, an A/D (Analog-to-Digital) converter, a single chip microcomputer and an LED liquid crystal display, wherein the pen body comprises an upper cover and a base, and the upper cover is buckled with the base; the test paper strip is partially extended out of the pen body; the power supply, the power amplifier, the A/D converter and the single chip microcomputer are arranged in the pen body, and the LED liquid crystal display is arranged on the outer side of the upper cover; and the two iron sheets, the power supply and the LED are connected in series through circuits, and the photoelectric sensor, the power amplifier, the A/D converter, the single chip microcomputer and the LED liquid crystal display are sequentially connected. The quantitative detection electronic pen disclosed by the utility model has the advantages of fast detection speed, simpleness in operation, automation and high precision.

Description

Disposable external diagnosis reagent detection by quantitative electronic pen

Technical field

The utility model relates to detection by quantitative electronic pen field, is specifically related to a kind of disposable external diagnosis reagent detection by quantitative electronic pen.

Background technology

Utilize the external diagnosis reagent of technology such as colloidal gold method, emulsion process, enzyme-linked method preparation, because of applied range, detection speed is fast, specificity is high, characteristics such as simple to operate are applied in the middle of the clinical assistant diagnosis in fields such as hormone, tumor markers, drugs, microorganism, diabetes widely.These reagent are qualitative detection usefulness mostly, need use with necessary instrument during detection by quantitative, and having slowed down detects speed; Moreover instrument needs professional's operation, is unfavorable for the popularization of basic unit; And, before using different types of reagent, need instrument is carried out resetting of parameter; Make complicated operationization, be badly in need of a kind of accurate, single-minded, rapid quantitative detection device on the market.

The utility model content

The purpose of the utility model is to overcome the defective of prior art, and a kind of result is provided accurate, easy to use, full-automatic disposable external diagnosis reagent detection by quantitative electronic pen.

The disposable external diagnosis reagent detection by quantitative electronic pen of the utility model comprises a body, test strips, iron plate, power supply, light emitting diode, photoelectric sensor, power amplifier, A/D analog to digital converter, single-chip microcomputer and LED LCD; Said body comprises loam cake and base, and said loam cake and said base fasten each other; Said test strips comprises detection zone and sample application zone; One end at said test strips detection zone place is inserted in said body inside; Be fixed on the said base; The sample application zone of said test strips is all or part of to protrude from said body, and said sample application zone each side has an iron plate to point to said sample application zone, and leaves the space between said iron plate and the said sample application zone; The position of the corresponding detection zone of a side of test strips is provided with said light emitting diode on the said base, and the position of the inboard corresponding test strips detection zone of said loam cake is provided with said photoelectric sensor; Said power supply, power amplifier, A/D analog to digital converter, single-chip microcomputer are positioned at said body inside, and said LED LCD is arranged at the said loam cake outside; Said two iron plates, power supply, light emitting diode are through the circuit series connection, and said photoelectric sensor, power amplifier, A/D analog to digital converter, single-chip microcomputer and LED LCD connect successively.

More excellent; Said test strips comprises substrate, filter appearance paper, all-glass paper, nitrocellulose filter and thieving paper; Said filter appearance paper, all-glass paper, nitrocellulose filter and thieving paper is tandem array and being fixed on the said substrate successively, and said substrate is fixed on the said base.

The detection zone of the utility model is positioned at said nitrocellulose filter, and sample application zone is positioned at said filter appearance paper.

More excellent, said detection zone is provided with detection line (T line) and nature controlling line (C line).

More excellent, the number of said detection line is 1 or 2.

More excellent, said disposable external diagnosis reagent detection by quantitative electronic pen also comprises cap, said cap is positioned at the side that said body is protruding with said sample application zone, said cap and said body clamping.Being provided with of cap can protect test strips to avoid polluting.

When the electronic pen of the utility model uses, drip testing sample in the sample application zone of test strips: testing sample is through the direction chromatography of capillary action to nitrocellulose membrane on the one hand, arrive the detection zone on the nitrocellulose membrane after, in T line and the colour developing of C line place; On the other hand; After dripping sample; Sample application zone expands and to contact with the iron plate of its both sides, connection light emitting diode and power supply, the light emitting diode that the is positioned at test strips detection zone one side irradiating and detecting district that emits beam; Its reflected light is detected by photoelectric sensor; Photoelectric sensor converts light signal into electric signal and further passes to power amplifier, A/D analog to digital converter, and the A/D analog to digital converter is that digital signal forms instruction with electrical signal conversion, and the single-chip microcomputer processing instruction also passes through the result that light-emitting diode display shows detection by quantitative.

When the electronic pen of the utility model is used to detect, can directly from a light-emitting diode display in the body outside, directly obtain the accurate data of test substance concentration the testing sample.

Test strips detects through immunochromatographic method, and this test strips can be used for the in-vitro diagnosis test strips of fast detecting for colloidal gold colloidal gold detection test paper strip, emulsion particle test strip, enzyme mark detection test paper bar etc.The colour developing principle of test strips comprises competition law and double antibody sandwich method:

1. when adopting competition law, the test substance concentration in the T line color depth and the sample is negative correlation, and the amount of test substance is many more, and the color of T line is shallow more;

2. when adopting double antibody sandwich method, the concentration of the test substance in the T line color depth and the sample is proportionate, and the amount of test substance is many more, and the color of T line is dark more.

In any case, the C line all should form, and the expression application of sample is correct with operation.Therefore whether the C line is can the work of indicator box reactive system normal, as the parameter of detection system, under the situation that the C line occurs, shows the concentration of test substance; The mistake that should show test results if the C line does not occur must be reformed.

The utility model compared with prior art, it is fast, simple to operate to have a detection speed, robotization, the advantage that degree of accuracy is high.

Description of drawings

Fig. 1: disposable external diagnosis reagent detection by quantitative electronic pen outside drawing (A. body 1. test strips 2. iron plate 9.LED LCD A1. loam cakes)

Fig. 2: disposable external diagnosis reagent detection by quantitative electronic pen removes loam cake figure (1. test strips 2. iron plates 3. power supplys 4. light emitting diodes 6. power amplifier 7.A/D analog to digital converters 8. Chip Microcomputer A 2. bases 11. detection zones 12. sample application zone)

Fig. 3: the inboard figure of disposable external diagnosis reagent detection by quantitative electronic pen loam cake (A1. loam cake 5. photoelectric sensors)

Fig. 4: the disposable external diagnosis reagent detection by quantitative electronic pen outside drawing (A. body B. cap 9.LED LCD) of band cap

Fig. 5: test strips schematic appearance (11. detection zones, 12. sample application zone, 13. substrates, 14. filter appearance paper, 15. all-glass papers, 16. nitrocellulose filters, 17. thieving papers, 111. detection lines, 112. nature controlling lines)

Fig. 6: disposable external diagnosis reagent detection by quantitative electronic pen light emitting diode wiring diagram (2. iron plate 3. power supplys 4. light emitting diodes)

Fig. 7: disposable external diagnosis reagent detection by quantitative electronic pen operation circuit figure (5. photoelectric sensor 6. power amplifier 7.A/D analog to digital converters 8. single-chip microcomputer 9.LED LCDs)

Embodiment

To combine embodiment that the utility model is done further to detail below, following examples only are used to explain the utility model, do not constitute the qualification to the utility model protection domain.

HCG shown in Fig. 1-4 (human chorionic gonadotrophin) disposable diagnostic reagent detection by quantitative electronic pen comprises a body A, test strips 1, iron plate 2, power supply 3, light emitting diode 4, photoelectric sensor 5, power amplifier 6, A/D analog to digital converter 7, single-chip microcomputer 8 and LED LCD 9; Body A comprises loam cake A1 and base A2, and loam cake A1 and base A2 fasten each other; Test strips 1 comprises detection zone 11 and sample application zone 12; It is inner that one end at test strips detection zone 11 places is inserted in a body A; Be fixed on the base A2; Sample application zone 12 an all or part of body A that protrude from of test strips 1, sample application zone 12 each side has an iron plate 2 to point to sample application zone 12, and leaves the space between iron plate 2 and the sample application zone 12; The position that base A2 goes up the corresponding detection zone 11 of a side of test strips 1 is provided with light emitting diode 4, and the position of the inboard corresponding test strips detection zone 11 of loam cake A1 is provided with photoelectric sensor 5; It is inner that power supply 3, power amplifier 6, A/D analog to digital converter 7, single-chip microcomputer 8 are positioned at a body A, and LED LCD 9 is arranged at the loam cake A1 outside; Two iron plates 2, power supply 3, light emitting diodes 4 are connected (as shown in Figure 6) through circuit, and photoelectric sensor 5, power amplifier 6, A/D analog to digital converter 7, single-chip microcomputer 8 and LED LCD 9 connect (as shown in Figure 7) successively.

Test strips 1 as shown in Figure 5; Comprise substrate 13, filter appearance paper 14, all-glass paper 15, nitrocellulose filter 16 and thieving paper 17; A filter appearance paper 14, all-glass paper 15, nitrocellulose filter 16 and thieving paper 17 is tandem array and being fixed on the substrate 13 successively, and substrate 13 is fixed on the base A2.The detection zone 11 of test strips 1 is positioned at nitrocellulose filter 16, and sample application zone 12 is positioned at filter appearance paper 14.Detection zone 11 is provided with detection line (T line) 111 and nature controlling line (C line) 112.The number of detection line 111 is 1.

The disposable external diagnosis reagent detection by quantitative of HCG electronic pen also comprises cap B, and cap B is positioned at the side that a body A is protruding with sample application zone 12, a cap B and a body A clamping, and the protection test strips is avoided polluting.

During use; Take down cap B, drip testing samples in the sample application zone of test strips 1 12: sample application zone 12 expands and contacts connection circuit with the iron plate 2 of its both sides; Read the result of detection from the light-emitting diode display in the loam cake A2 outside, directly obtain the definite information of test substance concentration in the testing sample.

Claims

1. a disposable external diagnosis reagent detection by quantitative electronic pen is characterized in that, comprises a body, test strips, iron plate, power supply, light emitting diode, photoelectric sensor, power amplifier, A/D analog to digital converter, single-chip microcomputer and LED LCD; Said body comprises loam cake and base, and said loam cake and said base fasten each other; Said test strips comprises detection zone and sample application zone; One end at said test strips detection zone place is inserted in said body inside; Be fixed on the said base; The sample application zone of said test strips is all or part of to protrude from said body, and said sample application zone each side has an iron plate to point to said sample application zone, and leaves the space between said iron plate and the said sample application zone; The position of the corresponding detection zone of a side of test strips is provided with said light emitting diode on the said base, and the position of the inboard corresponding test strips detection zone of said loam cake is provided with said photoelectric sensor; Said power supply, power amplifier, A/D analog to digital converter, single-chip microcomputer are positioned at said body inside, and said LED LCD is arranged at the said loam cake outside; Said two iron plates, power supply, light emitting diode are through the circuit series connection, and said photoelectric sensor, power amplifier, A/D analog to digital converter, single-chip microcomputer and LED LCD connect successively.

2. electronic pen as claimed in claim 1; It is characterized in that; Said test strips comprises substrate, filter appearance paper, all-glass paper, nitrocellulose filter and thieving paper; Said filter appearance paper, all-glass paper, nitrocellulose filter and thieving paper is tandem array and being fixed on the said substrate successively, and said substrate is fixed on the said base.

3. electronic pen as claimed in claim 1 is characterized in that said detection zone is provided with detection line and nature controlling line.

4. electronic pen as claimed in claim 3 is characterized in that, the number of said detection line is 1 or 2.

5. electronic pen as claimed in claim 1 is characterized in that, said disposable external diagnosis reagent detection by quantitative electronic pen also comprises cap, and said cap is positioned at the side that said body is protruding with said sample application zone, said cap and said body clamping.