CN1308509C - A silver containing chitosan fiber having antimicrobial function and preparation method - Google Patents
A silver containing chitosan fiber having antimicrobial function and preparation method Download PDFInfo
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- CN1308509C CN1308509C CNB2004100248681A CN200410024868A CN1308509C CN 1308509 C CN1308509 C CN 1308509C CN B2004100248681 A CNB2004100248681 A CN B2004100248681A CN 200410024868 A CN200410024868 A CN 200410024868A CN 1308509 C CN1308509 C CN 1308509C
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Abstract
The present invention relates to a silver-containing chitosan fiber with the antibacterial function and a preparation method. The silver-containing chitosan fiber with the antibacterial function is prepared from 90.0 to 99.9 wt% of chitosan powder and 0.1 to 10 wt% of silver compound tiny granules insoluble in water. The silver-containing chitosan fiber has obvious antibacterial effect and is used as medical dressing for effectively controlling the growth of bacteria on wounds.
Description
Technical field:
The present invention relates to the material field, be specifically related to a kind of argentiferous chitosan fiber and preparation method with antibacterial action.
Background technology:
Wound is a kind of common symptom, and the treatment wound need be used a large amount of medical dressing.Bleed at some and to suppurate on the more wound, medical dressing plays the effect that absorbs purulence blood on the wound, protection wound and promote its healing.
The wound that purulence blood is many increases to the breeding of bacterium a good environment is provided.Thereby the breeding of bacterium increase make wound infection slow down wound healing rate, increase patient's misery.Bacterium also can be entered in the medical dressing by the purulence blood on the wound, and enters when replacing dressing in the foul in the hospital, propagates in the lesion, causes when serious that the lesion infects.
Chitin (claiming chitin, chitin, glutelin, crab shell chitosan again) is a cellulose second largest natural macromolecular material afterwards, and its chemical constitution is (1,4)-2-acetamido-2-deoxidation-callose.Chitosan (claiming shitosan again) is a kind of macromolecule aminated polysaccharide that chitin obtains behind deacetylation, and its molecular structure is (1,4)-2-amine-2-deoxidation-callose.Chitosan can dissolve as solvent with 2% aqueous acetic acid.After can being squeezed into 5% the NaOH aqueous solution by spinneret orifice, the spinning solution that contains 5% chitosan forms fiber.
As a kind of fibrous material, chitosan fiber can be processed to yarn, woven fabric, knitted fabric and non-woven fabric material.The material of being made by chitosan fiber can be processed to medical dressing, is used to administer the wound of bleeding and suppurating.This class dressing has hygroscopicity and moisture retention preferably, more can promote the multiple of wound compared with traditional cotton gauze.
Silver ion has the excellent antibiotic bactericidal property.As a kind of medical material, silver ion is very low to the toxicity of human body, and the colloid that contains silver ion has been used to administer burn patient, plays the effect of antibiotic and sterilizing.
Silver ion also has very strong oxidisability.After adding contained organic carrier, silver ion can make the oxidation operation blackening freely, had reduced the anti-microbial property of product on the one hand, had also destroyed the attractive in appearance of product on the other hand.
Summary of the invention:
Technical problem to be solved by this invention is to improve the performance of existing chitosan fiber, and a kind of argentiferous chitosan fiber with antibacterial action is provided.
Argentiferous chitosan fiber with antibacterial action disclosed by the invention is that chitosan powder 90.0-99.9% and water-fast silver compound molecule 0.1-10% make by the percentage by weight prescription.
Wherein said water-fast silver compound molecule is meant that particle diameter is the sodium zirconium phosphate compound less than 1 micron silver, and its silver content is 3.0-4.0%.
The preferred percentage by weight prescription of argentiferous chitosan fiber of the present invention is: the sodium zirconium phosphate compound of chitosan powder 99.0% silver medal is 1.0%.
Another technical problem to be solved by this invention is to provide the preparation method of above-mentioned argentiferous chitosan fiber.
The preparation method of argentiferous chitosan fiber of the present invention comprises the following steps:
The chitosan powder of recipe quantity is dissolved in 2% aqueous acetic acid, adds water-fast silver compound particulate, after stirring, become spinning solution, clamp-on 5%NaOH through spinneret orifice and form fiber in water-soluble, wash, after the drying promptly.
It is carrier that the present invention adopts chitosan, is anti-biotic material with the molecule of the compound of water-fast silver, chitosan with 2% acetum dissolving back be processed into fiber after the molecule of silver-colored compound mixes.Because the particle of compound of silver is very little, can be in process by being distributed in behind spinneret orifice and the chitosan coprecipitation among the formed chitosan fiber.
The chitosan fiber that the present invention produced has the performance of general fiber, can be processed to yarn, woven fabric, knitted fabric and non-woven fabric material, also can be with forming coating cotton thread after polyester fiber or other fibre-coated.
The compound of silver of the present invention particularly silver the sodium zirconium phosphate compound in silver ion by the sodium zirconium phosphate combination, its carrier fibre is not had oxidisability, in process, can not make chitosan fiber oxidation blackening.
After being processed to yarn, woven fabric, knitted fabric and non-woven fabric material; product of the present invention can form medical dressing by cutting packing back; the more wound of suppurating that is used to bleed plays and absorbs purulence blood on the wound, prevents bacterial growth breeding, protection wound and promote the effect of its healing.
The experiment proved that the chitosan fiber antibacterial effect is more obvious separately for argentiferous chitosan fiber of the present invention, can effectively control the growth of bacterium on the wound, and safety non-toxic.
Description of drawings:
Fig. 1, embodiment 2 do not add the inhibition zone of the chitosan fiber of silver ion
Fig. 2, embodiment 2 contain the inhibition zone of silver ion chitosan fiber
The specific embodiment:
Embodiment 1,
The chitosan powder of 50 grams is dissolved in 2% aqueous acetic acid of 950 grams, the sodium zirconium phosphate compound powder (particle diameter is less than 1 micron) that adds the silver of 0.5 gram forms spinning solution through fully stirring the back, solution be 30 with measuring pump in hole count under the pressure, the aperture is to clamp-on in the water-bath that contains 5%NaOH on 150 microns the spinnerets to form strand, obtains containing the chitosan fiber of silver ion through washing and drying.The fiber of gained can be processed into fabric with the polyester fiber of 75 dtexs with woven or knitting method at the yarn of doing on the coating machine to obtain after coating is handled, be processed into non-weaving cloth with non-interlaced fabric equipment after also can becoming 5 centimeter length to fibre cutting, through being processed into gauze after the cutting packing for the usefulness that cures the wound.
Embodiment 2,
In order to observe the anti-microbial property of fiber, at first freeze and evenly be coated with a certain amount of Escherichia coli in the culture dish at beef, put into chitosan fiber that does not add silver ion and the chitosan fiber that contains silver ion then respectively, after 37 ℃ of constant temperature are cultivated 24h, take out the cell growing state of observing on each flat board.Fig. 1 has shown the inhibition zone of the chitosan fiber that does not add silver ion, and Fig. 2 has shown the inhibition zone that contains the silver ion chitosan fiber.As can be seen, contain the silver ion chitosan fiber and better anti-microbial property is arranged than the chitosan fiber that does not add silver ion.
Claims (3)
1, a kind of argentiferous chitosan fiber with antibacterial action is characterized in that this fiber is that chitosan powder 90.0-99.9% and water-fast silver compound molecule 0.1-10% make by the percentage by weight proportioning; Wherein water-fast silver compound molecule is meant that particle diameter is the sodium zirconium phosphate compound less than 1 micron silver, and its silver content is 3.0-4.0%.
2, a kind of argentiferous chitosan fiber with antibacterial action as claimed in claim 1 is characterized in that wherein said fiber is that chitosan powder 99.0%, silver-colored sodium zirconium phosphate compound 1.0% are made by the percentage by weight proportioning.
3, a kind of preparation method with argentiferous chitosan fiber of antibacterial action as claimed in claim 1 is characterized in that this method comprises the following steps:
The chitosan powder of proportional quantity is dissolved in 2% aqueous acetic acid, adds water-fast silver compound particulate, after stirring, become spinning solution, clamp-on 5%NaOH through spinneret orifice and form fiber in water-soluble, wash, after the drying promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100248681A CN1308509C (en) | 2004-06-02 | 2004-06-02 | A silver containing chitosan fiber having antimicrobial function and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100248681A CN1308509C (en) | 2004-06-02 | 2004-06-02 | A silver containing chitosan fiber having antimicrobial function and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1704510A CN1704510A (en) | 2005-12-07 |
| CN1308509C true CN1308509C (en) | 2007-04-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100248681A Expired - Fee Related CN1308509C (en) | 2004-06-02 | 2004-06-02 | A silver containing chitosan fiber having antimicrobial function and preparation method |
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| CN (1) | CN1308509C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012058962A1 (en) | 2010-11-03 | 2012-05-10 | 广东百合医疗科技有限公司 | Antimicrobial fiber, fabric and wound dressing containing nano metal and preparation method thereof |
| WO2013159668A1 (en) | 2012-04-23 | 2013-10-31 | 佛山市优特医疗科技有限公司 | Silvery antibacterial fibre, texture, and wound dressing, and preparation method thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101250759B (en) * | 2008-04-07 | 2010-09-22 | 宁阳华兴海慈新材料有限公司 | Medical chitosan fibre and preparation method thereof |
| GB0922664D0 (en) | 2009-12-24 | 2010-02-10 | Adv Med Solutions Ltd | Chitosan based antimicrobial absorbent material |
| CN103014914A (en) * | 2011-09-26 | 2013-04-03 | 李永兴 | Method for preparing medical high-efficiency disinfected chitosan fibers by using disinfectant |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456576A (en) * | 2003-03-14 | 2003-11-19 | 天津大学 | Bactericidal chitin and its preparation and method for making cellulose solvent weaving liquid |
-
2004
- 2004-06-02 CN CNB2004100248681A patent/CN1308509C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456576A (en) * | 2003-03-14 | 2003-11-19 | 天津大学 | Bactericidal chitin and its preparation and method for making cellulose solvent weaving liquid |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012058962A1 (en) | 2010-11-03 | 2012-05-10 | 广东百合医疗科技有限公司 | Antimicrobial fiber, fabric and wound dressing containing nano metal and preparation method thereof |
| WO2013159668A1 (en) | 2012-04-23 | 2013-10-31 | 佛山市优特医疗科技有限公司 | Silvery antibacterial fibre, texture, and wound dressing, and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1704510A (en) | 2005-12-07 |
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Owner name: JIAXING COLLEGE Free format text: FORMER OWNER: QIN YIMIN Effective date: 20060721 |
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Effective date of registration: 20060721 Address after: 314001 No. 56 South Yuexiu Road, Zhejiang, Jiaxing Applicant after: Jiaxing University Address before: 314001 No. 355, Wenchang Road, Jiaxing, Zhejiang Applicant before: Qin Yimin |
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Granted publication date: 20070404 Termination date: 20130602 |