CN1225291C - Water-soluble human body lubricant - Google Patents
Water-soluble human body lubricant Download PDFInfo
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- CN1225291C CN1225291C CN 200310111430 CN200310111430A CN1225291C CN 1225291 C CN1225291 C CN 1225291C CN 200310111430 CN200310111430 CN 200310111430 CN 200310111430 A CN200310111430 A CN 200310111430A CN 1225291 C CN1225291 C CN 1225291C
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- Prior art keywords
- lubricant
- human body
- water
- water soluble
- condom
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- 239000000314 lubricant Substances 0.000 title claims abstract description 42
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 29
- 241001116389 Aloe Species 0.000 claims abstract description 23
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 21
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 16
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 16
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 15
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 14
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 230000002421 anti-septic effect Effects 0.000 claims description 10
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 7
- 229960003415 propylparaben Drugs 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 6
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 6
- 239000003921 oil Substances 0.000 abstract description 5
- 239000002195 soluble material Substances 0.000 abstract description 4
- 239000000758 substrate Substances 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000003670 easy-to-clean Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 230000035807 sensation Effects 0.000 abstract description 2
- 210000000697 sensory organ Anatomy 0.000 abstract description 2
- 238000005461 lubrication Methods 0.000 abstract 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 210000000416 exudates and transudate Anatomy 0.000 abstract 1
- 231100000989 no adverse effect Toxicity 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 19
- 210000003491 skin Anatomy 0.000 description 11
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 9
- 238000001816 cooling Methods 0.000 description 7
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 6
- 229940082484 carbomer-934 Drugs 0.000 description 6
- 230000001568 sexual effect Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 210000004877 mucosa Anatomy 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- 206010012442 Dermatitis contact Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 239000005662 Paraffin oil Substances 0.000 description 2
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 2
- AFHJQYHRLPMKHU-OSYMLPPYSA-N aloin A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-OSYMLPPYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 208000010247 contact dermatitis Diseases 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229960005150 glycerol Drugs 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000001808 coupling effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- -1 dimethyl siloxane Chemical class 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a water soluble lubricant for a human body, which comprises 10 to 20 mass% of glycerol, 0 to 5 mass% of propanediol, 1 to 1.2 mass% aloe powder, 0.8 to 1.7 mass% of tackifier containing hydroxyethyl cellulose, 0.3 to 1.5 mass% of preservative and balance of water. Compared with a lubricant with an oil substrate, the water soluble lubricant for a human body has the following advantages that water soluble materials are used as lubrication main bodies, the lubrication degree of the water soluble lubricant is obviously enhanced as compared with the lubrication degree of a lubricant with oil substrates of silicon oil, etc., the water soluble lubricant for a human body is totally prepared from the water soluble materials, is compatible with the normal exudate of the human body of a female, has no unctuous sensation, is easy to clean, is easy to accept by the sense organ, and has no adverse effect to the human body, the properties of materials of a medical appliance and a condom can not be changed, the breakage phenomenon of a condom in the using process is reduced, and the normal properties of the medical appliance and the condom can not be lowered.
Description
Technical field
The lubricant that the present invention relates on human body, use, particularly: 1, in sexual life, be used to remedy the deficiency of women self secretions, alleviate and improve the lubricant of vaginal dryness symptom; The lubricant that uses when 2, diagnostor is checked in tract; 3, the lubricant that on condom, uses; Or the like.
Background technology
Enter in the process of tract at medical apparatus and instruments (diagnostors such as endoscope, colposcope, cervical clamps, medical catheter), often need be coated with proper amount of lubricating agent at medical apparatus surface, to reduce the damage of apparatus to tissue, also using the light liquid paraffin oil at most existing hospital-based outpatient obstetrical clinic, in-patient department as lubricant, liquid paraffin oil is difficult to clean, tissues such as vagina there is certain zest, and grow mycete easily, be badly in need of wanting a kind of fine soluble oil to be replaced.
In the production process of rubber condoms, also often drip the dimethyl siloxane (being commonly called as silicone oil) of about 0.2-0.35 gram on every condom surface, as interleaving agent, can avoid practising contraception adhesion between jacket layer and the layer, also can play simultaneously the effect of lubricant, can prevent the friction of condom and human epidermal and the damage of not accommodating of causing and epidermis cell.
In sexual life, many men and wives for the quality that improves sexual life on the genitals coated lubricant.The women crossed after climacteric, because its vagina thins down, gonad secretions is fewer and feweri, the reproductive tract endocrine lacks, make sexual's penis insert difficulty, have a strong impact on the quality of sexual life between the man and wife, they need to use human body lubricants more when having sexual intercourse, to alleviate and to improve the vaginal dryness symptom.
These above-mentioned lubricants should or not change the character of the material of medical apparatus and instruments and condom in human body untoward reaction being arranged, and should not reduce the normal performance of medical apparatus and instruments and condom.
Present widely used human body lubricants is generally the lubricant of oleaginous base, as vaseline and derivant thereof, food oil, mineral wet goods; Have much and studies show that, the lubricant of many oleaginous bases is with medical apparatus and instruments, when condom contacts, the security performance of the condom that meeting damage natural emulsion is made, medical gloves etc., such as mineral oil contact with condom be as short as for 60 seconds after, the intensity decreases of condom is about 90%, so all rubber condoms production commercial cities do not recommend consumer to use mineral oil to make lubricant on the condom surface.In addition, the intravital normal juice of the lubricant of oleaginous base and women is incompatible fully, in use or use greasy feeling, not easy cleaning are arranged later.
Summary of the invention
Technical problem to be solved by this invention is: a kind of water-soluble human body lubricants is provided, and this lubricant has no adverse reaction to human body, can not change the character of the material of medical apparatus and instruments and condom, can not reduce the normal performance of medical apparatus and instruments and condom.
The present invention solves the problems of the technologies described above the technical scheme that is adopted: it comprise the viscosifier that contain hydroxyethyl-cellulose, the 0.3-1.5% of Aloe powder, the 0.8-1.7% of propylene glycol, the 1-1.2% of medicinal glycerin, the 0-5% of 10-20% antiseptic, all the other are water; Above-mentioned percentage ratio is mass percent.
In the component of water-soluble human body lubricants of the present invention, glycerol, propylene glycol can increase viscosity, and excellent moistening effect is also arranged.
Comprise Aloe powder rather than Aloe juice in the component of the present invention, be because: fresh aloe juice contains barbaloin, resin, fear chemical substance such as quinone, and this type of chemical substance medically claims hapten.After fresh aloe juice is applied to skin, combine with epidermal protein matter, formation can make body that anaphylactoid material takes place, and medically claims holoantigen.The holoantigen material can change common lymphocytic activity in the skin, make common lymphocyte transformation become primed lymphocyte, primed lymphocyte can discharge multiple lymphokine, this type of lymphokine can make human body skin that serious inflammatory reaction takes place, cause skin capillary vascular expansion and large stretch of erythema occurs, it is outer and red swelling of the skin, vesicle and stream yellow fluid take place that blood plasma oozes out blood vessel, the contact dermatitis due to Here it is the fresh aloe juice.In addition, moisture more than 98% is arranged in Aloe original juice, its viscosity is smaller, excellent lubricant effect can not be arranged, in order to improve greasy property, can only increase concentration, just be to use spissated Aloe juice, but can cause the another one problem again, chemical substances such as promptly more barbaloin, resin, anthraquinone may cause contact dermatitis.
Nanofiltration membrane separation room temperature concentration technology is generally adopted in the production of Aloe powder, active component in the complete preservation Aloe original juice of energy, some useless compositions have also been filtered, contain in every kilogram of Aloe powder more than polysaccharide 12 grams, the content of lead, hydrargyrum, arsenic is all below 0.3ppm, Aloe self has certain antibacterial and anti-inflammation functions, simultaneously impaired vaginal mucosa is had repair, and the Aloe powder of graininess helps the dissolving and the absorption of human body of Aloe powder.
Comprise the viscosifier that contain hydroxyethyl-cellulose in the water-soluble human body lubricants component of the present invention, hydroxyethyl-cellulose is a white powder, not only be dissolved in cold water but also be dissolved in hot water, viscosity changes less in very wide pH value scope, high temperature or boil does not precipitate down, make it have large-scale dissolubility and viscosity characteristics, can with on a large scale in other water-soluble polymers, surfactant, salt coexistence, even can viscosity reduction in the high concentration electrolyte solution yet, water holding capacity exceeds one times than methylcellulose, has flow adjustment preferably.
Comprise antiseptic in the water-soluble human body lubricants component of the present invention, antiseptic can have anaerobe to be killed and inhibitory action preferably, is beneficial to the preservation of lubricant.
Water-soluble human body lubricants of the present invention is compared with the lubricant of oleaginous base, has the following advantages: 1, as lubricated main body, its lubricity obviously improves than the lubricant of oleaginous bases such as silicone oil water-soluble human body lubricants of the present invention with water-soluble material; 2, it is formulated that water-soluble human body lubricants of the present invention all adopts water-soluble material, dissolves each other with the normal juice of female body, do not have oily sensation, is easy to clean, more acceptant on the sense organ, and human body is had no adverse reaction; 3, can not change the character of the material of medical apparatus and instruments and condom, reduce the fracture phenomena that takes place in the use of condom; 4, can not reduce the normal performance of medical apparatus and instruments and condom.
Specific embodiments
The component of embodiment of the present invention 1-6 and content thereof (mass percent) see the following form:
| Embodiment | 1 | 2 | 3 | 4 | 5 | 6 |
| Medicinal glycerin | 16％ | 15％ | 15％ | 15％ | 10％ | 20％ |
| Aloe powder | 1％ | 1％ | 1.2％ | 1％ | 1.2％ | 1.2％ |
| Propylene glycol | 5％ | 4％ | 5％ | 5％ | 3％ | |
| Carbomer 934 | 0.9％ | 0.9％ | ||||
| Hydroxyethyl-cellulose | 1.5％ | 1.6％ | 1.6％ | 0.8％ | 0.8％ | 0.8％ |
| Methyl hydroxybenzoate | 0.1％ | 0.1％ | 0.15％ | 0.15％ | 0.15％ | |
| Propylparaben | 0.15％ | 0.15％ | 0.15％ | |||
| Chlorhexidine gluconate | 0.2％ | 0.2％ | 0.2％ | 1％ | ||
| Two imidazolidinyl urea | 0.1％ | 0.2％ | 0.2％ | 0.2％ | ||
| Water | 76.2％ | 78.1％ | 81.9％ | 77.1％ | 80.1％ | 74.1％ |
In the above-mentioned embodiment;
Aloe powder all adopts the product of Xiamen sweetening treatment Industrial Co., Ltd.; Used propylene glycol, hydroxyethyl-cellulose are medical grade, and institute's water is the injection stage deionization.
In the embodiment 1,2,4,5,6, the existing moisture-keeping function of propylene glycol is again a kind of penetrating agent, can increase the dissolving in water of methyl hydroxybenzoate, propylparaben simultaneously.
Hydroxyethyl-cellulose, carbomer are viscosifier, and through having experimental results show that the excellent compatibility energy, the outward appearance of product is good, and good stability, especially hydroxy ethyl fiber have extraordinary moistening effect.
Carbomer 934: white loose sprills, tool acidity, hygroscopicity and little special odor arranged, high viscosity, good stability, can be used for the high concentration gel, the characteristics of the gel tool water-soluble base that is mixed with carbomer 934, appearance transparent is attractive in appearance, and putting on the skin has special fine and smooth smooth feeling on skin, and is splendid with the skin coupling effect.According to document record, carbomer 934 is non-stimulated to mucosa, and sensitization not can be used as the substrate of oral formulations.
Methyl hydroxybenzoate, propylparaben, two imidazolidinyl urea all are antiseptic safely and efficiently, common food industry and cosmetic industry antiseptic, have characteristics such as non-volatile, avirulence, good stability, all effective in acid, alkaline media, and color, abnormal smells from the patient are atomic; Anaerobe had kill preferably and inhibitory action, normal and other antiseptic are used; With them composite later have wider antimicrobial spectrum and better safety.Two imidazolidinyl urea: very easily soluble in water, nontoxic for powdery solid colourless, odorless, chafe not, subject range pH4～9 of acid-base value are the antiseptic with antibacterial activity, and the compatibility is good, and broad-spectrum antiseptic is safe and efficient.
Chlorhexidine gluconate is all very low safe disinfection agent of a kind of toxicity, corrosivity and zest; To skin, mucosa nonirritant, be widely used in the sterilization of skin mucosa, wound surface and urinary organs, it is sterilized and bacteriostasis is good, stable in properties, easy to use.
The preparation method of embodiment of the present invention 1,2 is:
With purified water, be heated to 90 ℃, add the ultramicro powder Aloe powder then, stirred 30 minutes, get the A component; Take by weighing medicinal glycerin, propylene glycol, hydroxyethyl-cellulose, hydroxyethyl-cellulose is evenly joined under stirring in the mixed solution of medicinal glycerin, propylene glycol, continue to stir till hydroxyethyl-cellulose melts fully, obtain the B component; The B component is added A component, natural cooling under stirring; Thing temperature to be mixed drops to about about 60 ℃, adds the mixture of methyl hydroxybenzoate and chlorhexidine gluconate solution, stirs at a slow speed 30 minutes, and cooling obtains water-soluble human body lubricants.
The preparation method of embodiment of the present invention 3 is:
Get purified water, be heated to 90 ℃, add the ultramicro powder Aloe powder then, stirred 30 minutes, get the A component: take by weighing medicinal glycerin, hydroxyethyl-cellulose, hydroxyethyl-cellulose is evenly added in the medicinal glycerin under stirring, continue to stir till hydroxyethyl-cellulose melts fully, obtain the B component; The B component is added A component, natural cooling under stirring; Thing temperature to be mixed drops to about about 40 ℃, adds chlorhexidine gluconate, two imidazolidinyl urea, stirs at a slow speed 20 minutes, splashes into sodium hydroxide solution, and the mixture pH value is controlled between the 6-7, restir 20 minutes, and cooling obtains gel.
The preparation method of embodiment of the present invention 4 is:
Get load weighted carbomer 934 and soak, swelling 24 hours, add glycerol, hydroxyethyl-cellulose grind component A; Get load weighted methyl hydroxybenzoate, propylparaben, two imidazolidinyl urea, mixed with propylene glycol, stir and make its dissolving, get B component; The purified water of surplus is heated to 80 ℃, stirs adding ultramicro powder Aloe powder down, add component A and B component more successively, natural cooling under the stirring, to be cooled to about 40 ℃, regulate pH value between the 6.5-7 with triethanolamine, stir at a slow speed, cool off gel.
The preparation method of embodiment of the present invention 5 is:
Get load weighted carbomer 934 and soak, swelling 24 hours, add glycerol, hydroxyethyl-cellulose grind component A; Get load weighted methyl hydroxybenzoate, propylparaben, two imidazolidinyl urea, chlorhexidine gluconate, mixed with propylene glycol, stir and make its dissolving, get B component; The purified water of surplus is heated to 80 ℃, stirs and to add the ultramicro powder Aloe powder down, add component A more successively, B component, natural cooling under the stirring, cool off gel.
The preparation method of embodiment of the present invention 6 is:
With glycerol, hydroxy ethyl fiber mix component A; Get load weighted methyl hydroxybenzoate, propylparaben, two imidazolidinyl urea, mixed with propylene glycol, stir and make its dissolving, get B component; Purified water is heated to 80 ℃, stirs and to add the ultramicro powder Aloe powder down, add component A and B component more successively, natural cooling under the stirring, to be cooled to about 40 ℃, regulate pH value between the 6.5-7 with triethanolamine, stir at a slow speed, cool off gel.
To embodiment of the present invention 1-6 estimate, nasil, the water white transparency thick liquid does not have precipitation; No abnormal abnormal smells from the patient and foreign body.
The physical and chemical inspection index is:
Viscosity (25 ℃) Pa.S23～18
Relative density g/ml＞1.0
Acid-base value PH6.5～7.0
Skin and mucosa are produced pessimal stimulation and anaphylaxis.
Claims (5)
1, water-soluble human body lubricants is characterized in that: it comprise the viscosifier that contain hydroxyethyl-cellulose, the 0.3-1.5% of Aloe powder, the 0.8-1.7% of propylene glycol, the 1-1.2% of medicinal glycerin, the 0-5% of 10-20% antiseptic, all the other are water; Above-mentioned percentage ratio is mass percent.
2, lubricant as claimed in claim 1 is characterized in that: it also comprises the pH value regulator that is used for the pH value of lubricant is adjusted to 6-7.
3, lubricant as claimed in claim 1 or 2 is characterized in that: also contain carbomer in the viscosifier.
4, lubricant as claimed in claim 1 or 2 is characterized in that: antiseptic is one or more the combination in methyl hydroxybenzoate, propylparaben, chlorhexidine gluconate, the two imidazolidinyl urea.
5, lubricant as claimed in claim 2 is characterized in that: the pH value regulator is sodium hydroxide or triethanolamine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310111430 CN1225291C (en) | 2003-11-21 | 2003-11-21 | Water-soluble human body lubricant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310111430 CN1225291C (en) | 2003-11-21 | 2003-11-21 | Water-soluble human body lubricant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1544100A CN1544100A (en) | 2004-11-10 |
| CN1225291C true CN1225291C (en) | 2005-11-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310111430 Expired - Lifetime CN1225291C (en) | 2003-11-21 | 2003-11-21 | Water-soluble human body lubricant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1225291C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512338A (en) * | 2012-01-13 | 2012-06-27 | 北京国联诚辉医药技术有限公司 | Water-soluble human body lubricant and preparation method thereof |
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| US7709428B2 (en) * | 2005-02-23 | 2010-05-04 | Ansell Healthcare Products Llc | Thickened spreadable warming lubricant |
| CN102205152A (en) * | 2011-05-25 | 2011-10-05 | 青岛明药堂医药科技开发有限公司 | Human body lubricant and preparation method thereof |
| CN102989045B (en) * | 2012-11-12 | 2015-02-25 | 广州共禾医药科技有限公司 | Biocompatible water-soluble composition and use thereof |
| CN103785068B (en) * | 2014-02-19 | 2016-01-13 | 江苏苏云医疗器材有限公司 | A kind of soluble oil and preparation method thereof |
| CN104784761A (en) * | 2015-03-27 | 2015-07-22 | 桂林恒保健康用品有限公司 | Personal lubricant added with modified silicone oil |
| CN106178141A (en) * | 2016-08-17 | 2016-12-07 | 贵州金玖生物技术有限公司 | Water soluble medical lubricating jelly and preparation method thereof |
| CN107011962A (en) * | 2017-06-08 | 2017-08-04 | 苏州瑞奇丽新材料有限公司 | A kind of aqueous lubricating oil |
| CN107998461A (en) * | 2017-11-17 | 2018-05-08 | 深圳市宜丽健康科技发展有限公司 | A kind of sheath that is exclusively used in has the function of the soluble oil of composite antibacterial |
| CN110269958B (en) * | 2018-03-17 | 2021-11-23 | 北京旭泽医药科技有限公司 | Delivery-aid gel composition containing carbomer and preparation method thereof |
| CN108498876A (en) * | 2018-05-06 | 2018-09-07 | 李志军 | antibacterial lubricating gel |
| CN110354317B (en) * | 2019-08-22 | 2022-02-11 | 佛山市平创医疗科技有限公司 | Preparation method of embedding liquid and preparation method of water-soluble human body lubricating liquid |
-
2003
- 2003-11-21 CN CN 200310111430 patent/CN1225291C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512338A (en) * | 2012-01-13 | 2012-06-27 | 北京国联诚辉医药技术有限公司 | Water-soluble human body lubricant and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1544100A (en) | 2004-11-10 |
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Address after: Building A1, Phase II, Optics Valley Biological Innovation Park, No.1 Jiufeng 1st Road, Jiufeng Street, Donghu New Technology Development Zone, Wuhan City, Hubei Province, 430074 Patentee after: Lefusi Health Industry Co. Address before: 430074 contemporary science and technology building, 369 Lu Lu, Hongshan District, Wuhan, Hubei Patentee before: WUHAN JISSBON SANITARY PRODUCTS Co.,Ltd. |
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Granted publication date: 20051102 |