CN116870384A - Device, method and regulation device for generating Bessel beam - Google Patents

Device, method and regulation device for generating Bessel beam Download PDF

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Publication number
CN116870384A
CN116870384A CN202310837968.9A CN202310837968A CN116870384A CN 116870384 A CN116870384 A CN 116870384A CN 202310837968 A CN202310837968 A CN 202310837968A CN 116870384 A CN116870384 A CN 116870384A
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plane wave
annular
bessel
wave
plane
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他得安
王欢
江雪
李颖
何佳杰
何敏
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Fudan University
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Fudan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/007—Stimulation by mechanical vibrations, e.g. ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/0026—Stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering

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  • Engineering & Computer Science (AREA)
  • Rehabilitation Therapy (AREA)
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  • Mechanical Engineering (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

The application provides a device, a method and a regulating device for generating Bessel beams, wherein the device for generating Bessel beams comprises an acoustic wave emitting component, and the acoustic wave emitting component is configured to emit plane waves with a certain frequency; a plane wave adjusting component, which adjusts and outputs the plane wave to be Bessel wave beams; the focusing control component can adjust the relative position between the convergence position of the Bessel beams and the target area. According to the technical scheme, the long axis focusing of the acoustic energy in the field of medical ultrasonic regulation and control is realized, the target targeting part of ultrasonic stimulation is realized, and the accurate coverage of the ultrasonic on the acupuncture point area and/or certain areas of the nerve segments can be used for applying energy stimulation, so that the requirement of medical application on stimulation treatment of the acupuncture points or the nerve segments in simulation of ultrasonic medical treatment is met.

Description

Device, method and regulation device for generating Bessel beam
Technical Field
The application relates to the technical field of medical ultrasound, in particular to a device and method for generating Bessel beams and a regulating device.
Background
The Bessel beam is a special solution of a free space wave equation, has sound intensity distribution independent of the Z-axis position, shows diffraction-free characteristics, has good characteristics of small main lobe size, long focal depth, good directivity and the like, can have self-repairing feasibility, and has great application potential in the aspect of ultrasonic stimulation of deep target organs; classical ways of generating the bessel beam include axicon, circular seam, and holographic methods, and the axicon generates the bessel beam as the most common way, which has high conversion efficiency but uneven shape, thick cone geometry and structure of the axicon lens, and is not suitable for ergonomics and miniaturization of devices, so that the application in the acoustic field is less.
Ultrasonic waves are adopted as a propagation carrier of stimulation energy in the field of ultrasonic regulation, and the wave energy can effectively penetrate biological tissues with different depths. The ultrasonic stimulation targets the beneficial effects brought by organs or specific nerve plexuses, provides a new development opportunity for the treatment of diseases, and is critical for deep stimulation to realize the focusing of the long axis of the sound field and keep the focused sound field in vivo stability. The Bessel wave beam is generated in the current acoustic field, including active and passive modes, such as phased array regulation and control, but the Bessel wave beam is limited by factors such as a manufacturing process, a sound field regulation and control algorithm, circuit driving and the like, so that the cost is high and the Bessel wave beam is inconvenient; or corresponding wave beams are generated through the super-structure, the design of the acoustic holographic lens is mostly based on the range of audible sound, and the process difficulty of the acoustic holographic lens in the ultrasonic range is high.
When the ultrasonic regulation and control device needs to be positioned in certain specific nerve segment areas, long-axis focusing is carried out on ultrasonic energy, including sound waves are effectively collected in subcutaneous long needle-shaped areas, the appearance of a traditional axicon lens is uneven, the conical geometric appearance and the structure are thick, and the ultrasonic regulation and control device is not in accordance with ergonomics and is unfavorable for the miniaturization of devices; traditional axicon structure is thick and heavy, and under the condition that does not change the phase place, holographic lens makes the whole thinning of lens, but "type zigzag" lens, the appearance is uneven, can not fine laminating human body, has restricted medical clinical application to a certain extent.
Currently, in the prior art, for example, xu Zheng et al propose a planar acoustic lens having a multiple layer glass structure to convert a divergent beam into a Bessel-like beam. However, such lenses are not suitable for plane waves. In addition, holographic acoustic lenses are also the focus of current research, which can achieve modulation of the phase and amplitude of the output waveform through acoustic metamaterials. However, the problem with metamaterials is that their structural dimensions are much smaller than the wavelength and are difficult to use in the high frequency ultrasound field.
Disclosure of Invention
Based on the problems that in the prior art, the traditional axicon lens is uneven in appearance, thick in conical geometric appearance and thick in structure, and ultrasonic energy cannot be effectively collected in certain specific nerve segment areas or subcutaneous long needle-shaped areas or acupuncture points of organisms, the application provides a device for generating Bessel beams, which adjusts plane waves to be output into Bessel beams through a binarization plane acoustic lens structure and meets the distribution requirement of a long-axis focusing sound field. A first aspect of the present application provides an apparatus for generating a bessel beam, the apparatus comprising:
an acoustic wave emitting assembly configured to emit a plane wave of a certain frequency;
a plane wave adjusting component for converting plane wave into Bessel wave
Preferably, the plane wave adjusting assembly comprises: the diameter of the annular bulges is increased from inside to outside, and an annular cavity is formed between two adjacent annular bulges; the number of annular protrusions and the number of annular cavities may be configured to adjust the plane wave passing therethrough to be a bessel wave.
Preferably, the formation of the plurality of annular projections is configured to employ a first sound-transmitting material including a photosensitive resin or silica gel or the like as the first medium; the plurality of formed annular chambers are configured with a second acoustically transparent material comprising water or a medical gel or the like as a second medium.
Preferably, the plurality of annular protrusions and the plurality of annular cavities are configured to adjust the plane wave passing therethrough to be a bessel wave includes:
the plane wave adjusting component is configured to comprise a plurality of annular bulges and a plurality of annular cavities, and sound velocity C corresponding to materials of the annular bulges and the annular cavities is respectively determined according to the materials of the annular bulges and the annular cavities 1 ，C 2 ；
In the case of the frequency f of the plane wave emitted, according toDetermining preset heights d of a plurality of annular bulges;
and determining the cavity diameter of the annular cavity according to the sound field radiation diameter of the emitted plane wave, the preset height and the emitted plane wave frequency.
Preferably, each annular protrusion is configured to have a predetermined height; the preset height is configured to be determined by the frequency of the plane wave, and the materials of the first medium and the second medium.
Preferably, the apparatus further comprises:
a focus control assembly configured to adjust a relative position between a convergence position of the Bessel beam and a target area, the focus control assembly including a frequency adjustment assembly and/or a position adjustment assembly therein;
the frequency adjustment component is configured to adjust the emission frequency of the plane wave;
the position adjusting assembly comprises a hollow cylinder with scale values, one end of the hollow cylinder is provided with at least one layer of sound-transmitting film, one side wall of the hollow cylinder is provided with a spiral adjusting assembly, the cavity of the hollow cylinder is internally provided with the plane wave adjusting assembly, and the plane wave adjusting assembly is configured to enable the plane wave adjusting assembly to move up and down along the spiral adjusting assembly according to rotation of the hollow cylinder; the position information of the plane wave adjusting assembly is configured to be identified according to the scale value of the hollow cylinder; the acoustic wave transmitting assembly is configured to be fixed at a corresponding position of a certain scale value according to an expected convergence position of the Bessel beams.
Preferably, the plane wave adjusting assembly is configured to be fabricated by 3D printing.
A second aspect of the present application provides a method for implementing a bessel beam generation based on the apparatus for bessel beam generation of the first aspect, the method specifically including:
transmitting plane waves of a certain frequency;
the coherent plane waves propagating along the same angle are interfered to form Bessel beams through the adjustment of the plane wave adjusting component.
Preferably, the interference of the coherent plane waves propagating at the same angle through the adjustment of the plane wave adjusting component to form the Bessel beam comprises:
by setting a plurality of annular bulges and a plurality of annular cavities as the plane wave adjusting assembly, according to the materials of the annular bulges and the annular cavities, respectively determining the sound velocity C corresponding to the materials 1 ，C 2 The method comprises the steps of carrying out a first treatment on the surface of the In the case of the frequency f of the plane wave emitted, according toA preset height d of a plurality of annular protrusions is determined.
Preferably, the cavity diameter of the annular cavity is determined according to the sound field diameter of the emitted plane wave, the preset height and the frequency of the emitted plane wave.
Preferably, the method further comprises: and adjusting the relative position between the convergence position of the Bessel beam and the target area according to the target control parameter, and adjusting the emission frequency of the plane wave and/or the position information of the plane wave adjusting component through the focusing control component so that the convergence position is concentrated to the target area.
A third aspect of the application provides an ultrasound steering device comprising a device for generating a bessel beam as in one of the implementations described above.
Preferably, in the ultrasound modulation device, the convergence position of the Bessel beams is adjusted to at least include a target site simulating a certain part of an acupuncture point and/or a nerve segment.
The technical proposal provided by the application has at least the following beneficial technical effects:
the device for generating the Bessel beam can be used for adjusting plane waves with a certain frequency into the Bessel beam according to the plane waves, so that long-axis focusing in the sound propagation direction is realized in a simple and convenient sound field control mode;
the Bessel beam generating device based on the plane wave adjusting component is lighter and has a simple structure, and the ultrathin plane structure is more suitable for clinical application;
through the structure of the preset plane wave adjusting component, the material of the plane wave adjusting component is selected to enable the plane wave to be divided and output Bessel beams in a binarization mode, the long-axis focusing of acoustic energy in the field of medical ultrasonic regulation is achieved, energy stimulation is applied to accurate coverage of acupuncture point areas and/or certain areas of nerve segments of organisms, accordingly the requirement that medical treatment is applied to ultrasonic treatment to stimulate and treat simulated acupuncture points or nerve segments is met, and the possibility that ultrasonic treatment is applied to clinical treatment in traditional acupuncture simulation is also achieved.
Drawings
Fig. 1 is a block diagram of an apparatus for generating a bessel beam;
FIG. 2 is a schematic diagram of a periodic structure of an acoustic wave modifying member;
FIG. 3 illustrates a three-dimensional block diagram of a plane wave adjusting assembly;
fig. 4 shows another apparatus for generating a bessel beam;
FIG. 5 shows a schematic diagram of the structure of the focus control assembly;
fig. 6 shows a schematic diagram of a 3D printing technique to fabricate a plane wave adjustment assembly.
Fig. 7 shows a flow diagram of a method of generating a bessel beam;
FIG. 8 is a schematic view showing an acoustic wave phase adjuster
FIG. 9 is a schematic diagram showing an implementation of Bessel beam convergence position adjustment by acoustic frequency adjustment;
FIG. 10 is a graph showing glycosylated hemoglobin content of blank, model and stimulated groups before and after ultrasonic stimulation;
FIG. 11 is a graph showing interleukin levels in blank, model and stimulated groups before and after ultrasonic stimulation;
FIG. 12 is a graph showing insulin content in blank, model and stimulated groups before and after ultrasound stimulation;
fig. 13 three sets of comparison diagrams of normal rat islet slices, diabetic rat islet slices, and rat islet slices after ultrasound stimulation of the zu trie acupoint.
Detailed Description
Other advantages and effects of the present application will become apparent to those skilled in the art from the following disclosure, which describes the embodiments of the present application with reference to specific examples. The application may be practiced or carried out in other embodiments that depart from the specific details, and the details of the present description may be modified or varied from the spirit and scope of the present application. It is to be understood that the terms "center," "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are directional or positional relationships as indicated based on the drawings, merely to facilitate describing the application and simplify the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus are not to be construed as limiting the application. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", etc. may explicitly or implicitly include one or more such feature. In the description of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.
It should be noted that, unless explicitly stated or limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art in a specific case.
In the medical field, the therapeutic principle of the focused ultrasonic therapeutic system is to accurately focus the beam on a target site such as a focus by utilizing the characteristics that ultrasonic waves can penetrate through human tissues and can be focused in the tissues, so that super-energy generated by focusing acts on a target area and/or a target depth area, thereby achieving the effect of noninvasive therapy.
Example 1
As shown in fig. 1, an embodiment of the first aspect of the present application provides an apparatus for generating a bessel beam, including an acoustic wave transmitting assembly 10, the acoustic wave transmitting assembly 10 being configured to transmit plane waves of a certain frequency;
a plane wave adjusting component 20, the plane wave adjusting component 20 being configured to output a plane wave adjustment as a bessel beam.
It will be appreciated that the acoustic wave transmitting assembly 10 may excite the medical ultrasound transducer to transmit planar ultrasound waves at a frequency by an electrical signal generated by a signal generator.
It will be appreciated that, for sound waves in free space, the bessel beam satisfies the equation Helmholtz eqution of the cylindrical coordinate system, the sound intensity is distributed independently of the Z-axis position, and the sound wave transmitted by the plane wave adjusting component is bessel wave or approximate bessel wave, so that the non-diffraction characteristic of a finite distance is formed in the Z-axis direction, and long-axis focusing at the target site is realized through the target area 40, such as a medical ultrasonic transducer.
Specifically, the plane wave adjusting assembly 20 may include a plurality of annular protrusions 2031 sequentially disposed from inside to outside, the diameters of the plurality of annular protrusions 2031 sequentially increasing from inside to outside, and an annular cavity 2032 is formed between two adjacent annular protrusions 2031; the number of annular protrusions 2031 and the number of annular cavities 2032 are configured to output plane wave modifications by the plane wave modifying assembly as bessel beams.
In this embodiment, the phase adjustment of the plane wave is configured by providing a plurality of annular protrusions 2031 and a plurality of annular cavities 2032 that are periodically repeated.
As shown in fig. 2, a schematic diagram of the periodic structure of the phase adjustment of the plane wave in the present embodiment is shown. Specifically, the adjusting structure forms a periodic composition, the structure may include a plurality of annular protrusions 2031, a frequency phase difference value of an acoustic wave output by the annular protrusions 2031 and an acoustic wave output by the annular cavity 2032 is pi, an annular cavity 2032 is formed between the two annular protrusions, a phase difference between adjacent wave groups is pi, the pi phase corresponding to the annular protrusions 2031 and the 0 phase corresponding to the annular cavity 2032 divide the plane wave of radiation into a periodically repeated structure according to a radiation radius of the plane wave of radiation, the phase difference between adjacent wave groups after the plane wave passes through the periodic annular protrusions 2031 and the annular cavity 2032 satisfies pi, and the transmitted acoustic wave can satisfy or approximately satisfy Bessel beam characteristics through transmission of the plane acoustic lens 201, so that the ultrasonic wave can penetrate human tissues and realize long-axis focusing inside the tissues.
In this embodiment, the annular protrusion 2031 is configured to have a preset protrusion height, and the annular cavity 2032 and the annular protrusion 2031 are configured to have a preset pitch, which can also be simply understood as a cavity diameter of the annular cavity, and the preset protrusion height of the annular protrusion 2031 is defined according to the properties of the first acoustic transmission material and the second acoustic transmission material selected by the annular protrusion 2031 and the annular cavity 2032 so that the output is stabilized to have a phase change value pi between adjacent wave groups between acoustic wave phases, so that the planar ultrasonic wave is adjusted to be a bessel wave having bessel beam characteristics.
As shown in fig. 3, a three-dimensional structure of the plane wave adjusting assembly is shown, specifically, the three-dimensional structure comprises an arrangement structure between an annular protrusion 2031 and an annular cavity 2032, a plurality of annular protrusions 2031 are periodically and repeatedly arranged according to a certain preset phase difference value, a preset height of the plurality of annular protrusions 2031 can be confirmed based on a radiation frequency of plane waves and a radiation area of the plane waves, a period value of the annular protrusions 2031 which can be repeated, a space between the annular cavity 2032 and the annular protrusions 2031, and the like.
It will be appreciated that the spacing between the annular protrusion 2031 and the annular cavity 2032 is determined by the number of pi phases and 0 phases that are periodically repeated and/or the frequency of the plane wave radiated, and when the output plane wave frequency f is a certain value, the phase adjustment parameters that need to be adjusted correspondingly may include the preset height d of the annular protrusions 2031 that are periodically repeated, the number of annular protrusions 2031, the number of annular cavities 2032, the number of periodically repeated arrangements, the spacing between the annular cavities 2032 and the annular protrusions 2031 or the cavity diameter of the annular cavities, the material of the annular protrusions 2031 and the material of the annular cavities 2032, and so on.
In the present embodiment, the protrusion height d of the annular protrusion 2031 is configured to be determined by the frequency f of the radiated plane wave and the kinds of the first and second sound-transmitting materials, and the output ultrasonic wave is stabilized to have pi as the phase change value between the adjacent wave groups between the acoustic wave phases.
In the present embodiment, the plurality of annular protrusions 2031 and the plurality of annular cavities 2032 configured to adjust the plane wave passing therethrough to be a bessel wave includes:
the plane wave adjusting assembly is configured to include a plurality of annular protrusions 2031 and a plurality of annular cavities 2032, and sound velocity C corresponding to the materials is determined according to the materials of the annular protrusions 2031 and the annular cavities 2032, respectively 1 ，C 2 ；
In the case of a transmitted plane wave frequency f, according toDetermining a preset height d of a plurality of annular bulges;
the cavity diameter of the annular cavity 202 is determined according to the acoustic field radiation diameter of the emitted plane wave, the preset height d, the emitted plane wave frequency f, and the like.
In the present embodiment, the plurality of annular protrusions 2031 are configured to transmit plane waves using a first sound-transmitting material having a certain sound transmission rate such as photosensitive resin or silica gel as a first medium and output through the plane sound lens 201.
In the present embodiment, the annular cavities 2032 formed between the annular projections 2031 are configured to transmit plane waves using a second acoustic transmission material having a certain acoustic transmission rate such as water or medical gel as a second medium and output through the plane acoustic lens 201, adjusting the plane waves to be Bessel waves having Bessel beam characteristics.
In the present embodiment, each annular protrusion 2031 is configured to have a predetermined height; the preset height is determined by the frequency f of the plane wave and the materials of the first medium and the second medium. In this embodiment, the plane wave adjusting component 203 is configured to be manufactured by 3D printing.
In this embodiment, the material of the first sound-transmitting material as the first medium may be photosensitive resin, and the second sound-transmitting material may include water as the second medium, and a person skilled in the art may select a suitable first sound-transmitting material and/or second sound-transmitting material according to actual needs, which is not limited herein.
Example 2
On the basis of the foregoing embodiment 1, as shown in fig. 4, another apparatus for generating a bessel beam in this embodiment is shown. The apparatus further comprises: a focus control component 30, the focus control component 30 being configured to adjust the relative position between the convergence position of the bessel beam and the target area or target depth area 40.
In this embodiment, when the frequency of the radiated plane wave changes in the focus control module 30, the phase difference value of the adjacent sound wave groups of the sound wave transmitted by the plane sound lens 201 also changes, the convergence position of the formed bessel beam correspondingly changes, and the relative position between the convergence position of the bessel beam and the target area or the target depth area 40 can be adjusted by setting the target control parameter related to the focus control module 30.
A focus control assembly 30 configured to adjust the relative position between the convergence position of the bessel beams and the target area, wherein the focus control assembly 30 may be completely filled with a first or second acoustically transparent material or any other common acoustically transparent material, and the focus control assembly further comprises a frequency adjustment assembly 301 and/or a position adjustment assembly 302.
In particular, the frequency adjustment component 301 is configured to adjust the emission frequency of the plane wave by means of a super energy transducer or the like of some kind that may be used to adjust the frequency of the plane wave.
Specifically, the position adjusting assembly 302 includes a hollow cylinder 3021, one end of the hollow cylinder is provided with at least one layer of sound-transmitting film, a spiral adjusting assembly 3022 is provided on a side wall of the hollow cylinder 3021, and a plane wave adjusting assembly 203 is provided in a cavity of the hollow cylinder 3021; the plane wave adjusting assembly 203 is configured such that the plane wave adjusting assembly 203 can move up and down along the screw adjusting assembly 3022 according to the rotation of the hollow cylinder 3021 such that the output position of the plane wave adjusting assembly 203 moves accordingly; the plane wave adjustment assembly 203 position information is configured to be identifiable according to the scale value of the hollow cylinder 3021; the acoustic wave transmitting assembly 10 is configured to be fixed at a certain scale position according to the convergence position expected to generate the bessel beam, so as to enable the bessel beam to be focused at a certain target position, and achieve focusing of super energy in a target area.
Specifically, as shown in fig. 5, an acoustic membrane is disposed at one end of the hollow cylinder, a spiral adjusting assembly 3022 is disposed in a cavity of the hollow cylinder 3021, the spiral adjusting assembly 3022 may include a plurality of spiral structures, the plane wave adjusting assembly 203 is disposed in the hollow cylinder 3021, the hollow cylinder 3021 is rotated, the plane wave adjusting assembly 203 may move up and down along the threaded structure of the spiral adjusting assembly 3022, the hollow cylinder 3021 is provided with a scale value for displaying a height position of the plane wave adjusting assembly 203, and the convergence position of the acoustic wave transmitting assembly 10 may be fixed at a position corresponding to a certain scale value according to an expected convergence position of the bessel beam, so that the acoustic wave transmitting assembly may be focused at a certain target location, thereby realizing focusing of the super-power in the target area.
Specifically, the target control parameters are used to generate a focal spot formed at the focal position of the bessel beam, and the target control parameters may include size information of the focal position and/or depth information of the ultrasound intensity at which the focal position needs to be focused.
In this embodiment, the plane wave adjusting component 203 may be configured to be fabricated by 3D printing technology.
It will be appreciated that the device plane wave adjusting component 203 is fabricated by 3D printing, with the relative position between the convergence position of the bessel beam and the target area 40 determined by adjusting the target control parameters of the focus control component 30.
It will be appreciated that the means for generating a Bessel beam may be configured to bond the plane wave modifying assembly 203 to the ultrasound medical transducer via a coupling agent.
As shown in fig. 6, a schematic diagram of a 3D printing technique to fabricate a plane wave adjustment assembly is shown. In this embodiment, a 3D printing technology is used to manufacture the plane wave adjusting component, an ultrasonic medical transducer with a diameter of 30mm and a plane wave frequency of 2MHz is used to radiate plane waves, the protrusion height D of the annular protrusion 203, the interval L of the annular cavity, and the period repetition value n of the plane wave adjusting component 203 should be 1.1mm, 0.8mm and 11, respectively, so that the converging position of the-3 dB bessel beam of the sound wave radiated by the plane sound lens 201 is located at a position 25mm away from the transducer, and meanwhile, the relative position between the converging position of the bessel beam and the target area 40 can be adjusted by further adjusting parameters such as the preset protrusion height D of the relevant annular protrusion 2031, the interval L of the annular cavity 2032, and the period repetition value n with a first half period and a second half period.
The above-mentioned structure is merely illustrative, in this embodiment, the radiation of the bessel beam is implemented based on the binarized plane acoustic lens 201, the plane acoustic lens 201 is coupled with the plane wave adjusting component 203 which includes the photosensitive resin with the annular protrusion 2031 and the annular cavity 2032 as the water, and the transmitted sound wave is the bessel beam by the adjustment of the plane wave adjusting component 203; by setting the target control parameters related to the focus control assembly 30, such as the frequency f of the radiated plane wave, the protrusion height d of the annular protrusion 2031, the number n of periodic repetitions of the periodic structure, the spacing value L of the annular cavity 2032 and the annular protrusion 2031, etc., the relative position between the convergence position and the target area of the bessel beam can be adjusted, so that the size information of the convergence position and/or the depth information of the ultrasonic intensity of the convergence position satisfy the requirement of ultrasonic stimulation.
Example 3
On the basis of the foregoing certain embodiment, as shown in fig. 7, another embodiment of the present application includes a flowchart of a method for implementing a method for generating a bessel beam based on an apparatus for generating a bessel beam in the related embodiment of the present application, where the method may be used in the foregoing apparatus for generating a bessel beam, and the method for generating a bessel beam may specifically include:
step S1: transmitting plane waves of a certain frequency;
step S2: interference of coherent plane waves propagating along the same angle is carried out through adjustment of a plane wave adjusting component to form Bessel beams;
it can be understood that the medical ultrasonic transducer or any signal emitter emits sound waves with a certain frequency f, the sound waves are transmitted out of the Bessel beams by the phase adjustment parameters through the plane acoustic lens, and the convergence position of the Bessel beams is adjusted to a target position or a target area or a target depth area, so that long-axis focusing ultrasonic positioning is realized.
It will be appreciated that the size information of the convergence location of the bessel beams and the depth information of the ultrasound intensity of the convergence location meet the requirements of the ultrasound stimulation of the target site.
In the present embodiment, plane waves are adjusted and output as bessel beams by setting a plurality of annular projections 2031 and a plurality of annular cavities 2032 as the division points of the binarization optimal threshold and the materials of the annular projections 2031 and the annular cavities 2032.
By presetting the materials of the annular protrusion 2031 and the annular cavity 2032, the adjustment of the corresponding plane wave at a certain frequency f to be a bessel beam through the plane acoustic lens 201 includes:
according to the materials of the preset annular bulge and the annular cavity, respectively determining sound speeds C corresponding to the first sound-transmitting material and the second sound-transmitting material 1 ，C 2 ；
In the case of a plane wave frequency f of the emission,
according toA preset height d of the plurality of annular projections is determined.
In this embodiment, the cavity diameter of the annular cavity or the spacing L between one annular protrusion 2031 and the annular cavity 2032 is determined according to the diameter of the sound field radiated by the emitted plane wave with f having a certain frequency, the preset height d of the annular protrusion 2031.
As shown in fig. 8, a schematic diagram of the acoustic wave phase adjuster is shown. In the present embodiment, the arrangement structure between the annular protrusion 2031 and the annular cavity 2032 is composed of two parts of photosensitive resin and water, respectively, the annular protrusion 2031 is defined as pi phase, the material of the annular protrusion 2031 may be selected from photosensitive resin as the first sound-transmitting material (density 1160kgm -3 ，C 1 Sound velocity 2250ms -1 ) An annular cavity 2032, defined as phase 0, which may use water as the second acoustically transparent material, water (density 998kgm -3 ，C 2 Sound speed 1482ms -1 ) The cavity diameter of the annular cavity or the spacing L between one annular protrusion 2031 and the annular cavity 2032 is determined, the preset height of the protrusion of the annular protrusion 2031 is d,
in this embodiment, the phase difference between adjacent wave groups of the output binarized plane wave isThe preset height d of the following annular protrusions is obtained according to the material parameters of the plane acoustic lens 201:
in the case of the determination of the acoustic frequency of a plane wave, if the annular protrusion 2031 and the annular cavity 2032 are set such that the received transmitted adjacent wave groups are out of phaseIn agreement with the hologram lens setting), whereby the preset protrusion height d of the annular protrusion 2031 can be determined.
In the present embodiment, if the acoustic frequency f of the plane wave is changed, the phase difference value of the adjacent wave groups transmitted by the plane acoustic lens 201 is required toThe protrusion height d of the annular protrusion 2031 should be changed accordingly.
In the present embodiment, the plane wave frequency f is reduced and the adjacent acoustic wave group transmitted by the plane acoustic lens 201 is reduced while d remains unchangedThe convergence position of the long-axis focused sound field of the output Bessel beam formation changes.
In this embodiment, the method further includes: and adjusting the relative position between the convergence position of the Bessel beam and the target area according to the target control parameter, and adjusting the emission frequency of the plane wave and/or the position information of the plane wave adjusting component through the focusing control component so that the convergence position is concentrated to the target area. .
The component for adjusting the convergence position of the bessel beam may refer to the implementation manner in the first embodiment, and will not be described herein.
As shown in fig. 9, a schematic diagram of adjusting the convergence position of the bessel beam by adjusting the frequency of the sound wave is shown, specifically, in this embodiment, the frequency of the sound wave of the radiated plane wave is increased from 1.9MHz to 2.2MHz in a step of 1000KHz, after the sound wave passes through the device for emitting the bessel beam in the embodiment of the present application, the relative positions of the convergence position of the bessel beam transmitted by the plane sound lens 201 disposed on the plane wave adjusting component 203 between the target areas 40 are 23.05mm,25.15mm,26.65mm and 28.3mm, and the corresponding simulation verification results are respectively 23.2mm,25.06mm,26.60mm and 28.87mm, so that the relative positions between the convergence position of the bessel beam and the target areas 40 are adjusted by adjusting the frequency.
In an embodiment, after the acoustic wave is adjusted by the plane wave adjusting component 203, the bezier beam transmitted by the plane acoustic lens 201 adjusts the frequency of the plane wave, so as to achieve the relative position adjustment with the target area 40, and the long axis of the acoustic wave is focused on the target area or the target depth area according to the target control parameter, for example, the method includes simulating a certain part of the acupuncture point and/or the nerve segment, so that the size information of the convergence position of the bezier beam and the depth information of the ultrasonic intensity of the convergence position meet the requirement of ultrasonic stimulation of the target.
Example 4
The traditional ultrasonic focusing mode such as a concave spherical transducer or a concave lens transducer stimulates a small ellipsoidal-like area with a focus as a center, so that accurate coverage of the acupuncture point area including simulated acupuncture is difficult to achieve; the phased array focusing is limited by factors such as a phased array manufacturing process, a sound field regulation algorithm, circuit driving and the like, so that the phased array focusing is high in cost and inconvenient to apply to ultrasonic acupuncture. The acupuncture point is not a single point location but an area with a certain linear degree, so that the key of ultrasonic simulation acupuncture treatment is to realize long axis focusing of sound energy, and further simulate the local or whole of the acupuncture point or a certain nerve segment in the corresponding target location of the traditional acupuncture stimulation, the ultrasonic can realize noninvasive and accurate regulation and control on peripheral nerve, central nerve and the like in nerve regulation and control, and therefore, a simple and convenient sound field control mode in the embodiment realizes long axis focusing in the sound propagation direction, thereby meeting the requirement of ultrasonic simulation acupuncture positioning on the needed acupuncture point or a certain nerve segment local treatment requirement, realizing high accuracy and good safety.
On the basis of the foregoing certain embodiment, another embodiment of the present application further shows a device for implementing ultrasound modulation based on the device for generating a bessel beam based on the foregoing correlation, where the ultrasound wave output by the device can be modulated and controlled by the bessel beam focused on different positions, different sizes and focusing depth information.
In this embodiment, the convergence position of the Bessel beams is adjusted to include a certain part of the acupoints and/or nerve segments of the living body.
In this embodiment, the device for implementing ultrasound modulation may be configured to generate a focal position adjustment of the bessel beam, where the focal position of the bessel beam is adjusted to a target location including at least a portion of a simulated acupuncture point and/or a nerve segment, and apply a certain amount of ultrasound energy to the target location or target area. Specifically, for example, the plane wave emission frequency f is 1MHz, the binary bessel lens selects photosensitive resin as a first sound-transmitting material, water as a second sound-transmitting material, the distance l=2.1 between the protrusion and the annular cavity, the preset height d=2.17 of the annular protrusion, the number n=6 of the annular protrusions, and the binary bessel lens rotates to the position adjustment sleeve 20mm, so that the convergence position of the bessel beam is at the position of 5mm after transdermal.
The diabetes rats are used as the treatment subjects, and the experiments are divided into three groups, namely a normal SD rat control group, a diabetes SD rat ultrasonic acupoint stimulation group and a diabetes SD rat model group.
The specific molding and grouping method is as follows: SD rats were randomly divided into a normal control group (n=8) and an STZ induction group (n=32) after 1 week of adaptive feeding of SD rats purchased from Shanghai Laek laboratory animal Limited company (200-250 g); wherein, the normal control group is given with normal feed, and the STZ induction group is given with high-fat feed;
after 4 weeks, the STZ induction group was intraperitoneally injected with a freshly prepared STZ solution (60 mg/kg disposable 1% STZ solution), the normal control group was intraperitoneally injected with an equal dose of sodium citrate, and the intraperitoneal injection was completed within 30 min;
after the intraperitoneal injection of STZ for 72h and 1 week, the tail vein blood sampling is carried out to measure fasting blood glucose (fasting blood glucose, FBG), and the rats with the FBG exceeding 16.7mmol/L are DM molding success;
rats successfully modeled were divided into two groups, the diabetes ultrasound acupoint stimulation group 8, and the diabetes model group 8.
Selecting Zusanli acupoint as regulating target, fixing regulating device at Zusanli acupoint, setting pulse repetition period to 0.5ms, pulse duration to 140 μs, and pulse average sound intensity to 2.16w/cm 2 The preparation is stimulated for 20min every day, and is stimulated for 5 days every week, and the symptoms of the diabetic rats are obviously improved after 3 weeks: after the Zusanli acupoint of the diabetic mouse is stimulated by the ultrasonic regulation device, the glycosylated hemoglobin index is obviously reduced, the corresponding inflammatory factor interleukin 6 is also obviously reduced, and the islet section after ultrasonic stimulation shows that the islet is also improved, and the method is particularly shown in fig. 10, 11, 12 and 13.
In this embodiment, the specific test method, process and data adopted include the following:
all SD rats were anesthetized by intraperitoneal injection of 10mg/kg of 3% chloral hydrate, blood was collected from the abdominal aorta, centrifuged at 3500r/min for 15min, and the supernatant was collected;
detecting serum glycosylated hemoglobin by using a rat Glycosylated Hemoglobin (GHB) enzyme-linked immunosorbent assay (ELISA) kit, and strictly operating according to the steps of the ELISA kit specification;
the method comprises the steps of detecting IL-6 by using a rat interleukin 6 (IL-6) enzyme-linked immunosorbent assay (ELISA) kit, and strictly operating according to the specification steps of the ELISA kit;
insulin was detected using a rat Insulin (INS) enzyme-linked immunoassay (ELISA) kit, which was run strictly according to the ELISA kit instructions;
in this example, the kit brands are XLPCC.
Pancreatic tissue was fixed with 4% paraformaldehyde, paraffin embedded, serial sections were made along the long axis of the pancreatic mass, 6 sections of 4 μm were prepared at 2mm intervals, HE stained and the islet morphology was observed under a microscope.
In this embodiment, the converging position of the Bessel beams directly or indirectly acts on acupoints by focusing on the target area, so that the organism generates a corresponding simulated ultrasound biological effect, and the application prospect of focusing and applying energy to the long axis of the target targeting position of ultrasound to treat diseases of the organism and regulate the function of the organism is achieved by adopting the simulated organism nerve reflex, nerve-body fluid regulation, nerve-endocrine-immune regulation and other ways.
While the present application has been described with respect to various preferred embodiments, it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the application, and it is intended that the application be limited only by the terms of the appended claims. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims (11)

1. An apparatus for generating a beam of bessel, said apparatus comprising:
an acoustic wave emitting assembly configured to emit a plane wave of a certain frequency;
and the plane wave adjusting component converts the plane wave into Bessel wave.
2. The apparatus for generating a bessel beam according to claim 1, wherein the plane wave adjusting assembly comprises: the diameter of the annular bulges is increased from inside to outside, and an annular cavity is formed between two adjacent annular bulges; the number of annular protrusions and the number of annular cavities are configured to condition the plane wave passing through the plane wave conditioning assembly as a Bessel wave.
3. An apparatus for generating a bessel beam according to claim 2, wherein the formation of a plurality of the annular projections is configured to employ a material comprising a first acoustically transparent material as a first medium; the plurality of formed annular cavities are configured to include a second acoustically transparent material as a second medium.
4. An apparatus for generating a bessel beam according to claim 2, wherein the number of annular protrusions and the number of annular cavities are configured to adjust the plane wave passing therethrough to be bessel waves comprises:
the plane wave adjusting component is configured to comprise a plurality of annular bulges and a plurality of annular cavities, and sound velocity C corresponding to materials of the annular bulges and the annular cavities is respectively determined according to the materials of the annular bulges and the annular cavities 1 ，C 2 ；
In the case of the frequency f of the plane wave emitted, according toDetermining preset heights d of a plurality of annular bulges;
and determining the cavity diameter of the annular cavity according to the sound field radiation diameter of the emitted plane wave, the preset height and the emitted plane wave frequency.
5. A device for generating a bessel beam according to claim 3, wherein each of the annular projections is configured to have a predetermined height; the preset height is configured to be determined by the frequency of the plane wave and the materials of the first medium and the second medium.
6. An apparatus for generating a bessel beam according to claim 1, wherein said apparatus further comprises:
a focus control assembly configured to adjust a relative position between a convergence position of the Bessel beam and a target area, the focus control assembly including a frequency adjustment assembly and/or a position adjustment assembly therein;
the frequency adjustment component is configured to adjust the emission frequency of the plane wave;
the position adjusting assembly comprises a hollow cylinder with scale values, one end of the hollow cylinder is provided with at least one layer of sound-transmitting film, one side wall of the hollow cylinder is provided with a spiral adjusting assembly, the cavity of the hollow cylinder is internally provided with the plane wave adjusting assembly, and the plane wave adjusting assembly is configured to enable the plane wave adjusting assembly to move up and down along the spiral adjusting assembly according to rotation of the hollow cylinder; the position information of the plane wave adjusting assembly is configured to be identified according to the scale value of the hollow cylinder; the acoustic wave transmitting assembly is configured to be fixed at a corresponding position of a certain scale value according to an expected convergence position of the Bessel beams.
7. A method of effecting a bezier beam generation based on the bezier beam generating apparatus of any one of claims 1-6, said method comprising:
transmitting plane waves of a certain frequency;
the coherent plane waves propagating along the same angle are interfered to form Bessel beams through the adjustment of the plane wave adjusting component.
8. The method of generating a bessel beam according to claim 7, wherein the interfering of coherent plane waves propagating through the plane wave adjusting assembly at the same angle to form the bessel beam comprises:
by setting a plurality of annular bulges and a plurality of annular cavities as the plane wave adjusting assembly, according to the materials of the annular bulges and the annular cavities, respectively determining the sound velocity C corresponding to the materials 1 ，C 2 ；
In the case of the frequency f of the plane wave emitted, according toDetermining preset heights d of a plurality of annular bulges;
and determining the cavity diameter of the annular cavity according to the sound field radiation diameter of the emitted plane wave, the preset height and the emitted plane wave frequency.
9. The method of generating a bessel beam according to claim 7, further comprising: and adjusting the relative position between the convergence position of the Bessel beam and the target area according to the target control parameter, and adjusting the emission frequency of the plane wave and/or the position information of the plane wave adjusting component through the focusing control component so that the convergence position is concentrated to the target area.
10. An ultrasound steering device comprising a device for generating a bessel beam according to any one of claims 1 to 6.
11. The ultrasound modulation device according to claim 10, wherein the convergence position of the bessel beams is adjusted to include at least a targeting site simulating a portion of an acupuncture point and/or nerve segment.
CN202310837968.9A 2023-07-10 2023-07-10 Device, method and regulation device for generating Bessel beam Pending CN116870384A (en)

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CN202310837968.9A CN116870384A (en) 2023-07-10 2023-07-10 Device, method and regulation device for generating Bessel beam

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310837968.9A CN116870384A (en) 2023-07-10 2023-07-10 Device, method and regulation device for generating Bessel beam

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