CN115177543A - Antibacterial and anticarious composition containing L-lactate, oral care product and preparation method and application thereof - Google Patents
Antibacterial and anticarious composition containing L-lactate, oral care product and preparation method and application thereof Download PDFInfo
- Publication number
- CN115177543A CN115177543A CN202211057741.4A CN202211057741A CN115177543A CN 115177543 A CN115177543 A CN 115177543A CN 202211057741 A CN202211057741 A CN 202211057741A CN 115177543 A CN115177543 A CN 115177543A
- Authority
- CN
- China
- Prior art keywords
- lactate
- fluoride
- parts
- oral care
- humectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 title claims abstract description 88
- 229940116871 l-lactate Drugs 0.000 title claims abstract description 85
- 239000000203 mixture Substances 0.000 title claims abstract description 75
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title abstract description 16
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 74
- 239000000606 toothpaste Substances 0.000 claims abstract description 69
- 229940034610 toothpaste Drugs 0.000 claims abstract description 62
- 208000002925 dental caries Diseases 0.000 claims abstract description 21
- 229940091249 fluoride supplement Drugs 0.000 claims description 85
- 239000003906 humectant Substances 0.000 claims description 43
- 230000003385 bacteriostatic effect Effects 0.000 claims description 30
- 239000011259 mixed solution Substances 0.000 claims description 24
- 239000002562 thickening agent Substances 0.000 claims description 18
- 239000002202 Polyethylene glycol Substances 0.000 claims description 17
- 229920001223 polyethylene glycol Polymers 0.000 claims description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 239000004094 surface-active agent Substances 0.000 claims description 15
- 235000003599 food sweetener Nutrition 0.000 claims description 14
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 14
- 239000003765 sweetening agent Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
- 239000000600 sorbitol Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- MKJXYGKVIBWPFZ-CEOVSRFSSA-L calcium;(2s)-2-hydroxypropanoate Chemical compound [Ca+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O MKJXYGKVIBWPFZ-CEOVSRFSSA-L 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000011775 sodium fluoride Substances 0.000 claims description 8
- NGSFWBMYFKHRBD-DKWTVANSSA-M sodium;(2s)-2-hydroxypropanoate Chemical compound [Na+].C[C@H](O)C([O-])=O NGSFWBMYFKHRBD-DKWTVANSSA-M 0.000 claims description 8
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 7
- 235000015218 chewing gum Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000002324 mouth wash Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 235000013024 sodium fluoride Nutrition 0.000 claims description 7
- 229960000414 sodium fluoride Drugs 0.000 claims description 7
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 7
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 7
- 229960002799 stannous fluoride Drugs 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 229940112822 chewing gum Drugs 0.000 claims description 6
- 239000004225 ferrous lactate Substances 0.000 claims description 6
- 229940037907 ferrous lactate Drugs 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 229940051866 mouthwash Drugs 0.000 claims description 6
- PHZLMBHDXVLRIX-DKWTVANSSA-M potassium;(2s)-2-hydroxypropanoate Chemical compound [K+].C[C@H](O)C([O-])=O PHZLMBHDXVLRIX-DKWTVANSSA-M 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 5
- 230000000675 anti-caries Effects 0.000 claims description 4
- 238000007872 degassing Methods 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000002280 amphoteric surfactant Substances 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 239000003945 anionic surfactant Substances 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 229960003563 calcium carbonate Drugs 0.000 claims description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 125000002091 cationic group Chemical group 0.000 claims description 3
- 239000003093 cationic surfactant Substances 0.000 claims description 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 3
- 229960004029 silicic acid Drugs 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 235000019408 sucralose Nutrition 0.000 claims description 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 2
- 239000003082 abrasive agent Substances 0.000 claims 1
- -1 fluorine ions Chemical class 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 22
- 230000002195 synergetic effect Effects 0.000 abstract description 14
- 239000011737 fluorine Substances 0.000 abstract description 12
- 229910052731 fluorine Inorganic materials 0.000 abstract description 12
- 210000000214 mouth Anatomy 0.000 abstract description 11
- 230000003405 preventing effect Effects 0.000 abstract description 7
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract description 6
- 238000001179 sorption measurement Methods 0.000 abstract description 3
- 230000001680 brushing effect Effects 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 description 28
- 239000000047 product Substances 0.000 description 28
- 239000013588 oral product Substances 0.000 description 15
- 239000000126 substance Substances 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- 239000006072 paste Substances 0.000 description 11
- 230000002401 inhibitory effect Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 229940001447 lactate Drugs 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- 241000194019 Streptococcus mutans Species 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 4
- 239000004909 Moisturizer Substances 0.000 description 4
- 241000605862 Porphyromonas gingivalis Species 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 230000001333 moisturizer Effects 0.000 description 4
- 208000028169 periodontal disease Diseases 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 3
- 230000000170 anti-cariogenic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 206010018276 Gingival bleeding Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000001013 cariogenic effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- DEQJBORXLQWRGV-UHFFFAOYSA-N 2-hydroxypropanoic acid;iron Chemical compound [Fe].CC(O)C(O)=O.CC(O)C(O)=O DEQJBORXLQWRGV-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 206010061291 Mineral deficiency Diseases 0.000 description 1
- 241000973497 Siphonognathus argyrophanes Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- COTCLZIUSPWWJJ-UHFFFAOYSA-M [Na+].[O-]S(=O)=S Chemical compound [Na+].[O-]S(=O)=S COTCLZIUSPWWJJ-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000002814 agar dilution Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000000214 effect on organisms Effects 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940023486 oral product Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical group [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
- 239000001521 potassium lactate Substances 0.000 description 1
- 235000011085 potassium lactate Nutrition 0.000 description 1
- 229960001304 potassium lactate Drugs 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of oral care products, in particular to an L-lactate-containing antibacterial and anticarious composition, an oral care product, a preparation method and application thereof. The antibacterial and anticarious composition comprises two components of L-lactate and fluoride which are applied to the preparation of oral care products according to a certain proportion, presents a synergistic effect phenomenon on the antibacterial effect, and solves the technical problem of further improving the anticarious effect of the fluorine-containing toothpaste. The composition is applied to oral care products including toothpaste, and by the operations of brushing teeth, gargling and the like, the enrichment of fluorine ions can be promoted and the antibacterial and anticarious effects of the fluorine ions can be enhanced by utilizing the strong biological adsorbability of L-lactate and the adsorption effect of the L-lactate on the fluorine ions. The oral care composition containing the composition can help a user to effectively clean the oral cavity, has an enhanced effect of preventing dental caries, and has a good application prospect.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to an L-lactate-containing antibacterial and anticarious composition, an oral care product, a preparation method and application thereof.
Background
The discovery of fluoride anticarious is honored as one of the biggest contributions of oral preventive medicine in the 20 th century to human beings. The mechanism of fluoride anticaries action is researched a lot, and three main mechanisms of action exist. First, it promotes remineralization of early carious lesions by eating, drinking, or applying fluoride preparations, etc., when fluoride ions are present in the oral environment. This is believed to be the primary mechanism of action, namely, to promote the deposition of apatite on the enamel surface and to recalcify the decalcified carious tooth surface so that the repair process can begin before the cavity is formed. Second, fluoride ions can act directly on plaque, reducing the ability of bacteria in plaque to produce acid. When fluoride enters the plaque, this mineral interferes with and destroys various enzymes used by the bacteria to metabolize sugars, thereby reducing the bacteria's ability to produce acid. Third, when fluoride ions are present in saliva, it mixes with saliva and bacteria, and because fluoride inhibits the sugar absorption of bacteria in plaque, deprives bacteria of its primary nutrient source, and the acid production of bacteria is reduced or eliminated.
Fluoride prevents caries by inhibiting the growth and reproduction of cariogenic bacteria and slowing the rate of acid production. Streptococcus mutans, the major cariogenic bacterium of the teeth, is particularly sensitive to fluorine and can produce bacterial mutations or adaptations upon exposure to fluorine, and can even result in the production of fluorine-resistant bacteria, thereby altering the microbial micro-ecology of the bacteria. Although the fluorine-containing oral care product in the prior art is of five-flower eight, how to improve the anti-caries effect of fluoride and improve the utilization rate of the fluoride still is a problem to be solved urgently in the field of oral care products.
Disclosure of Invention
The invention aims to provide a bacteriostatic and anticarious composition containing L-lactate, which aims to solve the technical problem of further improving the anticarious effect of fluorine-containing toothpaste. The scheme effectively combines the L-lactate and the fluoride and uses the L-lactate and the fluoride in the oral cavity articles, combines and adds the L-lactate and the fluoride by utilizing the property characteristics of the two components, and experiments prove that the beneficial effects of the L-lactate and the fluoride are achieved, and the synergistic enhanced antibacterial and anticarious composition components are obtained, so that the L-lactate and the fluoride can help users to effectively clean the oral cavity, prevent decayed teeth and relieve symptoms such as gingival bleeding.
In order to achieve the purpose, the invention adopts the following technical scheme:
a bacteriostatic anticarious composition containing L-lactate comprises L-lactate and fluoride.
The scheme also provides an oral care product of the antibacterial and anticarious composition containing the L-lactate, wherein the oral care product comprises toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel and chewing gum.
The principle and the beneficial effects of the technical scheme are as follows:
the oral composition containing the L-lactate provided by the invention is added in a combined manner by utilizing the property characteristics of the L-lactate and the fluoride, and experiments prove that the beneficial effects of the oral composition are realized, so that the antibacterial and anticarious composition components which can be synergistically enhanced are obtained, a user is helped to effectively clean the oral cavity, and the symptoms of gingival bleeding, halitosis, caries prevention and the like are solved. The scheme simultaneously uses the L-lactate and the fluoride in the preparation of the oral cavity cleaning product, can obtain a relatively ideal antibacterial and anticarious effect, and further improves the effect of the fluoride. Particularly in actual oral care operations (e.g., brushing the teeth with toothpaste). The reason for the analysis by the inventors is that: the L-lactate can be effectively adhered to oral mucosa or tooth surface, and carboxyl ions contained in lactate ions can form intermolecular hydrogen bonds with fluorine ions, so that the adsorption force on the fluorine ions is increased, and the fluorine ions are strengthened to play a bacteriostatic and anticarious role.
In the technical scheme, two substances, namely L-lactate and fluoride, are used. L-lactate is a derivative of L-lactic acid, which is formed by losing protons of carboxyl groups in L-lactic acid molecules and changing the carboxyl groups into carboxylate ions, and is widely applied in the field of daily chemicals. The L-lactate has good biocompatibility due to the characteristic of levorotation, can be fused with mammals, can directly participate in human metabolism, has no side effect, and is widely applied to the fields of food, medicine and the like. L-lactate components such as L-calcium lactate, L-sodium lactate, L, potassium lactate, and L-ferrous lactate have antibacterial and tartar resisting effects in oral care products, and have positive effect in inhibiting gingivitis. In addition, the L-lactate is a good mineral fortifier due to high bioavailability, good taste, neutral pH value and high solubility, and can be used for corresponding mineral deficiency.
The L-lactate has the functions of oxidation resistance and bacteriostasis, so that the periodontitis can be effectively inhibited; fluoride is used as a caries preventing agent recognized in the industry, the caries preventing effect of the fluoride is influenced by the pH value, and the fluoride can exert a better caries preventing effect under a weak acid environment. The inventor originally aims to utilize the advantages of two substances and simultaneously add the two substances into an oral care product, and unexpectedly finds that the two substances have synergistic effect on the effect of inhibiting common bacteria in the oral environment besides the antioxidant, bacteriostatic and anticariogenic effects of the two substances. The inventor carries out a large number of bacteriostatic tests to verify that the L-lactate and fluoride are used together to have a synergistic effect, and the bacteriostatic effect of the bacteriostatic caries-preventing composition is obviously improved compared with that of the L-lactate and fluoride which are used singly. The inventor analyzes that the mechanism of the synergy of the two substances is as follows: the L-lactate has a better adsorption effect on organisms, and lactate ions in the L-lactate and fluoride ions can form intermolecular hydrogen bonds, so that the solubility and bioavailability of the fluoride ions are increased, and the bacteriostatic effect is further increased. Especially in the process of cleaning the oral cavity, the L-lactate has better adsorbability to biological membranes (oral mucosa, biological membranes formed by oral bacteria and the like), and in addition, the L-lactate has an antibacterial effect and can effectively change the oral environment. Secondly, lactate ions in the L-lactate can form intermolecular hydrogen bonds with fluoride ions, so that the solubility of the fluoride ions is increased, the fluoride ions are attached to teeth and other parts, and the dental caries prevention effect of the fluoride ions on oral cavities is improved.
The inventor further applies the bacteriostatic anticarious composition consisting of L-lactate and fluoride in toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum. In the using process, the two substances are synergistic, and the inhibition on oral bacteria can be realized. The antibacterial and anticarious composition has multiple protection effects on the oral cavity and can inhibit the breeding of streptococcus mutans. And because related oral pathogenic bacteria are inhibited, the antibacterial and anticariogenic composition also has certain potential for preventing and treating caries and periodontal disease.
In conclusion, the antibacterial and anticarious composition consisting of the L-lactate and the fluoride has the beneficial effects that:
(1) The L-lactate has good biocompatibility due to the characteristic of levorotation, can be well adsorbed on the surface of a biological membrane, is compatible with mammal, can directly participate in human metabolism, has a certain bacteriostatic action, can play a synergistic action with an antimicrobial agent, and can effectively play a role in inhibiting oral bacteria when added into an oral care product.
(2) Fluoride is often provided by oral care products, but has limited effectiveness. The L-lactate of the oral composition containing the L-lactate can be effectively adhered to oral mucosa or tooth surfaces, and lactate ions in the L-lactate can form hydrogen bonds with fluoride ions, so that the adhesion of the fluoride ions to oral cavities can be increased, and the bacteriostatic and anticarious effects of the fluoride ions are enhanced.
(3) The L-lactate and the fluoride are compounded and applied to toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel, chewing gum and other oral care products, so that the oral care product has multiple protection effects on the oral cavity and improves the antibacterial and anticarious effects of the oral care product.
Further, the weight percentage of the fluoride is 20-99.9%, and the rest component is L-lactate. By adopting the proportion, the L-lactate and the fluoride can fully play the roles of antibiosis and dental caries prevention.
Further, the L-lactate comprises at least one of L-sodium lactate, L-potassium lactate, L-calcium lactate and L-ferrous lactate. Experiments prove that the L-lactate can realize the synergistic interaction with fluoride, and the lactate is common and easy to obtain.
Further, the fluoride includes at least one of sodium fluoride, stannous fluoride, and sodium monofluorophosphate. The fluoride is commonly used in oral care products, is easy to obtain and has stable properties.
Further, the oral care product comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 10-70 parts of humectant, 0-60 parts of abrasive, 0.1-10 parts of thickener, 0.1-20 parts of surfactant, 0.1-2 parts of sweetener and 0.1-5 parts of essence. The bacteriostatic caries-preventing composition consisting of fluoride and L-lactate can be added into oral care products to clean the oral cavity and simultaneously realize bacteriostatic caries prevention. According to the formula, proper raw material dosage is selected, and products such as toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel, chewing gum and the like can be prepared.
Further, the oral care product comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 20-60 parts of humectant, 10-50 parts of abrasive, 0.5-3 parts of thickening agent, 0.1-5 parts of surfactant, 0.1-0.5 part of sweetening agent and 0.1-2 parts of essence. The formula is used for preparing the toothpaste, the toothpaste is the most common oral cleaning article with the highest use frequency, and the antibacterial and anticarious composition is added into the toothpaste, so that the use frequency of the antibacterial and anticarious composition can be increased, and better effects of inhibiting oral bacteria and preventing caries can be obtained.
Further, the moisturizer comprises a first moisturizer and a second moisturizer; the first humectant comprises at least one of glycerin, sorbitol and propylene glycol; the second humectant is polyethylene glycol.
By adopting the technical scheme, the glycerol, the sorbitol and the propylene glycol are humectants which can be used in the toothpaste, and the humectants need to be matched with the polyethylene glycol for use so as to ensure the stability of the toothpaste. Wherein, in the system containing L-lactate and fluoride, the sorbitol can most effectively maintain the stability of the paste and increase the bacteriostatic effect of the toothpaste.
Further, the abrasive includes at least one of calcium carbonate, hydrated silica, calcium hydrogen phosphate and calcium pyrophosphate; the thickening agent comprises at least one of hydroxyethyl cellulose, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium polyacrylate and carbomer; the surfactant comprises at least one of anionic, cationic, amphoteric, and nonionic surfactants; the sweetener comprises at least one of sodium saccharin and sucralose. The abrasive, the surfactant and the like are common substances in the prior art, and have the advantages of good safety and stability, low price and easy acquisition.
The technical scheme also provides a preparation method of the oral care product, which comprises the following steps in sequence:
s1: dispersing a thickening agent into polyethylene glycol, adding a first humectant, and fully swelling to form a mixed solution A;
s2: fully mixing fluoride and L-lactate, and dissolving the mixture with water to form a mixed solution B;
s3: adding a sweetening agent, a surfactant and water into the mixed solution A, and homogenizing to obtain a mixed solution C;
s4: fully stirring the mixed solution C and the mixed solution B to form a mixed solution D;
s5: adding a friction agent into the mixture D, and fully and uniformly mixing to obtain a mixture E;
s6: and adding essence into the mixture E, homogenizing, and degassing to obtain the product.
The principle and the beneficial effect of adopting the scheme are that:
the preparation method is suitable for preparing toothpaste. In the preparation process, the thickening agent and the polyethylene glycol are fully dispersed, and then the rest humectant is added for dispersion and swelling, so that the toothpaste (represented by oral care products) forms a stable frame structure. And secondly, the L-lactate and the fluoride are fully contacted and mixed, and then are fully dissolved by water, so that the L-lactate and the fluoride can be fully contacted, and the effects of the L-lactate and the fluoride in the aspects of caries resistance, bacteria inhibition and the like are improved. The final mixing is followed by the addition of other ingredients, and the preparation process ensures the stability of the toothpaste (representative of oral care products) and the efficacy of both L-lactate and fluoride.
In addition to toothpastes, the compositions of the present invention may also be used in the preparation of other oral cleaning products such as liquid toothpastes, mouth rinses, tooth powders, tooth gels and chewing gums. The composition formed by the L-lactate and the fluoride can be added to the corresponding product according to the conventional means in the prior art.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto. Unless otherwise specified, the technical means used in the following examples and experimental examples are conventional means well known to those skilled in the art, and the materials, reagents and the like used therein are commercially available.
Summary of protocol conditions:
(1) Composition comprising a metal oxide and a metal oxide
The bacteriostatic anticarious composition for oral products consists of fluoride in 20-99.9 wt% and L-lactate in the rest. The fluoride is one or more of sodium fluoride, sodium monofluorophosphate and stannous fluoride.
Both the L-lactate and fluoride are commercially available from commercial suppliers. Wherein the L-sodium lactate, the L-potassium lactate, the L-ferrous lactate and the L-calcium lactate are purchased from Zhengzhou Epson engineering Co., ltd and are in food grade. Fluorides (including sodium fluoride, stannous fluoride, sodium monofluorophosphate, etc.) are purchased from chemical group ltd, dawn north of Hubei, at cosmetic grade.
(2) Toothpaste prepared from the composition
The toothpaste containing the antibacterial and anticarious composition comprises the antibacterial and anticarious composition, an abrasive, a thickening agent, a humectant, a sweetening agent, a surfactant, other functional components, essence and water. The weight parts of each component are respectively as follows: 0.1-2.0 parts of fluoride, 0.1-1.0 part of L-lactate, 10-70 parts of humectant, 0-60 parts of abrasive, 0.1-10 parts of thickening agent, 0.1-20 parts of surfactant, 0.1-2 parts of sweetening agent and 0.1-5 parts of essence.
The purity of the fluoride is more than or equal to 99.5 percent; the purity of the L-lactate is more than or equal to 99.5 percent; the water is purified water. The fluoride comprises at least one of sodium fluoride, stannous fluoride and sodium monofluorophosphate; the L-lactate comprises at least one of L-calcium lactate, L-ferrous lactate, L-sodium lactate and L-potassium lactate.
The humectant is preferably present in an amount ranging from 20 to 60 parts, and includes at least one of glycerin, sorbitol, propylene glycol (first humectant) and polyethylene glycol (second humectant), with the first humectant preferably being glycerin. The mass ratio of the first humectant to the second humectant is 5-50, more preferably 40-50:10.
the content range of the abrasive is preferably 10 to 50 parts, and includes at least one of calcium carbonate, hydrated silica, calcium hydrogen phosphate and calcium pyrophosphate.
The content of the thickener is preferably 0.5-3 parts, and the thickener comprises at least one of hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate and carbomer.
The surfactant is preferably present in an amount ranging from 0.1 to 5 parts, and includes at least one of anionic, cationic, amphoteric and nonionic surfactants, such as sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium thiosulfonate or cocamidopropyl betaine, and the like.
The sweetener is preferably present in an amount ranging from 0.1 to 0.5 parts and includes at least one of saccharin sodium and sucralose.
The content of the essence is preferably 0.1-2 parts, and comprises at least one of herba Menthae, browse sesame oil, peppermint and anethole.
The preparation method of the toothpaste comprises the following steps:
s1: mixing the thickening agent and polyethylene glycol (second humectant) and fully dispersing, and adding the rest humectant (first humectant) for fully swelling to form mixed solution A.
S2: after the fluoride and the lactate are fully mixed, the mixture B is dissolved by water with the mass fraction of 10-15% (for the convenience of comparison, the water is uniformly used for 10% in the examples and the comparative examples).
S3: adding a sweetening agent, a surfactant and the rest water into the mixed solution A, and homogenizing to obtain a mixed solution C.
S4: and fully stirring the mixed solution C and the mixed solution B to form a mixed material D.
S5: adding a friction agent into the mixture D, and fully and uniformly mixing to obtain a mixture E;
s6: and adding essence into the mixture E, homogenizing, degassing to obtain a product, and filling into a toothpaste hose by a conventional method.
Examples 1-6 show the composition of bacteriostatic anticariogenic compositions, as follows:
example 1: bacteriostatic anticarious composition for oral products
The antibacterial and anticarious composition for the oral products comprises the following components in percentage by weight: 20 percent of sodium fluoride and 80 percent of L-sodium lactate.
Example 2: bacteriostatic anticarious composition for oral products
The antibacterial and anticarious composition for the oral products comprises the following components in percentage by weight: 30% of stannous fluoride and 70% of L-calcium lactate.
Example 3: antibacterial and anticarious composition for oral products
The antibacterial and anticarious composition for the oral products comprises the following components in percentage by weight: 40 percent of sodium monofluorophosphate and 60 percent of L-potassium lactate
Example 4: bacteriostatic anticarious composition for oral products
The antibacterial and anticarious composition for the oral products comprises the following components in percentage by weight: 99.9 percent of sodium fluoride and 0.1 percent of L-ferrous lactate.
Example 5: bacteriostatic anticarious composition for oral products
The antibacterial and anticarious composition for the oral products comprises the following components in percentage by weight: 25% of stannous fluoride and 75% of sodium L-lactate.
Example 6: bacteriostatic anticarious composition for oral products
The antibacterial and anticarious composition for the oral products comprises the following components in percentage by weight: 30% of sodium monofluorophosphate and 70% of L-calcium lactate.
Examples 7-16 illustrate the acquisition of a toothpaste containing a bacteriostatic anticaries composition, the toothpaste formulation being specified in Table 1. The total weight portion of the toothpaste is 100 portions, and when the sum of other toothpaste raw materials is less than 100 portions, the balance is supplemented by water.
Table 1: formula (unit: mass parts) of antibacterial anticarious toothpaste
Experimental example 1: bacteriostasis test
To verify the bacteriostatic effect of the toothpastes of the present invention, toothpastes with no L-lactate added but fluoride (group 2 in table 2), and toothpastes with L-lactate and fluoride (group 4 in table 2), and a control of the two toothpastes (group 1 and group 3 in table 2) were prepared, and the specific formulations are shown in table 2.
Table 2: toothpaste prescription table (100 parts by weight)
The four toothpaste groups shown in Table 2 were mixed and dissolved in agar culture by agar dilution method according to the minimum inhibitory concentration test method of disinfection technical Specification-2.1.8.3, 2002 by the Ministry of health, and then tested bacteria were inoculated, and the minimum inhibitory concentration of the antibacterial substance for inhibiting the growth of the tested bacteria was determined according to the growth of the bacteria, and the results are shown in tables 3-7.
Table 3: MIC test results with L-sodium lactate and/or fluoride
Table 4: MIC test results with L-calcium lactate and/or fluoride
Table 5: MIC test results with ferrous L-lactate and/or fluoride
Table 6: MIC test results with L-potassium lactate and/or fluoride
As shown in the results of the bacteriostatic tests in tables 3-6, the Minimal Inhibitory Concentrations (MICs) obtained in the experiments of the groups 2 and 3 have obvious bacteriostatic advantages compared with the blank control of the group 1. In the 4 groups in tables 3-6, compared with the 2 group and the 3 group, the inhibition effect of streptococcus mutans and the inhibition effect of porphyromonas gingivalis are both better, and the synergistic enhancement effect of the antibacterial effect is proved by adding L-lactate and fluoride. Among them, streptococcus mutans is a harmful bacterium mainly causing caries, and Porphyromonas gingivalis is a harmful bacterium mainly causing periodontal disease. Because the composition of the scheme can effectively inhibit bacteria related to caries and periodontal disease for the related bacteria, the antibacterial and anticarious composition also has certain potential for preventing and treating caries and periodontal disease.
The antibacterial and anticarious composition is not only used in toothpaste which is an oral product, but also is applicable to liquid toothpaste, mouthwash, tooth powder, tooth gel, chewing gum and other oral products.
Comparative example 1: influence of humectant on antibacterial effect and stability of ointment
The preparation methods of groups 1 to 5 of this comparative example 1 are basically the same as those of example 8, except for the difference in the formulation, and the formulation of this comparative example is shown in Table 7. In addition, since polyethylene glycol is not contained in groups 3 to 5, the thickener is dispersed in S1 as it is using the first humectant to form a mixed solution A.
Table 7: set of recipe (parts by weight) of 1 group to 5 groups of comparative example 1
The minimum concentrations (MIC) at which the anti-bacterial substance of example 8, groups 1, 2, 3, 4 and 5 of this comparative example 1 inhibited the growth of the test bacteria were examined with reference to the method of experimental example 1 were as follows (table 8):
table 8: MIC test results of 1-5 groups of comparative example 1
According to the experimental results, the following results are obtained: in example 8, 0.5 parts by weight of fluoride and 0.1 parts by weight of L-lactate were used together to prepare toothpaste, and the obtained toothpaste showed relatively ideal antibacterial effects against Streptococcus mutans and Porphyromonas gingivalis. The difference between group 1 and group 2 and example 8 is that when sorbitol, which is the first humectant, was replaced with glycerin or propylene glycol, the bacteriostatic effect of the obtained toothpaste was reduced by 5 times. This demonstrates that the selection of the appropriate humectant plays a very significant role in the exertion of the synergistic effect of fluoride and L-lactate. The difference between group 4 and example 8 is that: the second humectant does not adopt polyethylene glycol, and the thickening agent is not dispersed by using polyethylene glycol, so that the obtained toothpaste has a poor antibacterial effect. Group 3 differs from example 8 in that: the second humectant is not polyethylene glycol, and the first humectant is not sorbitol, so that the obtained toothpaste has an unsatisfactory antibacterial effect. The experimental results of groups 3 and 4 show that the addition of polyethylene glycol, in combination with sorbitol, plays an important role in the synergistic effect of fluoride and L-lactate. In the 5 groups, only sorbitol is used as the humectant, and other types of humectants are not compounded, so that the synergistic effect of the fluoride and the L-lactate is not exerted. In combination, although fluoride and L-lactate exhibit some synergy, other ingredients in the toothpaste formulation can also have an effect on whether or not such synergistic effects can be manifested. The combination of sorbitol and polyethylene glycol moisturizers maximizes the synergistic effect between fluoride and L-lactate. The inventors have analyzed that the best binding and enrichment of fluoride by L-lactate and the best adhesion of L-lactate to bacteria, which enhances the inhibition of both substances against bacteria, are found in toothpaste formulations containing certain amounts of sorbitol and polyethylene glycol.
In addition, the inventors have observed the stability of the toothpaste according to GB/T8372-2017. Taking 2 toothpaste samples from each group, storing 1 toothpaste sample at room temperature, placing the other toothpaste sample in a refrigerator at-8 + -1 deg.C for 8h, taking out, immediately placing in a constant temperature incubator at 45 + -1 deg.C, taking out after 8h, recovering room temperature, and observing stability. For the toothpaste of example 8, after the cap was opened, the paste did not overflow out of the tube mouth; inverting the toothpaste tube body, and dripping no liquid from the tube orifice within 10 s; compared with the sample stored at room temperature, the extruded toothpaste has normal fragrance and color, and the surface of the toothpaste is glossy. For the toothpastes of comparative examples 1 to 5, the toothpaste surfaces of group 1 and 2 were not glossy but did not affect the use. Oil separation of tail part and head part of the paste occurs in 3 groups, 4 groups and 5 groups respectively, namely solid phase and liquid phase are separated, and the paste is unstable. In the toothpaste containing L-lactate, fluoride and other components, the selection of the type of the humectant is very important for maintaining the stability of the paste, and the combination of the sorbitol and the polyethylene glycol can ensure the stability of the paste to the maximum extent.
The above experimental results show that the selection of a suitable humectant is very important for maintaining the stability of the toothpaste body containing L-lactate, and that the selection of a suitable humectant ensures that the ideal synergistic effect can be produced between L-lactate and fluoride.
Comparative example 2: influence of the manufacturing process on the stability of the paste
This comparative example 2 is substantially the same as example 8, except that the preparation method of the toothpaste is as follows:
the preparation method of the toothpaste comprises the following steps:
s1: mixing the thickening agent and polyethylene glycol (second humectant) and fully dispersing, and adding the rest humectant (first humectant) for fully swelling to form mixed solution A.
S2: adding fluoride and lactate into the mixed solution A, and homogenizing to obtain a mixed solution A'.
S3: adding a sweetening agent, a surfactant and water into the mixed solution A', and homogenizing to obtain a mixed material C.
S4: adding a friction agent into the mixture C, and fully and uniformly mixing to obtain a mixture D;
s5: and adding essence into the mixture D, homogenizing, degassing to obtain a product, and filling into a toothpaste hose by a conventional method.
The stability of the toothpaste of comparative example 2 was observed according to GB/T8372-2017, showing the visualization of inverting the toothpaste tube out of the water. The toothpaste with the cross section shows that the paste body is divided, and the surface of the toothpaste is rough, so that the use is influenced. The above experiments show that proper manufacturing process is very important for maintaining the stability of the paste when the toothpaste is prepared by using the formula of the scheme. Mixing humectant and thickener, mixing with sweetener and surfactant, and adding into solutionFluoride and lactate, and the paste prepared by the method has better stability. The minimum concentration (MIC) of the antibacterial substance inhibiting the growth of the test bacterium of this comparative example 2 was determined by referring to the method of Experimental example 1 as follows: streptococcus mutans 2X 10 3 Mu g/ml, 2X 10 Porphyromonas gingivalis 3 μg/ml。
The above results demonstrate that the exertion of the synergistic effect of L-lactate and fluoride, and the maintenance of paste stability under the present formulation, require specific manufacturing processes to be assured.
The foregoing is merely an example of the present invention and common general knowledge in the art of designing and/or characterizing particular aspects and/or features is not described in any greater detail herein. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several variations and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (10)
1. An antibacterial and anticarious composition containing L-lactate is characterized in that: including L-lactate and fluoride.
2. The bacteriostatic caries-preventing composition containing L-lactate according to claim 1, which is characterized in that: the weight percentage of the fluoride is 20-99.9%, and the rest component is L-lactate.
3. The bacteriostatic caries-preventing composition containing L-lactate according to claim 1, which is characterized in that: the L-lactate comprises at least one of L-sodium lactate, L-potassium lactate, L-calcium lactate and L-ferrous lactate.
4. The bacteriostatic caries-preventing composition containing L-lactate according to claim 1, which is characterized in that: the fluoride comprises at least one of sodium fluoride, stannous fluoride and sodium monofluorophosphate.
5. An oral care product comprising an L-lactate-containing bacteriostatic anticaries composition according to any one of claims 1 to 4, wherein the oral care product comprises toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel, and chewing gum.
6. The oral care implement of claim 5, wherein: the composite material comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 10-70 parts of humectant, 0-60 parts of abrasive, 0.1-10 parts of thickener, 0.1-20 parts of surfactant, 0.1-2 parts of sweetener and 0.1-5 parts of essence.
7. The oral care implement of claim 6, wherein: the composite material comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 20-60 parts of humectant, 10-50 parts of abrasive, 0.5-3 parts of thickener, 0.1-5 parts of surfactant, 0.1-0.5 part of sweetener and 0.1-2 parts of essence.
8. The oral care implement of claim 6 or 7, wherein the humectant comprises a first humectant and a second humectant; the first humectant comprises at least one of glycerin, sorbitol and propylene glycol; the second humectant is polyethylene glycol.
9. The oral care implement of claim 7 or 8, wherein the abrasive agent comprises at least one of calcium carbonate, hydrated silica, calcium hydrogen phosphate and calcium pyrophosphate; the thickening agent comprises at least one of hydroxyethyl cellulose, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium polyacrylate and carbomer; the surfactant comprises at least one of anionic, cationic, amphoteric, and nonionic surfactants; the sweetener comprises at least one of sodium saccharin and sucralose.
10. The method of manufacturing an oral care implement according to claim 9, wherein: the method comprises the following steps of:
s1: dispersing a thickening agent into polyethylene glycol, adding a first humectant, and fully swelling to form a mixed solution A;
s2: fully mixing fluoride and L-lactate, and dissolving with water to form a mixed solution B;
s3: adding a sweetening agent, a surfactant and water into the mixed solution A, and homogenizing to obtain a mixed solution C;
s4: fully stirring the mixed solution C and the mixed solution B to form a mixed solution D;
s5: adding a friction agent into the mixture D, and fully and uniformly mixing to obtain a mixture E;
s6: and adding essence into the mixture E, homogenizing, and degassing to obtain the product.
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