CN114958490A - Cleaning agent for removing sputum and preparation method thereof - Google Patents
Cleaning agent for removing sputum and preparation method thereof Download PDFInfo
- Publication number
- CN114958490A CN114958490A CN202210735545.1A CN202210735545A CN114958490A CN 114958490 A CN114958490 A CN 114958490A CN 202210735545 A CN202210735545 A CN 202210735545A CN 114958490 A CN114958490 A CN 114958490A
- Authority
- CN
- China
- Prior art keywords
- sputum
- cleaning agent
- stirring
- agent
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012459 cleaning agent Substances 0.000 title claims abstract description 73
- 206010036790 Productive cough Diseases 0.000 title claims abstract description 67
- 208000024794 sputum Diseases 0.000 title claims abstract description 67
- 210000003802 sputum Anatomy 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 238000005260 corrosion Methods 0.000 claims abstract description 24
- 230000007797 corrosion Effects 0.000 claims abstract description 23
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims abstract description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000004094 surface-active agent Substances 0.000 claims abstract description 20
- 108091005658 Basic proteases Proteins 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 14
- 108010028921 Lipopeptides Proteins 0.000 claims abstract description 13
- 239000003112 inhibitor Substances 0.000 claims abstract description 13
- 229960004543 anhydrous citric acid Drugs 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 9
- -1 hydroxyl ethylidene phosphonic acid Chemical compound 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 7
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 claims description 6
- 239000003599 detergent Substances 0.000 claims description 5
- OUNZARDETXBPIX-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)acetic acid Chemical compound CCCCCCCCCCCCOCCOCC(O)=O OUNZARDETXBPIX-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 235000019864 coconut oil Nutrition 0.000 claims description 3
- 239000003240 coconut oil Substances 0.000 claims description 3
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000000344 soap Substances 0.000 claims description 3
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims description 2
- HJVAFZMYQQSPHF-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;boric acid Chemical compound OB(O)O.OCCN(CCO)CCO HJVAFZMYQQSPHF-UHFFFAOYSA-N 0.000 claims description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 2
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 claims description 2
- 239000012964 benzotriazole Substances 0.000 claims description 2
- 239000000176 sodium gluconate Substances 0.000 claims description 2
- 229940005574 sodium gluconate Drugs 0.000 claims description 2
- 235000012207 sodium gluconate Nutrition 0.000 claims description 2
- 229940048842 sodium xylenesulfonate Drugs 0.000 claims description 2
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 238000004140 cleaning Methods 0.000 abstract description 10
- 239000003344 environmental pollutant Substances 0.000 description 19
- 231100000719 pollutant Toxicity 0.000 description 19
- 238000012360 testing method Methods 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- 239000006260 foam Substances 0.000 description 17
- 230000001680 brushing effect Effects 0.000 description 12
- 238000002791 soaking Methods 0.000 description 11
- 230000008569 process Effects 0.000 description 10
- 239000008213 purified water Substances 0.000 description 10
- 238000000354 decomposition reaction Methods 0.000 description 7
- 229940051841 polyoxyethylene ether Drugs 0.000 description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 238000003113 dilution method Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 101800000263 Acidic protein Proteins 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000005065 mining Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000012797 qualification Methods 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- 210000004969 inflammatory cell Anatomy 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012430 stability testing Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- WKPFIJAMMDLXDI-UHFFFAOYSA-N 1,2-thiazolidin-4-one Chemical compound O=C1CNSC1 WKPFIJAMMDLXDI-UHFFFAOYSA-N 0.000 description 1
- 239000010963 304 stainless steel Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 229910000589 SAE 304 stainless steel Inorganic materials 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002455 scale inhibitor Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/04—Carboxylic acids or salts thereof
- C11D1/06—Ether- or thioether carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/37—Mixtures of compounds all of which are anionic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D10/00—Compositions of detergents, not provided for by one single preceding group
- C11D10/04—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap
- C11D10/042—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap based on anionic surface-active compounds and soap
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/166—Organic compounds containing borium
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2041—Dihydric alcohols
- C11D3/2044—Dihydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2065—Polyhydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/28—Heterocyclic compounds containing nitrogen in the ring
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/30—Amines; Substituted amines ; Quaternized amines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/32—Amides; Substituted amides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/349—Organic compounds containing sulfur additionally containing nitrogen atoms, e.g. nitro, nitroso, amino, imino, nitrilo, nitrile groups containing compounds or their derivatives or thio urea
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38618—Protease or amylase in liquid compositions only
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/43—Solvents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Detergent Compositions (AREA)
Abstract
The invention discloses a cleaning agent for removing sputum and a preparation method thereof, belonging to the field of medical cleaning agents. The cleaning agent comprises the following components: 1-3% of lipopeptide, 5-6% of ethanolamine, 2-3% of anhydrous citric acid, 2-3% of hydroxyl ethylidene phosphonic acid, 8-10% of surfactant, 0.2-0.3% of corrosion inhibitor, 10-15% of solvent, 0.1% of alkaline protease Espers Duo 100L 5-8% of bacteriostatic agent and the balance of distilled water. The cleaning agent disclosed by the invention has the advantages of stable performance, obvious effect, good stability, safety, mildness and no corrosion, and can be used for manually cleaning medical tracheal tubes.
Description
Technical Field
The invention relates to the technical field of cleaning agents, and particularly relates to a cleaning agent for removing sputum and a preparation method thereof.
Background
Sputum is a fluid produced by respiratory irritation, also called sputum. The components comprise mucus, foreign matters, pathogenic microorganisms, various inflammatory cells, necrotic and desquamated mucosal epithelial cells and the like. The increase of the viscosity of the sputum is related to the increase of the content of acidic protein in the sputum, and the high content of calcium ions in the sputum can increase the viscosity. In respiratory tract infection, the DNA generated by the destruction of a large number of inflammatory cells significantly increases the viscosity of sputum to form so-called thick sputum which is not easy to discharge and is extremely difficult to clean after being adhered to other objects.
The tracheal cannula is an auxiliary respiratory channel of a patient subjected to tracheotomy, and can provide respiratory guarantee for the patient subjected to laryngeal surgery. The tracheal tube has a complex structure, can cause a large amount of sputum attached in the tracheal tube, and increases the cleaning difficulty. The tracheal cannula is difficult to clean up in the manual treatment process due to the complexity of the structure of the tracheal cannula, and the conventional multienzyme cleaning agent or alkaline cleaning agent on the market has almost no effect of softening and removing sputum. Many patents on medical multienzyme cleaning agents or alkaline cleaning agents (CN201210534832) disclose a medical multienzyme cleaning agent and a preparation method thereof, wherein the medical multienzyme cleaning agent comprises the following components in parts by weight: the number of the polymerized units of the polyoxyethylene ether of the lauryl alcohol polyoxyethylene ether is 20, and the number of the polymerized units of the polyoxyethylene ether of the octanol polyoxyethylene ether is 5. The method provides a preparation method of the medical multienzyme cleaning agent, has wide application range, does not have special research on the removal of tracheal cannula sputum, and has unobvious removal effect. A multienzyme cleaning agent for medical apparatus and its preparing process (CN201610694650) features that the new-type dispersing scale inhibitor is used as raw material, which not only has high-effect scale-inhibiting performance, but also has the functions of increasing cleaning performance and dispersing dirt, and the calcium ions on the cell membrane of bacteria can be chelated by said cleaning agent, so easily permeating the antiseptic into bacteria and resulting in better antiseptic effect. The prepared multienzyme cleaning agent has the advantages of high-efficiency scale inhibition, high dispersion, low residue, low foam, easy rinsing and the like. Belongs to the field of medical cleaning, and also is lack of research on the removal effect of the specific pollutant sputum, and the removal effect is not good.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the special cleaning agent for removing the sputum of the tracheal cannula, which has the advantages of obvious effect, good stability, safety, mildness, no corrosion, low foam and easy rinsing, and provides the best scheme for the centralized treatment of the tracheal cannula in a supply room.
In one aspect, the invention provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: 1-3% of lipopeptide, 5-6% of ethanolamine, 2-3% of anhydrous citric acid, 2-3% of hydroxyl-ethidium phosphonic acid, 8-10% of surfactant, 0.2-0.3% of corrosion inhibitor, 10-15% of solvent, 0.1% of alkaline protease Novietz Evestris Duo 100L 5-8%, and the balance of distilled water.
Preferably, the surfactant is one or more of coconut oil crude soap, sodium dodecyl benzene sulfonate, sodium laureth-6 carboxylate and sodium xylene sulfonate.
Preferably, the corrosion inhibitor is one or more of benzotriazole, sodium gluconate and triethanolamine borate.
Preferably, the solvent is one or more of propylene glycol, glycerol and polyethylene glycol.
Preferably, the bacteriostatic agent is one or two of 5-chloro-2-methyl-3 (2H) -isothiazolone and 2-methyl-3 (2H) -isothiazolinone.
On the other hand, the invention also provides a preparation method of the cleaning agent for removing sputum, which comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
s2: adding lipopeptide, ethanolamine and hydroxyl ethylidene phosphonic acid into the solution obtained in the step S1 in sequence, stirring until the solution is colorless and transparent and has no insoluble substances, and adding a bacteriostatic agent;
s3: adding a solvent, a corrosion inhibitor and a surfactant into the solution obtained in the step S2 in sequence, and stirring;
s4: and (3) slightly generating an exothermic reaction in the stirring process, and adding alkaline protease after the temperature of the solution obtained in the step S3 is reduced to room temperature, and stirring to obtain the product.
Preferably, in step S2, the stirring time is 1-2 h.
Preferably, in step S3, the stirring time is 30-60 min.
Preferably, in step S4, the stirring time is 1-2 h.
When in use, the cleaning agent is diluted by soft water or purified water according to the proportion of 1:30-50, and the sputum in the cannula can be effectively removed by softening and removing the sputum in a manual soaking mode.
Compared with the prior art, the invention has the following beneficial effects:
according to the cleaning agent for removing the sputum, disclosed by the invention, due to the addition of the specific biological surfactant lipopeptide and other surfactants, the interfacial tension between the sputum pollutant and an aqueous solution can be reduced through a compounding synergistic effect in the using process, and the rapid stripping of the sputum pollutant is facilitated. Meanwhile, the specific solvent ensures the rapid penetration and wetting of the surfactant and accelerates the softening, decomposition and stripping of sputum pollutants. The specific protease effectively decomposes acidic protein in the sputum so as to reduce the viscosity of the sputum, and is beneficial to decomposition and decontamination of pollutants. The specific pollutant of sputum is compounded by the surfactant and the biological enzyme, the specific formula enables the cleaning agent to rapidly soften and decompose the sputum in the soaking process for the dried sputum pollutant, and the tracheal cannula which can be used for centralized treatment of mass pollution can be simply washed after the action of the cleaning agent.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: lipopeptide 1%, ethanolamine 5%, anhydrous citric acid 2%, hydroxyl ethylidene phosphonic acid 2%, coconut oil crude soap 8%, corrosion inhibitor 0.2%, propylene glycol 10%, alkaline protease 5%, 5-chloro-2-methyl-3 (2H) -isothiazolone 0.1%, and the balance of distilled water.
The preparation method of the cleaning agent comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
s2: adding lipopeptide, ethanolamine and hydroxyl ethylidene phosphonic acid into the solution obtained in the step S1 in sequence, stirring for 1h until the solution is colorless, transparent and free of insoluble substances, and adding a bacteriostatic agent;
s3: adding the solvent, the corrosion inhibitor and the surfactant into the solution obtained in the step S2 in sequence, and stirring for 30 min;
s4: and (3) slightly generating an exothermic reaction in the stirring process, adding alkaline protease after the temperature of the solution obtained in the step S3 is reduced to room temperature, and stirring for 1 hour to obtain the product.
And (3) testing the stability: meets the requirement of the stability test of the effective period in the sanitary requirement of the medical cleaning agent.
The test method comprises the following steps: the storage was carried out at 37 ℃ for 90 days according to the method of the aging test for shelf life stability. And checking whether the cleaning agent is externally hung and changed.
And (3) test results: the product has no change in appearance after being stored for 90 days at 37 ℃ and is still light yellow.
And (3) corrosion test: the test method is carried out according to the determination of corrosivity of the cleaning agent for the traditional Chinese medicine in the medical cleaning agent sanitation requirement. Soaking 304 stainless steel sheet in stock solution of sputum-removing cleaning agent at 40 deg.C for 72 hr, and weighing the stainless steel sheet before and after soaking.
Calculation of the Metal Corrosion Rate (R):
r-corrosion rate in millimeters per year (mm/a);
m-weight of the sheet before test in grams (g);
m t -post-test sheet metal weight in grams (g);
m k -chemical treatment to remove the weight loss value of the corrosion product sample in grams (g), and if no chemical removal treatment is performed in the test, deleting m from the formula k A value;
S-Total surface area of the sheet, in square centimeters (cm) 2 )；
t-test time in hours (h):
d-density of the metallic material in kilograms per cubic meter (kg/m) 3 )。
The test calculation shows that R is 0.0046 and R is less than 0.0100, which indicates that the sputum removing cleaning agent has no corrosion to stainless steel basically.
And (3) testing the foam quantity: the foam quantity value of the sputum removing cleaning agent is 0 through the measurement of an SITA foam quantity tester, and the foam can not be tested almost, so that the sputum removing cleaning agent belongs to a typical low-foam cleaning agent.
Practical use case 1: 500ml of the cleaning agent prepared in the example 1 was sampled and placed in a 20L circulation box, and 15L of purified water was added to dilute and uniformly stir the mixture, and the mixture was labeled as experiment group A; the purchased fast and efficient multi-enzyme cleaning agent of Minnesota mining industry manufacturing medical equipment (Shanghai) Co., Ltd, imported from the United states, is marked as a control group B according to the same dilution method; the purchased specific alkaline enzyme-containing detergent of Wegener brand imported from Germany was labeled as control group C according to the same dilution method. Thirty overnight untreated tracheal tubes were randomly assigned to three groups by the clinical department and soaked in the experimental group a and the control group B, C, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, observing with a magnifier with a light source, and observing until no visible pollutant is detected. The yield comparison data is as follows:
through experimental contrast discovery, the effect of conventional multienzyme cleaner to softening decomposition hardly has to sleeve pipe sputum, and the cleaner effect of getting rid of the sputum of this embodiment modulation is showing, can high-efficient supplementary sleeve pipe sputum's basic processing.
Example 2
The embodiment provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: lipopeptide 3%, ethanolamine 4%, anhydrous citric acid 3%, hydroxyl ethylidene phosphonic acid 3%, sodium dodecyl benzene sulfonate 9%, corrosion inhibitor 0.2%, glycerol 13%, alkaline protease 8%, 2-methyl-3 (2H) -isothiazolinone 0.1%, and the balance of distilled water.
The preparation method of the cleaning agent comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
s2: adding lipopeptide, ethanolamine and hydroxyl ethylidene diphosponic acid into the solution obtained in the step S1 in sequence, stirring for 1h until the solution is colorless, transparent and free of insoluble substances, and then adding a bacteriostatic agent;
s3: adding the solvent, the corrosion inhibitor and the surfactant into the solution obtained in the step S2 in sequence, and stirring for 30 min;
s4: and (3) slightly generating an exothermic reaction in the stirring process, adding alkaline protease after the temperature of the solution obtained in the step S3 is reduced to room temperature, and stirring for 1 hour to obtain the product.
And (3) stability testing: the product has no change in appearance after being stored for 90 days at 37 ℃ and is still light yellow.
And (3) corrosion testing:
r is 0.0053, R is less than 0.0100, which indicates that the sputum removal cleaning agent has no corrosion to the stainless steel basically.
And (3) testing the foam quantity: the foam quantity value of the sputum removing cleaning agent is 0 through the measurement of an SITA foam quantity tester, and the foam can not be tested almost, so that the sputum removing cleaning agent belongs to a typical low-foam cleaning agent.
Practical use case 2: 500ml of the cleaning agent prepared in the example 2 is sampled and placed in a 20L turnover box, and 15L of purified water is added for dilution and uniform stirring, and the sample is marked as an experimental group A; the purchased fast and efficient multi-enzyme cleaning agent of Minnesota mining industry manufacturing medical equipment (Shanghai) Co., Ltd, imported from the United states, is marked as a control group B according to the same dilution method; the purchased specific alkaline enzyme-containing detergent, imported from germany under the brand name of wegener, was diluted in the same manner and labeled as control group C. Thirty overnight untreated tracheal tubes were randomly assigned to three groups by the clinical department and soaked in the experimental group a and the control group B, C, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, observing with a magnifier with a light source, and observing until no visible pollutant is detected. The yield comparison data is as follows:
through experimental contrast discovery, the effect of conventional multienzyme cleaner to softening decomposition hardly has to sleeve pipe sputum, and the cleaner effect of getting rid of the sputum of this embodiment modulation is showing, can high-efficient supplementary sleeve pipe sputum's basic processing.
Example 3
The embodiment provides a cleaning agent for removing sputum, which comprises the following components in percentage by weight: lipopeptide 2%, ethanolamine 6%, anhydrous citric acid 3%, hydroxyl ethylidene phosphonic acid 2%, sodium laureth-6 carboxylate 10%, corrosion inhibitor 0.3%, polyethylene glycol 15%, alkaline protease 7%, 5-chloro-2-methyl-3 (2H) -isothiazolone 0.1%, and the balance of distilled water.
The preparation method of the cleaning agent comprises the following steps:
s1: dissolving anhydrous citric acid in distilled water;
s2: adding lipopeptide, ethanolamine and hydroxyl ethylidene phosphonic acid into the solution obtained in the step S1 in sequence, stirring for 1h until the solution is colorless, transparent and free of insoluble substances, and adding a bacteriostatic agent;
s3: adding the solvent, the corrosion inhibitor and the surfactant into the solution obtained in the step S2 in sequence, and stirring for 30 min;
s4: and (3) slightly generating an exothermic reaction in the stirring process, adding alkaline protease after the temperature of the solution obtained in the step S3 is reduced to room temperature, and stirring for 1 hour to obtain the product.
And (3) stability testing: the product has no change in appearance after being stored for 90 days at 37 ℃ and is still light yellow.
And (3) corrosion test: r is 0.0059, R is 0.0100, which indicates that the sputum-removing cleaning agent has no corrosion to the stainless steel basically.
And (3) testing the foam quantity: the foam quantity value of the sputum removing cleaning agent is 0 through the measurement of an SITA foam quantity tester, and the foam can not be tested almost, so that the sputum removing cleaning agent belongs to a typical low-foam cleaning agent.
Practical use case 3: 500ml of the cleaning agent prepared in the example 3 was sampled and placed in a 20L circulation box, and 15L of purified water was added to dilute and uniformly stir the mixture, and the mixture was labeled as experiment group A; the purchased fast and efficient multi-enzyme cleaning agent of Minnesota mining industry manufacturing medical equipment (Shanghai) Co., Ltd, imported from the United states, is marked as a control group B according to the same dilution method; the purchased specific alkaline enzyme-containing detergent of Wegener brand imported from Germany was labeled as control group C according to the same dilution method. Thirty overnight untreated tracheal tubes were randomly assigned to three groups by the clinical department and soaked in the experimental group a and the control group B, C, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, observing with a magnifier with a light source, and observing until no visible pollutant is detected. The yield comparison data is as follows:
through experimental contrast discovery, the effect of conventional multienzyme cleaner to softening decomposition hardly has to sleeve pipe sputum, and the abluent effect of getting rid of the sputum of modulation is showing in this embodiment, can high-efficient supplementary sleeve pipe sputum's basic processing.
Comparative example 1
Comparative example 1 differs from example 1 in that: the surfactant is replaced by polyoxyethylene ether sodium sulfate.
500ml of the cleaning agent prepared in comparative example 1 was sampled and placed in a 20L circulation box, and 15L of purified water was added for dilution and uniform stirring, and the sample was marked as control group D; 500ml of the cleaning agent prepared in example 1 was sampled and placed in a 20L circulation box, diluted with 15L of purified water and stirred uniformly, and the sample was designated as test group A. Twenty overnight untreated tracheal tubes were randomly assigned to two groups by the clinical department and soaked in experimental group a and control group D, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, observing with a magnifier with a light source, and observing until no visible pollutant is detected. The yield comparison data is as follows:
through experimental comparison, the following results are found: the only difference between comparative example 1 and example 1 is that the surfactant used is different, and comparative example 1 uses a high foaming anionic surfactant such as sodium polyoxyethylene ether sulfate. In a comparative experiment of a cleaning effect test, the cleaning qualification rate of the cleaning agent prepared by the embodiment 1 of the invention is obviously higher than that of the control group D.
Comparative example 2
Comparative example 2 differs from example 2 in that: the solvent of example 1 was replaced by ethanol.
500ml of the cleaning agent prepared in comparative example 2 was sampled and placed in a 20L circulation box, and 15L of purified water was added for dilution and uniform stirring, and the sample was marked as control group D; 500ml of the cleaning agent prepared in example 2 was sampled and placed in a 20L circulation box, diluted with 15L of purified water and stirred uniformly, and the sample was designated as test group A. Twenty overnight untreated tracheal tubes were randomly assigned to two groups by the clinical department and soaked in experimental group a and control group D, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, observing with a magnifier with a light source, and observing until no visible pollutant is detected. The yield comparison data is as follows:
through experimental comparison, the following results are found: the only difference between comparative example 2 and example 2 is the different types of solvents used, and comparative example 2 uses common ethanol. In a comparative experiment of a cleaning effect test, the cleaning qualification rate of the cleaning agent prepared by the preparation method of the invention in example 2 is obviously higher than that of the control group D.
Comparative example 3
Comparative example 3 differs from example 3 in that: the alkaline protease of example 3 was replaced with alkaline protease from Nanning Pompe bioengineering GmbH.
500ml of the cleaning agent prepared in comparative example 3 was sampled and placed in a 20L circulation box, and 15L of purified water was added for dilution and uniform stirring, and the sample was marked as control group D; 500ml of the cleaning agent prepared in example 3 was sampled and placed in a 20L circulation box, diluted with 15L of purified water and stirred uniformly, and the sample was designated as test group A. Twenty overnight untreated tracheal tubes were randomly assigned to two groups by the clinical department and soaked in experimental group a and control group D, respectively. After soaking for 10min, washing and brushing with a soft brush for 5s, brushing for 1min, observing with a magnifier with a light source, and observing until no visible pollutant is detected. The yield comparison data is as follows:
through experimental comparison, the following results are found: the only difference between comparative example 3 and example 3 is the different types of alkaline proteases used, and comparative example 3 uses a common alkaline protease. In a comparative experiment of a cleaning effect test, the cleaning qualification rate of the cleaning agent prepared by the embodiment 3 of the invention is obviously higher than that of the control group D.
The action mechanism of the cleaning agent is as follows: according to the cleaning agent for removing the sputum, disclosed by the invention, due to the addition of the specific biological surfactant lipopeptide and other surfactants, the interfacial tension between the sputum pollutant and an aqueous solution can be reduced through a compounding synergistic effect in the using process, and the rapid stripping of the sputum pollutant is facilitated. Meanwhile, the specific solvent ensures the rapid penetration and wetting of the surfactant and also accelerates the softening, decomposition and stripping of sputum pollutants; the specific protease effectively decomposes acidic protein in the sputum so as to reduce the viscosity of the sputum, and is beneficial to decomposition and decontamination of pollutants. The cleaning agent is prepared by compounding a surfactant and a biological enzyme aiming at specific pollutants of sputum, the cleaning agent can rapidly soften and decompose the sputum for the dried sputum pollutants in the soaking process by a specific formula, and the tracheal cannula can be simply washed after the action of the cleaning agent to realize centralized treatment of mass pollution.
Although the present invention has been described in detail by way of preferred embodiments, the present invention is not limited thereto. Various equivalent modifications or substitutions can be made on the embodiments of the present invention by those skilled in the art without departing from the spirit and scope of the present invention, and these modifications or substitutions are within the scope of the present invention/any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (9)
1. The cleaning agent for removing sputum is characterized by comprising the following components in percentage by weight: 1-3% of lipopeptide, 5-6% of ethanolamine, 2-3% of anhydrous citric acid, 2-3% of hydroxyl-ethidium dihydrogen phosphonate, 8-10% of surfactant, 0.2-0.3% of corrosion inhibitor, 10-15% of solvent, 0.1% of alkaline protease Espers Duo 100L 5-8%, 0.1% of bacteriostatic agent and the balance of distilled water.
2. The cleansing agent for sputum removal according to claim 1, wherein the surfactant is one or more of coconut oil crude soap, sodium dodecylbenzenesulfonate, sodium laureth-6 carboxylate, and sodium xylene sulfonate.
3. The cleaning agent for removing sputum according to claim 1, wherein the corrosion inhibitor is one or more of benzotriazole, sodium gluconate, and triethanolamine borate.
4. The cleaning agent for removing sputum according to claim 1, wherein the solvent is one or more of propylene glycol, glycerol and polyethylene glycol.
5. The cleansing agent for sputum removal according to claim 1, wherein the bacteriostatic agent is one or two of 5-chloro-2-methyl-3 (2H) -isothiazolone and 2-methyl-3 (2H) -isothiazolinone.
6. The method for preparing a cleaning agent for sputum removal as claimed in any one of claims 1 to 5, comprising the steps of:
s1: dissolving anhydrous citric acid in distilled water;
s2: adding lipopeptide, ethanolamine and hydroxyl ethylidene phosphonic acid into the solution obtained in the step S1 in sequence, stirring until the solution is colorless and transparent and has no insoluble substances, and adding a bacteriostatic agent;
s3: adding a solvent, a corrosion inhibitor and a surfactant into the solution obtained in the step S2 in sequence, and stirring;
s4: and (5) after the temperature of the solution in the step S3 is reduced to room temperature, adding alkaline protease, and stirring to obtain the product.
7. The method of claim 6, wherein the stirring time in step S2 is 1-2 h.
8. The method for preparing a cleanser for removing sputum according to claim 6, wherein the stirring time in step S3 is 30-60 min.
9. The method of claim 6, wherein the stirring time in step S4 is 1-2 h.
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