CN114848584A - Preparation method of yellow hydrogel patch for traumatology - Google Patents
Preparation method of yellow hydrogel patch for traumatology Download PDFInfo
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- CN114848584A CN114848584A CN202210512892.8A CN202210512892A CN114848584A CN 114848584 A CN114848584 A CN 114848584A CN 202210512892 A CN202210512892 A CN 202210512892A CN 114848584 A CN114848584 A CN 114848584A
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- crosslinking
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- crosslinking component
- yellow
- traumatology
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
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- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 235000001014 amino acid Nutrition 0.000 claims description 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract
The invention discloses a preparation method of a yellow hydrogel patch for traumatology, which comprises the following steps of mixing a first crosslinking component, a second crosslinking component, a third crosslinking component and water to prepare a mixed solution; adding the yellow water of the traumatology department into the mixed solution, and uniformly stirring to form gel liquid; placing the gel liquid in a mold, and curing and molding to obtain a gel sheet; soaking the gel sheet in the post-crosslinking solution, and reacting to obtain a yellow hydrogel patch for the traumatology; the first crosslinking component comprises carrageenan, agar, gelatin, pectin, agar jelly or gillidin, the second crosslinking component comprises sodium alginate, sodium carboxymethyl cellulose or sodium carboxymethyl starch, the third crosslinking component comprises carboxymethyl chitosan, chitosan quaternary ammonium salt or chitosan oligosaccharide, and the post-crosslinking solution comprises a mixed solution of a pH regulator and a metal ion crosslinking agent. The invention aims to solve the problems of clothes pollution and poor water retention in the traditional usage mode of yellow water for traumatology.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine patches, in particular to a preparation method of a yellow hydrogel patch for traumatology.
Background
The SHANGSHUI is a topical Chinese medicinal liquid for treating traumatic injury, soft tissue injury and bone injury, and is developed by Chinese medicinal institute in Foshan city. The liquid is brown to brownish red suspension liquid, the main components comprise coptis chinensis, gardenia and the like, and the liquid has the functions of resisting inflammation, reducing swelling, promoting blood circulation, removing blood stasis, relieving pain and promoting tissue regeneration. Can be used for treating traumatic injury, soft tissue injury and bone injury with good therapeutic effect. The composition is administered topically and applied topically on affected parts.
The existing usage mode of the yellow water for the traumatology department has a plurality of inconveniences:
at present, gauze, cotton and polyurethane sponge are commonly used in clinic as main dressing of yellow water in the department of traumatology, and the traditional dressing is often stained with clothes when being applied, so that inconvenience is brought to patients; when the yellow water of the traumatology department is applied to the skin in the form of liquid medicine, the water in the liquid medicine is evaporated too fast, and the self water-retaining capability is not strong, so that the liquid medicine is dried in a short time.
Disclosure of Invention
The invention mainly aims to provide a preparation method of a traumatology yellow hydrogel patch, aiming at solving the problems of clothes pollution and poor water retention capacity of the traditional traumatology yellow water using mode.
In order to achieve the purpose, the invention provides a preparation method of a traumatology yellow hydrogel patch, which comprises the following steps:
mixing a first crosslinking component, a second crosslinking component, a third crosslinking component and water to prepare a mixed solution;
adding water of yellow color of the department of traumatology into the mixed solution, and uniformly stirring to form gel liquid;
placing the gel liquid in a mold, and curing and molding to obtain a gel sheet;
soaking the gel sheet in a post-crosslinking solution to react to obtain a yellow hydrogel patch for the traumatology;
the first crosslinking component comprises carrageenan, agar, gelatin, pectin, agar jelly or gliadin, the second crosslinking component comprises sodium alginate, sodium carboxymethyl cellulose or sodium carboxymethyl starch, the third crosslinking component comprises carboxymethyl chitosan, chitosan quaternary ammonium salt or chitosan oligosaccharide, and the post-crosslinking solution comprises a mixed solution of a pH regulator and a metal ion crosslinking agent.
Optionally, the first crosslinking component is carrageenan, the second crosslinking component is sodium alginate, and the third crosslinking component is carboxymethyl chitosan.
Optionally, the weight ratio of the first crosslinking component, the second crosslinking component, the third crosslinking component and the water is (0.2-2): (0.2-2): 100.
Optionally, in the step of adding traumatology yellow water into the mixed solution and uniformly stirring to form the gel liquid, the volume ratio of the traumatology yellow water to the mixed solution is 1: (0.1-10).
Optionally, the step of adding the traumatology yellow water into the mixed solution, and uniformly stirring to form a gel solution is carried out at the temperature of 70-85 ℃.
Optionally, the step of mixing the first crosslinking component, the second crosslinking component, the third crosslinking component and water to form a mixed solution comprises:
dispersing the first crosslinking component, the second crosslinking component and the third crosslinking component by using a dispersing agent, then mixing with water, and stirring at 70-85 ℃ to form a mixed solution, wherein the dispersing agent comprises glycerol, propylene glycol or butanediol.
Optionally, the pH adjuster comprises at least one of citric acid, lactic acid, tartaric acid, malic acid, phosphoric acid, gluconolactone, sodium hydroxide, sodium carbonate, sodium bicarbonate, ethanolamine, ethylenediamine, a basic amino acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, carbonic acid, acetic acid, barbituric acid, tris.
Optionally, the cross-linking agent comprises a calcium chloride solution.
Optionally, the pH regulator comprises a gluconolactone aqueous solution with a concentration of 0.06g/10mL, and the cross-linking agent comprises a calcium chloride aqueous solution with a mass percentage of 0.1%;
in the post-crosslinking solution, the volume ratio of the gluconolactone aqueous solution to the calcium chloride aqueous solution is 1 (0.1-10).
Optionally, in the step of soaking the gel sheet in a post-crosslinking solution to react to obtain the traumatology yellow hydrogel patch, the volume ratio of the gel solution to the post-crosslinking solution is (0.5-5): 10.
According to the technical scheme provided by the invention, the three-crosslinking system composite gel is used as a liquid medicine carrier of the wound yellow water to prepare the wound yellow water hydrogel patch, so that the water retention capacity of the medicament is effectively improved, the liquid medicine is prevented from being dried by distillation, more liquid medicine can be loaded under the same dressing area, and the liquid medicine is difficult to flow out during use, and the liquid medicine is prevented from polluting clothes; in addition, the gel patch is processable as compared with a liquid agent, can be processed into any shape as required, and is more suitable for administration to a specific site and an active site.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other related drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a graph showing the rheological properties of a gel sheet obtained in example 1;
FIG. 2 is a graph of the rheological properties of the gel patch prepared in example 1;
fig. 3 is a graph showing the rheological characteristics of the gel patch prepared in comparative example 1.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments.
It should be noted that those whose specific conditions are not specified in the examples were performed according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to achieve the purpose, the invention provides a preparation method of a traumatology yellow hydrogel patch, which comprises the following steps:
step S10, mixing the first crosslinking component, the second crosslinking component, the third crosslinking component and water to prepare a mixed solution.
The first crosslinking component comprises carrageenan, agar, gelatin, pectin, agar jelly or gillidin, the second crosslinking component comprises sodium alginate, sodium carboxymethylcellulose or sodium carboxymethyl starch, and the third crosslinking component comprises carboxymethyl chitosan, chitosan quaternary ammonium salt or chitosan oligosaccharide. That is, the first cross-linking component can be at least one selected from carrageenan, agar, gelatin, pectin, agar jelly and gillidin, the second cross-linking component can be at least one selected from sodium alginate, sodium carboxymethylcellulose and sodium carboxymethyl starch, the third cross-linking component can be at least one selected from carboxymethyl chitosan, chitosan quaternary ammonium salt and chitosan oligosaccharide, and the three cross-linking components are independently selected, that is, different cross-linking components are selected and matched to construct different types of three cross-linking systems, such as a carrageenan-sodium alginate-carboxymethyl chitosan cross-linking system, a gelatin-sodium carboxymethyl cellulose-chitosan quaternary ammonium salt cross-linking system, a gillidin-sodium carboxymethyl starch-chitosan oligosaccharide cross-linking system and the like, the cross-linking systems combined in the selected range can form stable high molecular compounds through non-covalent interaction, the crosslinking system can realize the transformation from liquid state to gel state through acid-base property and/or temperature control, and before changing the conditions of acid-base property and temperature, the system is liquid, has fluidity and thus processability, can be suitable for various molding processes such as blade coating, spin coating, dip coating, spray coating, mold perfusion and the like, has good industrialization prospect, is favorable for better mixing with the yellow water of the traumatology, and is favorable for more uniformly distributing the yellow water of the traumatology in the gel system. In addition, the time for the system to gel and the final degree of gel can be adjusted by controlling the process parameters (such as temperature, acidity and alkalinity, proportion relation of three crosslinking components and the like), and the development and improvement are better.
Further, as a preferred embodiment, in this embodiment, the first crosslinking component is carrageenan, the second crosslinking component is sodium alginate, and the third crosslinking component is carboxymethyl chitosan, and compared with the carrageenan-sodium alginate-carboxymethyl chitosan crosslinking system, the formed gel has a stronger water retention property, and the compatibility with the traumatic yellow water is optimal.
In a specific implementation, step S10 may be performed according to the following steps:
and S11, dispersing the first crosslinking component, the second crosslinking component and the third crosslinking component by using a dispersing agent, then mixing with water, and stirring at 70-85 ℃ to form a mixed solution, wherein the dispersing agent comprises glycerol, propylene glycol or butanediol.
In addition, in some embodiments, the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is (0.2-2): 100, and based on the mixing of the weight ratio, not only is raw material saved, but also the water retention property and the strength of the gel can be improved.
And step S20, adding the traumatology yellow water into the mixed solution, and uniformly stirring to form gel liquid.
In some embodiments, the weight ratio of the first crosslinking component, the second crosslinking component, the third crosslinking component and the water is (0.2-2): (0.2-2): 100, and the volume ratio of the traumatological yellow water and the mixed solution is 1: (0.1-10), so that the traumatology yellow water can be loaded to the maximum extent and is uniformly distributed in the gel.
In practical operation, in step S20, the stirring step is performed at a temperature of 70-85 ℃. Specifically, step S20 includes: and heating the mixed solution to 70-85 ℃, adding the yellow water of the traumatology department into the mixed solution, and uniformly stirring the mixture to form gel liquid.
It is understood that the gel liquid finally obtained in this step is a pre-gelled liquid in a liquid state having fluidity.
And step S30, placing the gel liquid in a mold, and curing and molding to obtain the gel sheet.
And placing the gel liquid loaded with the traumatology yellow water in a mould for curing and forming to obtain the gel sheet. It is understood that, in practical applications, different molding manners may be adopted based on different molding requirements (for example, the requirements are gel balls, gel lines, etc.), and for example, the gel liquid may be dropped into the low-temperature solvent to form the gel balls. In this embodiment, a mold having a fixed groove (which may be a square groove, a circular groove, or the like, but the invention is not limited thereto) is used, the gel liquid is poured into the mold, and the gel liquid is cooled to realize solidification molding, so as to obtain a sheet-shaped gel sheet. It can be understood that the gel liquid belongs to a heating melting-cooling gelling system, and is in a liquid state with good fluidity at 70-85 ℃, and is solidified when the temperature is reduced to room temperature, so that the gel liquid needs to be rapidly poured into a mold in an uncooled solidification state, namely in a liquid state.
And step S40, soaking the gel sheet in a post-crosslinking solution, and reacting to obtain the yellow hydrogel patch for traumatology.
Wherein the post-crosslinking solution comprises a mixed solution of a pH regulator and a metal ion crosslinking agent.
In this embodiment, a gel sheet (in a gel state) obtained after curing and molding a gel liquid is soaked in a post-crosslinking solution, and is further crosslinked through a crosslinking agent and an acid-base adjustment (a metal ion crosslinking agent can promote crosslinking of a first crosslinking component and a second crosslinking component, and an acid-base adjustment can promote crosslinking of the second crosslinking component and a third crosslinking component), so that the overall toughness and strength of the gel sheet are further improved.
Specifically, the pH regulator includes at least one of citric acid, lactic acid, tartaric acid, malic acid, phosphoric acid, gluconolactone, sodium hydroxide, sodium carbonate, sodium bicarbonate, ethanolamine, ethylenediamine, basic amino acids, sodium dihydrogen phosphate, potassium dihydrogen phosphate, carbonic acid, acetic acid, barbituric acid, and tris (hydroxymethyl) aminomethane. Preferably gluconolactone, and more preferably an aqueous solution of gluconolactone at a concentration of 0.06g/10mL, in comparison with the above, gluconolactone has a better effect of promoting the crosslinking of the second crosslinking component and the third crosslinking component, and is particularly effective in promoting the crosslinking between sodium alginate and carboxymethyl chitosan.
The crosslinking agent comprises a calcium chloride solution. More preferably, the calcium chloride aqueous solution is 0.1% by mass, and compared with the calcium chloride aqueous solution, the calcium chloride aqueous solution has a better effect of promoting the crosslinking of the second crosslinking component and the first crosslinking component, and is particularly effective in promoting the crosslinking between the sodium alginate and the carrageenan.
Based on the above embodiment, a preferred embodiment is further provided, in this embodiment, the pH adjusting agent includes a gluconolactone aqueous solution with a concentration of 0.06g/10mL, and the cross-linking agent includes a calcium chloride aqueous solution with a mass percentage of 0.1%; in the post-crosslinking solution, the volume ratio of the gluconolactone aqueous solution to the calcium chloride aqueous solution is 1 (0.1-10). When the amount of the pH regulator is limited to '0.06 g/10mL gluconolactone aqueous solution with the concentration and the volume ratio of the gluconolactone aqueous solution to the calcium chloride aqueous solution of 1 (0.1-10)', the pH environment of the post-crosslinking solution is appropriate, and secondary crosslinking can be rapidly promoted.
Furthermore, the volume ratio of the gel liquid to the post-crosslinking solution is (0.5-5): 10.
According to the technical scheme provided by the invention, the three-crosslinking system composite gel is used as a liquid medicine carrier of the wound yellow water to prepare the wound yellow water hydrogel patch, so that the water retention capacity of the medicament is effectively improved, the liquid medicine is prevented from being dried by distillation, more liquid medicine can be loaded under the same dressing area, and the liquid medicine is difficult to flow out during use, and the liquid medicine is prevented from polluting clothes; in addition, the gel patch is processable as compared with a liquid agent, can be processed into any shape as required, and is more suitable for administration to a specific site and an active site.
The technical solutions of the present invention are further described in detail with reference to the following specific examples, which should be understood as merely illustrative and not limitative.
Example 1
Uniformly dispersing carrageenan, sodium alginate and carboxymethyl chitosan powder by using 1 part of glycerol, then adding 9 parts of water, and stirring at 80 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is 1:1:1: 100.
Mixing the phase A with the liquid medicine of yellow water (volume ratio 1: 1) of traumatology department, and stirring uniformly at 80 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain the gel sheet loaded with the yellow water of the traumatology department.
Mixing a gluconolactone aqueous solution with the concentration of 0.06g/10mL and a calcium chloride aqueous solution with the mass percentage of 0.1% in equal volume (the volume ratio is 1: 1) to prepare a post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 1:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Example 2
Uniformly dispersing carrageenan, sodium alginate and carboxymethyl chitosan powder by using 1 part of glycerol, then adding 9 parts of water, and stirring at 70 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component, the second crosslinking component, the third crosslinking component and the water is 0.2:0.2:0.2: 100.
Mixing the phase A with the liquid medicine of yellow water (volume ratio 1: 1) of traumatology department, and stirring uniformly at 70 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain the gel sheet loaded with the yellow water of the traumatology department.
Mixing a gluconolactone aqueous solution with the concentration of 0.06g/10mL and a calcium chloride aqueous solution with the mass percentage of 0.1% in equal volume (the volume ratio is 1: 1) to prepare a post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 1:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Example 3
Uniformly dispersing carrageenan, sodium alginate and carboxymethyl chitosan powder by using 1 part of glycerol, then adding 9 parts of water, and stirring at 85 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is 2:2:2: 100.
Mixing phase A with SHANGKE HUANGSHUI liquid medicine (volume ratio 1: 1), and stirring at 85 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain the gel sheet loaded with the yellow water of the traumatology department.
Mixing a gluconolactone aqueous solution with the concentration of 0.06g/10mL and a calcium chloride aqueous solution with the mass percentage of 0.1% in equal volume (the volume ratio is 1: 1) to prepare a post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 1:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Example 4
Uniformly dispersing the powder of the Gelidine, the sodium carboxymethyl starch and the carboxymethyl chitosan by using 1 part of propylene glycol, then adding 9 parts of water, and stirring at 80 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is 1:1:1: 100.
Mixing the phase A with the liquid medicine of yellow water (volume ratio 1: 1) of traumatology department, and stirring uniformly at 80 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain the gel sheet loaded with the yellow water of the traumatology department.
Mixing barbituric acid aqueous solution with the concentration of 0.06g/10mL and calcium chloride aqueous solution with the mass percentage of 0.1% in equal volume (the volume ratio is 1: 1) to prepare post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 5:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Example 5
Uniformly dispersing agar, sodium alginate and carboxymethyl chitosan powder by using 1 part of glycerol, then adding 9 parts of water, and stirring at 80 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is 1:1:1: 100.
Mixing phase A with liquid medicine of yellow water (volume ratio of 0.1: 1) of traumatology department, and stirring at 80 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain the gel sheet loaded with the yellow water of the traumatology department.
Mixing 0.06g/10mL trihydroxymethyl amino aqueous solution and 0.1% calcium chloride aqueous solution in equal volume (volume ratio of 1: 1) to obtain post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 0.5:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Example 6
Uniformly dispersing gelatin, sodium carboxymethylcellulose and carboxymethyl chitosan powder with 1 part of glycerol, adding 9 parts of water, and stirring at 80 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is 1:1:1: 100.
Mixing the phase A with the liquid medicine of yellow water (volume ratio 10: 1) of traumatology department, and stirring uniformly at 80 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain gel sheets loaded with the traumatology yellow water.
Mixing a gluconolactone aqueous solution with the concentration of 0.06g/10mL and a calcium chloride aqueous solution with the mass percentage of 0.1% in equal volume (the volume ratio is 1: 1) to prepare a post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 1:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Example 7
Uniformly dispersing pectin, sodium alginate and chitosan quaternary ammonium salt powder by using 1 part of glycerol, then adding 9 parts of water, and stirring at 80 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is 1:1:1: 100.
Mixing the phase A with the liquid medicine of yellow water (volume ratio 1: 1) of traumatology department, and stirring uniformly at 80 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain the gel sheet loaded with the yellow water of the traumatology department.
Mixing a gluconolactone aqueous solution with the concentration of 0.06g/10mL and a calcium chloride aqueous solution with the mass percentage of 0.1% in equal volume (the volume ratio is 1:10) to prepare a post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 1:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Example 8
Uniformly dispersing white bean jelly, sodium alginate and chitosan oligosaccharide powder by using 1 part of butanediol, then adding 9 parts of water, and stirring at 80 ℃ to prepare a mixed solution serving as a phase A for later use; wherein the weight ratio of the first crosslinking component to the second crosslinking component to the third crosslinking component to the water is 1:1:1: 100.
Mixing the phase A with the liquid medicine of yellow water (volume ratio 1: 1) of traumatology department, and stirring uniformly at 80 deg.C to obtain phase B. Transferring the phase B into a culture dish before the phase B is cooled and solidified, and solidifying to obtain the gel sheet loaded with the yellow water of the traumatology department.
Mixing a gluconolactone aqueous solution with the concentration of 0.06g/10mL and a calcium chloride aqueous solution with the mass percentage of 0.1% in equal volume (the volume ratio is 1: 0.1) to prepare a post-crosslinking solution.
Soaking the gel sheet in a post-crosslinking solution (the volume ratio of the phase B to the post-crosslinking solution is 1:10), performing crosslinking reaction, and taking out after the reaction is finished to obtain the yellow hydrogel patch for the traumatology.
Comparative example 1
Fully mixing carrageenan, konjac glucomannan and anhydrous calcium chloride according to the weight ratio of 3:1:0.1 (dry mixing) to obtain powder A. 2 parts of powder A is uniformly dispersed with 10 parts of glycerin, and then 90 parts of yellow water for traumatology is added and fully stirred. Then, the mixture was heated and stirred continuously at 80 ℃ for 10 minutes to obtain a mixed material, and the mixed material was poured on a petri dish (the same size as that of the petri dish used in example 1) to be cooled and solidified, thereby obtaining a gel patch.
The gel sheet and the gel patch obtained by the primary crosslinking in example 1 and the gel patch obtained by the secondary crosslinking in comparative example 1 were used as samples, and the rheological properties of the above samples were measured by a rotational rheometer (germany HAAKE MARS 40).
The test method comprises the following steps: the gel sample was cut into a cylindrical shape having a diameter of 10mm and placed on an aluminum alloy parallel plate sample holder (diameter 10 mm). The strain amplitude was first optimized to ensure that all tests were performed in the Linear Viscoelastic Region (LVR) when the storage (G') and dissipation (G ") moduli were unaffected by strain. The dynamic storage modulus (G') and loss modulus (G ") are then measured as a function of time at selected strain amplitudes and oscillation frequencies to ensure that the measurement conditions do not disrupt the gelling process. The oscillation frequency used for the experiment was 1Hz and the strain was 0.001.
Where G' refers to the storage modulus, representing the elastic portion of the viscoelastic behavior, describing the solid state properties of the sample. G "refers to the loss modulus, describing the viscous portion of the viscoelastic behavior, which can also be considered the liquid property of the sample.
The results are shown in FIGS. 1 to 3. Wherein, FIG. 1 is a graph of rheological properties of a gel sheet obtained in example 1; fig. 2 is a graph showing the rheological characteristics of the gel patch prepared in example 1. As can be seen from fig. 1 and 2: the storage modulus G ' of the gel sheet is 300Pa, after secondary crosslinking, the storage modulus G ' of the gel patch is 14000Pa, obviously, the storage modulus G ' after secondary crosslinking is obviously improved, and the material has higher strength; in addition, the storage modulus G' of both the gel sheet and the gel patch is greater than the loss modulus G ", indicating that the system is transformed from a liquid state to a gel state after initial crosslinking.
In addition, fig. 3 is a graph of rheological characteristics of the gel patch prepared in comparative example 1, and comparing fig. 1, fig. 2 and fig. 3, it can be seen that the mechanical strength of "carrageenan-konjac gel system + metal ion" in comparative example 1 is greater than the "primary crosslinking" result and smaller than the "secondary crosslinking" result. The result shows that the mechanical strength of the carrageenan-sodium alginate-carboxymethyl chitosan gel system after secondary crosslinking is greater than that of the carrageenan-konjac glucomannan gel system and metal ion gel system.
And (3) evaporation test:
first, 10g of the yellow aqueous solution of traumatology department and the gel patch prepared in example 1 were respectively put in an oven at 40 ℃ for evaporation experiment. This experiment was used to simulate the evaporation rate (i.e. residence time) of the drug solution and gel on the skin surface. Experimental procedure, weighing every 10min, and testing for 60 min. The results are reported in Table 1.
TABLE 1
As a result: compared with the yellow water solution of the traumatology department, the yellow water gel patch of the traumatology department can obviously slow down the evaporation speed, has better retention effect on the yellow water liquid medicine of the traumatology department, and can prolong the retention time of the skin.
(II) the gel patches obtained in examples 2 to 8 were taken, placed in an oven at 40 ℃, subjected to evaporation test for 60min, weighed and the remaining ratio calculated, and the results are reported in Table 2.
TABLE 2
| Residual proportion (%) | |
| Example 2 | 59.84 |
| Example 3 | 70.25 |
| Example 4 | 62.15 |
| Example 5 | 60.32 |
| Example 6 | 62.48 |
| Example 7 | 66.68 |
| Example 8 | 64.62 |
As can be seen from the above table, the yellow hydrogel patch for traumatology department prepared in each example can keep above 59.84% after evaporation test for 60min, which indicates that the yellow hydrogel patch for traumatology department prepared by the invention has better water retention performance.
The above is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall be included in the scope of the present invention.
Claims (10)
1. A preparation method of a traumatology yellow hydrogel patch is characterized by comprising the following steps:
mixing a first crosslinking component, a second crosslinking component, a third crosslinking component and water to prepare a mixed solution;
adding the yellow water of the traumatology department into the mixed solution, and uniformly stirring to form gel liquid;
placing the gel liquid in a mold, and curing and molding to obtain a gel sheet;
soaking the gel sheet in a post-crosslinking solution to react to obtain a yellow hydrogel patch for the traumatology;
the first crosslinking component comprises carrageenan, agar, gelatin, pectin, agar jelly or gillidin, the second crosslinking component comprises sodium alginate, sodium carboxymethyl cellulose or sodium carboxymethyl starch, the third crosslinking component comprises carboxymethyl chitosan, chitosan quaternary ammonium salt or chitosan oligosaccharide, and the post-crosslinking solution comprises a mixed solution of a pH regulator and a metal ion crosslinking agent.
2. The method of preparing a yellow hydrogel patch according to claim 1 wherein said first cross-linking component is carrageenan, said second cross-linking component is sodium alginate, and said third cross-linking component is carboxymethyl chitosan.
3. The method of preparing a yellow hydrogel patch for trauma of claim 1 wherein the weight ratio of the first crosslinking component, the second crosslinking component, the third crosslinking component and water is (0.2-2): (0.2-2): 100.
4. The method of preparing a yellow hydrogel patch according to claim 3, wherein in the step of adding yellow water to the mixed solution and stirring the mixture to form a gel solution, the volume ratio of the yellow water to the mixed solution is 1: (0.1-10).
5. The method for producing a yellow hydrogel patch for traumatology department according to claim 1, wherein the step of adding the yellow hydrogel for traumatology department to the mixed solution and uniformly stirring to form a gel solution is carried out at a temperature of 70-85 ℃.
6. The method of making a yellow hydrogel patch of the wound of claim 1 wherein the step of mixing the first crosslinking component, the second crosslinking component, the third crosslinking component, and water to form a mixed solution comprises:
dispersing the first crosslinking component, the second crosslinking component and the third crosslinking component by using a dispersing agent, then mixing with water, and stirring at 70-85 ℃ to form a mixed solution, wherein the dispersing agent comprises glycerol, propylene glycol or butanediol.
7. The method of making a yellow hydrogel patch of claim 1 wherein said pH adjusting agent comprises at least one of citric acid, lactic acid, tartaric acid, meta-tartaric acid, malic acid, phosphoric acid, gluconolactone, sodium hydroxide, sodium carbonate, sodium bicarbonate, ethanolamine, ethylenediamine, basic amino acids, sodium dihydrogen phosphate, potassium dihydrogen phosphate, carbonic acid, acetic acid, barbituric acid, and tris.
8. The method of making a yellow hydrogel patch of trauma of claim 1 wherein said cross-linking agent comprises a calcium chloride solution.
9. The method of making a yellow hydrogel patch according to claim 1 wherein said pH modifier comprises an aqueous gluconolactone solution at a concentration of 0.06g/10mL and said cross-linking agent comprises an aqueous calcium chloride solution at a weight percent of 0.1%;
in the post-crosslinking solution, the volume ratio of the gluconolactone aqueous solution to the calcium chloride aqueous solution is 1 (0.1-10).
10. The method for producing a yellow hydrogel patch for traumatology department according to claim 9, wherein in the step of immersing the gel sheet in a post-crosslinking solution to react to obtain the yellow hydrogel patch for traumatology department, the volume ratio of the gel solution to the post-crosslinking solution is (0.5-5): 10.
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| CN114230814A (en) * | 2021-12-30 | 2022-03-25 | 佛山市中医院 | Hydrogel carrying traumatology yellow water and preparation method thereof |
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| CN109432505A (en) * | 2018-11-02 | 2019-03-08 | 华南农业大学 | A kind of porous grade composite medical gel stent and preparation method thereof of 3D printing building |
| CN110694102A (en) * | 2019-11-13 | 2020-01-17 | 中国矿业大学 | 3D printing hydrogel wound dressing with long-acting antibacterial effect |
| CN112940300A (en) * | 2019-12-10 | 2021-06-11 | 爱博诺德(北京)医疗科技股份有限公司 | Preparation method of crosslinked hyaluronic acid gel |
| CN112370567A (en) * | 2020-11-19 | 2021-02-19 | 南方医科大学南方医院 | Hydrogel active dressing with antibacterial and anti-inflammatory functions |
| CN112587726A (en) * | 2020-12-18 | 2021-04-02 | 南方科技大学 | Composite hydrogel stent and preparation method and application thereof |
| CN114230814A (en) * | 2021-12-30 | 2022-03-25 | 佛山市中医院 | Hydrogel carrying traumatology yellow water and preparation method thereof |
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