CN114010532A - Double-agent unidirectional slow-release skin repairing film and preparation method and application thereof - Google Patents
Double-agent unidirectional slow-release skin repairing film and preparation method and application thereof Download PDFInfo
- Publication number
- CN114010532A CN114010532A CN202111226044.2A CN202111226044A CN114010532A CN 114010532 A CN114010532 A CN 114010532A CN 202111226044 A CN202111226044 A CN 202111226044A CN 114010532 A CN114010532 A CN 114010532A
- Authority
- CN
- China
- Prior art keywords
- skin
- agent
- film
- oil
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000011159 matrix material Substances 0.000 claims abstract description 54
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 36
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 33
- 230000008439 repair process Effects 0.000 claims abstract description 20
- 230000009471 action Effects 0.000 claims abstract description 18
- 230000035699 permeability Effects 0.000 claims abstract description 6
- 230000001815 facial effect Effects 0.000 claims abstract description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 54
- 235000010413 sodium alginate Nutrition 0.000 claims description 54
- 239000000661 sodium alginate Substances 0.000 claims description 54
- 229940005550 sodium alginate Drugs 0.000 claims description 54
- 229920001661 Chitosan Polymers 0.000 claims description 53
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 36
- 239000008367 deionised water Substances 0.000 claims description 30
- 229910021641 deionized water Inorganic materials 0.000 claims description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 28
- 238000003756 stirring Methods 0.000 claims description 26
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 23
- 239000011259 mixed solution Substances 0.000 claims description 21
- 239000001110 calcium chloride Substances 0.000 claims description 20
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 20
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 18
- -1 glyceryl glucoside Chemical class 0.000 claims description 16
- 239000004615 ingredient Substances 0.000 claims description 16
- 230000003020 moisturizing effect Effects 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000003995 emulsifying agent Substances 0.000 claims description 10
- 229930182478 glucoside Natural products 0.000 claims description 10
- 238000005507 spraying Methods 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 9
- 239000003921 oil Substances 0.000 claims description 9
- 235000019198 oils Nutrition 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 8
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 8
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 8
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 8
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 7
- 239000011604 retinal Substances 0.000 claims description 6
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims description 6
- 230000003712 anti-aging effect Effects 0.000 claims description 5
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 5
- 230000002087 whitening effect Effects 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 4
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- 239000004909 Moisturizer Substances 0.000 claims description 4
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 4
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 4
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- 230000003266 anti-allergic effect Effects 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 4
- 230000001333 moisturizer Effects 0.000 claims description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 4
- 229940101267 panthenol Drugs 0.000 claims description 4
- 235000020957 pantothenol Nutrition 0.000 claims description 4
- 239000011619 pantothenol Substances 0.000 claims description 4
- 235000021283 resveratrol Nutrition 0.000 claims description 4
- 229940016667 resveratrol Drugs 0.000 claims description 4
- 230000002207 retinal effect Effects 0.000 claims description 4
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- 229940057910 shea butter Drugs 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- 229940032094 squalane Drugs 0.000 claims description 4
- 229930003799 tocopherol Natural products 0.000 claims description 4
- 229960001295 tocopherol Drugs 0.000 claims description 4
- 235000010384 tocopherol Nutrition 0.000 claims description 4
- 239000011732 tocopherol Substances 0.000 claims description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 3
- 229940048848 lauryl glucoside Drugs 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- GFLJSOROHICWQL-KBPBESRZSA-N (2s)-2-[[(2s)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)C)CC1=CC=C(O)C=C1 GFLJSOROHICWQL-KBPBESRZSA-N 0.000 claims description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 2
- URJOWNUVTORLNY-UHFFFAOYSA-N (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC1=CC(=O)C(OC(=O)CCCCCCCCCCCCCCC)=CO1 URJOWNUVTORLNY-UHFFFAOYSA-N 0.000 claims description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 claims description 2
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical group CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 claims description 2
- CCOQPGVQAWPUPE-UHFFFAOYSA-N 4-tert-butylcyclohexan-1-ol Chemical compound CC(C)(C)C1CCC(O)CC1 CCOQPGVQAWPUPE-UHFFFAOYSA-N 0.000 claims description 2
- 229940091886 4-tert-butylcyclohexanol Drugs 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 235000019489 Almond oil Nutrition 0.000 claims description 2
- 241000242757 Anthozoa Species 0.000 claims description 2
- 241000130781 Arnebia Species 0.000 claims description 2
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 2
- SMDOOINVMJSDPS-UHFFFAOYSA-N Astragaloside Natural products C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)=C1 SMDOOINVMJSDPS-UHFFFAOYSA-N 0.000 claims description 2
- 229920002498 Beta-glucan Polymers 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims description 2
- 240000001548 Camellia japonica Species 0.000 claims description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 2
- 244000035851 Chrysanthemum leucanthemum Species 0.000 claims description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- 244000163122 Curcuma domestica Species 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Natural products CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 2
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 2
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims description 2
- 229920002079 Ellagic acid Polymers 0.000 claims description 2
- 108010058643 Fungal Proteins Proteins 0.000 claims description 2
- 239000009429 Ginkgo biloba extract Substances 0.000 claims description 2
- 229920001503 Glucan Polymers 0.000 claims description 2
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 2
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 2
- 240000000950 Hippophae rhamnoides Species 0.000 claims description 2
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims description 2
- 241001534815 Hypsizygus marmoreus Species 0.000 claims description 2
- 240000007049 Juglans regia Species 0.000 claims description 2
- 235000009496 Juglans regia Nutrition 0.000 claims description 2
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 claims description 2
- 240000000599 Lentinula edodes Species 0.000 claims description 2
- 235000001715 Lentinula edodes Nutrition 0.000 claims description 2
- 244000062730 Melissa officinalis Species 0.000 claims description 2
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- 240000007817 Olea europaea Species 0.000 claims description 2
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 claims description 2
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 2
- 244000234609 Portulaca oleracea Species 0.000 claims description 2
- 235000001855 Portulaca oleracea Nutrition 0.000 claims description 2
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 2
- 244000046146 Pueraria lobata Species 0.000 claims description 2
- 241000124033 Salix Species 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 244000044822 Simmondsia californica Species 0.000 claims description 2
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- 229930003571 Vitamin B5 Natural products 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 102100035140 Vitronectin Human genes 0.000 claims description 2
- 108010031318 Vitronectin Proteins 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 2
- 229960005305 adenosine Drugs 0.000 claims description 2
- 229930002945 all-trans-retinaldehyde Natural products 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- 239000008168 almond oil Substances 0.000 claims description 2
- 229940069521 aloe extract Drugs 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229960000271 arbutin Drugs 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229940067599 ascorbyl glucoside Drugs 0.000 claims description 2
- 235000013793 astaxanthin Nutrition 0.000 claims description 2
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 2
- 229940022405 astaxanthin Drugs 0.000 claims description 2
- 239000001168 astaxanthin Substances 0.000 claims description 2
- QMNWISYXSJWHRY-XWJCTJPOSA-N astragaloside Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)C4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)CC3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-XWJCTJPOSA-N 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- 229940105847 calamine Drugs 0.000 claims description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 2
- 229960002079 calcium pantothenate Drugs 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000013869 carnauba wax Nutrition 0.000 claims description 2
- 239000004203 carnauba wax Substances 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 229940059958 centella asiatica extract Drugs 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 229940074979 cetyl palmitate Drugs 0.000 claims description 2
- 235000019480 chamomile oil Nutrition 0.000 claims description 2
- 239000010628 chamomile oil Substances 0.000 claims description 2
- 229940074992 chondrus crispus extract Drugs 0.000 claims description 2
- 235000019868 cocoa butter Nutrition 0.000 claims description 2
- 229940110456 cocoa butter Drugs 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 235000018597 common camellia Nutrition 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 235000003373 curcuma longa Nutrition 0.000 claims description 2
- 229940073499 decyl glucoside Drugs 0.000 claims description 2
- 229940105990 diglycerin Drugs 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 2
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 235000004132 ellagic acid Nutrition 0.000 claims description 2
- 229960002852 ellagic acid Drugs 0.000 claims description 2
- 229960003720 enoxolone Drugs 0.000 claims description 2
- 229940035423 ethyl ether Drugs 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 235000008524 evening primrose extract Nutrition 0.000 claims description 2
- 239000010475 evening primrose oil Substances 0.000 claims description 2
- 229940089020 evening primrose oil Drugs 0.000 claims description 2
- 235000001785 ferulic acid Nutrition 0.000 claims description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 2
- 229940114124 ferulic acid Drugs 0.000 claims description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 2
- 229910003472 fullerene Inorganic materials 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 229940068052 ginkgo biloba extract Drugs 0.000 claims description 2
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims description 2
- 229940107131 ginseng root Drugs 0.000 claims description 2
- 125000005456 glyceride group Chemical group 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229940072008 glycyrrhiza glabra extract Drugs 0.000 claims description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 2
- 235000002532 grape seed extract Nutrition 0.000 claims description 2
- 229940087603 grape seed extract Drugs 0.000 claims description 2
- 239000008169 grapeseed oil Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 229910052864 hemimorphite Inorganic materials 0.000 claims description 2
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims description 2
- 235000020721 horse chestnut extract Nutrition 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims description 2
- 229960004705 kojic acid Drugs 0.000 claims description 2
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 229940099690 malic acid Drugs 0.000 claims description 2
- 229960001855 mannitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- 229940060184 oil ingredients Drugs 0.000 claims description 2
- 229940114496 olive leaf extract Drugs 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 2
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
- 210000003668 pericyte Anatomy 0.000 claims description 2
- 229920002643 polyglutamic acid Polymers 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- YRJKYHIIYRGTCC-UHFFFAOYSA-M potassium;2-hydroxy-4-methoxybenzoate Chemical compound [K+].COC1=CC=C(C([O-])=O)C(O)=C1 YRJKYHIIYRGTCC-UHFFFAOYSA-M 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 235000020944 retinol Nutrition 0.000 claims description 2
- 229960003471 retinol Drugs 0.000 claims description 2
- 239000011607 retinol Substances 0.000 claims description 2
- 229960000342 retinol acetate Drugs 0.000 claims description 2
- 239000011770 retinyl acetate Substances 0.000 claims description 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 2
- 235000019173 retinyl acetate Nutrition 0.000 claims description 2
- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 229940084801 salvia miltiorrhiza root extract Drugs 0.000 claims description 2
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 claims description 2
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 235000020238 sunflower seed Nutrition 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims description 2
- 229960000401 tranexamic acid Drugs 0.000 claims description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 235000009492 vitamin B5 Nutrition 0.000 claims description 2
- 239000011675 vitamin B5 Substances 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 239000001717 vitis vinifera seed extract Substances 0.000 claims description 2
- 239000000341 volatile oil Substances 0.000 claims description 2
- 235000020234 walnut Nutrition 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- 235000014692 zinc oxide Nutrition 0.000 claims description 2
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 claims description 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 abstract description 5
- 239000000853 adhesive Substances 0.000 abstract description 3
- 230000001070 adhesive effect Effects 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 85
- 239000000047 product Substances 0.000 description 27
- 239000000499 gel Substances 0.000 description 16
- 239000000017 hydrogel Substances 0.000 description 16
- 239000012528 membrane Substances 0.000 description 14
- 206010040954 Skin wrinkling Diseases 0.000 description 12
- 230000037303 wrinkles Effects 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 6
- 210000003739 neck Anatomy 0.000 description 6
- 206010052428 Wound Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 235000020945 retinal Nutrition 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 4
- 230000032683 aging Effects 0.000 description 4
- 229910001424 calcium ion Inorganic materials 0.000 description 4
- 229910001425 magnesium ion Inorganic materials 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000002313 adhesive film Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 108010025899 gelatin film Proteins 0.000 description 3
- 238000001879 gelation Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- AEMOLEFTQBMNLQ-AZLKCVHYSA-N (2r,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-AZLKCVHYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 229920000447 polyanionic polymer Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- AEMOLEFTQBMNLQ-SYJWYVCOSA-N (2s,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-SYJWYVCOSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940069978 calcium supplement Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000012875 nonionic emulsifier Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a double-agent unidirectional slow-release skin repairing film and a preparation method and application thereof. The repair film includes a skin care base and a crosslinking agent. The skin-care matrix is smeared on the surface of skin, the cross-linking agent is sprayed, gel films with different densities can be formed on the surface of the smeared matrix layer, and the density degree of the films can be adjusted according to different skin requirements and environments, so that multiple purposes are realized. The double-agent unidirectional slow-release skin repairing film prepared by the invention has good antibacterial activity, skin-friendly property and biocompatibility, has wide application range, can be used for medical treatment such as wound dressing, and can also be used for skin care such as facial mask, hand film, neck film, and the like, and can achieve the purpose of skin repairing. The thickness, size, shape and air permeability of the double-agent unidirectional slow-release skin repairing film prepared by the invention can be regulated and controlled according to the individual requirements of users, and the action time is controllable. Meanwhile, the adhesive is soft and close to the skin, and after the adhesive is used, the substrate directly contacted with the skin is easy to uncover without tearing.
Description
Technical Field
The invention relates to the field of cosmetics and medicines, in particular to a double-agent unidirectional slow-release skin repairing film and a preparation method and application thereof.
Background
The hydrogel is a material with a three-dimensional cross-linked network structure formed by hydrophilic molecules through physical or chemical cross-linking, and is hydrophilic and insoluble in water. Hydrogel materials have good biocompatibility and biodegradability, and have recently gained wide attention in many fields such as biomedical, environmental hygiene, cosmetics, and food industries due to their excellent properties.
Hydrogels are currently used in the medical field primarily as medical dressings. The hydrogel dressing can keep the wound surface moist and continuously absorb the exudate of the wound surface as the functional wound surface dressing. Some hydrogels formed from biodegradable polymers can be degraded in time to avoid secondary damage when changing dressings. More importantly, the hydrogel dressing can be endowed with various excellent performances through structural design and functional integration, and further plays an important role in each process of wound healing. The hydrogel dressing has the advantages of high transparency, short gelation time, excellent swelling performance, wide raw material source, simple process, safety and no toxicity, and has good development and application prospects. If the hydrogel is applied to the field of skin care, the hydrogel has the advantages of softness, skin-sticking, good adjustability, convenience in use and the like.
Sodium alginate is a natural polysaccharide and is widely used in the preparation of hydrogels due to its good biocompatibility. Sodium alginate is a by-product obtained after extracting iodine and mannitol from brown algae such as kelp or Sargassum, and its molecules are composed of beta-D-mannuronic acid (M) and alpha-L-guluronic acid (alpha-L-guluronic acid, G) linked by a (1 → 4) linkage. Sodium alginate contains a large amount of-COO－The polyanion behavior can be shown in aqueous solution, and the polyanion has good water solubility, biocompatibility, viscosity and gel property. Carboxymethyl chitosan is a water-soluble chitosan derivative, is widely applied in the preparation process of hydrogel, and contains cations (-NH) on the molecular chain3+) A radical, which in turn contains an anion (-COO)－) The group has the characteristics of strong antibacterial property, good biocompatibility and the like. The sodium alginate and the carboxymethyl chitosan both have biocompatibility and biodegradability, are beneficial to tissue repair, and have wide application prospects in the aspect of skin repair.
It is worth mentioning that for sodium alginate and carboxymethyl chitosan, both of them can be cross-linked with divalent cations (such as calcium and magnesium ions) to form hydrogel, and the calcium and magnesium ions are also essential nutrients for skin. The normal concentration gradient of calcium ions in the epidermis layer of the skin is an important standard for maintaining the health of the skin, and calcium chloride is used as a skin calcium supplement agent, has a good percutaneous permeation and absorption effect, and is beneficial to promoting the recovery of the barrier function of sensitive skin and damaged skin. Magnesium ions have strong anti-inflammatory and soothing effects, can be combined with water to influence the proliferation and differentiation of epidermis and promote the renewal of skin cells, and magnesium chloride is helpful for soothing and repairing sensitive skin. If the sodium alginate and the carboxymethyl chitosan are crosslinked with calcium ions and magnesium ions, the sodium alginate and the carboxymethyl chitosan can be gelatinized on the surface of the skin to form a gel film, which has a certain effect on maintaining the good state of the skin.
Based on the method, the mixed solution of sodium alginate and carboxymethyl chitosan is used as a skin care matrix, various functional components are introduced according to requirements, the skin care matrix is smeared on the action part of the skin, and calcium chloride and/or magnesium chloride aqueous solution serving as a cross-linking agent is sprayed to form gel films with different densities on the surface of the smeared matrix layer. The formed gel film has controllable size and shape, is convenient to use and can meet various skin care requirements. The application range of the film can be changed along with the difference of the compactness of the film, the film with high compactness can be used for medical treatment such as wound dressing, and the film with lower compactness can be used for skin care such as facial mask, hand mask, neck mask, and the like. The double-agent unidirectional slow-release skin repairing film prepared by the invention is green, environment-friendly, soft and skin-attached, has good adjustability and convenient use, and has wide application prospect if being applied to the aspect of skin repairing.
Disclosure of Invention
The invention aims to provide a double-agent unidirectional slow-release skin repairing film, and aims to provide a preparation method and application of the double-agent unidirectional slow-release skin repairing film.
In order to achieve the purpose, the invention adopts the following specific technical scheme:
the double-agent unidirectional slow-release skin repair film is a double-agent type, so that the convenience of use of the product is ensured. The double agent comprises a skin care matrix and a cross-linking agent.
The skin-care matrix comprises the following components in percentage by mass:
sodium alginate: 0.3% -4.0%;
carboxymethyl chitosan: 0.3% -4.0%;
the functional components are as follows: 0.001% -12.0%;
the balance of deionized water;
the cross-linking agent comprises the following components in percentage by mass:
calcium chloride: 0.4% -1.0% and/or magnesium chloride: 0.4% -1.0%;
the balance being deionized water.
Further preferably, the double-agent unidirectional slow-release skin repair film comprises a skin care matrix and a cross-linking agent.
The skin-care matrix comprises the following components in percentage by mass:
sodium alginate: 0.3% -3.6%;
carboxymethyl chitosan: 0.3% -3.6%;
glyceryl polyether-26: 8.0% -12.0%;
other functional components: 0.001% -10.0%;
the balance of deionized water;
the cross-linking agent comprises the following components in percentage by mass:
calcium chloride: 0.4% -1.0% and/or magnesium chloride: 0.4% -1.0%;
the balance being deionized water.
More preferably, the skin care matrix comprises the following components in percentage by mass:
sodium alginate: 1.6% -3.6%;
carboxymethyl chitosan: 0.3% -2.4%;
glyceryl polyether-26: 9.0% -11.0%;
other functional components: 0.1% -8.0%;
the balance of deionized water;
the cross-linking agent comprises the following components in percentage by mass:
calcium chloride: 0.5% -1.0% and/or magnesium chloride: 0.5% -1.0%;
the balance being deionized water.
The double-agent unidirectional slow-release skin repairing film is prepared by the following steps:
(1) dissolving the sodium alginate and the carboxymethyl chitosan in the ratio into deionized water, and stirring to completely dissolve the sodium alginate and the carboxymethyl chitosan;
(2) adding the functional components into the mixed solution of sodium alginate and carboxymethyl chitosan at a proper temperature, and stirring or homogenizing to uniformly mix;
(3) dissolving a proper amount of calcium chloride and/or magnesium chloride in deionized water;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on an action part, spraying a cross-linking agent, and forming gel films with different densities on the surface of the coated matrix layer.
The amount range of sodium alginate and carboxymethyl chitosan used in the present invention is determined according to solubility and viscosity. The experimental result shows that when the concentration of the two is lower, the viscosity is lower, the adhesive force on the surface of the skin is weak, and the fixation on the target part of the skin is not facilitated; if the concentration is higher, the viscosity of the solution is higher, which is not favorable for spreading on the skin surface. Therefore, the invention selects sodium alginate: 0.3% -4.0%, carboxymethyl chitosan: 0.3% -4.0%, preferably sodium alginate: 0.3% -3.6%, carboxymethyl chitosan: 0.3 to 3.6 percent. The range of the effective components is determined by comprehensively referring to the conventional dosage and the influence on the viscosity of the system.
The cross-linking agent in the invention has the function of generating chemical bonds between the linear molecules of the sodium alginate and the carboxymethyl chitosan, so that the linear molecules are mutually connected to form a net structure. Therefore, after the sodium alginate, the carboxymethyl chitosan and the cross-linking agent are cross-linked, the formed film has good flexibility and adjustable density. If the concentration of the cross-linking agent is increased, the density of the film is increased, and conversely, if the concentration of the cross-linking agent is reduced, the density of the film is reduced. The research and experiment results show that when the concentration of the cross-linking agent is too high, the hydrogel is easy to break, and when the concentration is too low, the cross-linking time is too long. Therefore, the amount of the cross-linking agent is selected from the following components: 0.5% -1.0% and/or magnesium chloride: 0.5 to 1.0 percent.
Furthermore, in the two-agent unidirectional slow-release skin repair film, the skin care matrix further comprises an emulsifier; such emulsifiers include, but are not limited to, lauryl glucoside, decyl glucoside, polysorbate-80, and the like.
Further, the crosslinking agent includes, but is not limited to, calcium chloride, magnesium chloride, and the like.
The invention also provides a preparation method of the double-agent unidirectional slow-release skin repairing film, which comprises the following steps:
(1) dissolving sodium alginate and carboxymethyl chitosan in deionized water, and stirring to completely dissolve the sodium alginate and carboxymethyl chitosan;
(2) adding the functional components into the mixed solution of sodium alginate and carboxymethyl chitosan at a proper temperature, and stirring or homogenizing to uniformly mix;
(3) dissolving a proper amount of calcium chloride and/or magnesium chloride in deionized water;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on an action part, spraying a cross-linking agent, and forming gel films with different densities on the surface of the coated matrix layer.
Further, in the step (1), sodium alginate and carboxymethyl chitosan are dissolved in deionized water, uniformly stirred and heated to 75-80 ℃.
Further, the functional components in the step (2) are water-soluble, and if the functional components are high-temperature resistant, the functional components are directly added into the mixed solution and uniformly stirred; if the functional components are not high temperature resistant, adding the functional components after the mixed solution is cooled to room temperature.
Further, the functional component in the step (2) is oil-soluble, and after the emulsifier and the functional component are uniformly mixed, the emulsifier and the functional component are added into the mixed solution for homogenizing and emulsifying.
Furthermore, the emulsifier is preferably a nonionic emulsifier. At the moment, the oil drops are wrapped by hydrogel formed by sodium alginate and carboxymethyl chitosan, and the double-agent unidirectional slow-release skin repairing film is substantially in a hydrogel oil-in-water structure.
Further, in the step (3), calcium chloride and/or magnesium chloride are dissolved in deionized water at the temperature of 75-80 ℃, and are uniformly stirred and cooled to room temperature for later use.
Further, in the step (4), the skin-care matrix mixture obtained in the step (2) is coated on an action part, a cross-linking agent is sprayed, gel films with different densities are formed on the surface of the coated matrix layer, the thickness, the size, the shape and the air permeability of the gel films can be regulated and controlled according to the individual needs of users, and the action time is controllable.
Further, the functional components are one or more of moisturizing, anti-inflammatory, whitening, anti-aging, repairing and anti-allergy;
the moisturizing functional component is selected from one or more of natural moisturizers or synthetic moisturizers; natural humectants include, but are not limited to, xylitol, sorbitol, sodium hyaluronate, sodium PCA, panthenol, polyglutamic acid, betaine, trehalose, aloe extract, olive fruit oil, shea butter, camellia seed oil, jojoba seed oil, walnut seed oil, shiitake seed oil, shea butter, carnauba wax, olive oil, almond oil, and the like; synthetic humectants include, but are not limited to, glycerin, 1, 2-propanediol, diglycerin, 1, 3-propanediol, dipropylene glycol, 1, 3-butanediol, glyceryl polyether-26, glyceryl glucoside, hydrogenated lecithin, and the like;
the anti-inflammatory functional ingredients comprise but are not limited to glycyrrhiza glabra, dipotassium glycyrrhizinate, glycyrrhetinic acid, centella asiatica extract, gorgonia angustifolia extract, willow bark, horse chestnut extract, curcuma longa root, hypsizygus marmoreus, resveratrol, ferulic acid, beta glucan, avenin, tripeptide-1 copper, acetyl dipeptide-1 cetyl palmitate, panthenol (vitamin B5), 4-tert-butylcyclohexanol, arnebia oil and the like;
the whitening functional ingredients include but are not limited to arbutin, ascorbic acid, vitamin C ethyl ether, sodium ascorbyl phosphate, ascorbyl glucoside, kojic acid, kojic dipalmitate, glycolic acid, tartaric acid, azelaic acid, glycyrrhiza glabra extract, marguerite extract, nicotinamide, sunflower seed oil, ellagic acid, tranexamic acid, potassium methoxysalicylate, dipropylbiphenyl glycol and the like;
the anti-aging functional ingredients comprise but are not limited to tocopherol (vitamin E), tocopherol sodium phosphate, sodium hyaluronate, fullerene, ectoin, vitronectin, grape seed extract, resveratrol, retinol, nano retinal, adenosine, retinol acetate, ginkgo biloba extract, phytosterol, ceramide, ginseng root extract, grape seed oil, evening primrose oil, cocoa butter, chamomile oil, melissa officinalis essential oil, squalane, malic acid, astaxanthin, victory peptide and the like;
the repairing functional components include, but are not limited to, azelaic acid, glycine, calamine mixture, salicylic acid, Chondrus crispus extract, mannitol, ammonium glycyrrhizinate, hydrogenated coconut oil glycerides, kudzu root extract, hydrolyzed yeast protein, EGF pericyte growth factor, etc.;
the anti-allergy functional ingredients include but are not limited to allantoin, astragaloside, purslane, scutellaria, paeoniflorin, olive leaf extract, OPC glucan A, sea buckthorn oil, biological carbohydrate gum, salvia miltiorrhiza root extract and the like.
The invention also provides application of the double-agent unidirectional slow-release skin repairing film in skin repairing.
The double-agent unidirectional slow-release skin repair film prepared by the invention can adjust the compactness of the film according to different skin requirements and environments of users, thereby realizing different purposes. When the membrane is used for medical aspects such as wound dressing and the like, the compactness of the membrane can be selectively improved, and a completely airtight membrane is formed to isolate the pollution of the external environment; when the skin care mask is used for skin care such as facial masks, neck masks and the like, the compactness of the mask can be reduced, a semi-breathable film is formed, and the skin has a good breathable environment and can be isolated from pollution of the external environment.
The invention has the beneficial technical effects that:
1. the double-agent unidirectional slow-release skin repair film prepared by the invention consists of two parts, and the outside of the film can not only lock water but also avoid the pollution of outside air by virtue of gelation; the hydrogel is arranged inside the film, so that water can be retained, and different requirements can be met by introducing different functional components.
2. The double-agent unidirectional slow-release skin repair film prepared by the invention can realize unidirectional slow release, and the density of the film can be controlled by adjusting the amount of the cross-linking agent. The thickness, size and shape of the film can be regulated according to the individual requirements of users, and the action time is controllable.
3. The double-agent unidirectional slow-release skin repair film prepared by the invention is of a double-agent type, is soft and close to the skin, and is convenient to use. After the skin-care matrix is smeared on the surface of skin, the cross-linking agent is sprayed, gel films with different densities can be formed on the surface of the smeared matrix layer, and the matrix directly contacted with the skin is easy to uncover without tearing.
4. The double-agent unidirectional slow-release skin repair film prepared by the invention has the advantages of strong flexibility, mild skin friendliness, no toxic or irritant component, no preservative and environmental friendliness, and has wide application prospect in the aspect of skin repair. The method has the advantages of simple operation, mild preparation conditions, low cost, environmental protection and no environmental pollution.
5. The invention also solves the problem of long time for dissolving the sodium alginate and the carboxymethyl chitosan. Since sodium alginate and carboxymethyl chitosan are high molecular polymers and take a long time to completely dissolve, the dissolution of sodium alginate and carboxymethyl chitosan is promoted by stirring in the invention.
Drawings
Fig. 1 is an internal microstructure of a skin care matrix of a two-agent unidirectional sustained release skin repair film.
Fig. 2 shows the soft skin-contacting property of the two-dose unidirectional slow-release skin care films according to examples 1 and 2 of the present invention (a represents example 1, and b represents example 2).
Fig. 3 is a double-agent unidirectional slow-release skin repairing film which is soft, close to the skin, controllable in size and remarkable in effect.
Fig. 4 is a picture of the efficacy of the two-dose unidirectional slow release skin-repairing film used as an eye mask in example 2 of the present invention (a is before use, b is after 15 min).
Fig. 5 is a picture of the efficacy of the two-agent unidirectional slow release skin care film used as a neck mask in example 3 of the present invention (a is before use, b is after 15min use).
Fig. 6 shows that the density of the outer gel layer of the bi-agent unidirectional slow-release skin repair membrane is controllable and the air permeability is adjustable (a is a membrane with lower density and semi-permeability, and b is a membrane with high density and air impermeability).
Fig. 7 shows the skin moisturizing condition of the volunteers after 60min using the two-dose unidirectional sustained-release skin-repairing film of example 1.
Fig. 8 shows that the gelation degree of the external gel layer of the double-dose unidirectional slow-release skin repair film is controllable.
Detailed Description
The present invention is described in more detail below with reference to examples. These examples are merely illustrative of the best mode of carrying out the invention and do not limit the scope of the invention in any way.
[ example 1 ]
(1) Weighing sodium alginate and carboxymethyl chitosan, respectively dissolving the sodium alginate and the carboxymethyl chitosan in deionized water, wherein the mass percentage of the sodium alginate and the carboxymethyl chitosan are respectively 3.6 percent and 0.4 percent, uniformly stirring the mixture at room temperature, and heating the mixture to 80 ℃;
(2) directly adding the high-temperature-resistant water-soluble functional component into the mixed liquid obtained in the step (1), and stirring and uniformly mixing. The selected functional components are glycerol polyether-26 and glycerol glucoside, and the added mass percentage contents are 10.0 percent and 2.0 percent respectively;
(3) dissolving calcium chloride in deionized water at 80 ℃, adding 0.5% by mass, uniformly stirring, and cooling to room temperature for later use;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on the skin action part, and spraying the cross-linking agent calcium chloride solution obtained in the step (3) to form gel films with different densities on the surface of the coated matrix layer.
The obtained product is a transparent film with good flexibility, has the characteristics of softness and skin-close (as shown in figure 2a), is non-toxic and non-irritant, and has excellent moisturizing performance. The skin-care matrix is smeared on a required position, and a compact film is rapidly formed on the surface of the matrix layer after the cross-linking agent is sprayed, so that the film has good air permeability and can be pasted for a long time. And the use is convenient, the substrate directly contacted with the skin is easy to uncover, and the tearing feeling is avoided.
And (3) evaluating the efficacy:
6 volunteers were recruited for testing, and no other skin care products with moisturizing effect could be applied on the day of the test. The fixed area is selected on the face for testing, and the moisture content of the stratum corneum before and after the product is used is compared, so that the moisture content of the stratum corneum after the product is smeared is increased to 2-3 times before the product is used. And the volunteers reflect that the double-agent unidirectional slow-release skin repairing film of the invention is soft and skin-friendly (as shown in figure 3), has adjustable size and thickness, excellent moisturizing performance and more delicate skin after use, and the product is transparent and has good aesthetic property.
[ example 2 ]
(1) Weighing sodium alginate and carboxymethyl chitosan, respectively dissolving the sodium alginate and the carboxymethyl chitosan in deionized water, wherein the mass percentage of the sodium alginate and the carboxymethyl chitosan are respectively 3.2 percent and 0.8 percent, stirring the mixture evenly at room temperature, and heating the mixture to 80 ℃;
(2) directly adding the high-temperature-resistant water-soluble functional components of glyceryl polyether-26 and glyceryl glucoside into the mixed solution obtained in the step (1), and uniformly stirring. After the mixed solution is cooled to room temperature, adding water-soluble functional ingredient nano retinaldehyde, and uniformly stirring. The mass percentage of the glycerol polyether-26, the glycerol glucoside and the nano retinal are respectively 10.0 percent, 2.0 percent and 1.0 percent;
(3) dissolving calcium chloride in deionized water at 80 ℃, adding 0.5% by mass, uniformly stirring, and cooling to room temperature for later use;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on the skin action part, and spraying the cross-linking agent calcium chloride solution obtained in the step (3) to form gel films with different densities on the surface of the coated matrix layer.
The obtained product is a yellow transparent adhesive film with good flexibility, is soft and skin-adhered (as shown in figure 2 b), has good moisturizing performance and can also play a role in resisting aging. When in use, the skin-care matrix is smeared on a required position, and a compact gel film is rapidly formed on the surface of the matrix layer after the cross-linking agent is sprayed, so that the skin-care matrix can be pasted for a long time. And the use is convenient, the substrate directly contacted with the skin is easy to uncover, and the tearing feeling is avoided. And (3) evaluating the efficacy:
10 volunteers were recruited to perform experiments, and the double-dose unidirectional slow-release skin repair membrane is applied to eyes to be used as an eye mask, and the thickness and the size of the membrane can be adjusted according to requirements. After 15min, the volunteers had a significant reduction in the eye crow's feet (as shown in table 1 below). The growth area of the fishtail line of the volunteers before and after the product is used is compared to find that the product can effectively lighten the wrinkles of the eyes (as shown in figure 4), and the skin of the eyes is smoother without irritation to the eyes. According to the reflection of volunteers, the product has no uncomfortable feeling after being used for eyes, has good effects of softening and sticking skin, removing wrinkles and resisting aging, and has good aesthetic property because the product is yellow and transparent.
| Area of wrinkle growth region/mm2 | Area ratio of wrinkle growth region to selected region | |
| Before | 34.4 | 8.06％ |
| After | 21.62 | 5.15％ |
TABLE 1
[ example 3 ]
(1) Weighing sodium alginate and carboxymethyl chitosan, respectively dissolving the sodium alginate and the carboxymethyl chitosan in deionized water, wherein the mass percentage of the sodium alginate and the carboxymethyl chitosan are respectively 2.8 percent and 1.2 percent, uniformly stirring the mixture at room temperature, and heating the mixture to 80 ℃;
(2) directly adding high-temperature-resistant water-soluble functional components of glyceryl polyether-26 and glyceryl glucoside into the mixed solution obtained in the step (1), and uniformly stirring to obtain a mixed solution A; mixing the high-temperature-resistant oil-soluble functional component squalane and emulsifier lauryl glucoside, heating to 80 ℃, and uniformly mixing to obtain a mixed solution B. And adding the mixed solution B into the mixed solution A for homogenizing and emulsifying to obtain the skin-care matrix mixture. The addition percentage of the glycerol polyether-26, the glycerol glucoside, the squalane and the emulsifier is respectively 10.0 percent, 2.0 percent, 1.0 percent and 0.5 percent;
(3) dissolving calcium chloride in deionized water at 80 ℃, adding 0.5% by mass, uniformly stirring, and cooling to room temperature for later use;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on the skin action part, and spraying the cross-linking agent calcium chloride solution obtained in the step (3) to form gel films with different densities on the surface of the coated matrix layer.
The obtained product is a semitransparent sticking film with good flexibility, is soft and skin-sticking, is non-toxic and non-irritant, has good moisturizing performance, and can achieve the effects of resisting aging and removing wrinkles after being used for a long time. When in use, the skin-care matrix is smeared on a required position, and a compact film is rapidly formed on the surface of the matrix layer after the cross-linking agent is sprayed. And can be applied for a long time, is convenient to use, and the matrix directly contacted with the skin is easy to uncover without tearing.
And (3) evaluating the efficacy:
10 volunteers were recruited for the experiment and a two-dose unidirectional slow release skin repair membrane was used as a cervical membrane to act on the necks of the volunteers. The gel layer outside the membrane can lock water, and the effective components inside the membrane are slowly absorbed by the skin. After 15min, the wrinkles on the neck of the volunteer are obviously reduced, and the acting part is obviously white and glossy. The neck of volunteers before and after the product is used is compared to find that the product can effectively lighten wrinkles (as shown in figure 5) and has certain moisturizing performance. And the volunteers reflect that the product is soft and skin-sticking, the thickness and the size of the film are controllable, the action time is also controllable, and the wrinkle removing effect is obvious.
[ example 4 ]
(1) Weighing sodium alginate and carboxymethyl chitosan, respectively dissolving the sodium alginate and the carboxymethyl chitosan in deionized water, wherein the mass percentage of the sodium alginate and the carboxymethyl chitosan are respectively 3.2 percent and 0.8 percent, uniformly stirring the mixture at room temperature, and heating the mixture to 78 ℃;
(2) directly adding the high-temperature-resistant water-soluble functional component into the mixed liquid obtained in the step (1), and uniformly stirring. The selected functional components are glycerol polyether-26, glycerol glucoside and 1, 3-propylene glycol, and the added mass percentage contents are 10.0%, 2.0% and 3.0% respectively;
(3) dissolving calcium chloride in deionized water at 78 ℃, adding 0.5% by mass, uniformly stirring, and cooling to room temperature for later use;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on the skin action part, and spraying the crosslinking agent magnesium chloride solution obtained in the step (3) to form gel films with different densities on the surface of the coated matrix layer.
The obtained product is a transparent adhesive film with good flexibility, is soft and skin-adhering, has good moisturizing performance, and can achieve the effects of skin tendering and moisturizing after being adhered for a long time. When in use, the skin-care matrix is smeared on a required position, and a compact film is formed on the surface of the skin-care matrix layer after the cross-linking agent is sprayed. Can be applied for a long time, and the film has adjustable thickness, controllable size and shape, easy uncovering of the substrate directly contacted with the skin, and no tearing feeling.
And (3) evaluating the efficacy:
6 volunteers were recruited for the experiment and a two-dose unidirectional slow release skin rejuvenating film was applied to the face of the volunteer. The gel layer outside the membrane can lock water, and the effective components inside the membrane are slowly absorbed by the facial skin. The water content value of the stratum corneum of the face of the volunteer before and after the product is smeared by comparison can be found, and the water content of the stratum corneum is in an ascending trend after the product is used, which shows that the product has good moisturizing performance. And the volunteers reflect that the product is soft and close to the skin, the size and the shape of the film are controllable, and the action time is also controllable.
[ example 5 ]
(1) Weighing sodium alginate and carboxymethyl chitosan, respectively dissolving the sodium alginate and the carboxymethyl chitosan in deionized water, wherein the mass percentage of the sodium alginate and the carboxymethyl chitosan are respectively 3.0 percent and 1.0 percent, uniformly stirring the mixture at room temperature, and heating the mixture to 80 ℃;
(2) directly adding the high-temperature-resistant water-soluble functional components of glyceryl polyether-26 and glyceryl glucoside into the mixed solution obtained in the step (1), and uniformly stirring. After the mixed solution is cooled to room temperature, adding water-soluble functional ingredient nano retinaldehyde, and uniformly stirring. The mass percentage of the glycerol polyether-26, the glycerol glucoside and the nano retinal are respectively 10.0 percent, 2.0 percent and 1.0 percent;
(3) dissolving calcium chloride and magnesium chloride in deionized water at 80 ℃, adding the calcium chloride and the magnesium chloride in an amount of 0.5 percent and 0.5 percent respectively by mass, stirring uniformly, and cooling to room temperature for later use;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on the skin action part, and spraying the cross-linking agent calcium chloride and magnesium chloride mixed solution obtained in the step (3) to form gel films with different densities on the surface of the coated matrix layer.
The obtained product is a yellow adhesive film with good flexibility, is soft and skin-sticking, not only has good moisturizing performance, but also has the functions of removing wrinkles and resisting aging. When in use, the skin-care matrix is smeared on a required position, and a compact film is formed on the surface of the matrix layer after the cross-linking agent is sprayed, so that the skin-care matrix has good air permeability and can be pasted for a long time. And the thickness and the size of the film are controllable, and the substrate directly contacted with the skin is easy to uncover without tearing.
And (3) evaluating the efficacy:
10 volunteers were recruited for the experiment, and the double-dose unidirectional sustained-release skin repair film was applied to the eyes of the volunteers as an eye mask. After 15min, a significant reduction in the fishtail lines in the eyes of the volunteers was observed. The area of the fishtail line growing area of the volunteers before and after the product is used is compared to find that the product can effectively lighten the wrinkles, and the eye skin is more tender and has no irritation to the eye skin. According to the reflection of volunteers, the product is soft and skin-sticking, has no uncomfortable feeling to the skin around the eyes when in use, has good wrinkle removing and anti-aging effects, and has good aesthetic property because the product is yellow and transparent.
Compounding test research:
in the invention, after the sodium alginate and the carboxymethyl chitosan are compounded, the carboxymethyl chitosan has antibacterial property, so that no preservative is required to be additionally added. And the part directly contacted with the skin is a network interpenetrating structure of the two, and the network interpenetrating structure ensures that the material has the advantages of both inorganic materials such as toughness and high molecular materials such as elasticity. Therefore, after the sodium alginate and the carboxymethyl chitosan are compounded, the flexibility of the product is better. By controlling the variation method, only the ratio between sodium alginate and carboxymethyl chitosan is changed, and the change of the gelling time after spraying the cross-linking agent in different systems is examined (as shown in the following table 2). The results show that the gelling time is shorter when the sodium alginate content of the system is higher.
Table 2.
Claims (10)
1. The double-agent unidirectional slow-release skin repairing film is characterized by comprising a skin protecting matrix and a cross-linking agent;
the skin care matrix comprises the following components in percentage by mass:
sodium alginate: 0.3% -4.0%;
carboxymethyl chitosan: 0.3% -4.0%;
the functional components are as follows: 0.001% -12.0%;
the balance of deionized water;
the cross-linking agent comprises the following components in percentage by mass:
calcium chloride: 0.4% -1.0% and/or magnesium chloride: 0.4% -1.0%;
the balance being deionized water.
The double-agent unidirectional slow-release skin repairing film is prepared by the following steps:
(1) dissolving the sodium alginate and the carboxymethyl chitosan in the ratio into deionized water, and stirring to completely dissolve the sodium alginate and the carboxymethyl chitosan;
(2) adding the functional components into the mixed solution of sodium alginate and carboxymethyl chitosan at a proper temperature, and stirring or homogenizing to uniformly mix;
(3) dissolving a proper amount of calcium chloride and/or magnesium chloride in deionized water;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on an action part, spraying a cross-linking agent, and forming gel films with different densities on the surface of the coated matrix layer.
2. The two-agent unidirectional slow release skin repair film of claim 1, wherein the skin care matrix further comprises an emulsifier; such emulsifiers include, but are not limited to, lauryl glucoside, decyl glucoside, polysorbate-80, and the like.
3. The two-dose unidirectional slow-release skin-repairing film according to claim 1, wherein the functional ingredients are one or more of moisturizing, anti-inflammatory, whitening, anti-aging, repairing and anti-allergy;
the moisturizing functional component is selected from one or more of natural moisturizers or synthetic moisturizers; natural humectants include, but are not limited to, xylitol, sorbitol, sodium hyaluronate, sodium PCA, panthenol, polyglutamic acid, betaine, trehalose, aloe extract, olive fruit oil, shea butter, camellia seed oil, jojoba seed oil, walnut seed oil, shiitake seed oil, shea butter, carnauba wax, olive oil, almond oil, and the like; synthetic humectants include, but are not limited to, glycerin, 1, 2-propanediol, diglycerin, 1, 3-propanediol, 1, 3-butanediol, glyceryl polyether-26, glyceryl glucoside, hydrogenated lecithin, and the like;
the anti-inflammatory functional ingredients comprise but are not limited to glycyrrhiza glabra, dipotassium glycyrrhizinate, glycyrrhetinic acid, centella asiatica extract, gorgonia angustifolia extract, willow bark, horse chestnut extract, curcuma longa root, hypsizygus marmoreus, resveratrol, ferulic acid, beta glucan, avenin, tripeptide-1 copper, acetyl dipeptide-1 cetyl palmitate, panthenol (vitamin B5), 4-tert-butylcyclohexanol, arnebia oil and the like;
the whitening functional ingredients include but are not limited to arbutin, ascorbic acid, vitamin C ethyl ether, sodium ascorbyl phosphate, ascorbyl glucoside, kojic acid, kojic dipalmitate, glycolic acid, tartaric acid, azelaic acid, glycyrrhiza glabra extract, marguerite extract, nicotinamide, sunflower seed oil, ellagic acid, tranexamic acid, potassium methoxysalicylate, dipropylbiphenyl glycol and the like;
the anti-aging functional ingredients comprise but are not limited to tocopherol (vitamin E), tocopherol sodium phosphate, sodium hyaluronate, fullerene, ectoin, vitronectin, grape seed extract, resveratrol, retinol, nano retinal, adenosine, retinol acetate, ginkgo biloba extract, phytosterol, ceramide, ginseng root extract, grape seed oil, evening primrose oil, cocoa butter, chamomile oil, melissa officinalis essential oil, squalane, malic acid, astaxanthin, victory peptide and the like;
the repairing functional components include, but are not limited to, azelaic acid, glycine, calamine mixture, salicylic acid, Chondrus crispus extract, mannitol, ammonium glycyrrhizinate, hydrogenated coconut oil glycerides, kudzu root extract, hydrolyzed yeast protein, EGF pericyte growth factor, etc.;
the anti-allergy functional ingredients include but are not limited to allantoin, astragaloside, purslane, scutellaria, paeoniflorin, olive leaf extract, OPC glucan A, sea buckthorn oil, biological carbohydrate gum, salvia miltiorrhiza root extract and the like.
4. A method for preparing the two-dose unidirectional slow release skin care film according to any one of claims 1 to 3, which comprises the following steps:
(1) dissolving sodium alginate and carboxymethyl chitosan in deionized water, and stirring to completely dissolve the sodium alginate and carboxymethyl chitosan;
(2) adding the functional components into the mixed solution of sodium alginate and carboxymethyl chitosan at a proper temperature, and stirring or homogenizing to uniformly mix;
(3) dissolving a proper amount of calcium chloride and/or magnesium chloride in deionized water;
(4) and (3) coating the skin-care matrix mixture obtained in the step (2) on an action part, spraying a cross-linking agent, and forming gel films with different densities on the surface of the coated matrix layer.
5. The method for preparing the two-dose unidirectional slow-release skin-repairing film according to claim 4, wherein the sodium alginate and the carboxymethyl chitosan are dissolved in the deionized water in the step (1), uniformly stirred and heated to 75-80 ℃.
6. The method for preparing a two-dose unidirectional slow-release skin-care film according to claim 4, wherein the functional ingredient is water-soluble in the step (2), and if the functional ingredient is resistant to high temperature, the functional ingredient is directly added into the mixed solution and stirred uniformly; if the functional components are not high temperature resistant, adding the functional components after the mixed solution is cooled to room temperature.
7. The method for preparing a two-dose unidirectional slow-release skin-care film according to claim 4, wherein the functional ingredient is oil-soluble in step (2), and the emulsifying agent and the functional ingredient are uniformly mixed and then added to the mixed solution for homogeneous emulsification.
8. The method for preparing the two-dose unidirectional slow-release skin-repairing film according to claim 4, wherein in the step (3), the calcium chloride and/or the magnesium chloride are/is dissolved in the deionized water at 75-80 ℃, and are stirred uniformly and cooled to room temperature for later use.
9. The method for preparing the dual-agent unidirectional slow-release skin-care film as claimed in claim 4, wherein in the step (4), the skin-care matrix mixture obtained in the step (2) is coated on an action part, a cross-linking agent is sprayed, gel films with different densities are formed on the surface of the coated matrix layer, the thickness, size, shape and air permeability of the gel films can be controlled according to individual needs of users in a targeted manner, and the action time is controllable.
10. Use of a two-dose unidirectional slow release skin repair film according to any of claims 1 to 3 for skin repair; the repairing film can be used for medical treatment such as wound dressing, and skin care such as facial mask, hand mask and neck mask, and can achieve the purpose of skin repairing: such as moisturizing, acne removing, whitening, wound repairing, etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111226044.2A CN114010532A (en) | 2021-10-21 | 2021-10-21 | Double-agent unidirectional slow-release skin repairing film and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111226044.2A CN114010532A (en) | 2021-10-21 | 2021-10-21 | Double-agent unidirectional slow-release skin repairing film and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114010532A true CN114010532A (en) | 2022-02-08 |
Family
ID=80057038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111226044.2A Pending CN114010532A (en) | 2021-10-21 | 2021-10-21 | Double-agent unidirectional slow-release skin repairing film and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114010532A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115813816A (en) * | 2022-09-16 | 2023-03-21 | 江苏集萃功能材料研究所有限公司 | Mild gel mask and application thereof |
| CN115813802A (en) * | 2022-09-19 | 2023-03-21 | 江苏集萃功能材料研究所有限公司 | Cleaning gel mask |
| CN115836986A (en) * | 2022-09-16 | 2023-03-24 | 江苏集萃功能材料研究所有限公司 | Anti-allergy and relieving gel mask and preparation method and application thereof |
| CN116019729A (en) * | 2022-09-16 | 2023-04-28 | 江苏集萃功能材料研究所有限公司 | Acne-removing gel mask and preparation process thereof |
| KR102548087B1 (en) * | 2022-10-26 | 2023-06-28 | 주식회사 비아르랩 | Method for preparing a cosmetic composition for skin moisturizing, soothing and barrier strengthening containing ectoin, and cosmetic composition prepared therefof |
| CN116531275A (en) * | 2023-07-04 | 2023-08-04 | 北京青颜博识健康管理有限公司 | Microcapsule for relieving high-concentration vitamin C ethyl ether stimulation and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10258992A1 (en) * | 2002-12-19 | 2004-07-08 | Beisel, Günther | Pad used for dermatological applications comprises carrier material based on polymer, particularly alginic acid |
| CN101338036A (en) * | 2007-07-06 | 2009-01-07 | 舒晓正 | Biocompatible quick-gelatinizing hydrogels and method for preparing spray thereof |
| US20140200196A1 (en) * | 2013-01-17 | 2014-07-17 | Thomas Barrows | Hydrogel Tattoo Protection and Aftercare System |
| CN105709269A (en) * | 2016-03-01 | 2016-06-29 | 浙江大学 | Natural polymer liquid spray for wound protection |
| CN106492260A (en) * | 2016-12-22 | 2017-03-15 | 青岛琛蓝海洋生物工程有限公司 | A kind of alginate based aquagel dressing and preparation method thereof |
| CN110755365A (en) * | 2019-06-19 | 2020-02-07 | 江苏拓弘康恒医药有限公司 | Hydrogel based on mesenchymal stem cell exosomes and preparation method of spray thereof |
-
2021
- 2021-10-21 CN CN202111226044.2A patent/CN114010532A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10258992A1 (en) * | 2002-12-19 | 2004-07-08 | Beisel, Günther | Pad used for dermatological applications comprises carrier material based on polymer, particularly alginic acid |
| CN101338036A (en) * | 2007-07-06 | 2009-01-07 | 舒晓正 | Biocompatible quick-gelatinizing hydrogels and method for preparing spray thereof |
| US20140200196A1 (en) * | 2013-01-17 | 2014-07-17 | Thomas Barrows | Hydrogel Tattoo Protection and Aftercare System |
| CN105709269A (en) * | 2016-03-01 | 2016-06-29 | 浙江大学 | Natural polymer liquid spray for wound protection |
| CN106492260A (en) * | 2016-12-22 | 2017-03-15 | 青岛琛蓝海洋生物工程有限公司 | A kind of alginate based aquagel dressing and preparation method thereof |
| CN110755365A (en) * | 2019-06-19 | 2020-02-07 | 江苏拓弘康恒医药有限公司 | Hydrogel based on mesenchymal stem cell exosomes and preparation method of spray thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张劲峰;郝建波;张劲鹏;罗波;刘鹏;: "生物敷料的研究进展" * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115813816A (en) * | 2022-09-16 | 2023-03-21 | 江苏集萃功能材料研究所有限公司 | Mild gel mask and application thereof |
| CN115836986A (en) * | 2022-09-16 | 2023-03-24 | 江苏集萃功能材料研究所有限公司 | Anti-allergy and relieving gel mask and preparation method and application thereof |
| CN116019729A (en) * | 2022-09-16 | 2023-04-28 | 江苏集萃功能材料研究所有限公司 | Acne-removing gel mask and preparation process thereof |
| CN115813816B (en) * | 2022-09-16 | 2024-05-28 | 江苏集萃功能材料研究所有限公司 | Mild gel mask and application thereof |
| CN115813802A (en) * | 2022-09-19 | 2023-03-21 | 江苏集萃功能材料研究所有限公司 | Cleaning gel mask |
| KR102548087B1 (en) * | 2022-10-26 | 2023-06-28 | 주식회사 비아르랩 | Method for preparing a cosmetic composition for skin moisturizing, soothing and barrier strengthening containing ectoin, and cosmetic composition prepared therefof |
| CN116531275A (en) * | 2023-07-04 | 2023-08-04 | 北京青颜博识健康管理有限公司 | Microcapsule for relieving high-concentration vitamin C ethyl ether stimulation and preparation method and application thereof |
| CN116531275B (en) * | 2023-07-04 | 2023-10-13 | 北京青颜博识健康管理有限公司 | Microcapsule for relieving high-concentration vitamin C ethyl ether stimulation and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114010532A (en) | Double-agent unidirectional slow-release skin repairing film and preparation method and application thereof | |
| EP2253665B1 (en) | Freeze-dried composition | |
| CN106176286B (en) | Hyaluronic acid skin nursing film and preparation method and application | |
| WO2010143196A1 (en) | Novel synergistic transparent / translucent hydrogel composition; method of preparing it and a sheet / film made thereform | |
| US20030113356A1 (en) | Cosmetic devices | |
| CN104736136A (en) | Cosmetic or pharmaceutical moisturising ingredient | |
| US20100221306A1 (en) | Adhesive gel sheet for living organisms and sheet form cosmetics comprising the same | |
| EP2270082B1 (en) | Alginate-containing porous shaped mouldings | |
| KR101032125B1 (en) | Method for producing porous moulded bodies containing alginate | |
| CN109998937B (en) | Cosmetic series containing glycerol glucoside (alpha GG) and preparation method thereof | |
| CN107303253A (en) | It is a kind of to be used to be damaged renovation agent of skin and preparation method thereof | |
| CN114224779A (en) | Eye repair composition and application thereof | |
| CN112656740A (en) | Preparation method and application of dressing containing ginseng extract | |
| CN112716830A (en) | Starch-based skin repairing film and preparation method thereof | |
| US20060198805A1 (en) | Cosmetic and Pharmaceutical Masks for Skin Improvement | |
| EP3666259A1 (en) | Foamable aqueous compositions based on biopolymeres having use-flexible gas storage cell distribution | |
| CN109700747A (en) | A kind of skin care compositions and preparation method thereof with skin repair function | |
| CN109199923A (en) | A kind of atomizing sleep mask and preparation method thereof | |
| Baptista et al. | Bacterial polysaccharides: cosmetic applications | |
| EP1551373B1 (en) | Use of molded bodies for external application | |
| KR20090080647A (en) | Cosmetic composition containing herb extract for skin moisturizing effect and for enhancing skin elasticity | |
| WO2009032325A1 (en) | Shaped items containing a human pheromone component | |
| CN112386531A (en) | Gleditsia sinensis oligosaccharide mask and preparation method thereof | |
| US11612557B1 (en) | Lyophilic colloids | |
| RU2780260C1 (en) | Cosmetic for skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220208 |
|
| RJ01 | Rejection of invention patent application after publication |