CN113939518A - 作为激酶抑制剂的稠合三环化合物 - Google Patents
作为激酶抑制剂的稠合三环化合物 Download PDFInfo
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- CN113939518A CN113939518A CN202080020962.7A CN202080020962A CN113939518A CN 113939518 A CN113939518 A CN 113939518A CN 202080020962 A CN202080020962 A CN 202080020962A CN 113939518 A CN113939518 A CN 113939518A
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- C07F9/02—Phosphorus compounds
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- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Abstract
一类含有三环杂芳基化合物。具体地,提供了如下式(I)所示结构的化合物、含有式(I)化合物的药物组合物及所述化合物,以及这些化合物的同位素衍生物,手性异构体,变构体,不同的盐,前药,制剂等等。式(I)化合物能够有效抑制蛋白激酶(包括EGFR、EGFR(C797S)、ALK、和HPK1等),从而起到治疗各种肿瘤的作用。
Description
PCT国内申请,说明书已公开。
Claims (1)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (7)
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CN201910199527 | 2019-03-15 | ||
CN2019101995274 | 2019-03-15 | ||
CN2019105444177 | 2019-06-21 | ||
CN201910544417 | 2019-06-21 | ||
CN202010023799 | 2020-01-09 | ||
CN2020100237991 | 2020-01-09 | ||
PCT/IB2020/052388 WO2020188467A1 (zh) | 2019-03-15 | 2020-03-16 | 作为激酶抑制剂的稠合三环化合物 |
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CN113939518A true CN113939518A (zh) | 2022-01-14 |
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US (1) | US20220153766A1 (zh) |
CN (1) | CN113939518A (zh) |
WO (1) | WO2020188467A1 (zh) |
Families Citing this family (7)
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LT3873903T (lt) | 2018-10-31 | 2024-05-10 | Gilead Sciences, Inc. | Pakeistieji 6-azabenzimidazolo junginiai, kaip hpk1 inhibitoriai |
JP7273172B2 (ja) | 2018-10-31 | 2023-05-12 | ギリアード サイエンシーズ, インコーポレイテッド | Hpk1阻害活性を有する置換6-アザベンゾイミダゾール化合物 |
EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
WO2022100688A1 (zh) * | 2020-11-13 | 2022-05-19 | 南京红云生物科技有限公司 | Hpk1激酶调节剂、其制备方法与应用 |
KR20220090443A (ko) * | 2020-12-21 | 2022-06-29 | 주식회사 비투에스바이오 | 헤테로아릴 유도체 화합물 및 이의 용도 |
CN116848103A (zh) * | 2021-04-08 | 2023-10-03 | 杭州阿诺生物医药科技有限公司 | 高活性hpk1激酶抑制剂 |
CN117865993B (zh) * | 2023-01-10 | 2024-09-27 | 杭州师范大学 | 一种aak1抑制剂及其制备和应用 |
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CN102105150A (zh) * | 2008-05-21 | 2011-06-22 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
WO2017086829A1 (ru) * | 2015-11-19 | 2017-05-26 | Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") | Дихлорацетаты замещенных n4-[2-(диметилфосфиноил) фенил]-n2-(2-метокси-4-пиперидин-1-илфенил)-5-хлорпиримидин-2,4-диаминов в качестве модуляторов alk и egfr, предназначенных для лечения рака |
WO2017118438A1 (zh) * | 2016-01-08 | 2017-07-13 | 杭州英创医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
WO2018108084A1 (zh) * | 2016-12-12 | 2018-06-21 | 杭州英创医药科技有限公司 | 一类含有三环杂芳基的化合物 |
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2020
- 2020-03-16 CN CN202080020962.7A patent/CN113939518A/zh active Pending
- 2020-03-16 US US17/439,548 patent/US20220153766A1/en active Pending
- 2020-03-16 WO PCT/IB2020/052388 patent/WO2020188467A1/zh active Application Filing
Patent Citations (4)
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CN102105150A (zh) * | 2008-05-21 | 2011-06-22 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
WO2017086829A1 (ru) * | 2015-11-19 | 2017-05-26 | Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") | Дихлорацетаты замещенных n4-[2-(диметилфосфиноил) фенил]-n2-(2-метокси-4-пиперидин-1-илфенил)-5-хлорпиримидин-2,4-диаминов в качестве модуляторов alk и egfr, предназначенных для лечения рака |
WO2017118438A1 (zh) * | 2016-01-08 | 2017-07-13 | 杭州英创医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
WO2018108084A1 (zh) * | 2016-12-12 | 2018-06-21 | 杭州英创医药科技有限公司 | 一类含有三环杂芳基的化合物 |
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