CN112891228A - Dental glaze sealing agent and preparation method and application thereof - Google Patents
Dental glaze sealing agent and preparation method and application thereof Download PDFInfo
- Publication number
- CN112891228A CN112891228A CN202110146275.6A CN202110146275A CN112891228A CN 112891228 A CN112891228 A CN 112891228A CN 202110146275 A CN202110146275 A CN 202110146275A CN 112891228 A CN112891228 A CN 112891228A
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- China
- Prior art keywords
- hydroxyapatite
- sealing agent
- dental
- dental enamel
- erythritol
- Prior art date
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- Pending
Links
- 238000007789 sealing Methods 0.000 title claims abstract description 77
- 238000002360 preparation method Methods 0.000 title abstract description 14
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 78
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 77
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 74
- 210000003298 dental enamel Anatomy 0.000 claims abstract description 71
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 40
- 239000004386 Erythritol Substances 0.000 claims abstract description 39
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 39
- 235000019414 erythritol Nutrition 0.000 claims abstract description 39
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- 239000000022 bacteriostatic agent Substances 0.000 claims description 22
- 239000003906 humectant Substances 0.000 claims description 22
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- 238000000034 method Methods 0.000 claims description 10
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 9
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- 229960002675 xylitol Drugs 0.000 claims description 5
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
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- 229940085605 saccharin sodium Drugs 0.000 claims description 4
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 4
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 claims description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 3
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- 238000009472 formulation Methods 0.000 claims description 2
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- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
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- YTBSYETUWUMLBZ-IUYQGCFVSA-N D-erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 description 1
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- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of oral care, in particular to a dental glaze sealing agent and a preparation method and application thereof; the dental enamel sealing agent comprises hydroxyapatite and erythritol, and does not contain an abrasive and fluoride; the preparation method of the dental glaze sealing agent comprises the steps of adding water into erythritol and auxiliary materials for mixing, and then adding hydroxyapatite for mixing to form paste. The application of the dental enamel sealing agent comprises the step of coating the dental enamel sealing agent on the tooth surface at the rotating speed of 100-1000 r/min. The dental enamel sealing agent disclosed by the invention can be used for well repairing damaged tooth enamel, does not cause secondary damage and does not have the risk of poisoning.
Description
Technical Field
The invention relates to the technical field of oral care, in particular to a dental glaze sealing agent and a preparation method and application thereof.
Background
Along with the improvement of living standard of people, the oral health is increasingly paid attention to, and technologies such as ultrasonic tooth cleaning, sand blasting tooth cleaning, orthodontic treatment, whitening and the like are widely applied. Although these techniques bring about very good therapeutic results, they also bring about more or less negative problems, the inevitable mechanical rubbing causing more or less damage to the enamel (e.g. roughness, demineralization or surface cracks) and causing tooth sensitivity. In addition, some people who do not pay attention to oral hygiene, such that saccharides remain in the oral cavity, are decomposed into acids, erode tooth enamel and dentin exposed on the surface, produce demineralization of enamel and dentin, and also cause damage to enamel and tooth sensitivity.
In the related art, in order to improve the problems of enamel damage and tooth sensitivity, hydroxyapatite is used for repairing enamel; however, the enamel restorative provided by the related art is not good in restoration effect, is also prone to cause secondary damage, and has a poisoning risk.
Disclosure of Invention
The invention aims to provide a dental enamel sealing agent, a preparation method and application thereof.
The invention is realized by the following steps:
in a first aspect, the present invention provides a dental enamel sealant, which comprises hydroxyapatite and erythritol as ingredients and does not contain an abrasive and fluoride.
In an alternative embodiment, the hydroxyapatite has a particle size in the range of 5nm to 50 μm.
In an alternative embodiment, the hydroxyapatite has a particle size of 5nm to 200 nm.
In an alternative embodiment, the mass content of hydroxyapatite is less than or equal to 60 wt% and the mass content of erythritol is less than or equal to 20 wt%.
In an optional embodiment, the dental enamel sealing agent further comprises auxiliary materials, and the auxiliary materials comprise at least one of a binder, a humectant, a sweetener, a bacteriostatic agent, a preservative, a perfume and a pigment.
In an alternative embodiment, the binder comprises at least one of sodium carboxymethyl cellulose, xanthan gum, thickening silica, sodium carboxymethyl cellulose, sodium polyacrylate, and cellulose gum; and/or the presence of a gas in the gas,
the humectant comprises at least one of glycerol, sorbitol, polyvinyl alcohol, polyacrylic acid and butanediol; and/or the presence of a gas in the gas,
the sweetener comprises at least one of saccharin sodium, sodium cyclamate and xylitol; and/or the presence of a gas in the gas,
the bacteriostatic agent comprises at least one of methyl p-hydroxybenzoate and cetylpyridinium chloride.
In an alternative embodiment, the dental enamel sealing agent comprises the following components in percentage by mass:
1-30 wt% of hydroxyapatite;
1-10 wt% of erythritol;
0 wt% -10 wt% of adhesive;
1 to 50 weight percent of humectant;
0 wt% -0.5 wt% of sweetening agent;
0.001 to 0.1 weight percent of bacteriostatic agent;
0.1-3 wt% of essence;
0 to 0.5 weight percent of pigment;
the balance being water.
In a second aspect, the present invention provides a method of preparing a dental enamel sealant as in any of the preceding embodiments, comprising: mixing erythritol and adjuvants with water, adding hydroxyapatite, and mixing to obtain paste.
In an alternative embodiment, hydroxyapatite is added and mixed and vacuum degassed to form a paste.
In a third aspect, the present invention provides a use of a dental enamel sealant as in any of the preceding embodiments, comprising: the dental enamel sealing agent is coated on the tooth surface under the condition that the rotating speed is 100-1000 r/min.
The invention has the following beneficial effects:
the dental enamel sealing agent of the embodiment of the invention comprises hydroxyapatite and erythritol as components, and does not contain an abrasive and fluoride. Therefore, hydroxyapatite and erythritol can be used in a combined manner to play a synergistic effect of the hydroxyapatite and the erythritol, so that the remineralization and caries prevention effects are better; moreover, the dental glaze sealing agent does not contain a friction agent, so that the friction value of the dental glaze sealing agent can be effectively reduced, the abrasion to teeth is reduced when the dental glaze sealing agent is used, and the secondary damage to the teeth can be avoided; moreover, the dental enamel sealing agent does not contain fluoride, so that the poisoning risk of mistaken swallowing can be reduced.
The preparation method and the application of the dental enamel sealing agent provided by the embodiment of the invention comprise all the beneficial effects.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a Scanning Electron Microscope (SEM) morphology of micron-sized hydroxyapatite in Experimental example 1 of the present invention;
FIG. 2 is a Scanning Electron Microscope (SEM) morphology of nano-hydroxyapatite in Experimental example 1 of the present invention;
FIG. 3 is a graph comparing the abrasiveness (RDA) of different pastes of Experimental example 2 of the present invention against teeth;
FIG. 4 is a Scanning Electron Microscope (SEM) image of the enamel surface before the enamel sealing treatment in Experimental example 4 of the present invention;
FIG. 5 is a Scanning Electron Microscope (SEM) image of the enamel surface after the enamel sealing treatment in Experimental example 4 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The features and properties of the present invention are described in further detail below.
The invention provides a dental enamel sealing agent, which comprises hydroxyapatite and erythritol and does not contain an abrasive and fluoride.
Hydroxyapatite (HAP) is the main inorganic component constituting the hard tissue of the human body, and has a content of 65% in the human skeleton, 70% in the dentin, and more 95% in the enamel. The hydroxyapatite has good biocompatibility and bioactivity. The dental application in the related art mainly has the following effects: removing dental dirt: the hydroxyapatite has very strong adsorption effect on the components of the dental calculus. Repairing the tiny scars on the surface of the tooth: the hydroxyapatite can fill micro scar, so as to make tooth surface smoother and prevent bacteria and pigment from adhering. Remineralization, repairing initial-stage decayed teeth, sealing dentinal tubule holes and preventing decayed teeth: hydroxyapatite can be deposited on the surface of teeth and remineralized.
Erythritol as a food additive (sweetener) is widely applied to industries of food, beverage, medicine and the like. Erythritol has strong inhibiting effect on streptococcus mutans, can influence sugar metabolism and acid production, and can promote salivary secretion, thereby having good anticarious effect.
The erythritol and the hydroxyapatite are used in combination, so that the erythritol and the hydroxyapatite can play a synergistic role, and a better remineralization anticarious effect can be further obtained.
In the related art, the abrasive is used in toothpaste to clean teeth, and has high friction value RDA and an abrasive effect on teeth. The dental enamel sealing agent disclosed by the invention can effectively avoid the secondary damage of the enamel caused by friction without using a friction agent.
The components of the dental enamel sealing agent do not contain fluoride, and the good biocompatibility, bioactivity and strong adsorbability of hydroxyapatite can be utilized, so that a demineralization area can be remineralized after the enamel is demineralized, and the dental caries can be prevented; because the dental enamel sealing agent does not contain fluoride, the poisoning risk caused by mistaken swallowing can be avoided.
The granularity of the hydroxyapatite in the invention is 5nm-50 μm; in a preferred embodiment, the hydroxyapatite has a particle size of from 5nm to 200 nm.
The mass content of the hydroxyapatite in the invention is less than or equal to 60 wt%, and the mass content of the erythritol is less than or equal to 20 wt%.
Optionally, the dental glaze sealing agent further comprises acceptable auxiliary materials, and the auxiliary materials comprise at least one of a binder, a humectant, a sweetener, a bacteriostatic agent, a preservative, an essence and a pigment.
Further, the binder comprises at least one of sodium carboxymethylcellulose (CMC), xanthan gum, thickening silica, sodium carboxymethylcellulose, sodium polyacrylate, and cellulose chewing gum.
The humectant includes at least one of glycerin, sorbitol, polyvinyl alcohol, polyacrylic acid, and Butylene Glycol (BG).
The sweetener comprises at least one of saccharin sodium, sodium cyclamate and xylitol.
The bacteriostatic agent comprises at least one of methyl p-hydroxybenzoate and cetylpyridinium chloride.
In a preferred embodiment, the dental enamel sealing agent comprises the following components in percentage by mass:
1-30 wt% of hydroxyapatite;
1-10 wt% of erythritol;
0 wt% -10 wt% of adhesive;
1 to 50 weight percent of humectant;
0 wt% -0.5 wt% of sweetening agent;
0.001 to 0.1 weight percent of bacteriostatic agent;
0.1-3 wt% of essence;
0 to 0.5 weight percent of pigment;
the balance being water.
The invention also provides a preparation method of the dental enamel sealing agent, which comprises the steps of mixing all the components of the dental enamel sealing agent, and then carrying out vacuum degassing to prepare a paste.
Further, the preparation method of the dental glaze sealing agent comprises the steps of adding water into erythritol and auxiliary materials for mixing, adding hydroxyapatite for mixing to form paste; the paste is prepared by adding water into auxiliary materials such as erythritol, a humectant, an adhesive, a bacteriostatic agent and the like, uniformly mixing the auxiliary materials with hydroxyapatite, and performing vacuum degassing.
Hydroxyapatite and erythritol are main functional agents of the dental glaze sealing agent, wherein the hydroxyapatite is easy to agglomerate due to the micro/nano structure, and is difficult to disperse uniformly in the gelling process so as to influence the quality of the paste; according to the preparation method disclosed by the invention, the erythritol and the auxiliary materials are uniformly mixed, and then the hydroxyapatite is added, so that the dispersing performance of the hydroxyapatite can be improved, the agglomeration of the hydroxyapatite is avoided, the prepared paste is free from the phenomena of granulation and air holes, the paste is uniform and stable in quality, and the industrialized mass production is facilitated.
The dental enamel sealing agent of the present invention may be prepared by mixing and stirring with a mixer or a paste maker.
The invention also provides application of the dental sealing glaze agent, and the dental sealing glaze agent can be used for oral care, particularly after ultrasonic tooth cleaning and/or sand blasting tooth cleaning. Coating the dental enamel sealing agent on the tooth surface at the rotating speed of 100-; in a preferred embodiment, the speed of application of the dental sealer may be 500 r/min. When the dental enamel sealing agent is applied to the tooth surface, the dental enamel sealing agent is applied at a low rotating speed, so that the dental enamel sealing agent can be uniformly and reliably applied to the tooth surface, and the tooth surface can be reliably repaired.
It should be noted that, when the dental enamel sealing agent is used for oral care, a low-speed pneumatic hand-held device, an electric motor or a root canal motor (root canal preparation machine) can be selected, a brush head is installed, and the dental enamel sealing agent is dipped and smeared on the tooth surface at a low rotating speed of 100 plus 1000 r/min.
It should be further noted that, alternatively, the oral care may refer to daily tooth brushing care, and the user may choose to use an electric toothbrush or manually apply the dental enamel sealing agent of the present invention to the tooth surface, and the usage is similar to toothpaste, or directly as toothpaste.
The present invention will be described in detail below with specific examples.
Example 1
Mixing 60 wt% of hydroxyapatite with 20 wt% of water in balance; wherein the particle size of the hydroxyapatite is 5nm-50 μm.
Example 2
Mixing 55 wt% of hydroxyapatite with 18 wt% of water in balance; wherein the particle size of the hydroxyapatite is 5nm-200 nm.
Example 3
The dental glaze sealing agent comprises the following components in percentage by mass: 30 wt% of hydroxyapatite, 10 wt% of erythritol, 10 wt% of adhesive, 1 wt% of humectant, 0.5 wt% of sweetening agent, 0.1 wt% of bacteriostatic agent, 0.1 wt% of essence and the balance of water.
Adding erythritol, adhesive, humectant, sweetener, bacteriostatic agent, essence and water into a stirrer, mixing, adding hydroxyapatite, mixing, and vacuum degassing to obtain paste.
Wherein the particle size of the hydroxyapatite is 5nm-50 μm; the adhesive is sodium carboxymethyl cellulose (CMC); the humectant is glycerol; the sweetener is saccharin sodium; the bacteriostatic agent is methyl p-hydroxybenzoate.
The prepared dental sealing glaze agent is smeared on the brush head of the low-speed pneumatic hand phone and is smeared on the tooth surface at the low rotating speed of 100 r/min.
Example 4
The dental glaze sealing agent comprises the following components in percentage by mass: 1 wt% of hydroxyapatite, 1 wt% of erythritol, 8 wt% of adhesive, 50 wt% of humectant, 0.3 wt% of sweetening agent, 0.001 wt% of bacteriostatic agent, 3 wt% of essence, 0.5 wt% of pigment and the balance of water.
Adding erythritol, adhesive, humectant, sweetener, bacteriostatic agent, essence, pigment and water into a stirrer, mixing, adding hydroxyapatite, mixing, and vacuum degassing to obtain paste.
Wherein the particle size of the hydroxyapatite is 5nm-200 nm; the adhesive is xanthan gum and thickening silica; the humectant is sorbitol and polyvinyl alcohol; the sweetening agent is sodium cyclohexylamine sulfonate; the bacteriostatic agent is cetyl pyridinium chloride.
The prepared dental glaze sealing agent is smeared on a brush head connected with an electric motor and is smeared on the tooth surface at a low rotating speed of 1000 r/min.
Example 5
The dental glaze sealing agent comprises the following components in percentage by mass: 25 wt% of hydroxyapatite, 5 wt% of erythritol, 30 wt% of humectant, 0.1 wt% of sweetener, 0.008 wt% of bacteriostatic agent, 0.8 wt% of essence and the balance of water.
Adding erythritol, humectant, sweetener, bacteriostatic agent, essence and water into a stirrer, mixing, adding hydroxyapatite, mixing, and vacuum degassing to obtain paste.
Wherein the average particle size of the hydroxyapatite is 100 nm; the humectant is polyacrylic acid and butanediol; the sweetener is xylitol; the bacteriostatic agent is methyl p-hydroxybenzoate and cetylpyridinium chloride.
The prepared dental sealing glaze agent is smeared on the brush head of a root canal motor (root canal preparation machine) and is smeared on the tooth surface at a low rotating speed of 500 r/min.
Example 6
The dental glaze sealing agent comprises the following components in percentage by mass: 5 wt% of hydroxyapatite, 5 wt% of erythritol, 5 wt% of an adhesive, 45 wt% of a humectant, 0.05 wt% of a bacteriostatic agent, 2 wt% of essence, 0.1 wt% of a pigment, 0.5 wt% of a preservative, and the balance of water.
Adding erythritol, adhesive, humectant, bacteriostatic agent, essence, pigment, antiseptic and water into a stirrer, mixing, adding hydroxyapatite, mixing, and vacuum degassing to obtain paste.
Wherein the particle size of the hydroxyapatite is 200nm-20 μm; the adhesive is carboxymethylcellulose sodium, sodium polyacrylate and cellulose chewing gum; the humectant is glycerol and sorbitol; the bacteriostatic agent is methyl p-hydroxybenzoate.
The prepared dental sealing glaze agent is smeared on the brush head of the low-speed pneumatic hand phone and is smeared on the tooth surface at the low rotating speed of 300 r/min.
The advantageous effects of the dental enamel sealing agent of the present invention will be described in detail below in experimental examples.
Experimental example 1: to illustrate the effect of the hydroxyapatite powder size (micro-scale and nano-scale) and mass ratio in the glaze encapsulation agent on the performance of the glaze encapsulation agent. The scanning electron microscope topography of the micron-sized hydroxyapatite is shown in figure 1, and the scanning electron microscope topography of the hydroxyapatite with the average particle size of nanometer-sized hydroxyapatite is shown in figure 2. Set 6 formulas in table 1 and prepare 6 groups of glaze sealers. The appearance, PH, flatulence and stability of the paste of each set of glaze sealants were measured separately, and the results are shown in table 2.
Table 1: formula of glaze sealing agent
The preparation method of the dental enamel sealing agent comprises the following steps:
s1, weighing erythritol, sodium carboxymethylcellulose, xanthan gum, thickening silicon dioxide, BG, xylitol and cetyl pyridinium chloride, adding water, uniformly mixing, and swelling into a gel liquid for later use;
s2, adding hydroxyapatite, mint essence and titanium dioxide, and stirring at 1000rpm for 30 min;
s3, degassing in vacuum to form a paste;
and S4, filling.
Table 2: effect of hydroxyapatite powder size and mass ratio on glaze sealer Performance
According to the results in table 2, it can be seen that the paste of micron-sized hydroxyapatite is coarser, and as the addition ratio increases, the paste is coarser, and even the solid-liquid separation phenomenon occurs. And for nano-grade hydroxyapatite, the paste is relatively fine and smooth, and the solid-liquid separation phenomenon is avoided. When the fifth group of nano-hydroxyapatite with the mass proportion of about 5-25% is adopted, the paste has the best quality.
Experimental example 2: radiation of dentin abrasionThe radio active teeth abrasion (RDA) experiment is a standard method for internationally detecting the influence of tooth abrasion of the paste. Irradiating the dentin with gamma rays to generate radioactive nuclide phosphorus32And P. Then, the test paste was homogenized and brushed for 1500 times on a vertical brushing machine. The influence of the toothpaste on the dentin abrasion can be analyzed by measuring the activity of the radionuclide phosphorus in the paste homogenate. 3 groups of samples were prepared and assigned as invention group, control group, and control group 2.
Wherein the invention group is the third group in table 1. The control group replaced 50% of the hydroxyapatite in the third group of formulations in table 1 with calcium carbonate, i.e. the control group contained an equal amount of a mixture of hydroxyapatite and calcium carbonate. Control 2 was a commercially available plain hydroxyapatite toothpaste.
The abrasiveness (RDA) of the different pastes was tested to characterize the extent of damage to the teeth using the method described above, and the results are shown in figure 3. As can be seen from fig. 3, the RDA value of the inventive group is much lower than that of the commercially available hydroxyapatite toothpaste, and the abrasion degree to the teeth is significantly reduced. On the one hand, benefits from the absence of the addition of high RDA value frictionizers; on the other hand, the particles of the hydroxyapatite are spherical, the surface is smooth and round, and the abrasion to teeth is reduced.
Experimental example 3 (in vitro remineralization experiment of enamel artificial early caries) this experiment investigated the in vitro remineralization efficacy of enamel artificial early caries using erythritol in combination with hydroxyapatite in dental enamel sealer using a Quantitative Light-induced fluorescence (QLF) method. The inventive group was added with erythritol and hydroxyapatite at the same time (i.e., the third group in table 2), and the control group contained no erythritol and the same components. 20g of dental sealing glaze paste is taken, 40ml of purified water is added, and the mixture is uniformly stirred to prepare toothpaste slurry. 14 specimens were prepared by cutting in-vitro human teeth longitudinally, coating the enamel surface with nail polish and windowing 2X 3mm2Then, the mixture was immersed in a home-made demineralizing liquid at 37 ℃. The formula of the demineralizing liquid is 10mMKH2 PO4(ii) a 50mM lactic acid; 100mM NaCl, pH 4.0-5.0. 5 days later, preparing a sample of early carious lesion with demineralization under the surface layer; samples were randomly divided into 2 groups of 7.After nail polish is removed, each specimen is respectively soaked in 3mL of toothpaste slurry, 1 time each in the morning and afternoon every day, and 3 minutes each time; after soaking, the resulting solution was rinsed twice with 1.5ml of deionized water and then stored in simulated mouth Saliva (SOF) at 37 ℃ (specific components: 137.35mM NaCl, 0.90mM CaCl)2、3.01mM KCl、7.17mM K2HPO4·3H2O、4.17mM NaHCO3、1.53mM MgCl2·6H2O、20.00mM HCl、0.51mM Na2SO4And Tris to pH 7.0) for 14 days. QLF images of all specimens were taken on days 3, 7, and 14 of the treatment, respectively. Placing the specimen at 10mW/cm2And under the purple blue light of 290-450 nm, a machine head with a built-in micro CCD camera passes through a 520nm high-pass filter, and the image is shot and stored by adopting software (QLF probability 3.0) carried by the system. The amount of lesion fluorescence loss (F) was calculated using methods known in the literature (de Josselin de Jong E, SundstromF, Westerling Het al. CariesRes 1995, 29: 2-7.). Lesion area (mm)2) The fluorescence loss in the lesion area is greater than 5%. Δ Q (%, mm)2) The product of the lesion area and the amount of fluorescence lost. Δ Q corresponds to the total amount of mineral loss in the lesion as measured by longitudinal apparent microsoft radiography techniques, and a decrease in Δ Q indicates lesion remineralization. The results for Δ Q are shown in table 3; it can be seen that for the erythrose alcohol + hydroxyapatite group, Δ Q decreased from the initial 108 to 14.2 with a variation as high as 93.8; whereas the hydroxyapatite group decreased from the initial 106 to 28.9 with a change of only 77.1. Therefore, the erythritol and the hydroxyapatite are combined to play a synergistic effect, and the remineralization and caries prevention effects are better.
Table 3: delta Q parameter changes in the enamel specimens of the erythrol alcohol + hydroxyapatite group and the hydroxyapatite group
Experimental example 4 (tooth body external sealing glaze experiment): in order to determine the glazing effect of the dental glazing agent, the isolated dog teeth are sampled by a hot-insert sample machine, polished and polished by silicon carbide water sand paper with the granularity of 80, 200, 400, 1000 and 2000 respectively until the surface is bright and flat, polished and polished by polishing paper, and ultrasonically cleaned for 3min in deionized water for later use, so as to obtain a sample with exposed dentin pores (a typical picture is shown in figure 4). Appropriate samples of dental enamel were selected and randomly divided into 2 groups of 5 each. Enamel specimens were treated 3 times per day.
The treatment method comprises the following steps:
the sealing operation was performed using a commercially available electric motor with the most preferred dental sealer (i.e., group five) prepared in experimental example 1. The rotating speed is set to be 500r/min, and the glaze sealing time is 10 s. And after the glaze sealing is finished, cleaning and drying by ultrasonic waves, and after the surface of the sample is sprayed with gold, performing SEM characterization analysis on the enamel surface repairing condition by a scanning field emission electron microscope. The results are shown in FIG. 5.
As can be seen in fig. 4, the exposed dentinal pores on the tooth surface are clearly visible without the use of the enamel sealing agent. As can be seen from FIG. 5, after the use of the enamel sealing agent, the tooth surface has been covered with a restorative protective layer and the dentinal pores have been substantially closed. The comparison proves that the enamel sealing agent has the capabilities of quickly sealing dentinal tubules, repairing enamel damage and reducing tooth sensitivity, and can meet the expected application.
In conclusion, the dental enamel sealing agent prepared by the preparation method can jointly use hydroxyapatite and erythritol, and the synergistic effect of the hydroxyapatite and the erythritol is exerted, so that the remineralization and caries prevention effects are better; moreover, the dental glaze sealing agent does not contain a friction agent, so that the friction value of the dental glaze sealing agent can be effectively reduced, the abrasion to teeth is reduced when the dental glaze sealing agent is used, and the secondary damage to the teeth can be avoided; moreover, the dental enamel sealing agent does not contain fluoride, so that the poisoning risk of mistaken swallowing can be reduced.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A dental enamel sealing agent is characterized in that the ingredients of the dental enamel sealing agent comprise hydroxyapatite and erythritol, and the dental enamel sealing agent does not contain an abrasive agent and fluoride.
2. The dental enamel sealing agent according to claim 1, wherein the hydroxyapatite has a particle size of 5nm to 50 μm.
3. The dental enamel sealing agent according to claim 2, wherein the hydroxyapatite has a particle size of 5nm to 200 nm.
4. The dental enamel sealing agent according to claim 1, wherein the mass content of the hydroxyapatite is less than or equal to 60 wt%, and the mass content of the erythritol is less than or equal to 20 wt%.
5. The dental enamel sealing agent according to claim 1, further comprising an auxiliary material, wherein the auxiliary material comprises at least one of a binder, a humectant, a sweetener, a bacteriostatic agent, a preservative, a perfume and a pigment.
6. The dental enamel formulation of claim 5, wherein the binder comprises at least one of sodium carboxymethylcellulose, xanthan gum, thickening silica, sodium carboxymethylcellulose, sodium polyacrylate, and cellulose gum; and/or the presence of a gas in the gas,
the humectant comprises at least one of glycerin, sorbitol, polyvinyl alcohol, polyacrylic acid and butanediol; and/or the presence of a gas in the gas,
the sweetening agent comprises at least one of saccharin sodium, sodium cyclamate and xylitol; and/or the presence of a gas in the gas,
the bacteriostatic agent comprises at least one of methyl p-hydroxybenzoate and cetylpyridinium chloride.
7. The dental enamel sealing agent according to claim 5, wherein the dental enamel sealing agent comprises the following components in percentage by mass:
1-30 wt% of hydroxyapatite;
1-10 wt% of erythritol;
0 wt% -10 wt% of the adhesive;
1-50 wt% of the humectant;
0 wt% -0.5 wt% of sweetening agent;
0.001 to 0.1 weight percent of bacteriostatic agent;
0.1-3 wt% of essence;
0 to 0.5 weight percent of pigment;
the balance being water.
8. A method for preparing a dental sealer according to any one of claims 5 to 7, comprising: and adding water into the erythritol and the auxiliary materials for mixing, and then adding the hydroxyapatite for mixing to form paste.
9. The method of claim 8, comprising: adding the hydroxyapatite, mixing, and vacuum degassing to obtain the paste.
10. Use of a dental sealer according to any of claims 1-7, comprising: the dental enamel sealing agent is coated on the tooth surface at the rotating speed of 100-1000 r/min.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114196312A (en) * | 2021-12-29 | 2022-03-18 | 苏州嘉乐威新材料股份有限公司 | Environment-friendly water-based paint and preparation method thereof |
| WO2023058512A1 (en) * | 2021-10-07 | 2023-04-13 | 株式会社西尾 | Surface treatment kit for teeth |
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